DE69233214D1 - Für säugetierphosphodiesterasen kodierende dns - Google Patents

Für säugetierphosphodiesterasen kodierende dns

Info

Publication number
DE69233214D1
DE69233214D1 DE69233214T DE69233214T DE69233214D1 DE 69233214 D1 DE69233214 D1 DE 69233214D1 DE 69233214 T DE69233214 T DE 69233214T DE 69233214 T DE69233214 T DE 69233214T DE 69233214 D1 DE69233214 D1 DE 69233214D1
Authority
DE
Germany
Prior art keywords
phosphodiesterases
dna encoding
nucleotide sequences
expression products
mammal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69233214T
Other languages
English (en)
Other versions
DE69233214T2 (de
Inventor
A Beavo
Kelley Bentley
Harry Charbonneau
K Sonnenburg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Original Assignee
University of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington filed Critical University of Washington
Publication of DE69233214D1 publication Critical patent/DE69233214D1/de
Application granted granted Critical
Publication of DE69233214T2 publication Critical patent/DE69233214T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/37—Assays involving biological materials from specific organisms or of a specific nature from fungi
    • G01N2333/39—Assays involving biological materials from specific organisms or of a specific nature from fungi from yeasts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69233214T 1991-04-19 1992-04-20 Für säugetierphosphodiesterasen kodierende dns Expired - Lifetime DE69233214T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68835691A 1991-04-19 1991-04-19
US688356 1991-04-19
PCT/US1992/003222 WO1992018541A1 (en) 1991-04-19 1992-04-20 Dna encoding mammalian phosphodiesterases

Publications (2)

Publication Number Publication Date
DE69233214D1 true DE69233214D1 (de) 2003-10-30
DE69233214T2 DE69233214T2 (de) 2004-07-01

Family

ID=24764099

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69233214T Expired - Lifetime DE69233214T2 (de) 1991-04-19 1992-04-20 Für säugetierphosphodiesterasen kodierende dns
DE69233785T Expired - Lifetime DE69233785D1 (de) 1991-04-19 1992-04-20 diert

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69233785T Expired - Lifetime DE69233785D1 (de) 1991-04-19 1992-04-20 diert

Country Status (10)

Country Link
US (10) US5389527A (de)
EP (2) EP1386967B1 (de)
JP (2) JP3354149B2 (de)
AT (2) ATE250629T1 (de)
CA (1) CA2085881C (de)
DE (2) DE69233214T2 (de)
DK (1) DK0535216T3 (de)
ES (2) ES2348458T3 (de)
HK (1) HK1013297A1 (de)
WO (1) WO1992018541A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2693200B1 (fr) * 1992-07-01 1994-08-19 Inst Nat Sante Rech Med Nouveaux polypeptides ayant une activité de récepteur sérotoninergique, acides nucléiques codant pour ces polypeptides et utilisations.
KR960700338A (ko) * 1993-01-29 1996-01-19 우에하라 아키라 환상 뉴클레오티드 분해효소 및 그의 제조법
PT652960E (pt) * 1993-05-27 2001-08-30 Icos Corp Materiais para fosfodiesterases especificas e de ligacao do mpg ciclico e respectivos metodos
US5672509A (en) * 1993-08-25 1997-09-30 Pfizer Inc. hPDE IV-C: a human phosphodiesterase IV isozyme
US5605797A (en) * 1994-09-15 1997-02-25 Board Of Trustees Operating Michigan State University Bovine β-mannosidase gene and methods of use
IL115177A0 (en) * 1994-09-16 1995-12-31 Immunomedics Inc Phosphorus-32 labeling of antibodies for cancer therapy
US5885834A (en) * 1996-09-30 1999-03-23 Epstein; Paul M. Antisense oligodeoxynucleotide against phosphodiesterase
US5858694A (en) * 1997-05-30 1999-01-12 Cell Pathways, Inc. Method for identifying compounds for inhibition of cancerous lesions
WO1999017119A1 (en) 1997-09-26 1999-04-08 University Of Washington Simultaneous particle separation and chemical reaction
CA2321224A1 (en) * 1998-02-23 1999-08-26 Icos Corporation Phosphodiesterase 10
JP2995464B2 (ja) * 1998-05-15 1999-12-27 株式会社島精機製作所 横編機における編目ループの預け置き装置
AU5619100A (en) * 1999-06-16 2001-01-02 Incyte Genomics, Inc. Intracellular signaling molecules
GB9922124D0 (en) * 1999-09-17 1999-11-17 Pfizer Ltd Phosphodiesterase enzymes
GB9922125D0 (en) * 1999-09-17 1999-11-17 Pfizer Ltd Phosphodiesterase enzymes
AU1073201A (en) * 1999-10-05 2001-05-10 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Tyrosine-dna phosphodiesterases (tdp) and related polypeptides, nucleic acids, vectors, tdp-producing host cells, antibodies and methods of use
US7087736B1 (en) 1999-10-05 2006-08-08 The United States Of America As Represented By The Department Of Health And Human Services Tyrosine DNA phosphodiesterases (TDP) and related polypeptides nucleic acids vectors TDP producing host cells antibodies and methods of use
AU2001275401A1 (en) * 2000-06-08 2001-12-17 Incyte Genomics, Inc. Intracellular signaling proteins
US7179614B2 (en) * 2000-09-14 2007-02-20 Mount Sinai School Of Medicine Screening methods to identify compounds that modulate type I phosphodiesterase (PDE) activity
US6376225B1 (en) * 2001-01-05 2002-04-23 Pe Corporation (Ny) Isolated human phosphodiesterase proteins, nucleic acid molecules encoding human phosphodiesterase proteins, and uses thereof
IL158488A0 (en) * 2001-04-20 2004-05-12 Sinai School Medicine Tir3 a novel taste receptor
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
US6479493B1 (en) 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
US20040038223A1 (en) * 2001-10-02 2004-02-26 Glennda Smithson Novel proteins and nucleic acids encoding same
US20040092461A1 (en) * 2002-11-11 2004-05-13 Isis Pharmaceuticals Inc. Modulation of phosphodiesterase 1B expression
AU2003271661A1 (en) * 2002-10-01 2004-04-23 Bayer Healthcare Ag Regulation of human pde1a
WO2004031375A2 (en) * 2002-10-01 2004-04-15 Bayer Healthcare Ag Regulation of human 3’, 5’ cyclic nucleotide phosphodiesterase pde1c
US7132274B2 (en) * 2003-05-08 2006-11-07 Mcgill University Method for identifying modulators of CLK-1 and UbiF activity
JP2006133164A (ja) * 2004-11-09 2006-05-25 Fyuuensu:Kk カルモデュリンの構造変化を検出する方法、カルモデュリンの構造変化に影響を与える活性を有する物質を探索する方法
US8637528B2 (en) 2007-03-27 2014-01-28 Omeros Corporation Use of PDE7 inhibitors for the treatment of movement disorders
CN113930434A (zh) * 2021-12-08 2022-01-14 河北农业大学 磷酸二酯酶基因及其蛋白的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980281A (en) * 1988-02-10 1990-12-25 Housey Gerard M Method of screening for protein inhibitors and activators
US6080540A (en) * 1990-04-20 2000-06-27 Cold Spring Harbor Laboratory Cloning of mammalian genes in microbial organisms and methods for pharmacological screening

Also Published As

Publication number Publication date
US5789553A (en) 1998-08-04
JP2002051776A (ja) 2002-02-19
ATE469228T1 (de) 2010-06-15
US6642040B2 (en) 2003-11-04
CA2085881A1 (en) 1992-10-20
ES2348458T3 (es) 2010-12-07
EP0535216A1 (de) 1993-04-07
US20040126866A1 (en) 2004-07-01
ES2204891T3 (es) 2004-05-01
US5800987A (en) 1998-09-01
US20020151024A1 (en) 2002-10-17
US7122363B2 (en) 2006-10-17
WO1992018541A1 (en) 1992-10-29
US5389527A (en) 1995-02-14
EP0535216A4 (en) 1995-08-30
JP3408526B2 (ja) 2003-05-19
US6015677A (en) 2000-01-18
CA2085881C (en) 2002-06-25
EP1386967A2 (de) 2004-02-04
JP3354149B2 (ja) 2002-12-09
US20060275871A1 (en) 2006-12-07
US5602019A (en) 1997-02-11
EP1386967A3 (de) 2004-02-25
US5580771A (en) 1996-12-03
US7842478B2 (en) 2010-11-30
DE69233214T2 (de) 2004-07-01
EP0535216B1 (de) 2003-09-24
ATE250629T1 (de) 2003-10-15
DK0535216T3 (da) 2004-02-02
DE69233785D1 (de) 2010-07-08
HK1013297A1 (en) 1999-08-20
EP1386967B1 (de) 2010-05-26
JPH05508079A (ja) 1993-11-18
US5776752A (en) 1998-07-07

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