DE69308852D1 - Vitamin d derivate - Google Patents

Vitamin d derivate

Info

Publication number
DE69308852D1
DE69308852D1 DE69308852T DE69308852T DE69308852D1 DE 69308852 D1 DE69308852 D1 DE 69308852D1 DE 69308852 T DE69308852 T DE 69308852T DE 69308852 T DE69308852 T DE 69308852T DE 69308852 D1 DE69308852 D1 DE 69308852D1
Authority
DE
Germany
Prior art keywords
pct
deuterium
sec
hydrogen
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69308852T
Other languages
English (en)
Other versions
DE69308852T2 (de
Inventor
Claus Bretting
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Application granted granted Critical
Publication of DE69308852D1 publication Critical patent/DE69308852D1/de
Publication of DE69308852T2 publication Critical patent/DE69308852T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69308852T 1992-07-03 1993-06-07 Vitamin d derivate Expired - Fee Related DE69308852T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929214202A GB9214202D0 (en) 1992-07-03 1992-07-03 Chemical compounds
PCT/DK1993/000196 WO1994001398A1 (en) 1992-07-03 1993-06-07 Vitamin d analogues

Publications (2)

Publication Number Publication Date
DE69308852D1 true DE69308852D1 (de) 1997-04-17
DE69308852T2 DE69308852T2 (de) 1997-11-27

Family

ID=10718182

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69308852T Expired - Fee Related DE69308852T2 (de) 1992-07-03 1993-06-07 Vitamin d derivate

Country Status (17)

Country Link
US (1) US5545633A (de)
EP (1) EP0648207B1 (de)
JP (1) JPH08504746A (de)
KR (1) KR100285146B1 (de)
AT (1) ATE150013T1 (de)
AU (1) AU667378B2 (de)
CA (1) CA2131631A1 (de)
DE (1) DE69308852T2 (de)
DK (1) DK0648207T3 (de)
ES (1) ES2101319T3 (de)
FI (1) FI106120B (de)
GB (1) GB9214202D0 (de)
GR (1) GR3023407T3 (de)
HU (1) HU222775B1 (de)
NZ (1) NZ253026A (de)
RU (1) RU2114825C1 (de)
WO (1) WO1994001398A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9226860D0 (en) * 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Novel treatment
DE4427690A1 (de) * 1994-08-04 1996-02-08 Bogdahn Ulrich Prof Deuterium enthaltende pharmazeutische Zusammensetzung als Zytostatikum oder Tumor-Therapeutikum
DK0717034T3 (da) * 1994-12-14 1999-10-18 Duphar Int Res Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser
TW422696B (en) * 1995-03-20 2001-02-21 Katsuhiko Mukai Ophthalmic composition containing active vitamin D
GB9526208D0 (en) 1995-12-21 1996-02-21 Res Inst Medicine Chem Chemical compounds
GB9721156D0 (en) * 1997-10-06 1997-12-03 Leo Pharm Prod Ltd Novel vitamin d analogues
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
ATE425178T1 (de) * 2001-10-19 2009-03-15 Isotechnika Inc Synthese von cyclosporinanalogen
US8404667B2 (en) * 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
WO2006051106A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
NZ555282A (en) * 2004-11-22 2010-12-24 Wisconsin Alumni Res Found 17,20(z)-dehydro vitamin D analogs and their uses
US8193169B2 (en) * 2006-04-06 2012-06-05 Wisconsin Alumni Research Foundation (20R)-2α-methyl-19,26,2-trinor-vitamin D analogs
US8222236B2 (en) 2008-07-10 2012-07-17 Wisconsin Alumni Research Foundation 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs
US7648974B1 (en) * 2008-07-10 2010-01-19 Wisconsin Alumni Research Foundation 19-nor-vitamin D analogs with 3,2-dihydrofuran ring
US7713953B2 (en) * 2008-07-10 2010-05-11 Wisconsin Alumni Research Foundation 2-methylene-(22E)-25-(1-methylene-hexyl)-26,27-cyclo-22-dehydro-19-nor-vitamin D analogs
US7879829B2 (en) * 2008-07-10 2011-02-01 Wisconsin Alumni Research Foundation 19-nor-vitamin D analogs with 1,2-dihydrofuran ring
US8399439B2 (en) 2008-07-10 2013-03-19 Wisconsin Alumni Research Foundation 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs
US7888339B2 (en) 2008-07-10 2011-02-15 Wisconsin Alumni Research Foundation 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs
US8193170B2 (en) * 2008-07-10 2012-06-05 Wisconsin Alumni Research Foundation 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs
US7893043B2 (en) * 2008-07-10 2011-02-22 Wisconsin Alumni Research Foundation 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs
BRPI0916769A2 (pt) * 2008-07-15 2017-09-26 Theracos Inc derivados de benzilbenzeno deuterados e métodos de uso
CN107019795A (zh) 2009-01-27 2017-08-08 博格有限责任公司 用于减轻与化疗有关的副作用的维生素d3化合物
MX366076B (es) 2009-08-14 2019-06-27 Berg Llc Vitamina d3 y analogos de la misma para tratar alopecia.
AU2010300528B2 (en) 2009-10-02 2016-02-11 Wisconsin Alumni Research Foundation (20S,22E)-2-methylene-19-nor-22-ene-1alpha,25-dihydroxyvitamin D3 analogs
WO2011041596A2 (en) 2009-10-02 2011-04-07 Wisconsin Alumni Research Foundation 19-nor-vitamin d analogs with 1,2-or 3,2-cyclopentene ring
JP6059716B2 (ja) 2011-06-03 2017-01-11 ウイスコンシン アラムニ リサーチ ファンデーション （２２Ｅ）−２−メチレン−２６，２７−シクロ−２２−デヒドロ−１α−ヒドロキシ−１９−ノルビタミンＤ３誘導体
WO2013003307A1 (en) 2011-06-28 2013-01-03 Wisconsin Alumni Research Foundation 2-methylene-(22e)-25-hexanoyl-24-oxo-26,27-cyclo-22-dehydro-19-nor-vitamin d analogs
WO2013012644A1 (en) 2011-07-18 2013-01-24 Wisconsin Alumni I Research Foundation 2-methylene-20(21)-dehydro-19,24,25,26,27,-pentanor-vitamin d analogs
US9416102B2 (en) 2013-01-23 2016-08-16 Wisconsin Alumni Research Foundation (22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 analogs
NZ714801A (en) 2013-05-29 2021-07-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
DK3223808T3 (en) 2014-11-25 2019-03-25 Trophea Dev Ab TREATMENT OF HUDATROPHY WITH A COMBINATION OF TRIIODTHYROEDIC ACID (TRIAC) AND DEHYDROEPIANDROSTERON (DHEA)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i

Also Published As

Publication number Publication date
ATE150013T1 (de) 1997-03-15
WO1994001398A1 (en) 1994-01-20
GB9214202D0 (en) 1992-08-12
CA2131631A1 (en) 1994-01-20
NZ253026A (en) 1997-07-27
DK0648207T3 (da) 1997-06-23
FI950023A (fi) 1995-01-02
GR3023407T3 (en) 1997-08-29
JPH08504746A (ja) 1996-05-21
FI106120B (fi) 2000-11-30
EP0648207B1 (de) 1997-03-12
KR100285146B1 (ko) 2001-04-02
AU667378B2 (en) 1996-03-21
ES2101319T3 (es) 1997-07-01
RU2114825C1 (ru) 1998-07-10
DE69308852T2 (de) 1997-11-27
AU4311193A (en) 1994-01-31
HU9402484D0 (en) 1994-11-28
RU94046411A (ru) 1996-10-10
HU222775B1 (hu) 2003-10-28
EP0648207A1 (de) 1995-04-19
HUT68025A (en) 1995-05-29
KR950700876A (ko) 1995-02-20
US5545633A (en) 1996-08-13
FI950023A0 (fi) 1995-01-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LEO PHARMA A/S ZWEITNAME: LEO PHARMACEUTICAL PRODU

8339 Ceased/non-payment of the annual fee