KR930703022A - 피부암의 가시화를 위한 생물학적 염색조성물,이것의 제조방법 및 사용방법 - Google Patents

피부암의 가시화를 위한 생물학적 염색조성물,이것의 제조방법 및 사용방법

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Publication number
KR930703022A
KR930703022A KR1019930701988A KR930701988A KR930703022A KR 930703022 A KR930703022 A KR 930703022A KR 1019930701988 A KR1019930701988 A KR 1019930701988A KR 930701988 A KR930701988 A KR 930701988A KR 930703022 A KR930703022 A KR 930703022A
Authority
KR
South Korea
Prior art keywords
visualization
manufacturing
skin cancer
toluidine blue
dyeing composition
Prior art date
Application number
KR1019930701988A
Other languages
English (en)
Other versions
KR100242727B1 (ko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of KR930703022A publication Critical patent/KR930703022A/ko
Application granted granted Critical
Publication of KR100242727B1 publication Critical patent/KR100242727B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Transceivers (AREA)
  • Mobile Radio Communication Systems (AREA)
KR1019930701988A 1991-10-31 1992-10-07 상피암의 현장윤곽묘사를위한생물학적염색조성물,이들의제조방법및사용방법 KR100242727B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78552091A 1991-10-31 1991-10-31
US7/785520 1991-10-31
PCT/US1992/008722 WO1993008847A1 (en) 1991-10-31 1992-10-07 Biological stain composition, method of preparation and method of use for delineation of epitheleal cancer

Publications (2)

Publication Number Publication Date
KR930703022A true KR930703022A (ko) 1993-11-29
KR100242727B1 KR100242727B1 (ko) 2000-03-02

Family

ID=25135780

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930701988A KR100242727B1 (ko) 1991-10-31 1992-10-07 상피암의 현장윤곽묘사를위한생물학적염색조성물,이들의제조방법및사용방법

Country Status (12)

Country Link
US (1) US5372801A (ko)
EP (1) EP0565668B1 (ko)
JP (1) JP3549880B2 (ko)
KR (1) KR100242727B1 (ko)
AT (1) ATE181510T1 (ko)
AU (1) AU661727B2 (ko)
CA (1) CA2097695C (ko)
DE (1) DE69229471T2 (ko)
DK (1) DK0565668T3 (ko)
ES (1) ES2133143T3 (ko)
GR (1) GR3031233T3 (ko)
WO (1) WO1993008847A1 (ko)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6417003B1 (en) * 1993-01-14 2002-07-09 Zila, Inc. Method and kit for epithelial cancer screening
FI97630C (fi) * 1995-02-23 1997-01-27 Carefibres Oy Kuitumateriaali ja menetelmä sen valmistamiseksi
US5605812A (en) * 1995-05-19 1997-02-25 Charm Sciences, Inc. Test kit and method for the quantitative determination of coliform bacteria and E. coli
ATE198222T1 (de) * 1995-10-05 2001-01-15 Blz Gmbh Verfahren zur herstellung eines schneidwerkzeuges
EP0814847B1 (en) * 1996-01-16 2003-11-05 Zila, Inc. Methods and compositions for in-vivo detection of oral cancers and precancerous conditions
PT823852E (pt) * 1996-02-29 2004-08-31 Zila Inc Vareta com tampao pre-embalado para despistagem de cancro epitelial
US6083487A (en) * 1997-08-25 2000-07-04 Advanced Photodynamic Technologies, Inc. Methylene blue and toluidene blue mediated fluorescence diagnosis of cancer
WO1999025388A1 (en) * 1997-11-13 1999-05-27 Zila, Inc. In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue
US6086852A (en) * 1997-11-13 2000-07-11 Zila, Inc. In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue
US6194573B1 (en) * 1997-11-13 2001-02-27 Zila, Inc. Process for manufacture of in vivo stain composition
CA2250731C (en) 1997-11-13 2006-03-14 Douglas D. Burkett In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue
ES2248061T3 (es) * 2000-01-31 2006-03-16 Zila, Inc. Compuestos de tincion in vivo y metodos de utilizacion para identificar tejidos displasicos.
AU2000237154A1 (en) * 2000-02-28 2001-09-12 Zila, Inc. Method for detecting and killing epithelial cancer cells
US6649144B1 (en) * 2000-02-28 2003-11-18 Zila, Inc. Method for detecting and killing epithelial cancer cells
WO2002003048A1 (en) * 2000-06-30 2002-01-10 Zila, Inc. Methylene blue diagnostic agent and diagnostic methods for detection of epithelial cancer
WO2002002149A1 (en) * 2000-06-30 2002-01-10 Zila, Inc. Rhodamine diagnostic agent and diagnostic methods for detection of epithelial cancer
WO2002007693A1 (en) * 2000-07-20 2002-01-31 Zila, Inc. Improved diagnostic method for detecting dysplastic epithelial tissue
US20040146919A1 (en) * 2002-05-18 2004-07-29 Burkett Douglas D. Method for early prediction of the onset of invasive cancer
EP1322339A4 (en) * 2000-09-26 2004-05-26 Zila Inc METHOD FOR EARLY Predicting the Occurrence of INVASIVE CANCER.
IL159975A0 (en) * 2001-12-14 2004-06-20 Zila Inc Stain-directed molecular analysis for cancer prognosis and diagnosis
US20030017158A1 (en) * 2002-03-08 2003-01-23 Bernal Samuel D. Method for detecting and killing epithelial cancer cells
BRPI0215775A2 (pt) * 2002-06-04 2016-07-05 Zila Inc substância do fármaco azul de toluidina o (toluidine blue o) e aplicação do mesmo para tingimento in vivo e tratamento quimioterápico de tecidos displásicos.
US20060110326A1 (en) * 2002-06-04 2006-05-25 Zila, Inc. Toluidine blue o drug substance and use thereof for in vitro staining and chemotherapeutic treatment of dysplastic tissues
US7910531B2 (en) 2004-06-17 2011-03-22 C2C Technologies Llc Composition and method for producing colored bubbles
AT501919B1 (de) * 2005-06-14 2008-09-15 Erber Ag Probiotischer, gesundheits- bzw. leistungsfördernder futtermittel- und/oder trinkwasserzusatz für tiere sowie seine verwendung
US20080299182A1 (en) * 2007-03-01 2008-12-04 Shuyuan Zhang Methods and formulations for topical gene therapy
US20090023138A1 (en) * 2007-07-17 2009-01-22 Zila Biotechnology, Inc. Oral cancer markers and their detection
IT1398643B1 (it) 2010-03-04 2013-03-08 Cosmo Technologies Ltd Composizione solida per la somministrazione orale di coloranti, e utilizzo diagnostico della stessa
CN102221526A (zh) * 2011-03-09 2011-10-19 叶欣 用于筛选口腔内膜细胞早期病变的组合试剂及其使用方法
PT106082A (pt) * 2012-01-04 2013-07-04 Fernando Jorge Neves Ferreira Composição fixadora para citologia, método de fixação de células e suas aplicações
RU2700680C1 (ru) * 2019-03-14 2019-09-18 Федеральное государственное автономное образовательное учреждение высшего образования "Дальневосточный федеральный университет" (ДВФУ) Способ хирургического лечения меланомы кожи
IT202100018434A1 (it) * 2021-07-13 2023-01-13 Diapath S P A Composizioni coloranti per campioni biologici, citologici, istologici e autoptici.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2571593A (en) * 1950-10-16 1951-10-16 Abbott Lab Preparation of stable leuco toluidine blue o solutions
US3743088A (en) * 1971-01-18 1973-07-03 R Henkin Diagnostic device and method of treatment
US4181128A (en) * 1975-11-28 1980-01-01 Massachusetts Institute Of Technology Virus inactivation applicator and the like
US4321251A (en) * 1979-12-19 1982-03-23 The United States Of America As Represented By The Department Of Health And Human Services Detection of malignant lesions of the oral cavity utilizing toluidine blue rinse
US4977177A (en) * 1985-04-30 1990-12-11 Nippon Petrochemicals Company, Ltd. Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents
JP2681053B2 (ja) * 1989-02-27 1997-11-19 三井サイテック株式会社 紙の製造法
US5018531A (en) * 1989-09-07 1991-05-28 Hartman William B Skin blemish measuring and recording system and method

Also Published As

Publication number Publication date
ATE181510T1 (de) 1999-07-15
CA2097695C (en) 2000-08-08
DE69229471T2 (de) 1999-11-25
JPH06507419A (ja) 1994-08-25
AU2778892A (en) 1993-06-07
ES2133143T3 (es) 1999-09-01
DE69229471D1 (de) 1999-07-29
KR100242727B1 (ko) 2000-03-02
JP3549880B2 (ja) 2004-08-04
GR3031233T3 (en) 1999-12-31
EP0565668A1 (en) 1993-10-20
DK0565668T3 (da) 2000-01-31
CA2097695A1 (en) 1993-05-01
US5372801A (en) 1994-12-13
WO1993008847A1 (en) 1993-05-13
EP0565668B1 (en) 1999-06-23
AU661727B2 (en) 1995-08-03
EP0565668A4 (en) 1994-09-07

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