ES2142877T3 - Procedimiento para convertir taxanos en bacatina iii y 10-desacetilbacatina iii. - Google Patents
Procedimiento para convertir taxanos en bacatina iii y 10-desacetilbacatina iii.Info
- Publication number
- ES2142877T3 ES2142877T3 ES93920109T ES93920109T ES2142877T3 ES 2142877 T3 ES2142877 T3 ES 2142877T3 ES 93920109 T ES93920109 T ES 93920109T ES 93920109 T ES93920109 T ES 93920109T ES 2142877 T3 ES2142877 T3 ES 2142877T3
- Authority
- ES
- Spain
- Prior art keywords
- iii
- desacetilbacatine
- bacatine
- taxanes
- convert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Abstract
UN PROCESO PARA LA PREPARACION DE UN COMPUESTO DE FORMULA (II) DONDE R1 = H O R1 COCH3, QUE COSISTE EN PONER EN CONTACTO UNA MEZCLA QUE CONTIENE AL MENOS UN COMPUESTO DE TAXANO QUE TIENE UN ENLACE DE ESTER EN LA POSICION C-13 CON AL MENOS UNA SAL REDUCTORA BOROHIDRURO, EN UN SOLVENTE DE REACCION EN PRESENCIA DE UN ACIDO LEWIS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/930,840 US5202448A (en) | 1992-08-14 | 1992-08-14 | Processes of converting taxanes into baccatin III |
US07/986,852 US5256801A (en) | 1992-08-14 | 1992-12-04 | Processes of converting taxanes into 10-deacetylbaccatin III |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2142877T3 true ES2142877T3 (es) | 2000-05-01 |
Family
ID=27130001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93920109T Expired - Lifetime ES2142877T3 (es) | 1992-08-14 | 1993-08-16 | Procedimiento para convertir taxanos en bacatina iii y 10-desacetilbacatina iii. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5256801A (es) |
EP (1) | EP0656000B1 (es) |
JP (1) | JP2958119B2 (es) |
KR (1) | KR0177588B1 (es) |
AT (1) | ATE189454T1 (es) |
AU (1) | AU5015693A (es) |
CA (1) | CA2142354C (es) |
DE (1) | DE69327789T2 (es) |
DK (1) | DK0656000T3 (es) |
ES (1) | ES2142877T3 (es) |
GR (1) | GR3033069T3 (es) |
NZ (1) | NZ255790A (es) |
PT (1) | PT656000E (es) |
WO (1) | WO1994004519A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5449790A (en) * | 1994-04-06 | 1995-09-12 | Hauser Chemical Research, Inc. | Preparation of 10-deacetylbaccatin III and 7-protected-10-deacetylbaccatin III derivatives from 10-deacetyl taxol A, 10-deacetyl taxol B, and 10-deacetyl taxol C |
US5629433A (en) * | 1994-07-18 | 1997-05-13 | Hauser, Inc. | Selective process for the deacylation and deacetylation of taxol and taxanes |
WO1998013359A1 (de) * | 1996-09-24 | 1998-04-02 | Marigen S.A. | Ultramikroemulsionen aus spontan dispergierbaren konzentraten mit antitumoral und antiviral wirksamen estern von baccatin-iii-verbindungen |
FR2795731B1 (fr) | 1999-07-02 | 2001-09-07 | Warner Lambert Co | PROCEDE DE PREPARATION DE [1,4] DIAZEPINO [6,7,1-hi] INDOL-4-ONES SUBSTITUEES |
CA2385528C (en) | 1999-10-01 | 2013-12-10 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
US6495705B2 (en) | 2000-03-16 | 2002-12-17 | Napro Biotherapeutics, Inc. | Efficient process for the production of 10-DAB III by selective hydrazinolysis of various taxanes |
US6281368B1 (en) * | 2000-03-16 | 2001-08-28 | Napro Biotherapeutics, Inc. | Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities of taxanes to obtain 10-DAB III |
US20050250954A1 (en) * | 2004-05-04 | 2005-11-10 | Phytogen Life Sciences Inc. | Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes |
US20050240036A1 (en) * | 2004-04-23 | 2005-10-27 | Phytogen Life Sciences Inc. | Semi-synthesis of taxane intermediates from a mixture of taxanes |
US20050272807A1 (en) * | 2004-06-04 | 2005-12-08 | Phytogen Life Sciences Inc. | Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel |
KR100816491B1 (ko) | 2005-11-17 | 2008-03-24 | 주식회사 삼양제넥스 | 탁산류 함유 물질로부터 13-디하이드록시바카틴 ⅲ 및10-디아세틸파클리탁셀의 추출 및 정제 방법 |
GB0701523D0 (en) * | 2007-01-26 | 2007-03-07 | Chatham Biotec Ltd | Semi-synthetic process for the preparation of taxane derivatives |
-
1992
- 1992-12-04 US US07/986,852 patent/US5256801A/en not_active Expired - Fee Related
-
1993
- 1993-08-16 DK DK93920109T patent/DK0656000T3/da active
- 1993-08-16 AT AT93920109T patent/ATE189454T1/de not_active IP Right Cessation
- 1993-08-16 NZ NZ255790A patent/NZ255790A/en unknown
- 1993-08-16 ES ES93920109T patent/ES2142877T3/es not_active Expired - Lifetime
- 1993-08-16 WO PCT/US1993/007706 patent/WO1994004519A1/en active IP Right Grant
- 1993-08-16 AU AU50156/93A patent/AU5015693A/en not_active Abandoned
- 1993-08-16 KR KR1019950700565A patent/KR0177588B1/ko not_active IP Right Cessation
- 1993-08-16 CA CA002142354A patent/CA2142354C/en not_active Expired - Fee Related
- 1993-08-16 EP EP93920109A patent/EP0656000B1/en not_active Expired - Lifetime
- 1993-08-16 JP JP6506470A patent/JP2958119B2/ja not_active Expired - Lifetime
- 1993-08-16 DE DE69327789T patent/DE69327789T2/de not_active Expired - Fee Related
- 1993-08-16 PT PT93920109T patent/PT656000E/pt unknown
-
2000
- 2000-03-27 GR GR20000400758T patent/GR3033069T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1994004519A1 (en) | 1994-03-03 |
EP0656000B1 (en) | 2000-02-02 |
DK0656000T3 (da) | 2000-08-07 |
PT656000E (pt) | 2000-07-31 |
CA2142354A1 (en) | 1994-03-03 |
ATE189454T1 (de) | 2000-02-15 |
KR950702975A (ko) | 1995-08-23 |
EP0656000A4 (en) | 1995-07-19 |
AU5015693A (en) | 1994-03-15 |
US5256801A (en) | 1993-10-26 |
CA2142354C (en) | 1999-05-04 |
NZ255790A (en) | 1996-03-26 |
JPH08503452A (ja) | 1996-04-16 |
JP2958119B2 (ja) | 1999-10-06 |
DE69327789D1 (de) | 2000-03-09 |
DE69327789T2 (de) | 2000-07-06 |
GR3033069T3 (en) | 2000-08-31 |
KR0177588B1 (ko) | 1999-03-20 |
EP0656000A1 (en) | 1995-06-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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