DE69327789T2 - Verfahren zur umwandung von taxanen in baccatin iii und 10-desacetylbaccatin iii - Google Patents

Verfahren zur umwandung von taxanen in baccatin iii und 10-desacetylbaccatin iii

Info

Publication number
DE69327789T2
DE69327789T2 DE69327789T DE69327789T DE69327789T2 DE 69327789 T2 DE69327789 T2 DE 69327789T2 DE 69327789 T DE69327789 T DE 69327789T DE 69327789 T DE69327789 T DE 69327789T DE 69327789 T2 DE69327789 T2 DE 69327789T2
Authority
DE
Germany
Prior art keywords
iii
taxans
converting
desacetylbaccatin
baccatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69327789T
Other languages
English (en)
Other versions
DE69327789D1 (de
Inventor
R Carver
R Prout
A Ewald
L Henderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tapestry Pharmaceuticals Inc
Original Assignee
Tapestry Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/930,840 external-priority patent/US5202448A/en
Application filed by Tapestry Pharmaceuticals Inc filed Critical Tapestry Pharmaceuticals Inc
Publication of DE69327789D1 publication Critical patent/DE69327789D1/de
Application granted granted Critical
Publication of DE69327789T2 publication Critical patent/DE69327789T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69327789T 1992-08-14 1993-08-16 Verfahren zur umwandung von taxanen in baccatin iii und 10-desacetylbaccatin iii Expired - Fee Related DE69327789T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/930,840 US5202448A (en) 1992-08-14 1992-08-14 Processes of converting taxanes into baccatin III
US07/986,852 US5256801A (en) 1992-08-14 1992-12-04 Processes of converting taxanes into 10-deacetylbaccatin III
PCT/US1993/007706 WO1994004519A1 (en) 1992-08-14 1993-08-16 Process of converting taxanes into baccatin iii and 10-deacetylbaccatin iii

Publications (2)

Publication Number Publication Date
DE69327789D1 DE69327789D1 (de) 2000-03-09
DE69327789T2 true DE69327789T2 (de) 2000-07-06

Family

ID=27130001

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69327789T Expired - Fee Related DE69327789T2 (de) 1992-08-14 1993-08-16 Verfahren zur umwandung von taxanen in baccatin iii und 10-desacetylbaccatin iii

Country Status (14)

Country Link
US (1) US5256801A (de)
EP (1) EP0656000B1 (de)
JP (1) JP2958119B2 (de)
KR (1) KR0177588B1 (de)
AT (1) ATE189454T1 (de)
AU (1) AU5015693A (de)
CA (1) CA2142354C (de)
DE (1) DE69327789T2 (de)
DK (1) DK0656000T3 (de)
ES (1) ES2142877T3 (de)
GR (1) GR3033069T3 (de)
NZ (1) NZ255790A (de)
PT (1) PT656000E (de)
WO (1) WO1994004519A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5449790A (en) * 1994-04-06 1995-09-12 Hauser Chemical Research, Inc. Preparation of 10-deacetylbaccatin III and 7-protected-10-deacetylbaccatin III derivatives from 10-deacetyl taxol A, 10-deacetyl taxol B, and 10-deacetyl taxol C
US5629433A (en) * 1994-07-18 1997-05-13 Hauser, Inc. Selective process for the deacylation and deacetylation of taxol and taxanes
WO1998013359A1 (de) * 1996-09-24 1998-04-02 Marigen S.A. Ultramikroemulsionen aus spontan dispergierbaren konzentraten mit antitumoral und antiviral wirksamen estern von baccatin-iii-verbindungen
FR2795731B1 (fr) 1999-07-02 2001-09-07 Warner Lambert Co PROCEDE DE PREPARATION DE [1,4] DIAZEPINO [6,7,1-hi] INDOL-4-ONES SUBSTITUEES
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6495705B2 (en) 2000-03-16 2002-12-17 Napro Biotherapeutics, Inc. Efficient process for the production of 10-DAB III by selective hydrazinolysis of various taxanes
US6281368B1 (en) 2000-03-16 2001-08-28 Napro Biotherapeutics, Inc. Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities of taxanes to obtain 10-DAB III
US20050250954A1 (en) * 2004-05-04 2005-11-10 Phytogen Life Sciences Inc. Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes
US20050240036A1 (en) * 2004-04-23 2005-10-27 Phytogen Life Sciences Inc. Semi-synthesis of taxane intermediates from a mixture of taxanes
US20050272807A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
KR100816491B1 (ko) 2005-11-17 2008-03-24 주식회사 삼양제넥스 탁산류 함유 물질로부터 13-디하이드록시바카틴 ⅲ 및10-디아세틸파클리탁셀의 추출 및 정제 방법
GB0701523D0 (en) * 2007-01-26 2007-03-07 Chatham Biotec Ltd Semi-synthetic process for the preparation of taxane derivatives

Also Published As

Publication number Publication date
DK0656000T3 (da) 2000-08-07
US5256801A (en) 1993-10-26
CA2142354C (en) 1999-05-04
WO1994004519A1 (en) 1994-03-03
PT656000E (pt) 2000-07-31
EP0656000B1 (de) 2000-02-02
NZ255790A (en) 1996-03-26
DE69327789D1 (de) 2000-03-09
ES2142877T3 (es) 2000-05-01
ATE189454T1 (de) 2000-02-15
EP0656000A4 (de) 1995-07-19
AU5015693A (en) 1994-03-15
JPH08503452A (ja) 1996-04-16
GR3033069T3 (en) 2000-08-31
KR0177588B1 (ko) 1999-03-20
EP0656000A1 (de) 1995-06-07
KR950702975A (ko) 1995-08-23
CA2142354A1 (en) 1994-03-03
JP2958119B2 (ja) 1999-10-06

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee