DE69229471D1 - Biologische färbemittelzusammensetzung, verfarren zu seiner herstellung und verwendung zur markierung der umrisse von epithel karsinomen - Google Patents

Biologische färbemittelzusammensetzung, verfarren zu seiner herstellung und verwendung zur markierung der umrisse von epithel karsinomen

Info

Publication number
DE69229471D1
DE69229471D1 DE69229471T DE69229471T DE69229471D1 DE 69229471 D1 DE69229471 D1 DE 69229471D1 DE 69229471 T DE69229471 T DE 69229471T DE 69229471 T DE69229471 T DE 69229471T DE 69229471 D1 DE69229471 D1 DE 69229471D1
Authority
DE
Germany
Prior art keywords
epithelic
carsinomas
marking
outline
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69229471T
Other languages
English (en)
Other versions
DE69229471T2 (de
Inventor
Mark Malmros
Raymond Tucci
Pier Cipriani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zila Inc
Original Assignee
Zila Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zila Inc filed Critical Zila Inc
Publication of DE69229471D1 publication Critical patent/DE69229471D1/de
Application granted granted Critical
Publication of DE69229471T2 publication Critical patent/DE69229471T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Transceivers (AREA)
DE69229471T 1991-10-31 1992-10-07 Biologische färbemittelzusammensetzung, verfarren zu seiner herstellung und verwendung zur markierung der umrisse von epithel karsinomen Expired - Fee Related DE69229471T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78552091A 1991-10-31 1991-10-31
PCT/US1992/008722 WO1993008847A1 (en) 1991-10-31 1992-10-07 Biological stain composition, method of preparation and method of use for delineation of epitheleal cancer

Publications (2)

Publication Number Publication Date
DE69229471D1 true DE69229471D1 (de) 1999-07-29
DE69229471T2 DE69229471T2 (de) 1999-11-25

Family

ID=25135780

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69229471T Expired - Fee Related DE69229471T2 (de) 1991-10-31 1992-10-07 Biologische färbemittelzusammensetzung, verfarren zu seiner herstellung und verwendung zur markierung der umrisse von epithel karsinomen

Country Status (12)

Country Link
US (1) US5372801A (de)
EP (1) EP0565668B1 (de)
JP (1) JP3549880B2 (de)
KR (1) KR100242727B1 (de)
AT (1) ATE181510T1 (de)
AU (1) AU661727B2 (de)
CA (1) CA2097695C (de)
DE (1) DE69229471T2 (de)
DK (1) DK0565668T3 (de)
ES (1) ES2133143T3 (de)
GR (1) GR3031233T3 (de)
WO (1) WO1993008847A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6417003B1 (en) * 1993-01-14 2002-07-09 Zila, Inc. Method and kit for epithelial cancer screening
FI97630C (fi) * 1995-02-23 1997-01-27 Carefibres Oy Kuitumateriaali ja menetelmä sen valmistamiseksi
US5605812A (en) * 1995-05-19 1997-02-25 Charm Sciences, Inc. Test kit and method for the quantitative determination of coliform bacteria and E. coli
DE59606241D1 (de) * 1995-10-05 2001-01-25 Blz Gmbh Verfahren zur herstellung eines schneidwerkzeuges
WO1997026018A1 (en) * 1996-01-16 1997-07-24 Zila Pharmaceuticals, Inc. Methods and compositions for in-vivo detection of oral cancers and precancerous conditions
JPH11504557A (ja) * 1996-02-29 1999-04-27 ジラ・ファーマスーティカルス・インコーポレーテッド 上皮癌選別の為の方法及び事前包装スワブ棒
US6083487A (en) * 1997-08-25 2000-07-04 Advanced Photodynamic Technologies, Inc. Methylene blue and toluidene blue mediated fluorescence diagnosis of cancer
US6086852A (en) * 1997-11-13 2000-07-11 Zila, Inc. In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue
US6194573B1 (en) * 1997-11-13 2001-02-27 Zila, Inc. Process for manufacture of in vivo stain composition
AU5357498A (en) * 1997-11-13 1999-06-07 Zila, Inc. (in vivo) stain composition, process of manufacture, and methods of use to identify dysplastic tissue
CA2250731C (en) 1997-11-13 2006-03-14 Douglas D. Burkett In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue
EP1165087B1 (de) * 2000-01-31 2005-09-07 Zila, Inc. In vivo färbemittel und verwendungsmethoden zur identifizierung von dysplastischem gewebe
US6649144B1 (en) * 2000-02-28 2003-11-18 Zila, Inc. Method for detecting and killing epithelial cancer cells
WO2001064110A1 (en) * 2000-02-28 2001-09-07 Zila, Inc. Method for detecting and killing epithelial cancer cells
IL148342A0 (en) * 2000-06-30 2002-09-12 Zila Inc Methylenen blue diagnostic agent and diagnostic methods for detection of epithelial cancer
NZ517445A (en) * 2000-06-30 2004-03-26 Zila Inc Rhodamine diagnostic agent and diagnostic methods for detection of epithelial cancer
US6967015B1 (en) * 2000-07-20 2005-11-22 Zila, Inc. Diagnostic method for detecting dysplastic epithelial tissue
US20040146919A1 (en) * 2002-05-18 2004-07-29 Burkett Douglas D. Method for early prediction of the onset of invasive cancer
JP2004509637A (ja) * 2000-09-26 2004-04-02 ジラ・インコーポレーテッド 浸潤癌の発生の早期予測のための方法
AU2002347835A1 (en) * 2001-12-14 2003-07-24 Zila Biotechnology, Inc. Light-directed molecular analysis for cancer prognosis and diagnosis
US20030017158A1 (en) * 2002-03-08 2003-01-23 Bernal Samuel D. Method for detecting and killing epithelial cancer cells
WO2003103569A2 (en) * 2002-06-04 2003-12-18 Zila Inc. Toluidine blue o drug substance and use thereof for in vivo staining and chemotherapeutic treatment of dysplastic tissues
US20060110326A1 (en) * 2002-06-04 2006-05-25 Zila, Inc. Toluidine blue o drug substance and use thereof for in vitro staining and chemotherapeutic treatment of dysplastic tissues
US7910531B2 (en) 2004-06-17 2011-03-22 C2C Technologies Llc Composition and method for producing colored bubbles
AT501919B1 (de) * 2005-06-14 2008-09-15 Erber Ag Probiotischer, gesundheits- bzw. leistungsfördernder futtermittel- und/oder trinkwasserzusatz für tiere sowie seine verwendung
US20080299182A1 (en) * 2007-03-01 2008-12-04 Shuyuan Zhang Methods and formulations for topical gene therapy
US20090023138A1 (en) * 2007-07-17 2009-01-22 Zila Biotechnology, Inc. Oral cancer markers and their detection
IT1398643B1 (it) * 2010-03-04 2013-03-08 Cosmo Technologies Ltd Composizione solida per la somministrazione orale di coloranti, e utilizzo diagnostico della stessa
CN102221526A (zh) * 2011-03-09 2011-10-19 叶欣 用于筛选口腔内膜细胞早期病变的组合试剂及其使用方法
PT106082A (pt) * 2012-01-04 2013-07-04 Fernando Jorge Neves Ferreira Composição fixadora para citologia, método de fixação de células e suas aplicações
RU2700680C1 (ru) * 2019-03-14 2019-09-18 Федеральное государственное автономное образовательное учреждение высшего образования "Дальневосточный федеральный университет" (ДВФУ) Способ хирургического лечения меланомы кожи
IT202100018434A1 (it) * 2021-07-13 2023-01-13 Diapath S P A Composizioni coloranti per campioni biologici, citologici, istologici e autoptici.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2571593A (en) * 1950-10-16 1951-10-16 Abbott Lab Preparation of stable leuco toluidine blue o solutions
US3743088A (en) * 1971-01-18 1973-07-03 R Henkin Diagnostic device and method of treatment
US4181128A (en) * 1975-11-28 1980-01-01 Massachusetts Institute Of Technology Virus inactivation applicator and the like
US4321251A (en) * 1979-12-19 1982-03-23 The United States Of America As Represented By The Department Of Health And Human Services Detection of malignant lesions of the oral cavity utilizing toluidine blue rinse
US4977177A (en) * 1985-04-30 1990-12-11 Nippon Petrochemicals Company, Ltd. Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents
JP2681053B2 (ja) * 1989-02-27 1997-11-19 三井サイテック株式会社 紙の製造法
US5018531A (en) * 1989-09-07 1991-05-28 Hartman William B Skin blemish measuring and recording system and method

Also Published As

Publication number Publication date
CA2097695C (en) 2000-08-08
WO1993008847A1 (en) 1993-05-13
JP3549880B2 (ja) 2004-08-04
AU2778892A (en) 1993-06-07
AU661727B2 (en) 1995-08-03
ES2133143T3 (es) 1999-09-01
EP0565668B1 (de) 1999-06-23
DK0565668T3 (da) 2000-01-31
GR3031233T3 (en) 1999-12-31
KR100242727B1 (ko) 2000-03-02
EP0565668A4 (en) 1994-09-07
EP0565668A1 (de) 1993-10-20
ATE181510T1 (de) 1999-07-15
US5372801A (en) 1994-12-13
CA2097695A1 (en) 1993-05-01
KR930703022A (ko) 1993-11-29
DE69229471T2 (de) 1999-11-25
JPH06507419A (ja) 1994-08-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee