ES2115017T3 - Semi sintesis de derivados de taxano mediante el uso de alcoxidos de metales. - Google Patents
Semi sintesis de derivados de taxano mediante el uso de alcoxidos de metales.Info
- Publication number
- ES2115017T3 ES2115017T3 ES93302650T ES93302650T ES2115017T3 ES 2115017 T3 ES2115017 T3 ES 2115017T3 ES 93302650 T ES93302650 T ES 93302650T ES 93302650 T ES93302650 T ES 93302650T ES 2115017 T3 ES2115017 T3 ES 2115017T3
- Authority
- ES
- Spain
- Prior art keywords
- taxane derivatives
- taxane
- metal
- metal alcoxides
- semi synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000002184 metal Substances 0.000 abstract 2
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 229940123237 Taxane Drugs 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE PRESENTA UN PROCESO PARA PREPARAR DERIVADOS DE TAXANO TALES COMO EL TAXOL SUMINISTRANDO UN ALCOXIDO DE METAL QUE TENGA EL NUCLEO DE TAXANO BI, TRI O TETRACICLICO, HACIENDO REACCIONAR EL ALCOXIDO DE METAL CON OXACINONA PARA FORMAR UN PRODUCTO INTERMEDIO Y CONVIRTIENDO EL PRODUCTO INTERMEDIO EN EL DERIVADO DEL TAXANO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/863,829 US5254703A (en) | 1992-04-06 | 1992-04-06 | Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2115017T3 true ES2115017T3 (es) | 1998-06-16 |
Family
ID=25341881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93302650T Expired - Lifetime ES2115017T3 (es) | 1992-04-06 | 1993-04-05 | Semi sintesis de derivados de taxano mediante el uso de alcoxidos de metales. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5254703A (es) |
EP (1) | EP0568203B1 (es) |
JP (1) | JP3394284B2 (es) |
AT (1) | ATE163929T1 (es) |
CA (1) | CA2092962C (es) |
DE (1) | DE69317320T2 (es) |
DK (1) | DK0568203T3 (es) |
ES (1) | ES2115017T3 (es) |
GR (1) | GR3026433T3 (es) |
SG (1) | SG43898A1 (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6521660B2 (en) | 1991-09-23 | 2003-02-18 | Florida State University | 3′-alkyl substituted taxanes and pharmaceutical compositions containing them |
US5489601A (en) * | 1991-09-23 | 1996-02-06 | Florida State University | Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them |
US5728850A (en) * | 1991-09-23 | 1998-03-17 | Florida State University | Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them |
US6011056A (en) | 1991-09-23 | 2000-01-04 | Florida State University | C9 taxane derivatives and pharmaceutical compositions containing them |
US6028205A (en) * | 1991-09-23 | 2000-02-22 | Florida State University | C2 tricyclic taxanes |
US6794523B2 (en) | 1991-09-23 | 2004-09-21 | Florida State University | Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them |
US6005138A (en) | 1991-09-23 | 1999-12-21 | Florida State University | Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them |
US6018073A (en) * | 1991-09-23 | 2000-01-25 | Florida State University | Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them |
US5739362A (en) * | 1991-09-23 | 1998-04-14 | Florida State University | Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them |
US6495704B1 (en) | 1991-09-23 | 2002-12-17 | Florida State University | 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes |
US5998656A (en) * | 1991-09-23 | 1999-12-07 | Florida State University | C10 tricyclic taxanes |
US5728725A (en) * | 1991-09-23 | 1998-03-17 | Florida State University | C2 taxane derivaties and pharmaceutical compositions containing them |
US5654447A (en) * | 1991-09-23 | 1997-08-05 | Florida State University | Process for the preparation of 10-desacetoxybaccatin III |
US6335362B1 (en) * | 1991-09-23 | 2002-01-01 | Florida State University | Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them |
US5721268A (en) * | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
US5714513A (en) * | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
FR2698871B1 (fr) | 1992-12-09 | 1995-02-24 | Rhone Poulenc Rorer Sa | Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
US6339164B1 (en) | 1993-01-29 | 2002-01-15 | Florida State University | C2 substituted phenyl taxane derivatives and pharmaceutical compositions containing them |
FR2702212B1 (fr) * | 1993-03-02 | 1995-04-07 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
US6710191B2 (en) | 1993-03-05 | 2004-03-23 | Florida State University | 9β-hydroxytetracyclic taxanes |
EP0687260B1 (en) * | 1993-03-05 | 2003-02-19 | Florida State University | Process for the preparation of 9-desoxotaxanes |
US5405972A (en) * | 1993-07-20 | 1995-04-11 | Florida State University | Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes |
US6005120A (en) * | 1993-07-20 | 1999-12-21 | Florida State University | Tricyclic and tetracyclic taxanes |
US5840748A (en) * | 1995-10-02 | 1998-11-24 | Xechem International, Inc. | Dihalocephalomannine and methods of use therefor |
US5654448A (en) * | 1995-10-02 | 1997-08-05 | Xechem International, Inc. | Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes |
US5807888A (en) * | 1995-12-13 | 1998-09-15 | Xechem International, Inc. | Preparation of brominated paclitaxel analogues and their use as effective antitumor agents |
US6177456B1 (en) | 1995-10-02 | 2001-01-23 | Xechem International, Inc. | Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor |
US5854278A (en) * | 1995-12-13 | 1998-12-29 | Xechem International, Inc. | Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents |
AU724499B2 (en) * | 1996-05-06 | 2000-09-21 | Florida State University | 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof |
US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
DE69812395T2 (de) | 1997-08-21 | 2004-02-05 | Florida State University, Tallahassee | Verfahren zur synthese von taxanen |
US6150537A (en) * | 1997-12-12 | 2000-11-21 | Emory University | Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents |
US6156789A (en) * | 1998-03-17 | 2000-12-05 | Rhone-Poulenc Rorer S.A. | Method for treating abnormal cell proliferation in the brain |
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
DE10032256C2 (de) * | 2000-07-03 | 2003-06-05 | Infineon Technologies Ag | Chip-ID-Register-Anordnung |
KR20020066808A (ko) * | 2001-02-14 | 2002-08-21 | 주식회사 삼양제넥스 | 비대칭 아미노히드록실레이션반응을 이용한 탁센 유도체의제조방법 |
WO2004033442A2 (en) * | 2002-10-09 | 2004-04-22 | Chatham Biotec Ltd. | Novel taxanes and methods related to use and preparation thereof |
US7202370B2 (en) * | 2003-10-27 | 2007-04-10 | Conor Medsystems, Inc. | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III |
US20070246683A1 (en) * | 2006-04-24 | 2007-10-25 | David Paul Miller | Reduced dusting gypsum composites and method of making them |
PL388144A1 (pl) | 2009-05-29 | 2010-12-06 | Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością | Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4418470A (en) | 1981-10-21 | 1983-12-06 | General Electric Company | Method for fabricating silicon-on-sapphire monolithic microwave integrated circuits |
FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2601676B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Procede de preparation du taxol et du desacetyl-10 taxol |
US4942184A (en) * | 1988-03-07 | 1990-07-17 | The United States Of America As Represented By The Department Of Health And Human Services | Water soluble, antineoplastic derivatives of taxol |
FR2629818B1 (fr) * | 1988-04-06 | 1990-11-16 | Centre Nat Rech Scient | Procede de preparation du taxol |
FR2629819B1 (fr) * | 1988-04-06 | 1990-11-16 | Rhone Poulenc Sante | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii |
US5136060A (en) * | 1989-11-14 | 1992-08-04 | Florida State University | Method for preparation of taxol using an oxazinone |
US5015744A (en) * | 1989-11-14 | 1991-05-14 | Florida State University | Method for preparation of taxol using an oxazinone |
-
1992
- 1992-04-06 US US07/863,829 patent/US5254703A/en not_active Expired - Lifetime
-
1993
- 1993-03-30 CA CA002092962A patent/CA2092962C/en not_active Expired - Fee Related
- 1993-04-05 EP EP93302650A patent/EP0568203B1/en not_active Expired - Lifetime
- 1993-04-05 SG SG1996004436A patent/SG43898A1/en unknown
- 1993-04-05 DK DK93302650.2T patent/DK0568203T3/da active
- 1993-04-05 ES ES93302650T patent/ES2115017T3/es not_active Expired - Lifetime
- 1993-04-05 JP JP10006093A patent/JP3394284B2/ja not_active Expired - Fee Related
- 1993-04-05 DE DE69317320T patent/DE69317320T2/de not_active Expired - Fee Related
- 1993-04-05 AT AT93302650T patent/ATE163929T1/de not_active IP Right Cessation
-
1998
- 1998-03-20 GR GR980400623T patent/GR3026433T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US5254703A (en) | 1993-10-19 |
CA2092962C (en) | 1999-01-19 |
EP0568203A1 (en) | 1993-11-03 |
GR3026433T3 (en) | 1998-06-30 |
SG43898A1 (en) | 1997-11-14 |
CA2092962A1 (en) | 1993-10-07 |
DE69317320D1 (de) | 1998-04-16 |
JPH06145157A (ja) | 1994-05-24 |
DK0568203T3 (da) | 1998-05-04 |
ATE163929T1 (de) | 1998-03-15 |
EP0568203B1 (en) | 1998-03-11 |
JP3394284B2 (ja) | 2003-04-07 |
DE69317320T2 (de) | 1998-07-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2115017T3 (es) | Semi sintesis de derivados de taxano mediante el uso de alcoxidos de metales. | |
ES357468A1 (es) | Procedimiento para la preparacion de 2-aril-v-triazoles. | |
ES330471A1 (es) | Procedimiento para la produccion de un pentacosapeptido. | |
ES2055833T3 (es) | Procedimiento para la obtencion de 4-metilentetrahidropirano. | |
MY6500169A (en) | The new organic compound tylosin, its hydrolysis product desmycosin & methods for preparing same | |
ES354728A1 (es) | Procedimiento para la produccion de piperidonas. | |
JPS5216500A (en) | Method for production of carbide. | |
CA597392A (en) | Low pressure atomizer nozzle for oil burners | |
BE602985A (fr) | Procédé de préparation de bore de grande pureté. | |
GB1078724A (en) | Improvements in the production of pregnane derivatives | |
CA594414A (en) | Process for the production of boranates | |
GB1321723A (en) | 17-cyano-steroids and processes for their preparation | |
ES201100Y (es) | Gorra para uso deportivo tal como para el tiro de preci- sion. | |
GB960454A (en) | Steroid compounds and their production | |
ES416022A1 (es) | Procedimiento para la preparacion de di-(1-isoquinoli)-di- (2-piridil)-butanos. | |
GB1037914A (en) | Improvements relating to roof supports for mine workings | |
AU6197865A (en) | Olephinic amorphous curable terpolymers of alpha olephines and polycyclic orthcondensed polyenes having one or more conjugated alkylidene substituents, and process for the production thereof | |
CA590867A (en) | Production of refractory metals such as titanium, etc. | |
CA702812A (en) | Process for producing nitrogen-rich organic materials especially for use as fertilizers | |
CA741794A (en) | Process for the production of organic nitrogen compounds | |
GB873239A (en) | Chloroquine derivatives | |
CA606628A (en) | Process for the production of high molecular earth alkali metal complex compounds | |
CA698078A (en) | Production of tubular carbon articles | |
CA698186A (en) | Production of tubular carbon articles | |
ES148506U (es) | Panel modulo de centralizacion de reactancias. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 568203 Country of ref document: ES |