DE69304528T2 - Verfahren zur bestimmung der menge eines schilddrüsenhormon-liganden in einer biologischen flüssigkeit und satz zur durchführung dieses verfahrens - Google Patents

Verfahren zur bestimmung der menge eines schilddrüsenhormon-liganden in einer biologischen flüssigkeit und satz zur durchführung dieses verfahrens

Info

Publication number
DE69304528T2
DE69304528T2 DE69304528T DE69304528T DE69304528T2 DE 69304528 T2 DE69304528 T2 DE 69304528T2 DE 69304528 T DE69304528 T DE 69304528T DE 69304528 T DE69304528 T DE 69304528T DE 69304528 T2 DE69304528 T2 DE 69304528T2
Authority
DE
Germany
Prior art keywords
ligand
thyroid hormone
amount
test tube
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69304528T
Other languages
English (en)
Other versions
DE69304528T3 (de
DE69304528D1 (de
Inventor
Andreas Bergmann
Joachim Struck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BRAHMS GmbH
Original Assignee
BRAHMS Diagnostica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6458274&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69304528(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by BRAHMS Diagnostica GmbH filed Critical BRAHMS Diagnostica GmbH
Priority to DE69304528T priority Critical patent/DE69304528T3/de
Application granted granted Critical
Publication of DE69304528D1 publication Critical patent/DE69304528D1/de
Publication of DE69304528T2 publication Critical patent/DE69304528T2/de
Publication of DE69304528T3 publication Critical patent/DE69304528T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/686—Anti-idiotype
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/971—Capture of complex after antigen-antibody reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/817—Steroids or hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/822—Identified hapten
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/824—Immunological separation techniques

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
DE69304528T 1992-05-06 1993-04-22 Verfahren zur bestimmung der menge eines schilddrüsenhormon-liganden in einer biologischen flüssigkeit und satz zur durchführung dieses verfahrens Expired - Lifetime DE69304528T3 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE69304528T DE69304528T3 (de) 1992-05-06 1993-04-22 Verfahren zur bestimmung der menge eines schilddrüsenhormon-liganden in einer biologischen flüssigkeit und satz zur durchführung dieses verfahrens

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4214922A DE4214922C2 (de) 1992-05-06 1992-05-06 Verfahren zur quantitativen Bestimmung des Anteils der freien Form eines Schilddrüsenhormon-Liganden in einer biologischen Flüssigkeit und Kit zur Durchführung eines solchen Verfahrens
DE69304528T DE69304528T3 (de) 1992-05-06 1993-04-22 Verfahren zur bestimmung der menge eines schilddrüsenhormon-liganden in einer biologischen flüssigkeit und satz zur durchführung dieses verfahrens
PCT/EP1993/000981 WO1993022675A1 (en) 1992-05-06 1993-04-22 Method for the determination of the amount of a ligand in a biological fluid and kit for carrying out such a method

Publications (3)

Publication Number Publication Date
DE69304528D1 DE69304528D1 (de) 1996-10-10
DE69304528T2 true DE69304528T2 (de) 1997-03-20
DE69304528T3 DE69304528T3 (de) 2002-12-05

Family

ID=6458274

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4214922A Expired - Fee Related DE4214922C2 (de) 1992-05-06 1992-05-06 Verfahren zur quantitativen Bestimmung des Anteils der freien Form eines Schilddrüsenhormon-Liganden in einer biologischen Flüssigkeit und Kit zur Durchführung eines solchen Verfahrens
DE69304528T Expired - Lifetime DE69304528T3 (de) 1992-05-06 1993-04-22 Verfahren zur bestimmung der menge eines schilddrüsenhormon-liganden in einer biologischen flüssigkeit und satz zur durchführung dieses verfahrens

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE4214922A Expired - Fee Related DE4214922C2 (de) 1992-05-06 1992-05-06 Verfahren zur quantitativen Bestimmung des Anteils der freien Form eines Schilddrüsenhormon-Liganden in einer biologischen Flüssigkeit und Kit zur Durchführung eines solchen Verfahrens

Country Status (12)

Country Link
US (1) US5639670A (de)
EP (1) EP0639272B2 (de)
JP (1) JP3234947B2 (de)
KR (1) KR950701075A (de)
AT (1) ATE142339T1 (de)
AU (1) AU4040993A (de)
CA (1) CA2132830A1 (de)
DE (2) DE4214922C2 (de)
FI (1) FI944658A0 (de)
HU (1) HUT69994A (de)
NO (1) NO943759D0 (de)
WO (1) WO1993022675A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4328070C1 (de) * 1993-08-20 1994-11-24 Henning Berlin Gmbh Verfahren zur Bestimmung eines Analyten in einem Volumen einer flüssigen Probe sowie seine Anwendung zur Bestimmung von anti-TSH-Rezeptor-Autoantikörpern in einem Patientenserum
DE19548028A1 (de) * 1995-12-21 1997-06-26 Bayer Ag Verfahren zur Herstellung eines synthetischen Kalibrators für den Einsatz in Sandwich-Immunoassays, bestehend aus einem Antikörper gegen einen der im Assay benutzten Antikörper und einer Sequenz des Analyten
US7271009B1 (en) * 1997-11-18 2007-09-18 Bio-Rad Laboratories, Inc. Multi-analyte diagnostic test for thyroid disorders
US6153440A (en) * 1998-09-23 2000-11-28 The Regents Of The University Of California Simultaneous measurement of free triiodothyronine and free thyroxine by equilibrium dialysis and immunoassay
DE19907094C1 (de) 1999-02-19 2000-04-13 Brahms Diagnostica Gmbh Verwendung von blockierenden Anti-TSH-Rezeptor-Antikörpern bei der Therapie von Hyperthyreosen sowie monoklonale Antikörper für eine solche Verwendung
AU2001251413B2 (en) * 2000-04-13 2004-07-29 Bio-Rad Laboratories, Inc. Multi-analyte diagnostic test for thyroid disorders
US8956823B2 (en) * 2007-08-20 2015-02-17 Bio-Rad Laboratories, Inc. Anti-antibody reagent
CA2926306C (en) 2013-11-05 2022-12-06 F. Hoffmann-La Roche Ag A method for determining the total amount and/or concentration of an analyte in a sample
CN108802369A (zh) * 2018-05-31 2018-11-13 湖南远璟生物技术有限公司 一种游离三碘甲状腺原氨酸磁微粒化学发光免疫定量检测试剂盒及其制备方法
CN108802361A (zh) * 2018-05-31 2018-11-13 湖南远璟生物技术有限公司 一种四碘甲状腺原氨酸酶结合物的制备方法
CN108802370A (zh) * 2018-05-31 2018-11-13 湖南远璟生物技术有限公司 一种三碘甲状腺原氨酸酶结合物的制备方法
CN108562752A (zh) * 2018-05-31 2018-09-21 湖南远璟生物技术有限公司 一种游离甲状腺素磁微粒化学发光免疫定量检测试剂盒及其制备方法
CN113125697B (zh) * 2019-12-31 2024-03-26 科美博阳诊断技术(上海)有限公司 一种睾酮均相化学发光检测试剂盒及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS604422B2 (ja) * 1976-10-07 1985-02-04 持田製薬株式会社 抗原の定量方法
US4366143A (en) * 1979-09-24 1982-12-28 Amersham International Public Limited Company Assay for the free portion of substances in biological fluids
US5304498A (en) * 1982-03-19 1994-04-19 Ekins Roger Philip Method and composition for free ligand assay
DE3382044D1 (de) * 1982-03-19 1991-01-17 Ekins Verfahren zur pruefung von freien liganden.
EP0089806B1 (de) * 1982-03-22 1989-06-28 AMERSHAM INTERNATIONAL plc Bestimmung des freien Anteils von Substanzen in biologischen Flüssigkeiten
DE3377531D1 (en) * 1982-09-29 1988-09-01 Serono Diagnostics Ltd Immunoassay of antigens
ZA837119B (en) * 1982-10-07 1984-12-24 Amersham Int Plc Assay for the free portion of substances in biological fluids
GB8317124D0 (en) * 1983-06-23 1983-07-27 Ekins R P Free ligand assay
GB2158578B (en) * 1984-05-08 1988-03-09 Farmos Group Ltd Immunometric method for the determination of a hapten
DE3727238A1 (de) * 1987-08-14 1989-02-23 Henning Berlin Gmbh Immunologisches bestimmungsverfahren zur bestimmung von hapteneigenschaften aufweisenden freien substanzen
GB8800419D0 (en) * 1988-01-08 1988-02-10 Amersham Int Plc Method for measuring free fraction of ligands in biological fluids
GB8812213D0 (en) * 1988-05-24 1988-06-29 Ares Serono Res & Dev Ltd Method of assay

Also Published As

Publication number Publication date
CA2132830A1 (en) 1993-11-11
JPH07507388A (ja) 1995-08-10
DE69304528T3 (de) 2002-12-05
KR950701075A (ko) 1995-02-20
FI944658A (fi) 1994-10-05
HUT69994A (en) 1995-09-28
EP0639272B2 (de) 2002-07-10
JP3234947B2 (ja) 2001-12-04
DE4214922A1 (de) 1993-11-11
ATE142339T1 (de) 1996-09-15
DE69304528D1 (de) 1996-10-10
NO943759L (no) 1994-10-06
US5639670A (en) 1997-06-17
EP0639272A1 (de) 1995-02-22
HU9402865D0 (en) 1995-01-30
WO1993022675A1 (en) 1993-11-11
FI944658A0 (fi) 1994-10-05
AU4040993A (en) 1993-11-29
DE4214922C2 (de) 1996-06-13
NO943759D0 (no) 1994-10-06
EP0639272B1 (de) 1996-09-04

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Owner name: B.R.A.H.M.S AG, 16761 HENNIGSDORF, DE

8366 Restricted maintained after opposition proceedings
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Owner name: B.R.A.H.M.S GMBH, 16761 HENNIGSDORF, DE