DE69230041T2 - Muramylverbindungen zur behandlung von septischem schock - Google Patents
Muramylverbindungen zur behandlung von septischem schockInfo
- Publication number
- DE69230041T2 DE69230041T2 DE69230041T DE69230041T DE69230041T2 DE 69230041 T2 DE69230041 T2 DE 69230041T2 DE 69230041 T DE69230041 T DE 69230041T DE 69230041 T DE69230041 T DE 69230041T DE 69230041 T2 DE69230041 T2 DE 69230041T2
- Authority
- DE
- Germany
- Prior art keywords
- muramyl
- pct
- acetyl
- date
- septic shock
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 206010040070 Septic Shock Diseases 0.000 title abstract 2
- 230000036303 septic shock Effects 0.000 title abstract 2
- 239000002158 endotoxin Substances 0.000 abstract 2
- 206010006895 Cachexia Diseases 0.000 abstract 1
- 206010063743 Hypophagia Diseases 0.000 abstract 1
- PIJXCSUPSNFXNE-QRZOAFCBSA-N N-acetyl-4-(N-acetylglucosaminyl)muramoyl-L-alanyl-D-isoglutamine Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@@H]1[C@@H](NC(C)=O)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 PIJXCSUPSNFXNE-QRZOAFCBSA-N 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 125000001446 muramyl group Chemical group N[C@@H](C=O)[C@@H](O[C@@H](C(=O)*)C)[C@H](O)[C@H](O)CO 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000001698 pyrogenic effect Effects 0.000 abstract 1
- 230000006433 tumor necrosis factor production Effects 0.000 abstract 1
- 208000016261 weight loss Diseases 0.000 abstract 1
- 230000004580 weight loss Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919124500A GB9124500D0 (en) | 1991-11-19 | 1991-11-19 | Compounds for medicinal use |
| GB929210013A GB9210013D0 (en) | 1992-05-08 | 1992-05-08 | Compounds for medicinal use |
| PCT/GB1992/002137 WO1993010148A1 (en) | 1991-11-19 | 1992-11-19 | Muramyl compounds for treatment of septic shock |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69230041D1 DE69230041D1 (de) | 1999-10-28 |
| DE69230041T2 true DE69230041T2 (de) | 2000-01-05 |
Family
ID=26299886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69230041T Expired - Lifetime DE69230041T2 (de) | 1991-11-19 | 1992-11-19 | Muramylverbindungen zur behandlung von septischem schock |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5506204A (de) |
| EP (1) | EP0615522B1 (de) |
| JP (1) | JP3628689B2 (de) |
| AT (1) | ATE184883T1 (de) |
| AU (1) | AU666890B2 (de) |
| CA (1) | CA2123912C (de) |
| DE (1) | DE69230041T2 (de) |
| RU (1) | RU2139086C1 (de) |
| WO (1) | WO1993010148A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9320820D0 (en) * | 1993-10-08 | 1993-12-01 | Biokine Tech Ltd | Compounds for medicinal use |
| GB9413935D0 (en) * | 1994-07-11 | 1994-08-31 | Peptech Uk Ltd | Use of maramyl peptide compounds |
| GB9419011D0 (en) * | 1994-09-21 | 1994-11-09 | Peptech Uk Ltd | Use of muramyl peptide compounds |
| WO1997005889A1 (en) * | 1995-08-03 | 1997-02-20 | Slesarev Vladimir I | Non-specific vaccination by d-amino-acid containing compounds |
| US6200955B1 (en) * | 1996-06-11 | 2001-03-13 | Commonwealth Biotechnologies, Inc. | Heparin binding peptides |
| US5834435A (en) * | 1996-11-27 | 1998-11-10 | Slesarev; Vladimir I. | Inhibition of TNF-α pleiotropic and cytotoxic effects |
| EP1053001B1 (de) | 1998-02-13 | 2010-12-15 | Amylin Pharmaceuticals, Inc. | Neue verbindungen mit gemischter amylin aktivität |
| IL152157A0 (en) | 2000-04-18 | 2003-05-29 | Lilly Co Eli | Process for preparing lipid ii |
| WO2001079268A2 (en) * | 2000-04-18 | 2001-10-25 | Eli Lilly And Company | A glycopeptide and preparation thereof |
| US7112564B2 (en) * | 2003-04-09 | 2006-09-26 | Zylacta Corporation | Biodegradable glucosaminemuramyl peptides for apoptosis modulation |
| WO2005007676A2 (en) * | 2003-07-10 | 2005-01-27 | Rajadhyaksha V J | Glycopeptides for the treatment of als and other metabolic and autoimmune disorders |
| ES2856081T3 (es) | 2007-04-16 | 2021-09-27 | Occlutech Holding Ag | Oclusor para la oclusión de una orejuela auricular y procedimiento de producción del mismo |
| US8188058B2 (en) | 2007-04-19 | 2012-05-29 | University of Pittsburgh—of the Commonwealth System of Higher Education | Use of toll-like receptor-9 agonists, toll-like receptor-4 antagonists, and/or nuclear oligomerization domain-2 agonists for the treatment or prevention of toll-like receptor-4-associated disorders |
| US8518903B2 (en) | 2007-04-19 | 2013-08-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Use of toll-like receptor-9 agonists |
| US10668092B2 (en) | 2010-09-24 | 2020-06-02 | The John Hopkins University | Compositions and methods for treatment of inflammatory disorders |
| US9072760B2 (en) | 2010-09-24 | 2015-07-07 | University of Pittsburgh—of the Commonwealth System of Higher Education | TLR4 inhibitors for the treatment of human infectious and inflammatory disorders |
| WO2012088425A2 (en) | 2010-12-22 | 2012-06-28 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Gap junction-enhancing agents for treatment of necrotizing enterocolitis and inflammatory bowel disease |
| US9562066B2 (en) | 2012-09-25 | 2017-02-07 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Oral therapy of necrotizing enterocolitis |
| EA025690B1 (ru) * | 2014-07-15 | 2017-01-30 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Ранозаживляющее средство, обладающее иммуностимулирующим и антиоксидантным эффектами |
| RU2584089C1 (ru) * | 2015-06-15 | 2016-05-20 | Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Саратовский Государственный Медицинский Университет Имени В.И. Разумовского" Министерства Здравоохранения Российской Федерации | Способ снижения летального эффекта бактериального липополисахарида in vitro |
| JP2024511067A (ja) | 2021-03-19 | 2024-03-12 | トレインド セラピューティクス ディスカバリー，インコーポレーテッド | 訓練された免疫を調節するための化合物およびその使用方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU727647A1 (ru) * | 1977-11-02 | 1980-04-15 | Институт биоорганической химии им.М.М.Шемякина | Гликопептиды,обладающие противоопухолевой активностью и способ их получени |
| JPS5543030A (en) * | 1978-09-21 | 1980-03-26 | Dai Ichi Seiyaku Co Ltd | Prophylactic and remedy for microbial infection disease |
| FR2449697A1 (fr) * | 1979-02-20 | 1980-09-19 | Anvar | Nouveaux muramyl-peptides substitues sur un azote peptidique et medicaments les contenant |
| JP2545279B2 (ja) * | 1987-09-02 | 1996-10-16 | 第一製薬株式会社 | 血小板減少予防及び治療剤 |
-
1992
- 1992-11-19 DE DE69230041T patent/DE69230041T2/de not_active Expired - Lifetime
- 1992-11-19 US US08/244,154 patent/US5506204A/en not_active Expired - Lifetime
- 1992-11-19 JP JP50910693A patent/JP3628689B2/ja not_active Expired - Lifetime
- 1992-11-19 AT AT92923873T patent/ATE184883T1/de active
- 1992-11-19 RU RU94027574A patent/RU2139086C1/ru active
- 1992-11-19 CA CA002123912A patent/CA2123912C/en not_active Expired - Lifetime
- 1992-11-19 EP EP92923873A patent/EP0615522B1/de not_active Expired - Lifetime
- 1992-11-19 WO PCT/GB1992/002137 patent/WO1993010148A1/en active IP Right Grant
- 1992-11-19 AU AU29492/92A patent/AU666890B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07508497A (ja) | 1995-09-21 |
| ATE184883T1 (de) | 1999-10-15 |
| WO1993010148A1 (en) | 1993-05-27 |
| CA2123912C (en) | 2007-04-17 |
| EP0615522A1 (de) | 1994-09-21 |
| RU2139086C1 (ru) | 1999-10-10 |
| EP0615522B1 (de) | 1999-09-22 |
| AU2949292A (en) | 1993-06-15 |
| JP3628689B2 (ja) | 2005-03-16 |
| CA2123912A1 (en) | 1993-05-27 |
| RU94027574A (ru) | 1996-07-20 |
| DE69230041D1 (de) | 1999-10-28 |
| US5506204A (en) | 1996-04-09 |
| AU666890B2 (en) | 1996-02-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: PEPTECH LTD., MACQUARIE PARK, NEUSUEDWALES, AU |