RU94046411A - Производные витамина д, способ их получения, фармацевтическая композиция на их основе и способ ее получения, способ лечения - Google Patents

Производные витамина д, способ их получения, фармацевтическая композиция на их основе и способ ее получения, способ лечения

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Publication number
RU94046411A
RU94046411A RU94046411/04A RU94046411A RU94046411A RU 94046411 A RU94046411 A RU 94046411A RU 94046411/04 A RU94046411/04 A RU 94046411/04A RU 94046411 A RU94046411 A RU 94046411A RU 94046411 A RU94046411 A RU 94046411A
Authority
RU
Russia
Prior art keywords
synthesis
derivatives
compounds
vitamin
preparing
Prior art date
Application number
RU94046411/04A
Other languages
English (en)
Other versions
RU2114825C1 (ru
Inventor
Оге Свенсгор Бреттинг Клаус
Dk]
Original Assignee
Лео Фармасьютикал Продактс А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб) (DK)
Лео Фармасьютикал Продактс А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лео Фармасьютикал Продактс А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб) (DK), Лео Фармасьютикал Продактс А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб) filed Critical Лео Фармасьютикал Продактс А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб) (DK)
Publication of RU94046411A publication Critical patent/RU94046411A/ru
Application granted granted Critical
Publication of RU2114825C1 publication Critical patent/RU2114825C1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к соединениям, которые проявляют противовоспалительное и имунномодулирующее действие, также как сильную активность в индуцировании дифференциации и ингибировании пролиферации некоторых клеток.

Claims (1)

  1. Изобретение относится к соединениям, которые проявляют противовоспалительное и имунномодулирующее действие, также как сильную активность в индуцировании дифференциации и ингибировании пролиферации некоторых клеток.
RU94046411A 1992-07-03 1993-06-07 Производные витамина d RU2114825C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9214202.5 1992-07-03
GB929214202A GB9214202D0 (en) 1992-07-03 1992-07-03 Chemical compounds

Publications (2)

Publication Number Publication Date
RU94046411A true RU94046411A (ru) 1996-10-10
RU2114825C1 RU2114825C1 (ru) 1998-07-10

Family

ID=10718182

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94046411A RU2114825C1 (ru) 1992-07-03 1993-06-07 Производные витамина d

Country Status (17)

Country Link
US (1) US5545633A (ru)
EP (1) EP0648207B1 (ru)
JP (1) JPH08504746A (ru)
KR (1) KR100285146B1 (ru)
AT (1) ATE150013T1 (ru)
AU (1) AU667378B2 (ru)
CA (1) CA2131631A1 (ru)
DE (1) DE69308852T2 (ru)
DK (1) DK0648207T3 (ru)
ES (1) ES2101319T3 (ru)
FI (1) FI106120B (ru)
GB (1) GB9214202D0 (ru)
GR (1) GR3023407T3 (ru)
HU (1) HU222775B1 (ru)
NZ (1) NZ253026A (ru)
RU (1) RU2114825C1 (ru)
WO (1) WO1994001398A1 (ru)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9226860D0 (en) * 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Novel treatment
DE4427690A1 (de) * 1994-08-04 1996-02-08 Bogdahn Ulrich Prof Deuterium enthaltende pharmazeutische Zusammensetzung als Zytostatikum oder Tumor-Therapeutikum
DK0717034T3 (da) * 1994-12-14 1999-10-18 Duphar Int Res Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser
TW422696B (en) 1995-03-20 2001-02-21 Katsuhiko Mukai Ophthalmic composition containing active vitamin D
GB9526208D0 (en) * 1995-12-21 1996-02-21 Res Inst Medicine Chem Chemical compounds
GB9721156D0 (en) 1997-10-06 1997-12-03 Leo Pharm Prod Ltd Novel vitamin d analogues
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
ES2326040T3 (es) * 2001-10-19 2009-09-29 Isotechnika Inc. Sintesis de analogos de ciclosporina.
US8404667B2 (en) * 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
JP2008519808A (ja) 2004-11-12 2008-06-12 ビオエクセル エスピーエー 膀胱癌治療のためのビタミンｄ誘導体及び抗増殖薬の併用
DE602005021702D1 (de) * 2004-11-22 2010-07-15 Wisconsin Alumni Res Found 2-methylen-19-nor-1alpha-hydroxy-17-enhormopregnacalziferol und anwendungen davon
US8193169B2 (en) * 2006-04-06 2012-06-05 Wisconsin Alumni Research Foundation (20R)-2α-methyl-19,26,2-trinor-vitamin D analogs
US7648974B1 (en) * 2008-07-10 2010-01-19 Wisconsin Alumni Research Foundation 19-nor-vitamin D analogs with 3,2-dihydrofuran ring
US8399439B2 (en) 2008-07-10 2013-03-19 Wisconsin Alumni Research Foundation 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs
US7879829B2 (en) * 2008-07-10 2011-02-01 Wisconsin Alumni Research Foundation 19-nor-vitamin D analogs with 1,2-dihydrofuran ring
US7888339B2 (en) 2008-07-10 2011-02-15 Wisconsin Alumni Research Foundation 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs
US8193170B2 (en) 2008-07-10 2012-06-05 Wisconsin Alumni Research Foundation 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs
US7713953B2 (en) * 2008-07-10 2010-05-11 Wisconsin Alumni Research Foundation 2-methylene-(22E)-25-(1-methylene-hexyl)-26,27-cyclo-22-dehydro-19-nor-vitamin D analogs
US7893043B2 (en) * 2008-07-10 2011-02-22 Wisconsin Alumni Research Foundation 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs
US8222236B2 (en) 2008-07-10 2012-07-17 Wisconsin Alumni Research Foundation 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs
BRPI0916769A2 (pt) * 2008-07-15 2017-09-26 Theracos Inc derivados de benzilbenzeno deuterados e métodos de uso
CA2981549A1 (en) 2009-01-27 2010-08-05 Berg Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
SG10201404883YA (en) 2009-08-14 2014-10-30 Berg Llc Vitamin d3 and analogs thereof for treating alopecia
US8445468B2 (en) 2009-10-02 2013-05-21 Wisconsin Alumni Research Foundation (20S,22E)-2-methylene-19-nor-22-ene-1α,25-dihydroxyvitamin D3
US8217023B2 (en) 2009-10-02 2012-07-10 Wisconsin Alumni Research Foundation 19-nor-vitamin D analogs with 1,2- or 3,2-cyclopentene ring
AU2012262174B2 (en) 2011-06-03 2016-12-01 Wisconsin Alumni Research Foundation (22E)-2-methylene-26,27-cyclo-22-dehydro-1alpha-hydroxy-19-norvitamin D3 derivatives
US10479764B2 (en) 2011-06-28 2019-11-19 Wisconsin Alumni Research Foundation 2-methylene-(22E)-25-hexanoyl-24-oxo-26,27-cyclo-22-dehydro-19-nor-vitamin D analogs
US20130178449A1 (en) 2011-07-18 2013-07-11 Wisconsin Alumni Research Foundation 2-Methylene-20(21)-Dehydro-19,24,25,26,27-Pentanor-Vitamin D Analogs
US9416102B2 (en) 2013-01-23 2016-08-16 Wisconsin Alumni Research Foundation (22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 analogs
AU2014274099A1 (en) 2013-05-29 2015-12-24 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin D
CN106999457B (zh) 2014-11-25 2020-02-11 特洛弗发展公司 使用三碘甲腺乙酸(triac)和脱氢表雄酮(dhea)的组合治疗皮肤萎缩

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i

Also Published As

Publication number Publication date
JPH08504746A (ja) 1996-05-21
EP0648207B1 (en) 1997-03-12
FI950023A0 (fi) 1995-01-02
FI106120B (fi) 2000-11-30
DE69308852D1 (de) 1997-04-17
DE69308852T2 (de) 1997-11-27
DK0648207T3 (da) 1997-06-23
KR100285146B1 (ko) 2001-04-02
ATE150013T1 (de) 1997-03-15
AU667378B2 (en) 1996-03-21
AU4311193A (en) 1994-01-31
HU9402484D0 (en) 1994-11-28
CA2131631A1 (en) 1994-01-20
GR3023407T3 (en) 1997-08-29
WO1994001398A1 (en) 1994-01-20
KR950700876A (ko) 1995-02-20
FI950023A (fi) 1995-01-02
US5545633A (en) 1996-08-13
NZ253026A (en) 1997-07-27
HUT68025A (en) 1995-05-29
ES2101319T3 (es) 1997-07-01
RU2114825C1 (ru) 1998-07-10
EP0648207A1 (en) 1995-04-19
GB9214202D0 (en) 1992-08-12
HU222775B1 (hu) 2003-10-28

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Effective date: 20050608