DE69332805D1 - Aspertokinasegenvarianten - Google Patents
AspertokinasegenvariantenInfo
- Publication number
- DE69332805D1 DE69332805D1 DE69332805T DE69332805T DE69332805D1 DE 69332805 D1 DE69332805 D1 DE 69332805D1 DE 69332805 T DE69332805 T DE 69332805T DE 69332805 T DE69332805 T DE 69332805T DE 69332805 D1 DE69332805 D1 DE 69332805D1
- Authority
- DE
- Germany
- Prior art keywords
- corynebacterium
- lysine
- threonine
- coding
- released
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
- Ceramic Products (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10145093A JP3473042B2 (ja) | 1992-04-28 | 1993-04-27 | 変異型アスパルトキナーゼ遺伝子 |
JP10145093 | 1993-04-27 | ||
PCT/JP1993/001809 WO1994025605A1 (en) | 1993-04-27 | 1993-12-14 | Variant aspartokinase gene |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69332805D1 true DE69332805D1 (de) | 2003-04-30 |
DE69332805T2 DE69332805T2 (de) | 2004-02-19 |
Family
ID=14301034
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69332805T Expired - Lifetime DE69332805T2 (de) | 1993-04-27 | 1993-12-14 | Aspertokinasegenvarianten |
Country Status (8)
Country | Link |
---|---|
US (1) | US5688671A (de) |
EP (1) | EP0699759B1 (de) |
JP (1) | JP3473042B2 (de) |
AT (1) | ATE235555T1 (de) |
DE (1) | DE69332805T2 (de) |
DK (1) | DK0699759T3 (de) |
ES (1) | ES2191680T3 (de) |
WO (1) | WO1994025605A1 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2730025C1 (ru) * | 2017-06-30 | 2020-08-14 | СиДжей ЧеилДжеданг Корпорейшн | Новый вариант аспартокиназы и способ получения L-аминокислоты с использованием этого варианта |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6696561B1 (en) | 1909-07-09 | 2004-02-24 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport |
JP3473042B2 (ja) * | 1992-04-28 | 2003-12-02 | 味の素株式会社 | 変異型アスパルトキナーゼ遺伝子 |
US5877179A (en) * | 1992-09-29 | 1999-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Xanthines for identifying CFTR--binding compounds useful for activating chloride conductance in animal cells |
US20020086370A1 (en) * | 1995-06-07 | 2002-07-04 | Seiko Otsuna | Method of producing l-lysine |
JP4035855B2 (ja) | 1996-06-05 | 2008-01-23 | 味の素株式会社 | L−リジンの製造法 |
SK285201B6 (sk) * | 1996-12-05 | 2006-08-03 | Ajinomoto Co., Inc. | Rekombinantná DNA, autonómne reprodukovaná v bunkách koryneformnej baktérie, koryneformná baktéria a spôsob výroby L-lyzínu, vektor pVK7 |
JP4075087B2 (ja) * | 1996-12-05 | 2008-04-16 | 味の素株式会社 | L−リジンの製造法 |
CA2336967C (en) | 1998-07-10 | 2010-06-29 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | A3 adenosine receptor antagonists |
AU3837400A (en) * | 1999-04-19 | 2000-11-02 | Kyowa Hakko Kogyo Co. Ltd. | Novel desensitized aspartokinase |
US7270984B1 (en) | 1999-06-25 | 2007-09-18 | Basf Aktiengesellschaft | Polynucleotides encoding a 6-phosphogluconolactonase polypeptide from corynebacterium glutamicum |
SK18862001A3 (sk) | 1999-06-25 | 2002-11-06 | Basf Aktiengesellschaft | Gény Corynebacterium glutamicum kódujúce proteíny metabolických dráh |
US6884614B1 (en) | 1999-07-01 | 2005-04-26 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins |
DE1246922T1 (de) | 1999-07-01 | 2003-03-20 | Basf Ag | Für proteine des phosphoenolpyruvat:zucker phosphotransferase systems kodierende gene aus corynebacterium glutamicum |
DE60027161D1 (de) | 1999-07-02 | 2006-05-18 | Ajinomoto Kk | Für das saccharose-pts-enzym ii kodierende dna |
US6797509B1 (en) | 1999-07-09 | 2004-09-28 | Degussa-Huls Ag | Nucleotide sequences which code for the tal gene |
BR0013996A (pt) | 1999-09-15 | 2002-05-14 | Basf Plant Science Gmbh | Planta transformada e seus descendentes, gene translocador de atp/adp, estrutura gênica, vetor, sementes, tecidos ou células ou material, processo para preparar uma planta e utilização de plantas trasformadas |
JP2001120269A (ja) * | 1999-10-22 | 2001-05-08 | Ajinomoto Co Inc | 発酵法によるl−リジンの製造法 |
ATE417094T1 (de) * | 1999-12-24 | 2008-12-15 | Ajinomoto Kk | Verfahren zur herstellung von l-aminosäure |
US6927046B1 (en) * | 1999-12-30 | 2005-08-09 | Archer-Daniels-Midland Company | Increased lysine production by gene amplification using coryneform bacteria |
AU3091301A (en) | 2000-01-14 | 2001-07-24 | Us Health | Methanocarba cycloalkyl nucleoside analogues |
DE10210527A1 (de) | 2002-03-09 | 2003-09-18 | Degussa | Allele des aceA-Gens aus coryneformen Bakterien |
WO2007086546A1 (en) * | 2006-01-26 | 2007-08-02 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using a bacterium of enterobacteriaceae family with attenuated expression of the aldh gene |
WO2007119574A2 (en) | 2006-03-23 | 2007-10-25 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using bacterium of the enterobacteriaceae family with attenuated expression of a gene coding for small rna |
EP2386650B1 (de) * | 2006-04-07 | 2013-07-03 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Lysin unter Verwendung des gap Promotors |
WO2007119890A1 (en) * | 2006-04-18 | 2007-10-25 | Ajinomoto Co., Inc. | A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE sfmACDFH-fimZ CLUSTER OR THE fimZ GENE |
JP2009165355A (ja) * | 2006-04-28 | 2009-07-30 | Ajinomoto Co Inc | L−アミノ酸を生産する微生物及びl−アミノ酸の製造法 |
EP2035569A1 (de) * | 2006-06-01 | 2009-03-18 | Ajinomoto Co., Inc. | Verfahren zur herstellung einer l-aminosäure unter verwendung eines bakteriums der familie enterobacteriaceae mit abgeschwächter expression des rcsa-gens |
RU2337961C2 (ru) * | 2006-07-04 | 2008-11-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | СПОСОБ ПОЛУЧЕНИЯ L-ТРЕОНИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia, В КОТОРОЙ ИНАКТИВИРОВАН ОПЕРОН rspAB |
EP1881076A1 (de) * | 2006-07-17 | 2008-01-23 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Aminosäuren |
BRPI0715584B8 (pt) * | 2006-07-19 | 2017-02-21 | Ajinomoto Kk | método para produzir um l-aminoácido |
JP2010017081A (ja) | 2006-10-10 | 2010-01-28 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
WO2008072761A2 (en) * | 2006-12-11 | 2008-06-19 | Ajinomoto Co., Inc. | Method for producing an l-amino acid |
RU2006143864A (ru) * | 2006-12-12 | 2008-06-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНОВ cynT, cynS, cynX, ИЛИ cynR, ИЛИ ИХ КОМБИНАЦИИ |
RU2006145712A (ru) * | 2006-12-22 | 2008-06-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Способ получения l-аминокислот методом ферментации с использованием бактерий, обладающих повышенной способностью к утилизации глицерина |
JP2010110217A (ja) * | 2007-02-22 | 2010-05-20 | Ajinomoto Co Inc | L−アミノ酸生産菌及びl−アミノ酸の製造法 |
JP5217780B2 (ja) * | 2008-02-08 | 2013-06-19 | 味の素株式会社 | L−アミノ酸を生産する微生物及びl−アミノ酸の製造法 |
CN102089437B (zh) | 2008-07-09 | 2014-11-05 | 味之素株式会社 | 生产氨基羟基苯甲酸盐类化合物的方法 |
JP2012029565A (ja) | 2008-11-27 | 2012-02-16 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
US8518957B2 (en) | 2009-12-02 | 2013-08-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methanocarba adenosine derivatives, pharmaceutical compositions, and method of reducing intraocular pressure |
EP2374873A1 (de) | 2010-04-08 | 2011-10-12 | Technische Universität Hamburg-Harburg | Modifizierte Aspartatkinase aus dem Corynebacterium und ihre Verwendung bei der Aminosäureherstellung |
JP6183358B2 (ja) | 2012-05-29 | 2017-08-23 | 味の素株式会社 | 3−アセチルアミノ−4−ヒドロキシ安息香酸の製造方法 |
DE102012016716A1 (de) | 2012-08-22 | 2014-02-27 | Forschungszentrum Jülich GmbH | Verfahren zur Herstellung von Vektoren enthaltend ein für in seiner feedback-Inhibierung gemindertes oder ausgeschaltetes Enzym kodierendes Gen und deren Verwendung für die Herstellung von Aminosäuren und Nukleotiden |
EP2940144A1 (de) | 2014-04-30 | 2015-11-04 | Evonik Degussa GmbH | Verfahren zur Produktion von L-Lysin unter Verwendung eines alkaliphilen Bakteriums |
EP2940039A1 (de) | 2014-04-30 | 2015-11-04 | Evonik Degussa GmbH | Verfahren zur Produktion von L-Aminosäuren in Corynebakterien unter Verwendung eines Glycin spaltenden Systems |
JP6415845B2 (ja) * | 2014-04-30 | 2018-10-31 | 日本テクニカ株式会社 | 展示物の展示及び収容用ケースの構造 |
PL2940143T3 (pl) | 2014-04-30 | 2020-06-29 | Evonik Operations Gmbh | Sposób wytwarzania L-aminokwasów z użyciem bakterii bazofilowych |
DE102014208199A1 (de) | 2014-04-30 | 2015-11-05 | Evonik Degussa Gmbh | Verfahren zur Produktion von L-Aminosäuren unter Verwendung eines alkaliphilen Bakteriums |
EP3456833A1 (de) | 2017-09-18 | 2019-03-20 | Evonik Degussa GmbH | Methode zur fermentativen production von l-aminosäuren |
EP3467099A1 (de) * | 2017-10-05 | 2019-04-10 | Evonik Degussa GmbH | Verfahren zur fermentativen herstellung von l-aminosäuren |
EP3498853A1 (de) | 2017-12-14 | 2019-06-19 | Evonik Degussa GmbH | Verfahren zur fermentativen herstellung von l-lysin |
EP3594355A1 (de) | 2018-07-12 | 2020-01-15 | Evonik Operations GmbH | Verfahren zur fermentativen herstellung von l-lysin |
EP3599282B1 (de) | 2018-07-24 | 2021-03-17 | Evonik Operations GmbH | Verfahren zur fermentativen herstellung von l-lysin |
RU2019128538A (ru) | 2018-09-26 | 2021-03-11 | Эвоник Оперейшенс ГмбХ | Способ ферментативного получения l-лизина |
EP3660158A1 (de) | 2018-11-29 | 2020-06-03 | Evonik Operations GmbH | Verfahren zur fermentativen herstellung von l-lysin |
EP3670525A1 (de) | 2018-12-18 | 2020-06-24 | Evonik Operations GmbH | Verfahren zur fermentativen herstellung von l-lysin unter verwendung von c.-glutamicum-stämmen mit einem mutierten kup-transporter |
US10829746B2 (en) | 2019-01-23 | 2020-11-10 | Evonik Operations Gmbh | Method for the fermentative production of L-lysine |
WO2021048353A1 (en) | 2019-09-11 | 2021-03-18 | Evonik Operations Gmbh | Coryneform bacteria with a heterologous threonine transporter and their use in the production of l-threonine |
WO2023041425A1 (en) | 2021-09-20 | 2023-03-23 | Evonik Operations Gmbh | Method for the fermentative production of l-lysine using c. glutamicum strains expressing modified gluconate repressor proteins gntr1 and gntr2 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5763095A (en) * | 1980-09-30 | 1982-04-16 | Ajinomoto Co Inc | Production of l-lysine through fermentation process |
DE3908201A1 (de) * | 1989-03-14 | 1990-09-27 | Degussa | Verfahren zur fermentativen herstellung von l-lysin |
JP3473042B2 (ja) * | 1992-04-28 | 2003-12-02 | 味の素株式会社 | 変異型アスパルトキナーゼ遺伝子 |
JPH06261766A (ja) * | 1993-03-16 | 1994-09-20 | Mitsubishi Petrochem Co Ltd | フィードバックインヒビションの解除されたアスパルトキナーゼをコードする遺伝子dna及びその利用 |
-
1993
- 1993-04-27 JP JP10145093A patent/JP3473042B2/ja not_active Expired - Fee Related
- 1993-12-14 WO PCT/JP1993/001809 patent/WO1994025605A1/ja active IP Right Grant
- 1993-12-14 US US08/532,828 patent/US5688671A/en not_active Expired - Lifetime
- 1993-12-14 DE DE69332805T patent/DE69332805T2/de not_active Expired - Lifetime
- 1993-12-14 DK DK94902116T patent/DK0699759T3/da active
- 1993-12-14 ES ES94902116T patent/ES2191680T3/es not_active Expired - Lifetime
- 1993-12-14 EP EP94902116A patent/EP0699759B1/de not_active Expired - Lifetime
- 1993-12-14 AT AT94902116T patent/ATE235555T1/de not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2730025C1 (ru) * | 2017-06-30 | 2020-08-14 | СиДжей ЧеилДжеданг Корпорейшн | Новый вариант аспартокиназы и способ получения L-аминокислоты с использованием этого варианта |
Also Published As
Publication number | Publication date |
---|---|
EP0699759A1 (de) | 1996-03-06 |
US5688671A (en) | 1997-11-18 |
ATE235555T1 (de) | 2003-04-15 |
JPH0662866A (ja) | 1994-03-08 |
EP0699759A4 (de) | 1999-09-22 |
DK0699759T3 (da) | 2003-09-15 |
ES2191680T3 (es) | 2003-09-16 |
EP0699759B1 (de) | 2003-03-26 |
JP3473042B2 (ja) | 2003-12-02 |
DE69332805T2 (de) | 2004-02-19 |
WO1994025605A1 (en) | 1994-11-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69332805D1 (de) | Aspertokinasegenvarianten | |
DE3466894D1 (en) | Coryneform bacteria carrying recombinant plasmids and their use in the fermentative production of l-threonine and l-isoleucine | |
JPS643006A (en) | Hydrophobic precipitated silica and its production and use as reinforcing material for silicone elastmer | |
DE69330518D1 (de) | Dna, die aspartokinase iii-mutanten kodiert und ihre verwendung zur herstellung von l-threonin durch fermentation | |
DE69637492D1 (de) | Anwendung von glukosetransportmutanten tur herstellung von verbindungen des aromatischen syntheseweges | |
PL266680A1 (en) | Method of obtaining il-6 and of its application | |
AU5224596A (en) | Plants with modified stamen cells | |
DK0387867T3 (da) | Præparat indeholdende D-cycloserin og D-alanin til forbedring af hukommelse og indlæringsevne eller til behandling af en kognitiv eller psykotisk lidelse | |
DE3667106D1 (en) | Modified silicone rubber, its use in lenses and lenses produced with this material | |
GR3023277T3 (en) | Control of microsporogenesis using externally inducible promoter sequences | |
AU600253B2 (en) | Expression of eucaryotic proteins | |
ES547436A0 (es) | Un procedimiento para producir un adn complementario clonadoo su adn modificado que codifica un polipeptido de factor denecrosis de tumores | |
EP0137348A3 (en) | Recombinant dna, bacteria carrying said recombinant dna and a process for producing l-threonine or l-isoleucine using said bacteria | |
EP0191349A3 (en) | A peptide compound and antiserum produced by using this compound | |
EP0202711A3 (en) | Membrane for membrane switches and composing elements thereof | |
ES279461U (es) | Rotula para articulaciones | |
GB2163753B (en) | Optical plastics material using methacrylic resin and fluoro-copolymer | |
GR3033685T3 (en) | Mutant interleukin 6 with improved biological activity over wild interleukin 6. | |
ES2115208T3 (es) | Proteina de la superficie celular de brevibacterium lactofermentum. | |
EP0222726A3 (de) | Mutierte codierende Sequenz | |
NO894249L (no) | Fremgangsmaate for reduksjon av aggregatinnholdet i veksthormonliknende materialer. | |
EP0358692A4 (de) | Impfstoff gegen cholera. | |
ES291608U (es) | Patilla flexible para monturas de gafas | |
EP0179721A3 (de) | Schlafinduzierende Mittel | |
ES2016466A6 (es) | Un reactor simbiotico para el tratamiento y depuracion de aguas residuales. |