DE69333229D1 - Verfahren zur reinigung eines neurotrophen faktors aus pigmentiertem retinalen epithelgewebe - Google Patents

Verfahren zur reinigung eines neurotrophen faktors aus pigmentiertem retinalen epithelgewebe

Info

Publication number
DE69333229D1
DE69333229D1 DE69333229T DE69333229T DE69333229D1 DE 69333229 D1 DE69333229 D1 DE 69333229D1 DE 69333229 T DE69333229 T DE 69333229T DE 69333229 T DE69333229 T DE 69333229T DE 69333229 D1 DE69333229 D1 DE 69333229D1
Authority
DE
Germany
Prior art keywords
cleaning
neurotrophic factor
epithelial tissue
retinal epithelial
pigmented retinal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69333229T
Other languages
English (en)
Other versions
DE69333229T2 (de
Inventor
V Johnson
Joyce Tombran-Tink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Southern California USC
Original Assignee
University of Southern California USC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Southern California USC filed Critical University of Southern California USC
Publication of DE69333229D1 publication Critical patent/DE69333229D1/de
Application granted granted Critical
Publication of DE69333229T2 publication Critical patent/DE69333229T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
DE69333229T 1992-06-04 1993-06-04 Verfahren zur reinigung eines neurotrophen faktors aus pigmentiertem retinalen epithelgewebe Expired - Lifetime DE69333229T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89421592A 1992-06-04 1992-06-04
US894215 1992-06-04
PCT/US1993/005358 WO1993024529A1 (en) 1992-06-04 1993-06-04 Retinal pigmented epithelium derived neurotrophic factor

Publications (2)

Publication Number Publication Date
DE69333229D1 true DE69333229D1 (de) 2003-11-06
DE69333229T2 DE69333229T2 (de) 2004-08-12

Family

ID=25402767

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69333229T Expired - Lifetime DE69333229T2 (de) 1992-06-04 1993-06-04 Verfahren zur reinigung eines neurotrophen faktors aus pigmentiertem retinalen epithelgewebe

Country Status (6)

Country Link
EP (2) EP1415994A1 (de)
JP (3) JPH07508646A (de)
AU (1) AU4406993A (de)
CA (1) CA2137377C (de)
DE (1) DE69333229T2 (de)
WO (1) WO1993024529A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840686A (en) * 1992-09-24 1998-11-24 The United States Of America As Represented By The Department Of Health And Human Services Pigment epithelium-derived factor: characterization of its novel biological activity and sequences encoding and expressing the protein and methods of use
US6319687B1 (en) * 1992-09-24 2001-11-20 The United States Of America As Represented By The Department Of Health And Human Services Pigment epithelium-derived factor: characterization, genomic organization and sequence of PEDF gene
US6451763B1 (en) * 1992-06-04 2002-09-17 The United States Of America As Represented By The Department Of Health And Human Services Retinal pigmented epithelium derived neurotrophic factor and methods of use
US6472585B1 (en) 1994-04-25 2002-10-29 Genentech, Inc. Cardiotrophin-1 defective mouse
US7258983B2 (en) 1994-04-25 2007-08-21 Genentech, Inc. Cardiotrophin-1 compositions and methods for the treatment of tumor
DE69535221T2 (de) * 1994-04-25 2007-09-13 Genentech, Inc., South San Francisco Cardiotrophin und verwendung davon
US5534615A (en) * 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US5804376A (en) * 1995-05-02 1998-09-08 Incyte Pharmaceuticals, Inc. Pancreas-derived serpin
CA2298018C (en) 1997-07-23 2008-12-16 Northwestern University Methods and compositions for inhibiting angiogenesis
US7105496B2 (en) 1998-07-23 2006-09-12 Northwestern University Methods and compositions for inhibiting angiogenesis
US6797691B1 (en) 1997-07-23 2004-09-28 Northwestern University Methods and compositions for inhibiting angiogenesis
US6821775B1 (en) 2000-02-11 2004-11-23 Genvec, Inc. Viral vector encoding pigment epithelium-derived factor
JP2004516001A (ja) * 2000-02-23 2004-06-03 ノースウエスタン・ユニバーシテイ 新脈管形成を阻害するための方法および組成物
US20030158112A1 (en) 2002-02-15 2003-08-21 Johns Hopkins University School Of Medicine Selective induction of apoptosis to treat ocular disease
US20040166091A1 (en) 2003-02-24 2004-08-26 Genvec, Inc. Materials and methods for treating disorders of the ear
WO2006046584A1 (ja) * 2004-10-26 2006-05-04 Santen Pharmaceutical Co., Ltd. 視細胞障害治療剤
US8173591B2 (en) 2004-11-16 2012-05-08 Yeda Research And Development Co. Variants of pigment epithelium derived factor and uses thereof
WO2006064512A1 (en) * 2004-12-13 2006-06-22 Unichem Laboratories Limited A process of fractionating and storing proteins
US8106010B2 (en) 2005-11-14 2012-01-31 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Variants of pigment epithelium derived factor and uses thereof
WO2014040302A1 (en) * 2012-09-17 2014-03-20 Yeou-Ping Tsao Use of pedf-derived polypeptides for treating alopecia and/or hair depigmentation
TWI710635B (zh) 2014-10-09 2020-11-21 美商珍維克公司 編碼人類無調同源物-1(hath1)之腺病毒載體
JP6522063B2 (ja) * 2017-08-10 2019-05-29 マクカイ メモリアル ホスピタル 脱毛症及び／又は毛髪色素脱失を治療するためのｐｅｄｆ由来のポリペプチドの使用
WO2020069352A1 (en) * 2018-09-27 2020-04-02 The Regents Of The University Of California Assays for cell-based therapies or treatments

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor

Also Published As

Publication number Publication date
EP0662087B1 (de) 2003-10-01
EP0662087A4 (de) 1997-01-29
AU4406993A (en) 1993-12-30
EP1415994A1 (de) 2004-05-06
JP2004262947A (ja) 2004-09-24
JP2005112863A (ja) 2005-04-28
CA2137377A1 (en) 1993-12-09
WO1993024529A1 (en) 1993-12-09
EP0662087A1 (de) 1995-07-12
JPH07508646A (ja) 1995-09-28
CA2137377C (en) 2011-03-08
DE69333229T2 (de) 2004-08-12

Similar Documents

Publication Publication Date Title
DE69333229D1 (de) Verfahren zur reinigung eines neurotrophen faktors aus pigmentiertem retinalen epithelgewebe
DE69414079D1 (de) Verfahren zur Herstellung eines Farbfilters
DE69231239D1 (de) Verfahren zur Bedienung eines Prozessors
ATE373613T1 (de) Verfahren zur herstellung eines dosierinhalators
DE69324986D1 (de) Verfahren zur Herstellung eines diffusionsgebundenen Zerstäubungs-Target-Bauteil
DE69300916D1 (de) Verfahren zur Herstellung eines beschichteten Schleifmittels.
DE69302736D1 (de) Verfahren zur Herstellung eines Polierwerkzeuges und nach diesem Verfahren hergestelltes Werkzeug
DE69303585T2 (de) Verfahren zur Herstellung eines Motivs
DE69308755T2 (de) Verfahren zur Herstellung eines Musters durch Silylierung
DE69223297D1 (de) Verfahren zur Herstellung eines Filters und Vorrichtung zur Durchführung des Verfahrens
DE69427987D1 (de) Verfahren zur Herstellung eines Teiges
DE69520640T2 (de) Verfahren zur Impulsstrom-Doppeldüsen-Fällung
DE69411088D1 (de) Verfahren zur Fertigbearbeitung eines Grünkörpers
DE69314202T2 (de) Verfahren zur Herstellung eines Wischvliesstoffs
DE69327343T2 (de) Verfahren zur Pressformung eines rohrförmigen Behälters
DE69512298T2 (de) Verfahren zur Herstellung eines mit Diamanten beschichteten Gegenstandes
DE69603636T2 (de) Verfahren zur Herstellung eines Hohlkörpers
DE69115999D1 (de) Verfahren zur Herstellung eines Maskenmusters
DE69708980T2 (de) Verfahren zur Reinigung eines Kohlenwasserstoffstroms
DE69417773T2 (de) Verfahren zur Herstellung eines p-Fuchsons
DE69518385D1 (de) Verfahren zur Herstellung eines steifen Schaumgegenstandes
DE69629157D1 (de) Verfahren zur Herstellung eines Farbfilters
DE69426147D1 (de) Verfahren zur Herstellung eines Farbfilters
DE59508299D1 (de) Verfahren zur Herstellung eines Färbereihilfsmittels
DE69820438T2 (de) Verfahren zur Erzeugung eines Flüssigkeits-Nebelschleiers

Legal Events

Date Code Title Description
8364 No opposition during term of opposition