DE69227380D1 - Verfahren zur bestimmung und behandlung von alzheimer-krankheit - Google Patents
Verfahren zur bestimmung und behandlung von alzheimer-krankheitInfo
- Publication number
- DE69227380D1 DE69227380D1 DE69227380T DE69227380T DE69227380D1 DE 69227380 D1 DE69227380 D1 DE 69227380D1 DE 69227380 T DE69227380 T DE 69227380T DE 69227380 T DE69227380 T DE 69227380T DE 69227380 D1 DE69227380 D1 DE 69227380D1
- Authority
- DE
- Germany
- Prior art keywords
- determining
- alzheimer disease
- treating alzheimer
- treating
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPK943891 | 1991-11-12 | ||
AU9438/91 | 1991-11-12 | ||
AU3374/92 | 1992-07-08 | ||
AUPL337492 | 1992-07-08 | ||
PCT/AU1992/000610 WO1993010459A1 (en) | 1991-11-12 | 1992-11-12 | A method for assaying and treating alzheimer's disease |
Publications (3)
Publication Number | Publication Date |
---|---|
DE69227380D1 true DE69227380D1 (de) | 1998-11-26 |
DE69227380T2 DE69227380T2 (de) | 1999-04-08 |
DE69227380T3 DE69227380T3 (de) | 2007-01-11 |
Family
ID=25644152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69227380T Expired - Lifetime DE69227380T3 (de) | 1991-11-12 | 1992-11-12 | Verfahren zur bestimmung und behandlung von alzheimer-krankheit |
Country Status (7)
Country | Link |
---|---|
US (2) | US5705401A (de) |
EP (1) | EP0613560B2 (de) |
JP (1) | JP3277211B2 (de) |
AU (1) | AU669493B2 (de) |
CA (1) | CA2123211C (de) |
DE (1) | DE69227380T3 (de) |
WO (1) | WO1993010459A1 (de) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3277211B2 (ja) * | 1991-11-12 | 2002-04-22 | プラナ・バイオテクノロジー・リミテッド | アルツハイマー病の試験方法と治療方法 |
EP1060750B1 (de) * | 1993-03-29 | 2005-12-07 | Queen's University At Kingston | Propan-1,3-disulphonsäure und deren pharmazeutisch akzeptable Salze zur Behandlung von Amyloidosis |
US20040208875A1 (en) | 1995-03-15 | 2004-10-21 | Queen's University At Kingston | Method for treating amyloidosis |
US5872101A (en) * | 1995-01-06 | 1999-02-16 | Sibia Neurosciences, Inc. | Methods of treating neurodegenerative disorders using protease inhibitors |
US5804560A (en) * | 1995-01-06 | 1998-09-08 | Sibia Neurosciences, Inc. | Peptide and peptide analog protease inhibitors |
US5789426A (en) * | 1995-01-20 | 1998-08-04 | Cornell Research Foundation, Inc. | Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation |
DE19518845A1 (de) * | 1995-05-23 | 1996-11-28 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an Phytinsäure |
JPH0925234A (ja) * | 1995-07-12 | 1997-01-28 | Wakunaga Pharmaceut Co Ltd | 脳疾患改善剤 |
AU6887996A (en) * | 1995-09-01 | 1997-04-01 | Washington University School Of Medicine | Method of reducing neurotoxic injury with zinc chelators |
IL115465A0 (en) * | 1995-09-29 | 1995-12-31 | Yeda Res & Dev | Assay for the diagnosis of dementia |
AUPN649395A0 (en) * | 1995-11-10 | 1995-12-07 | Ramsay Health Care Pty Ltd | A method for diagnosing alzheimer's disease |
GB9610829D0 (en) * | 1996-05-23 | 1996-07-31 | Medical Res Council | Screening of agents for treatment of azlheimers disease |
JP2000516606A (ja) * | 1996-08-13 | 2000-12-12 | ピー・エヌ・ゲロリマトス・ソシエテ・アノニム | アルツハイマー病の処置用医薬組成物の製造におけるキレート化剤クリオキノールの使用 |
US7045531B1 (en) | 1997-03-11 | 2006-05-16 | The General Hospital Corporation | Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator |
WO1998040071A1 (en) * | 1997-03-11 | 1998-09-17 | The General Hospital Corporation | Identification of agents for use in the treatment of alzheimer's disease |
ES2177024T3 (es) | 1997-08-21 | 2002-12-01 | Gerolymatos P N Sa | Empleo de la fanquinoma para el tratamiento de la enfermedaad de alzheimer. |
US5980914A (en) * | 1997-08-22 | 1999-11-09 | P.N. Gerolymatos S.A. | Clioquinol for the treatment of Parkinson's disease |
US5994323A (en) * | 1997-12-31 | 1999-11-30 | P.N. Gerolymatos S.A. | Pharmaceutical compositions comprising clioquinol in combination with vitamin B12 and therapeutic and prophylactic uses thereof |
WO1999045139A1 (en) | 1998-03-05 | 1999-09-10 | Board Of Regents, The University Of Texas System | Diagnostic assay for late-onset alzheimer's disease |
US20020025944A1 (en) * | 2000-04-28 | 2002-02-28 | Bush Ashley I. | Use of clioquinol for the therapy of Alzheimer's disease |
US20050112543A1 (en) * | 1998-03-11 | 2005-05-26 | The General Hospital Corporation | Method of screening for drugs useful in treating Alzheimer's disease |
US6638711B1 (en) | 1999-04-29 | 2003-10-28 | The General Hospital Corporation | Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation activity but does not inhibit superoxide-dependent hydrogen peroxide formation |
US6323218B1 (en) * | 1998-03-11 | 2001-11-27 | The General Hospital Corporation | Agents for use in the treatment of Alzheimer's disease |
TR200101892T2 (tr) | 1999-01-07 | 2001-11-21 | P.N. Gerolymatos S.A. | Hafıza bozukluklarının tedavisi veya önlenmesi için fankuinonun kullanımı. |
DE19909357A1 (de) * | 1999-03-03 | 2000-09-07 | Gerd Multhaup | Kupferagonist, der an die Kupferbindungsstelle von APP bindet und/oder eine hemmende Wirkung auf die Freisetzung des Amyloid-Aß-Peptids ausübt |
US6087118A (en) * | 1999-03-04 | 2000-07-11 | Bristol-Myers Squibb Company | Method for diagnosing alzheimer's disease |
US7592304B2 (en) | 1999-10-01 | 2009-09-22 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
US6608042B2 (en) * | 2000-03-28 | 2003-08-19 | Aventis Pharma, S.A. | Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof |
WO2002005634A2 (en) | 2000-07-13 | 2002-01-24 | University Of South Florida | Transgenic animal and methods |
US20020172676A1 (en) * | 2001-05-16 | 2002-11-21 | George Jackowski | Method of treatment of alzheimer's disease and device therefor |
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
US7517868B2 (en) * | 2004-07-19 | 2009-04-14 | Ip-6 Research Inc | Phytic citrate compounds and process for preparing the same |
CA2592320C (en) | 2004-12-22 | 2015-11-24 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
DE102005037298A1 (de) * | 2005-08-08 | 2007-03-08 | Christine Jaschek | Verwendung von Kalium-, Magnesium-, Calcium- und Zink-Elektrolyten zur Behandlung des Elementemangel- und Austrocknungssyndroms Alzheimer und anderer Demenzen |
RU2432362C2 (ru) | 2005-11-30 | 2011-10-27 | Эбботт Лэборетриз | Моноклональные антитела и их применения |
DK1954718T3 (en) | 2005-11-30 | 2014-12-15 | Abbvie Inc | Anti-A-globulomer antibodies antigenbindingsgrupper thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods for producing said antibodies, |
EP2808032B1 (de) * | 2005-12-12 | 2018-08-01 | AC Immune S.A. | A beta spezifische monoklonale antikörper mit therapeutischen eigenschaften |
WO2007125385A2 (en) | 2005-12-22 | 2007-11-08 | Neurochem (International) Limited | Treatment of renal disorders, diabetic nephopathy and dyslipidemias |
CA2657681C (en) * | 2006-07-14 | 2019-03-19 | Ac Immune S.A. | Humanized antibodies against beta amyloid protein |
BRPI0717794B8 (pt) | 2006-10-12 | 2021-05-25 | Bellus Health International Ltd | composto e composição farmacêutica de ácido 3-amino-1-propanosulfônico |
US8455626B2 (en) * | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
US20100203044A1 (en) * | 2006-12-22 | 2010-08-12 | Anatoly Nikolaev | Dr6 antagonists and uses thereof in treating neurological disorders |
US20100311767A1 (en) * | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
ES2529174T3 (es) * | 2007-06-12 | 2015-02-17 | Ac Immune S.A. | Anticuerpos humanizados para amiloide beta |
US8613923B2 (en) * | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
ES2609918T3 (es) * | 2007-10-05 | 2017-04-25 | Genentech, Inc. | Uso de anticuerpo anti-amiloide beta en enfermedades oculares |
EP2586795B1 (de) * | 2007-10-05 | 2018-05-16 | Genentech, Inc. | Verwendung eines Anti-Amyloid-Beta-Antikörpers bei Augenkrankheiten |
CN102124336A (zh) * | 2008-06-12 | 2011-07-13 | 健泰科生物技术公司 | 用于筛选抑制神经变性的化合物的方法 |
BRPI0921837A2 (pt) | 2008-11-25 | 2016-01-12 | Biogen Idec Inc | anticorpos isolados ou fragmentos de antígeno de ligação dos mesmos que podem se ligar especificamente a um polipeptídio dr6, métodos in vitro de promover a sobrevivência de uma célula do sistema nervoso, usos de um antagonista dr6 e métodos in vitro de inibir a ligação de dr6 com p75 |
JP2013510871A (ja) * | 2009-11-12 | 2013-03-28 | ジェネンテック, インコーポレイテッド | 樹状突起棘の密度を促す方法 |
MX336196B (es) | 2010-04-15 | 2016-01-11 | Abbvie Inc | Proteinas de union a amiloide beta. |
EP2598882B1 (de) | 2010-07-30 | 2017-07-26 | AC Immune S.A. | Sichere und funktionelle humanisierte antikörper für die verwendung in der behandlung von einer amyloidose |
MX358739B (es) | 2010-08-14 | 2018-09-03 | Abbvie Inc Star | Proteinas de union a amiloide beta. |
WO2012027794A2 (en) * | 2010-09-01 | 2012-03-08 | The Mental Health Research Institute Of Victoria | Method of treatment and agents useful for same |
US20140302532A1 (en) | 2011-04-12 | 2014-10-09 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury |
WO2012142666A1 (en) * | 2011-04-19 | 2012-10-26 | The Mental Health Research Institute Of Victoria | Method of modulating amine oxidase activity and agents useful for same |
EP2717886B1 (de) * | 2011-06-08 | 2021-09-01 | Chelation Partners Incorporated | Metallchelatierende gemische und verfahren zur regulierung des wachstums oder der aktivitäten einer lebenden zelle oder eines organismus |
US10279054B2 (en) * | 2013-07-09 | 2019-05-07 | Mayo Foundation For Medical Education And Research | Pet imaging of zinc transport |
EP3039431A4 (de) * | 2013-08-27 | 2017-05-03 | CRC for Mental Health Ltd. | Verfahren zur identifizierung von biomarkern neurologischer krankheiten und diagnose von neurologischen krankheiten |
US20210071183A1 (en) * | 2018-02-26 | 2021-03-11 | The Trustees Of Columbia University In The City Of New York | Zinc associated treatment for and diagnosis of cachexia |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4281061A (en) * | 1979-07-27 | 1981-07-28 | Syva Company | Double antibody for enhanced sensitivity in immunoassay |
US4419365A (en) * | 1981-12-21 | 1983-12-06 | Ciba-Geigy Corporation | Method of treating Alzheimer's disease |
US4847082A (en) * | 1987-01-21 | 1989-07-11 | Robert Sabin | Method of treatment of Alzheimer's disease using phytic acid |
US4837219A (en) * | 1987-11-05 | 1989-06-06 | Jeffrey Hutterer | Medication for Alzheimer's disease |
US4837164A (en) * | 1988-04-27 | 1989-06-06 | Bionix Corporation | Methods for diagonosing, monitoring and controlling the onset and progression of certain dementias and impeding memory loss or improving impairment of memory |
US5234814A (en) * | 1989-06-01 | 1993-08-10 | Du Pont Merck Pharmaceutical Company | Diagnostic assay for alzheimer's disease |
JPH05507470A (ja) * | 1990-04-12 | 1993-10-28 | アクゾ・エヌ・ヴエー | Mca28a32によって認識される抗原ctaa28a32 |
JPH05506990A (ja) * | 1990-04-24 | 1993-10-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | プロテアーゼ ネキシン―2の精製、検出、及び使用方法 |
AU8215391A (en) * | 1990-06-29 | 1992-01-23 | Case Western Reserve University | Diagnostic and prognostic methods based on soluble derivatives of the beta amyloid protein precursor |
AU643835B2 (en) * | 1990-08-17 | 1993-11-25 | Boston University | Proteases causing abnormal degradation of amyloid beta-protein precursor |
JPH04126095A (ja) * | 1990-09-14 | 1992-04-27 | Asahi Chem Ind Co Ltd | 新規モノクローナル抗体及びそれを産生するハイブリドーマ |
CA2372251A1 (en) * | 1991-01-21 | 1992-08-06 | Michael John Mullan | Test and model for alzheimer's disease |
JPH04252954A (ja) * | 1991-01-29 | 1992-09-08 | Asahi Chem Ind Co Ltd | タンパクの測定方法、試薬及びキット |
JPH04252955A (ja) * | 1991-01-29 | 1992-09-08 | Asahi Chem Ind Co Ltd | 蛋白質の測定方法、試薬及びキット |
JPH04252956A (ja) * | 1991-01-29 | 1992-09-08 | Asahi Chem Ind Co Ltd | タンパク質の測定方法、試薬及びキット |
JP3277211B2 (ja) * | 1991-11-12 | 2002-04-22 | プラナ・バイオテクノロジー・リミテッド | アルツハイマー病の試験方法と治療方法 |
TW327194B (en) * | 1992-05-01 | 1998-02-21 | American Cyanamid Co | Novel amyloid precursor proteins and methods of using same |
-
1992
- 1992-11-12 JP JP50882493A patent/JP3277211B2/ja not_active Expired - Fee Related
- 1992-11-12 AU AU29263/92A patent/AU669493B2/en not_active Ceased
- 1992-11-12 EP EP92923431A patent/EP0613560B2/de not_active Expired - Lifetime
- 1992-11-12 US US08/240,720 patent/US5705401A/en not_active Expired - Lifetime
- 1992-11-12 CA CA002123211A patent/CA2123211C/en not_active Expired - Fee Related
- 1992-11-12 WO PCT/AU1992/000610 patent/WO1993010459A1/en active IP Right Grant
- 1992-11-12 DE DE69227380T patent/DE69227380T3/de not_active Expired - Lifetime
-
2003
- 2003-11-19 US US10/716,924 patent/US20040265847A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2123211A1 (en) | 1993-05-27 |
JP3277211B2 (ja) | 2002-04-22 |
JPH07503316A (ja) | 1995-04-06 |
WO1993010459A1 (en) | 1993-05-27 |
CA2123211C (en) | 2008-09-16 |
AU669493B2 (en) | 1996-06-13 |
EP0613560B1 (de) | 1998-10-21 |
DE69227380T2 (de) | 1999-04-08 |
EP0613560A4 (de) | 1995-05-17 |
EP0613560A1 (de) | 1994-09-07 |
DE69227380T3 (de) | 2007-01-11 |
US5705401A (en) | 1998-01-06 |
US20040265847A1 (en) | 2004-12-30 |
EP0613560B2 (de) | 2006-06-21 |
AU2926392A (en) | 1993-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: PRANA BIOTECHNOLOGY LTD., SOUTH MELBOURNE, VICTORI |
|
8366 | Restricted maintained after opposition proceedings |