DE69326513T2 - Inhibitor des Angiotensin-konvertierenden Enzyms und Verfahren zu seiner Herstellung - Google Patents

Inhibitor des Angiotensin-konvertierenden Enzyms und Verfahren zu seiner Herstellung

Info

Publication number
DE69326513T2
DE69326513T2 DE69326513T DE69326513T DE69326513T2 DE 69326513 T2 DE69326513 T2 DE 69326513T2 DE 69326513 T DE69326513 T DE 69326513T DE 69326513 T DE69326513 T DE 69326513T DE 69326513 T2 DE69326513 T2 DE 69326513T2
Authority
DE
Germany
Prior art keywords
inhibitor
preparation
converting enzyme
angiotensin converting
angiotensin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69326513T
Other languages
English (en)
Other versions
DE69326513D1 (de
Inventor
Yasunori Nakamura
Toshiaki Takano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Soft Drinks Co Ltd
Original Assignee
Calpis Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calpis Co Ltd filed Critical Calpis Co Ltd
Application granted granted Critical
Publication of DE69326513D1 publication Critical patent/DE69326513D1/de
Publication of DE69326513T2 publication Critical patent/DE69326513T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dairy Products (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE69326513T 1992-07-23 1993-07-14 Inhibitor des Angiotensin-konvertierenden Enzyms und Verfahren zu seiner Herstellung Expired - Lifetime DE69326513T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4197239A JP2782142B2 (ja) 1992-07-23 1992-07-23 アンジオテンシン変換酵素阻害剤及びその製造法

Publications (2)

Publication Number Publication Date
DE69326513D1 DE69326513D1 (de) 1999-10-28
DE69326513T2 true DE69326513T2 (de) 2000-04-13

Family

ID=16371168

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69326513T Expired - Lifetime DE69326513T2 (de) 1992-07-23 1993-07-14 Inhibitor des Angiotensin-konvertierenden Enzyms und Verfahren zu seiner Herstellung

Country Status (5)

Country Link
US (1) US5449661A (de)
EP (1) EP0583074B1 (de)
JP (1) JP2782142B2 (de)
CN (1) CN1058020C (de)
DE (1) DE69326513T2 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0156678B1 (ko) * 1996-01-11 1998-10-15 이상윤 안지오텐신 전환효소 저해제
JP4065038B2 (ja) * 1996-08-07 2008-03-19 カルピス株式会社 計算作業負荷ストレス緩和剤
PA8442401A1 (es) * 1996-12-09 2000-05-24 Guilford Pharm Inc Inhibidores polipropilos de ciclofilina
JP3028411B2 (ja) 1997-09-26 2000-04-04 カルピス株式会社 トリペプチド高生産性ラクトバチルス・ヘルベチカス乳酸菌
US6962904B1 (en) * 1998-03-13 2005-11-08 Connective Tissue Imagineering Elastin peptide analogs and uses thereof
JP4290792B2 (ja) * 1999-01-11 2009-07-08 カルピス株式会社 造粒物、その製法及びこれを用いた錠剤
DK1142481T4 (da) 1999-01-11 2009-12-21 Calpis Co Ltd Fremgangsmåde til fremstilling af fermenteret mælk indeholdende et peptid, der inhiberer et angiotensinomdannende enzym og fremgangsmåde til fremstilling af mælkeserum
JP4205227B2 (ja) * 1999-01-11 2009-01-07 カルピス株式会社 ペプチド含有液の精製方法
GB9912852D0 (en) * 1999-06-02 1999-08-04 Regen Therapeutics Plc Peptides
EP1214293A1 (de) 1999-09-08 2002-06-19 Guilford Pharmaceuticals Inc. Nicht-peptidische cyclophilin bindende verbindungen und ihre verwendung
FI113741B (fi) * 1999-11-01 2004-06-15 Valio Oy Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi
GB0001825D0 (en) * 2000-01-26 2000-03-22 Regen Therapeutics Plc Peptides
AU2001245547A1 (en) * 2000-03-13 2001-09-24 Monsanto Technology Llc Process for producing peptide sequences possessing anti-hypertension activity
WO2001081368A2 (en) * 2000-04-21 2001-11-01 Monsanto Technology Llc Blood-pressure reducing polypeptides containing vpp derived from microorganisms
WO2001081366A2 (en) * 2000-04-21 2001-11-01 Monsanto Technology Llc Purification of ace inhibiting polypeptides containing vpp from milk
CA2435829A1 (en) 2001-01-25 2002-08-01 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
WO2002071854A1 (en) * 2001-03-09 2002-09-19 Unilever N.V. Fermented milk product
FI112031B (fi) 2002-02-25 2003-10-31 Valio Oy Biologisesti aktiivisen tuotteen uusi käyttö
US20030165574A1 (en) * 2002-03-01 2003-09-04 Ward Loren Spencer Compositions and methods for treatment of body weight conditions
PL378232A1 (pl) * 2003-01-06 2006-03-20 Unilever N.V. Fermentowany produkt mleczny, zawierający tripeptydy VPP i/albo IPP
US7718171B2 (en) 2003-04-07 2010-05-18 Chr. Hansen A/S Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus
EP1669463B1 (de) 2003-08-01 2008-10-15 Calpis Co., Ltd. Caseinhydrolysat, verfahren zur dessen herstellung sowie dessen verwendung
EP1727440A1 (de) * 2004-03-19 2006-12-06 Campina Nederland Holding B.V. Verfahren zur herstellung eines nahrungsmittelbestandteils und nahrungsmittelprodukts mit angiotensin-i-konvertierendes-enzym-hemmenden eigenschaften sowie so erhaltene produkte
US20070172474A1 (en) * 2004-04-02 2007-07-26 University Of Tennessee Research Foundiation Dairy components effective for fat loss
EP1685764A1 (de) 2005-01-27 2006-08-02 Globus Egg Sciences B.V. Funktionelle Lebensmittelprodukte mit blutdrucksenkender Wirkung
CN101084004A (zh) * 2004-12-22 2007-12-05 帝斯曼知识产权资产管理有限公司 单个酶促步骤中的血压降低寡肽
CN1908009B (zh) * 2004-12-29 2010-09-08 山东大学 中国毛虾蛋白降压肽及其制备方法与应用
US20090123605A1 (en) * 2005-02-09 2009-05-14 Wilhelmus Antonius J Van Benthum Food Products Comprising Hydrolysed Milk Solids With Improved Taste
EP1888086A4 (de) * 2005-04-11 2009-09-16 Univ Tennessee Res Foundation Stabile milchproduktbestandteile mit fettreduzierender wirkung
US20090042809A1 (en) * 2005-04-28 2009-02-12 Luppo Edens Blood Pressure Lowering Protein Hydrolysates
WO2007013426A1 (ja) 2005-07-26 2007-02-01 Calpis Co., Ltd. 発酵乳の製造方法及び発酵乳飲食品
EA200870259A1 (ru) * 2006-02-14 2009-02-27 Калпис Ко., Лтд. Сосудорасширяющее средство
CA2642539C (en) 2006-02-14 2013-01-08 Calpis Co., Ltd. Agent for preventing arteriosclerosis, agent for suppressing vascular intimal thickening and agent for improving vascular endothelial function
EP1820405B1 (de) * 2006-02-20 2011-03-30 Compagnie Gervais Danone Neue Lactobacillus Helveticus Stämme
PL1820851T3 (pl) 2006-02-20 2012-07-31 Gervais Danone Sa Szczepy Lactobacillus helveticus nie fermentujące laktozy
DE602006004956D1 (de) 2006-02-20 2009-03-12 Gervais Danone Sa Neue Stämme von Lactobacillus helveticus
US20090111758A1 (en) * 2006-05-15 2009-04-30 Valio Ltd. Use of therapeutically useful peptides
BRPI0809319A2 (pt) 2007-03-27 2014-09-23 Calpis Co Ltd Agente para suprimir espessamento de parede de coração, agente profilático para hipertrofia cardíaca, agente profilático para insuficiência cardíaca, e, alimento funcional
EP2371375A4 (de) * 2008-12-15 2013-01-02 Calpis Co Ltd Peptide zur hemmung von hautalterung
JP2010163400A (ja) 2009-01-19 2010-07-29 Kikkoman Corp 新規アンジオテンシン変換酵素阻害ペプチド
FI20095146A (fi) 2009-02-18 2010-08-19 Valio Oy Menetelmä elintarvikevalmisteen maun parantamiseksi
EP2824110A4 (de) 2012-03-09 2015-12-30 Morinaga Milk Industry Co Ltd Dipeptidylpeptidase-iv-hemmer
CN110028550B (zh) * 2016-07-07 2022-08-05 华东理工大学 降血压肽和降血压蛋白质及其应用
WO2021195718A1 (en) * 2020-04-02 2021-10-07 Ahtesh Fatah Bashir Milk fermentation process

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1186732B (it) * 1985-06-05 1987-12-16 Eniricerche Spa Decapeptidi ad azione ipotensiva e procedimento per la loro preparazione
JP2956975B2 (ja) * 1989-10-05 1999-10-04 マルハ株式会社 オキアミ中のアンジオテンシン変換酵素阻害活性の増強法
EP0445606B1 (de) * 1990-02-27 1997-01-22 The Agency of Industrial Science and Technology Oligopeptide, sie enthaltende pharmazeutische und Futterzusammensetzung und Benützung von Oligopeptiden
JP3149199B2 (ja) * 1991-03-12 2001-03-26 カルピス株式会社 アンジオテンシン変換酵素阻害ペプチド

Also Published As

Publication number Publication date
EP0583074A2 (de) 1994-02-16
EP0583074A3 (de) 1995-03-01
JPH0640944A (ja) 1994-02-15
EP0583074B1 (de) 1999-09-22
US5449661A (en) 1995-09-12
JP2782142B2 (ja) 1998-07-30
DE69326513D1 (de) 1999-10-28
CN1090201A (zh) 1994-08-03
CN1058020C (zh) 2000-11-01

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Legal Events

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8364 No opposition during term of opposition