DE69317320T2 - Teilsynthese von Taxanderivaten mittels Metallalkoxiden und Oxazinonen - Google Patents

Teilsynthese von Taxanderivaten mittels Metallalkoxiden und Oxazinonen

Info

Publication number
DE69317320T2
DE69317320T2 DE69317320T DE69317320T DE69317320T2 DE 69317320 T2 DE69317320 T2 DE 69317320T2 DE 69317320 T DE69317320 T DE 69317320T DE 69317320 T DE69317320 T DE 69317320T DE 69317320 T2 DE69317320 T2 DE 69317320T2
Authority
DE
Germany
Prior art keywords
oxazinones
metal alkoxides
taxane derivatives
partial synthesis
taxane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69317320T
Other languages
English (en)
Other versions
DE69317320D1 (de
Inventor
Robert A Holton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florida State University
Original Assignee
Florida State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Florida State University filed Critical Florida State University
Publication of DE69317320D1 publication Critical patent/DE69317320D1/de
Application granted granted Critical
Publication of DE69317320T2 publication Critical patent/DE69317320T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69317320T 1992-04-06 1993-04-05 Teilsynthese von Taxanderivaten mittels Metallalkoxiden und Oxazinonen Expired - Fee Related DE69317320T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/863,829 US5254703A (en) 1992-04-06 1992-04-06 Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones

Publications (2)

Publication Number Publication Date
DE69317320D1 DE69317320D1 (de) 1998-04-16
DE69317320T2 true DE69317320T2 (de) 1998-07-23

Family

ID=25341881

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69317320T Expired - Fee Related DE69317320T2 (de) 1992-04-06 1993-04-05 Teilsynthese von Taxanderivaten mittels Metallalkoxiden und Oxazinonen

Country Status (10)

Country Link
US (1) US5254703A (de)
EP (1) EP0568203B1 (de)
JP (1) JP3394284B2 (de)
AT (1) ATE163929T1 (de)
CA (1) CA2092962C (de)
DE (1) DE69317320T2 (de)
DK (1) DK0568203T3 (de)
ES (1) ES2115017T3 (de)
GR (1) GR3026433T3 (de)
SG (1) SG43898A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US6011056A (en) 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US6521660B2 (en) 1991-09-23 2003-02-18 Florida State University 3′-alkyl substituted taxanes and pharmaceutical compositions containing them
US6335362B1 (en) 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US5728725A (en) * 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US5998656A (en) * 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US6005138A (en) 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5721268A (en) * 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US6339164B1 (en) 1993-01-29 2002-01-15 Florida State University C2 substituted phenyl taxane derivatives and pharmaceutical compositions containing them
FR2702212B1 (fr) * 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
DK0687260T3 (da) * 1993-03-05 2003-06-10 Univ Florida State Fremgangsmåde til fremstillingen af 9-desoxotaxaner
US6710191B2 (en) * 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
US5405972A (en) * 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
US5840748A (en) * 1995-10-02 1998-11-24 Xechem International, Inc. Dihalocephalomannine and methods of use therefor
US5854278A (en) * 1995-12-13 1998-12-29 Xechem International, Inc. Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents
US5654448A (en) * 1995-10-02 1997-08-05 Xechem International, Inc. Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
US5807888A (en) * 1995-12-13 1998-09-15 Xechem International, Inc. Preparation of brominated paclitaxel analogues and their use as effective antitumor agents
US6177456B1 (en) 1995-10-02 2001-01-23 Xechem International, Inc. Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor
WO1997042181A1 (en) * 1996-05-06 1997-11-13 Florida State University 1-deoxy baccatin iii, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
ES2195378T3 (es) 1997-08-21 2003-12-01 Univ Florida State Procedimiento para la sintesis de taxanos.
US6150537A (en) * 1997-12-12 2000-11-21 Emory University Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
EP2289549A3 (de) 1999-10-01 2011-06-15 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
DE10032256C2 (de) * 2000-07-03 2003-06-05 Infineon Technologies Ag Chip-ID-Register-Anordnung
KR20020066808A (ko) * 2001-02-14 2002-08-21 주식회사 삼양제넥스 비대칭 아미노히드록실레이션반응을 이용한 탁센 유도체의제조방법
WO2004033442A2 (en) * 2002-10-09 2004-04-22 Chatham Biotec Ltd. Novel taxanes and methods related to use and preparation thereof
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
US20070246683A1 (en) * 2006-04-24 2007-10-25 David Paul Miller Reduced dusting gypsum composites and method of making them
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4418470A (en) 1981-10-21 1983-12-06 General Electric Company Method for fabricating silicon-on-sapphire monolithic microwave integrated circuits
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone

Also Published As

Publication number Publication date
EP0568203B1 (de) 1998-03-11
US5254703A (en) 1993-10-19
EP0568203A1 (de) 1993-11-03
JP3394284B2 (ja) 2003-04-07
DE69317320D1 (de) 1998-04-16
CA2092962A1 (en) 1993-10-07
ES2115017T3 (es) 1998-06-16
SG43898A1 (en) 1997-11-14
JPH06145157A (ja) 1994-05-24
ATE163929T1 (de) 1998-03-15
DK0568203T3 (da) 1998-05-04
GR3026433T3 (en) 1998-06-30
CA2092962C (en) 1999-01-19

Similar Documents

Publication Publication Date Title
DE69317320T2 (de) Teilsynthese von Taxanderivaten mittels Metallalkoxiden und Oxazinonen
GR3020647T3 (en) Pyranyl cyanoguanidine derivatives
GR3029764T3 (en) Method of preparing a radioactive rhenium complex solution.
NO973253L (no) Sidekjedeholdig taxan og fremgangsmåte til fremstilling derav
FI910857A0 (fi) Foerfarande foer framstaellning av oxetanoner.
EG19389A (en) Process for preparing of pyranyl cyanoguanidine derivatives.
HU9400803D0 (en) New beta-lactames and process for producing taxane derivatives with them
DK0503453T3 (da) Fremgangsmåde til fremstilling af cephalosporiner og mellemprodukter i denne fremgangsmåde
EE03071B1 (et) Karbasolooni derivaadid ja nende saamise protsess
ES2184761T3 (es) Derivados de taxanos c10 y composiciones farmaceuticas.
EP0543095A3 (en) Method for producing 2-amino-6-halogenopurine and synthesis intermediate therefor
EP0274064A3 (en) 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene pgi2 derivatives
ES502073A0 (es) Metodo de producir lactamas antihipertensoras
ATE104959T1 (de) Verfahren zur herstellung von vitamin a aldehyd.
JPS5798257A (en) 3,4-disubstituted azetidine-2-one compound and its preparation
ES381403A1 (es) Procedimiento para la obtencion de derivados basicamente sustituidos de la 2,4-(1h, 3h)-quinazolindiona.
DK0506235T3 (da) Glyceraldehyd-3-pentanid og fremgangsmåde til fremstilling af samme
DE3464915D1 (en) (5-(2-aminomethyl-imidazol-1-yl)-1,3-dialkyl-1h-pyrazol-4-yl)(aryl)methanones and processes for their production
HU9201664D0 (en) Process for the production of intermedier nizatidine and its derivatives

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee