ES2098928T3 - Catalizadores de oxazaborolidina enantioselectivos. - Google Patents
Catalizadores de oxazaborolidina enantioselectivos.Info
- Publication number
- ES2098928T3 ES2098928T3 ES94910502T ES94910502T ES2098928T3 ES 2098928 T3 ES2098928 T3 ES 2098928T3 ES 94910502 T ES94910502 T ES 94910502T ES 94910502 T ES94910502 T ES 94910502T ES 2098928 T3 ES2098928 T3 ES 2098928T3
- Authority
- ES
- Spain
- Prior art keywords
- enantioselectivos
- reduction
- oxazaborolidine
- oxazaborolidine catalyst
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- BDOLXPFAFMNDOK-UHFFFAOYSA-N oxazaborolidine Chemical compound B1CCON1 BDOLXPFAFMNDOK-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003054 catalyst Substances 0.000 title 1
- 238000006722 reduction reaction Methods 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0201—Oxygen-containing compounds
- B01J31/0211—Oxygen-containing compounds with a metal-oxygen link
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds
- B01J31/0252—Nitrogen containing compounds with a metal-nitrogen link, e.g. metal amides, metal guanidides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0271—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds also containing elements or functional groups covered by B01J31/0201 - B01J31/0231
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/12—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
- B01J31/14—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides of aluminium or boron
- B01J31/146—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides of aluminium or boron of boron
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/022—Boron compounds without C-boron linkages
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/60—Reduction reactions, e.g. hydrogenation
- B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Abstract
LA REDUCCION DE BORANO ENANTIOSELECTIVA DE CETONAS PROQUIRALES PARA OBTENER ALCOHOLES OPTICAMENTE PUROS SE CONSIGUE DE FORMA EFECTIVA REALIZANDO LA REDUCCION EN PRESENCIA DE CANTIDADES CATALIZADORAS DE LAS NUEVAS Y VALIOSAS COMPOSICIONES DE OXAZABOROLIDINA DE FORMULA (I) Y (II). LAS COMPOSICIONES DE FORMULA (I) Y (II) PUEDEN AISLARSE Y PURIFICARSE DE FORMA PREVIA A SU UTILIZACION EN LAS REACCIONES DE REDUCCION O EN LOS COMPUESTOS DE FORMULAS (I) Y (II) Y PUEDEN GENERARSE IN SITU.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6189593A | 1993-05-14 | 1993-05-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2098928T3 true ES2098928T3 (es) | 1997-05-01 |
Family
ID=22038846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94910502T Expired - Lifetime ES2098928T3 (es) | 1993-05-14 | 1994-04-12 | Catalizadores de oxazaborolidina enantioselectivos. |
Country Status (20)
Country | Link |
---|---|
US (2) | US6005133A (es) |
EP (1) | EP0698028B1 (es) |
JP (1) | JP2706851B2 (es) |
KR (1) | KR0180262B1 (es) |
CN (1) | CN1048498C (es) |
AT (1) | ATE149171T1 (es) |
AU (1) | AU674067B2 (es) |
CA (1) | CA2161969C (es) |
DE (1) | DE69401813T2 (es) |
DK (1) | DK0698028T3 (es) |
ES (1) | ES2098928T3 (es) |
FI (1) | FI108297B (es) |
GR (1) | GR3022924T3 (es) |
IL (1) | IL109563A (es) |
MY (1) | MY111215A (es) |
NO (1) | NO302822B1 (es) |
NZ (1) | NZ262945A (es) |
TW (1) | TW416958B (es) |
WO (1) | WO1994026751A1 (es) |
ZA (1) | ZA943295B (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2302651A1 (es) * | 2006-05-10 | 2008-07-16 | Chemagis Ltd. | Proceso para preparacion de montelukast y precursores del mismo. |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU659929B2 (en) * | 1992-05-14 | 1995-06-01 | Pfizer Inc. | Enantioselective oxazaborolidine catalysts |
GB9420616D0 (en) * | 1994-10-12 | 1994-11-30 | Merck Sharp & Dohme | Method, compositions and use |
US5840746A (en) * | 1993-06-24 | 1998-11-24 | Merck Frosst Canada, Inc. | Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases |
US5495054A (en) * | 1994-05-31 | 1996-02-27 | Sepracor, Inc. | Tetrahydroindeno[1,2-D][1,3,2]oxazaboroles and their use as enantioselective catalysts |
EP0713848B1 (en) * | 1994-10-28 | 1999-09-08 | SUMIKA FINE CHEMICALS Company, Limited | Process for producing optically active carbinols |
DE19506021C1 (de) * | 1995-02-22 | 1996-06-27 | Forschungszentrum Juelich Gmbh | Verfahren zur enantioselektiven Reduktion von Ketonen mit chemischen Katalysatoren |
DE19857765A1 (de) * | 1998-12-15 | 2000-06-21 | Clariant Gmbh | Verfahren zur Herstellung von para-Oxadiazolyl-phenyl-boronsäuren |
KR100375571B1 (ko) * | 1999-11-25 | 2003-03-15 | 조병태 | 광학 활성 알파-술폰옥시알코올, 이의 제조 방법 및 이를이용한 광학 활성 에폭사이드 화합물의 제조 방법 |
US6509472B2 (en) * | 2000-09-11 | 2003-01-21 | Schering Corporation | 4-Cyclohexyl-1,3,2-oxazaborolidine chiral accessories |
US7109345B1 (en) | 2003-02-07 | 2006-09-19 | Margarita Ortiz-Marciales | Efficient and convenient procedure for the synthesis of B-alkylated oxazaborolidines derived from ephedrine and norephedrine |
FR2860795B1 (fr) * | 2003-10-09 | 2006-04-07 | Ppg Sipsy | Procede de preparation in situ de composes chiraux derives de complexes d'oxazaborolidine-borane utiles dans les reactions de reduction asymetrique |
FR2860794B1 (fr) | 2003-10-09 | 2006-02-03 | Ppg Sipsy | Procede de preparation in situ de composes chiraux derives de complexes d'oxazaborolidine-borane utiles dans les reactions de reduction asymetrique |
SG155231A1 (en) * | 2005-06-13 | 2009-09-30 | Basf Ag | Process for synthesis of dialkoxyorganoboranes |
US20080200672A1 (en) * | 2005-08-30 | 2008-08-21 | Margarita Ortiz-Marciales | Highly enantioselective carbonyl reduction with borane catalyzed by chiral spiroborate esters derived from chiral beta-aminoalcohols |
RU2009102149A (ru) * | 2006-06-26 | 2010-08-10 | Басф Се (De) | Комплексы боран-простой эфир |
CN105061225B (zh) * | 2015-08-07 | 2017-03-08 | 辽宁科技大学 | 一种双手性氨基醇化合物及其制备方法和应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3137723A (en) * | 1961-09-25 | 1964-06-16 | Olin Mathieson | Boron containing heterocyclic compounds and process for producing them |
JPS6118790A (ja) * | 1984-07-05 | 1986-01-27 | Sumitomo Chem Co Ltd | 光学活性ボラン錯体およびその製造法 |
US4943635A (en) * | 1987-08-27 | 1990-07-24 | President & Fellows Of Harvard College | Enantioselective reduction of ketones |
AU660701B2 (en) * | 1991-07-22 | 1995-07-06 | Pfizer Inc. | Process for the preparation of intermediates in the synthesis of chiral thiazolidine-2,4-dione derivatives |
AU659929B2 (en) * | 1992-05-14 | 1995-06-01 | Pfizer Inc. | Enantioselective oxazaborolidine catalysts |
-
1994
- 1994-03-05 TW TW083101923A patent/TW416958B/zh not_active IP Right Cessation
- 1994-04-12 CN CN94192064A patent/CN1048498C/zh not_active Expired - Fee Related
- 1994-04-12 JP JP6518440A patent/JP2706851B2/ja not_active Expired - Fee Related
- 1994-04-12 NZ NZ262945A patent/NZ262945A/en unknown
- 1994-04-12 WO PCT/IB1994/000066 patent/WO1994026751A1/en active IP Right Grant
- 1994-04-12 KR KR1019950705071A patent/KR0180262B1/ko not_active IP Right Cessation
- 1994-04-12 ES ES94910502T patent/ES2098928T3/es not_active Expired - Lifetime
- 1994-04-12 AT AT94910502T patent/ATE149171T1/de not_active IP Right Cessation
- 1994-04-12 EP EP94910502A patent/EP0698028B1/en not_active Expired - Lifetime
- 1994-04-12 DK DK94910502.7T patent/DK0698028T3/da active
- 1994-04-12 DE DE69401813T patent/DE69401813T2/de not_active Expired - Fee Related
- 1994-04-12 AU AU62896/94A patent/AU674067B2/en not_active Ceased
- 1994-04-12 CA CA002161969A patent/CA2161969C/en not_active Expired - Fee Related
- 1994-05-05 IL IL10956394A patent/IL109563A/xx not_active IP Right Cessation
- 1994-05-12 MY MYPI94001194A patent/MY111215A/en unknown
- 1994-05-13 ZA ZA943295A patent/ZA943295B/xx unknown
- 1994-05-13 FI FI942240A patent/FI108297B/fi not_active IP Right Cessation
-
1995
- 1995-10-10 US US08/530,363 patent/US6005133A/en not_active Expired - Fee Related
- 1995-11-13 NO NO954566A patent/NO302822B1/no not_active IP Right Cessation
-
1997
- 1997-03-26 GR GR970400610T patent/GR3022924T3/el unknown
-
1999
- 1999-04-26 US US09/299,487 patent/US6037505A/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2302651A1 (es) * | 2006-05-10 | 2008-07-16 | Chemagis Ltd. | Proceso para preparacion de montelukast y precursores del mismo. |
Also Published As
Publication number | Publication date |
---|---|
DK0698028T3 (da) | 1997-08-25 |
DE69401813D1 (de) | 1997-04-03 |
IL109563A0 (en) | 1994-08-26 |
ZA943295B (en) | 1995-11-13 |
EP0698028B1 (en) | 1997-02-26 |
FI942240A0 (fi) | 1994-05-13 |
KR0180262B1 (ko) | 1999-05-15 |
US6037505A (en) | 2000-03-14 |
TW416958B (en) | 2001-01-01 |
GR3022924T3 (en) | 1997-06-30 |
CN1124962A (zh) | 1996-06-19 |
JPH08506345A (ja) | 1996-07-09 |
IL109563A (en) | 2000-02-29 |
NZ262945A (en) | 1996-08-27 |
ATE149171T1 (de) | 1997-03-15 |
NO954566D0 (no) | 1995-11-13 |
DE69401813T2 (de) | 1997-06-05 |
NO954566L (no) | 1995-11-13 |
US6005133A (en) | 1999-12-21 |
CA2161969A1 (en) | 1994-11-24 |
NO302822B1 (no) | 1998-04-27 |
FI942240A (fi) | 1994-11-15 |
MY111215A (en) | 1999-09-30 |
AU6289694A (en) | 1994-12-12 |
WO1994026751A1 (en) | 1994-11-24 |
JP2706851B2 (ja) | 1998-01-28 |
CA2161969C (en) | 1998-11-03 |
EP0698028A1 (en) | 1996-02-28 |
CN1048498C (zh) | 2000-01-19 |
FI108297B (fi) | 2001-12-31 |
AU674067B2 (en) | 1996-12-05 |
KR960702468A (ko) | 1996-04-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2098928T3 (es) | Catalizadores de oxazaborolidina enantioselectivos. | |
ATE216360T1 (de) | Sulfinsäurederivate und deren herstellung und verwendung | |
ES2092345T3 (es) | Compuestos organicos de silicio que contienen radicales glicosido, y procesos para su preparacion. | |
DK0554343T3 (da) | Liposomer af kurvand stabiliseret i en DNA-gel | |
ES2096275T3 (es) | Catalizadores de oxazaborolidina enantioselectivos | |
ES2104090T3 (es) | Nuevas 3',5'-di-t-butil-4'-hidroxi-flavonas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen. | |
BR7908260A (pt) | Composicao catalisadora e processo para converter gas de sintese | |
IT1100807B (it) | Composizioni stabilizzate alla luce uv,contenenti 1,5-diazacicloalcani sostituit come composti di nuovo tipo e sintesi di tali composti | |
ID22856A (id) | Pemurnian etilena oksida dengan cara distilasi | |
ATA220386A (de) | Vergasungsreaktor fuer die herstellung brennbarer gase aus abfaellen | |
ES2150203T3 (es) | Procedimiento de fabricacion de (met)acrilatos de alquilimidazolidona. | |
BR0312469A (pt) | Processo para a preparação de composto, e, composto | |
BR8705619A (pt) | Processo para inibir microorganismos | |
ATE234612T1 (de) | Carotenoidwirkstoffe zur hemmung der umwandlung von epithelzellen in melanome | |
JPS5711818A (en) | Novel crystalline silicate and its preparation | |
BR8605899A (pt) | Processo para produzir alcool m-hidroxibenzilico | |
ES2148003T3 (es) | Procedimiento para la fabricacion de polihidroxieteres. | |
IT7826932A0 (it) | Processo di depurazione biologica di acque usate. | |
BR8506565A (pt) | Lama de alcool ou agua de substancias carbonizadas,bem como processo e equipamento para sua producao | |
AR011735A1 (es) | Proceso para la sintesis de intermediarios de carbapenem y compuestos intermediarios utiles en la sintesis. | |
ES2030676T3 (es) | Procedimiento para la preparacion de alquilaril eteres. | |
IT7923828A0 (it) | Reattore per la depurazione biologica delle acque di rifiuto. | |
LV10009A (lv) | Gazgipsa - sulfopora formmaisijuma izgatavosanas panemiens | |
IT1214994B (it) | Meccanismo per il posizionamento di sbozzi da laminare nella produzione di anelli. | |
IT1114368B (it) | Misuratore oleodinamico di reazione all'allungamento |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 698028 Country of ref document: ES |