DE69332220D1 - Lösliche analoga von probucol - Google Patents

Lösliche analoga von probucol

Info

Publication number
DE69332220D1
DE69332220D1 DE69332220T DE69332220T DE69332220D1 DE 69332220 D1 DE69332220 D1 DE 69332220D1 DE 69332220 T DE69332220 T DE 69332220T DE 69332220 T DE69332220 T DE 69332220T DE 69332220 D1 DE69332220 D1 DE 69332220D1
Authority
DE
Germany
Prior art keywords
chamber
tray
test strip
reaction vessel
fluid conduit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69332220T
Other languages
English (en)
Other versions
DE69332220T2 (de
Inventor
Sampath Parthasarathy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Atherogenics Inc
Original Assignee
Atherogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atherogenics Inc filed Critical Atherogenics Inc
Publication of DE69332220D1 publication Critical patent/DE69332220D1/de
Application granted granted Critical
Publication of DE69332220T2 publication Critical patent/DE69332220T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Materials For Medical Uses (AREA)
DE69332220T 1992-04-30 1993-04-30 Lösliche analoga von probucol Expired - Fee Related DE69332220T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/876,557 US5262439A (en) 1992-04-30 1992-04-30 Soluble analogs of probucol
PCT/US1993/004071 WO1993021914A1 (en) 1992-04-30 1993-04-30 Soluble analogs of probucol

Publications (2)

Publication Number Publication Date
DE69332220D1 true DE69332220D1 (de) 2002-09-26
DE69332220T2 DE69332220T2 (de) 2003-05-08

Family

ID=25368007

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69332220T Expired - Fee Related DE69332220T2 (de) 1992-04-30 1993-04-30 Lösliche analoga von probucol

Country Status (12)

Country Link
US (1) US5262439A (de)
EP (2) EP1161946A3 (de)
JP (1) JP3179494B2 (de)
AT (1) ATE222490T1 (de)
AU (1) AU4225493A (de)
CA (1) CA2134679C (de)
CY (1) CY2426B1 (de)
DE (1) DE69332220T2 (de)
DK (1) DK0637959T3 (de)
ES (1) ES2181688T3 (de)
PT (1) PT637959E (de)
WO (1) WO1993021914A1 (de)

Families Citing this family (50)

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US5677291A (en) * 1993-12-10 1997-10-14 Hoechst Marion Roussel, Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
AU2006202461B2 (en) * 1997-05-14 2009-12-03 Atherogenics, Inc. Compositions and methods for the inhibition of the expression of VCAM-1
AU2002300328B2 (en) * 1997-05-14 2006-04-13 Atherogenics, Inc Compounds and methods for the inhibition of the expression of VCAM-1
EP1468989A3 (de) * 1997-05-14 2008-12-03 Atherogenics, Inc. Verbindungen und Methoden zur Hemmung der VCAM-1 Expression
US6852878B2 (en) * 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
NZ528906A (en) 1997-05-14 2005-06-24 Atherogenics Inc Compounds and methods for the inhibition of the expression of VCAM-1
EP1695959A1 (de) * 1997-05-14 2006-08-30 Atherogenics, Inc. Verbindungen und Methoden zur Hemmung der VCAM-1 Expression
EP1607089A1 (de) * 1997-05-14 2005-12-21 Atherogenics, Inc. Monoester von Probucol zur Behandlung von kardiovaskulären Krankheiten und Entzündungskrankheiten
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
CN1261803A (zh) * 1997-07-01 2000-08-02 埃瑟若詹尼克斯公司 抗氧化剂增强对细胞过度增生性疾病的治疗
US6254853B1 (en) * 1998-05-08 2001-07-03 Vyrex Corporation Water soluble pro-drugs of propofol
US6887712B1 (en) * 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
JP2003530383A (ja) * 2000-04-11 2003-10-14 アセロジエニクス・インコーポレイテツド 血漿ｈｄｌコレステロールレベルを上昇させ、ｈｄｌ機能性を向上させる化合物および方法
US6323359B1 (en) * 2000-05-02 2001-11-27 Salsbury Chemicals, Inc. Process for preparing probucol derivatives
AUPQ872800A0 (en) * 2000-07-12 2000-08-03 Heart Research Institute, The Compositions and methods for treating cardiovascular disorders
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
JP4334233B2 (ja) * 2001-04-11 2009-09-30 アセロジエニクス・インコーポレイテツド プロブコールモノエステルによって血漿ｈｄｌコレステロールレベルを上昇させ、ｈｄｌの機能性を改善するための方法
US6651862B2 (en) 2001-04-30 2003-11-25 Illinois Tool Works Inc. Trim-type fastener driving tool
CA2464717A1 (en) * 2001-10-25 2003-05-15 Atherogenics, Inc. Compounds and methods for treating transplant rejection
IL161741A0 (en) * 2001-11-09 2005-11-20 Atherogenics Inc Methods of reversing and preventingcardiovascular pathologies
ITMI20020597A1 (it) * 2002-03-22 2003-09-22 Nicox Sa Derivati del probucolo
AU2003253887A1 (en) * 2002-07-12 2004-02-02 Atherogenics, Inc. Novel salt forms of poorly soluble probucol esters and ethers
AU2003266165A1 (en) * 2002-09-13 2004-04-30 Hossein Dovlatabadi Methods and compositons for the use of d-malic acid to decrease serum triglyceride, cholesterol, and lipoprotein levels
MXPA05007548A (es) * 2003-01-13 2005-10-20 Atherogenics Inc Procedimiento para preparar esteres y eteres de probucol y derivados del mismo.
CH696357A5 (de) * 2003-02-14 2007-05-15 Siegfried Ltd Verfahren zur Herstellung von Probucolverbindungen.
GB0321613D0 (en) * 2003-09-15 2003-10-15 Drug Discovery Lab As Compounds
US20060025481A1 (en) * 2004-02-09 2006-02-02 Strange Matthew L Process for preparation of probucol derivatives and polymorphic forms thereof
US7294736B2 (en) * 2004-04-09 2007-11-13 Cambrex Charles City, Inc. Process for preparation of probucol derivatives
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US7294737B2 (en) * 2004-04-20 2007-11-13 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
AU2005262390B2 (en) * 2004-07-01 2011-09-22 Atherogenics, Inc. Compounds and methods for treating diabetic vascular diseases
EP1844009A4 (de) * 2004-12-17 2010-04-21 Roland O Stocker Zusammensetzungen und verfahren zur behandlung von herzkreislauferkrankungen
US20060194981A1 (en) * 2005-02-26 2006-08-31 Jass Paul A Process for preparation of probucol derivatives
US7345191B2 (en) * 2005-02-26 2008-03-18 Cambrex Charles City, Inc. Process for preparation of probucol derivatives
CA2606414A1 (en) * 2005-04-21 2006-11-02 Atherogenics, Inc. Process for the separation of probucol derivatives
EP1776970A1 (de) * 2005-10-12 2007-04-25 Albert Schömig Implantat mit Mehrfachbeschichtung
EP1916006A1 (de) * 2006-10-19 2008-04-30 Albert Schömig Wachs oder Harz beschichtetes Implantat
EP1913960A1 (de) 2006-10-19 2008-04-23 Albert Schömig Beschichtetes Implantat
BRPI0809423A2 (pt) * 2007-03-26 2014-09-09 Salutria Pharmaceuticals Llc Usos e composições de derivados de probucol para o tratamento de diabetes
US20080280985A1 (en) * 2007-03-27 2008-11-13 Scott Robert A D Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes
US7897776B2 (en) 2007-04-23 2011-03-01 Salutria Pharmaceuticals Llc Sulfonamide containing compounds for treatment of inflammatory disorders
JP2010531354A (ja) * 2007-06-26 2010-09-24 アストラゼネカ アクチボラグ カルボキシ基で一置換されたプロブコール誘導体の単離方法
US20170224647A1 (en) * 2014-08-04 2017-08-10 Universita 'Degli Studi Parma New mdr1 inhibitors for overcoming multidrug resistance
CN106905208B (zh) * 2017-02-27 2018-09-07 江西瑞雅药业有限公司 普罗布考前药及其制备方法和药物组合物
CN108299263B (zh) 2018-01-30 2020-12-01 北京德默高科医药技术有限公司 一种普罗布考衍生物及其制备方法与应用

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US3862332A (en) * 1967-05-11 1975-01-21 Dow Chemical Co Method of lowering serum cholesterol
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FR2133024A5 (en) * 1971-04-06 1972-11-24 Aries Robert Bis-(4-nicotinoyloxyphenylthio) propanes - with hypocholesterolaemic and hypolipaemic activity
FR2168137A1 (en) * 1972-01-17 1973-08-31 Dynachim Sarl Bis 4-hydroxyphenylthioalkane esters - with hypocholesterolaemic and hypolipaemic activities
DE3442639A1 (de) * 1984-11-22 1986-05-22 Dr. Madaus & Co, 5000 Köln Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten
US4719237A (en) * 1986-01-28 1988-01-12 Merrell Dow Pharmaceuticals Inc. Cardiac antiarrythmic method employing probucol
US4985465A (en) * 1989-07-14 1991-01-15 Hendler Sheldon S Method for inhibiting viral and retroviral infections

Also Published As

Publication number Publication date
US5262439A (en) 1993-11-16
EP1161946A2 (de) 2001-12-12
EP1161946A3 (de) 2003-12-10
CA2134679C (en) 2003-11-25
DK0637959T3 (da) 2002-12-23
EP0637959A1 (de) 1995-02-15
JPH07506373A (ja) 1995-07-13
ES2181688T3 (es) 2003-03-01
AU4225493A (en) 1993-11-29
WO1993021914A1 (en) 1993-11-11
CY2426B1 (en) 2004-11-12
ATE222490T1 (de) 2002-09-15
DE69332220T2 (de) 2003-05-08
CA2134679A1 (en) 1993-11-11
PT637959E (pt) 2002-12-31
EP0637959A4 (de) 1995-03-29
JP3179494B2 (ja) 2001-06-25
EP0637959B1 (de) 2002-08-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee