DE69326513D1 - Inhibitor des Angiotensin-konvertierenden Enzyms und Verfahren zu seiner Herstellung - Google Patents

Inhibitor des Angiotensin-konvertierenden Enzyms und Verfahren zu seiner Herstellung

Info

Publication number
DE69326513D1
DE69326513D1 DE69326513T DE69326513T DE69326513D1 DE 69326513 D1 DE69326513 D1 DE 69326513D1 DE 69326513 T DE69326513 T DE 69326513T DE 69326513 T DE69326513 T DE 69326513T DE 69326513 D1 DE69326513 D1 DE 69326513D1
Authority
DE
Germany
Prior art keywords
inhibitor
preparation
converting enzyme
angiotensin converting
angiotensin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69326513T
Other languages
English (en)
Other versions
DE69326513T2 (de
Inventor
Yasunori Nakamura
Toshiaki Takano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Soft Drinks Co Ltd
Original Assignee
Calpis Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calpis Co Ltd filed Critical Calpis Co Ltd
Application granted granted Critical
Publication of DE69326513D1 publication Critical patent/DE69326513D1/de
Publication of DE69326513T2 publication Critical patent/DE69326513T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dairy Products (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE69326513T 1992-07-23 1993-07-14 Inhibitor des Angiotensin-konvertierenden Enzyms und Verfahren zu seiner Herstellung Expired - Lifetime DE69326513T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4197239A JP2782142B2 (ja) 1992-07-23 1992-07-23 アンジオテンシン変換酵素阻害剤及びその製造法

Publications (2)

Publication Number Publication Date
DE69326513D1 true DE69326513D1 (de) 1999-10-28
DE69326513T2 DE69326513T2 (de) 2000-04-13

Family

ID=16371168

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69326513T Expired - Lifetime DE69326513T2 (de) 1992-07-23 1993-07-14 Inhibitor des Angiotensin-konvertierenden Enzyms und Verfahren zu seiner Herstellung

Country Status (5)

Country Link
US (1) US5449661A (de)
EP (1) EP0583074B1 (de)
JP (1) JP2782142B2 (de)
CN (1) CN1058020C (de)
DE (1) DE69326513T2 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0156678B1 (ko) * 1996-01-11 1998-10-15 이상윤 안지오텐신 전환효소 저해제
JP4065038B2 (ja) * 1996-08-07 2008-03-19 カルピス株式会社 計算作業負荷ストレス緩和剤
AR010744A1 (es) * 1996-12-09 2000-07-12 Guildford Pharmaceuticals Inc Inhibidores polipropilos de ciclofilina
JP3028411B2 (ja) 1997-09-26 2000-04-04 カルピス株式会社 トリペプチド高生産性ラクトバチルス・ヘルベチカス乳酸菌
US6962904B1 (en) * 1998-03-13 2005-11-08 Connective Tissue Imagineering Elastin peptide analogs and uses thereof
ATE305224T1 (de) * 1999-01-11 2005-10-15 Calpis Co Ltd Verfahren zur herstellung von sauermilch enthaltend ein inhibitionspeptid fuer ein angiotensin konvertierendes enzym sowie ein verfahren zur herstellung von milchserum
JP4205227B2 (ja) * 1999-01-11 2009-01-07 カルピス株式会社 ペプチド含有液の精製方法
JP4290792B2 (ja) 1999-01-11 2009-07-08 カルピス株式会社 造粒物、その製法及びこれを用いた錠剤
GB9912852D0 (en) * 1999-06-02 1999-08-04 Regen Therapeutics Plc Peptides
JP2003508512A (ja) 1999-09-08 2003-03-04 ギルフォード ファーマシュウティカルズ インコーポレイテッド 非ペプチド性サイクロフィリン結合化合物とその用途
FI113741B (fi) 1999-11-01 2004-06-15 Valio Oy Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi
GB0001825D0 (en) * 2000-01-26 2000-03-22 Regen Therapeutics Plc Peptides
AU2001245547A1 (en) * 2000-03-13 2001-09-24 Monsanto Technology Llc Process for producing peptide sequences possessing anti-hypertension activity
AU2001255469A1 (en) * 2000-04-21 2001-11-07 Monsanto Technology Llc Purification of ace inhibiting polypeptides containing vpp from milk
WO2001081368A2 (en) * 2000-04-21 2001-11-01 Monsanto Technology Llc Blood-pressure reducing polypeptides containing vpp derived from microorganisms
US6656971B2 (en) 2001-01-25 2003-12-02 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
WO2002071854A1 (en) * 2001-03-09 2002-09-19 Unilever N.V. Fermented milk product
FI112031B (fi) 2002-02-25 2003-10-31 Valio Oy Biologisesti aktiivisen tuotteen uusi käyttö
US20030165574A1 (en) * 2002-03-01 2003-09-04 Ward Loren Spencer Compositions and methods for treatment of body weight conditions
MXPA05007267A (es) * 2003-01-06 2005-09-08 Unilever Nv Producto de leche fermentada que comprende tripeptidos val-pro-pro (vpp) e ile-pro-pro (ipp).
US7718171B2 (en) 2003-04-07 2010-05-18 Chr. Hansen A/S Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus
UA87278C2 (ru) 2003-08-01 2009-07-10 Калпис Ко., Лтд. Пептиды, которые биологически не разлагаются; ингибитор ангиотензинпревращающего фермента, лекарственное средство и функциональный пищевой продукт
JP2007529206A (ja) * 2004-03-19 2007-10-25 カンピーナ ネーダーランド ホールディング ビー．ブイ． アンジオテンシン−ｉ−変換酵素阻害特性を有する食品成分及び食品の調製方法、並びにその方法により得られる製品
NZ550944A (en) * 2004-04-02 2009-12-24 Univ Tennessee Res Foundation Dairy components effective for fat loss
EP1685764A1 (de) 2005-01-27 2006-08-02 Globus Egg Sciences B.V. Funktionelle Lebensmittelprodukte mit blutdrucksenkender Wirkung
EP1827477B1 (de) 2004-12-22 2015-10-21 DSM IP Assets B.V. Blutdruck senkende oligopeptide in einem enzymatischen schritt
CN1908009B (zh) * 2004-12-29 2010-09-08 山东大学 中国毛虾蛋白降压肽及其制备方法与应用
DE602006005788D1 (de) * 2005-02-09 2009-04-30 Unilever Nv Lebensmittelprodukte mit hydrolysierten milchfeststoffen mit verbessertem geschmack
CN101193647A (zh) * 2005-04-11 2008-06-04 田纳西大学研究基金会 有效减少脂肪的稳定的奶制品成分
US20090042809A1 (en) * 2005-04-28 2009-02-12 Luppo Edens Blood Pressure Lowering Protein Hydrolysates
AU2006273395B2 (en) * 2005-07-26 2012-10-04 Calpis Co., Ltd. Process for production of fermented milk and fermented milk beverage/food
WO2007094340A1 (ja) 2006-02-14 2007-08-23 Calpis Co., Ltd. 血管拡張剤
CA2642539C (en) * 2006-02-14 2013-01-08 Calpis Co., Ltd. Agent for preventing arteriosclerosis, agent for suppressing vascular intimal thickening and agent for improving vascular endothelial function
ATE548445T1 (de) 2006-02-20 2012-03-15 Gervais Danone Sa Laktose nicht fermentierende lactobacillus helveticus
DE602006020977D1 (de) * 2006-02-20 2011-05-12 Gervais Danone Sa Neue Lactobacillus Helveticus Stämme
ES2320482T3 (es) 2006-02-20 2009-05-22 Compagnie Gervais Danone Nuevas cepas de lactobacillus helveticus.
JP2009537492A (ja) 2006-05-15 2009-10-29 ヴァリオ・リミテッド 治療上有用なペプチドの新規用途
EP2138184B1 (de) 2007-03-27 2013-09-18 Calpis Co., Ltd. Tripeptiden zur verwendung in der vorbeugung glomerulärer nierenerkrankung
WO2010071132A1 (ja) * 2008-12-15 2010-06-24 カルピス株式会社 皮膚老化抑制ペプチド
JP2010163400A (ja) 2009-01-19 2010-07-29 Kikkoman Corp 新規アンジオテンシン変換酵素阻害ペプチド
FI20095146A (fi) 2009-02-18 2010-08-19 Valio Oy Menetelmä elintarvikevalmisteen maun parantamiseksi
JP5832049B2 (ja) 2012-03-09 2015-12-16 森永乳業株式会社 ジペプチジルペプチダーゼ−ｉｖ阻害剤
CN106188227B (zh) * 2016-07-07 2019-09-24 华东理工大学 降血压肽和降血压蛋白质及其应用
US20230180778A1 (en) * 2020-04-02 2023-06-15 Fatah Bashir Ahtesh Milk fermentation process

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1186732B (it) * 1985-06-05 1987-12-16 Eniricerche Spa Decapeptidi ad azione ipotensiva e procedimento per la loro preparazione
JP2956975B2 (ja) * 1989-10-05 1999-10-04 マルハ株式会社 オキアミ中のアンジオテンシン変換酵素阻害活性の増強法
DE69124274T2 (de) * 1990-02-27 1997-08-14 Agency Ind Science Techn Oligopeptide, sie enthaltende pharmazeutische und Futterzusammensetzung und Benützung von Oligopeptiden
JP3149199B2 (ja) * 1991-03-12 2001-03-26 カルピス株式会社 アンジオテンシン変換酵素阻害ペプチド

Also Published As

Publication number Publication date
US5449661A (en) 1995-09-12
EP0583074B1 (de) 1999-09-22
EP0583074A3 (de) 1995-03-01
DE69326513T2 (de) 2000-04-13
CN1090201A (zh) 1994-08-03
JP2782142B2 (ja) 1998-07-30
JPH0640944A (ja) 1994-02-15
EP0583074A2 (de) 1994-02-16
CN1058020C (zh) 2000-11-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition