DE69217774T2 - Sulfatierte Glykosaminoglycanoidderivate - Google Patents

Sulfatierte Glykosaminoglycanoidderivate

Info

Publication number
DE69217774T2
DE69217774T2 DE69217774T DE69217774T DE69217774T2 DE 69217774 T2 DE69217774 T2 DE 69217774T2 DE 69217774 T DE69217774 T DE 69217774T DE 69217774 T DE69217774 T DE 69217774T DE 69217774 T2 DE69217774 T2 DE 69217774T2
Authority
DE
Germany
Prior art keywords
group
sulfate
alkyl
aryl
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69217774T
Other languages
German (de)
English (en)
Other versions
DE69217774D1 (de
Inventor
Maurice Petitou
Boeckel Constant Adriaan A Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Elf Sanofi SA
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elf Sanofi SA, Akzo Nobel NV filed Critical Elf Sanofi SA
Application granted granted Critical
Publication of DE69217774D1 publication Critical patent/DE69217774D1/de
Publication of DE69217774T2 publication Critical patent/DE69217774T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/08—Polyoxyalkylene derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69217774T 1991-08-23 1992-08-17 Sulfatierte Glykosaminoglycanoidderivate Expired - Lifetime DE69217774T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91402299 1991-08-23

Publications (2)

Publication Number Publication Date
DE69217774D1 DE69217774D1 (de) 1997-04-10
DE69217774T2 true DE69217774T2 (de) 1997-06-26

Family

ID=8208605

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69217774T Expired - Lifetime DE69217774T2 (de) 1991-08-23 1992-08-17 Sulfatierte Glykosaminoglycanoidderivate

Country Status (19)

Country Link
EP (1) EP0529715B1 (https=)
JP (1) JP3048198B2 (https=)
KR (1) KR100274115B1 (https=)
AT (1) ATE149504T1 (https=)
AU (1) AU656610B2 (https=)
BR (1) BR1100632A (https=)
CA (1) CA2076063C (https=)
DE (1) DE69217774T2 (https=)
DK (1) DK0529715T3 (https=)
ES (1) ES2101026T3 (https=)
FI (1) FI111726B (https=)
GR (1) GR3023580T3 (https=)
HK (1) HK1002032A1 (https=)
HU (2) HUT62594A (https=)
IL (1) IL102758A (https=)
NO (1) NO179452C (https=)
NZ (1) NZ244057A (https=)
TW (1) TW213470B (https=)
ZA (1) ZA926029B (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2157388C (en) * 1993-03-01 1998-12-15 Daniel P. Witt Analogs for specific oligosaccharide-protein interactions and uses thereof
FR2704226B1 (fr) * 1993-04-22 1995-07-21 Sanofi Elf 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
IL120722A (en) * 1996-05-08 1999-07-14 Akzo Nobel Nv Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them
FR2751334B1 (fr) 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
IL126893A (en) * 1997-11-19 2003-05-29 Akzo Nobel Nv Sulfated pentasaccharide derivatives and pharmaceutical compositions containing them
FR2773801B1 (fr) * 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
US6083933A (en) * 1999-04-19 2000-07-04 Stellar International Inc. Treatment of cystitis-like symptoms with chondroitin sulfate following administration of a challenge solution
FR2814463B1 (fr) * 2000-09-22 2002-11-15 Sanofi Synthelabo Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
AU2002243630A1 (en) 2001-01-23 2002-08-06 Massachusetts Institute Of Technology Solid- and solution -phase synthesis of heparin and other glycosaminoglycans
AU2003302238A1 (en) 2002-12-03 2004-06-23 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
US20040161476A1 (en) 2003-02-19 2004-08-19 Hahn Sungtack Samuel Cystitis treatment with high dose chondroitin sulfate
WO2006017726A2 (en) 2004-08-05 2006-02-16 Ivax Drug Research Institute Ltd Polysulfated glycosides and salts thereof
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
TWI403334B (zh) 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
KR101529061B1 (ko) 2008-05-30 2015-06-16 모멘타 파머슈티컬스 인코포레이티드 당류 구조물, 그리고 이러한 구조물의 제조 및 사용 방법
FR2938541B1 (fr) * 2008-11-20 2011-08-26 Sanofi Aventis Pentasaccharide cristallise,son procede d'obtention et son utilisation pour la preparation d'idraparinux
FR2949115B1 (fr) 2009-08-14 2012-11-02 Sanofi Aventis OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949114B1 (fr) 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
WO2012042123A1 (fr) 2010-09-10 2012-04-05 Sanofi Polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
FR2970969B1 (fr) 2011-01-27 2013-10-18 Sanofi Aventis Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
EP2578594A1 (en) 2011-10-04 2013-04-10 Sanofi Process of preparation of L-iduronic acid comprising a decarboxylation/intramolecular cyclisation tandem reaction
EP4416163A1 (en) * 2021-10-14 2024-08-21 Owlstone Medical Limited Method for the synthesis of evoc probes

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3017407A (en) * 1958-08-18 1962-01-16 Riker Laboratories Inc Process for producing polysulfuric acid esters of polysaccharides
GB1110939A (en) * 1965-10-06 1968-04-24 Meito Sangyo Kk Sulphuric acid esters of disaccharides and hexitols,and their use as antipeptic ulcer agents
HU172937B (hu) * 1975-12-18 1979-01-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh khondroitin-sernoj kisloty s mestno anestezirujuhhim ehffektom
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
FR2543145B1 (fr) * 1983-03-24 1986-10-17 Sanofi Sa Nouveaux sulfates de xylanes, leur procede de preparation et leur activite anti-thrombotique et hypolipemiante
AU607690B2 (en) * 1985-12-24 1991-03-14 Marion Laboratories, Inc. Use of synthetic sulfated saccharides to enhance wound healing
EP0300099A1 (en) * 1987-07-20 1989-01-25 Akzo N.V. New pentasaccharides
EP0454220B1 (en) * 1990-04-23 1993-08-18 Akzo Nobel N.V. Carbohydrate derivatives comprising a trisaccharide unit
EP2301618B1 (en) * 2009-09-23 2011-12-07 Covidien AG A dilation device for dilating an opening

Also Published As

Publication number Publication date
NO179452B (no) 1996-07-01
IL102758A (en) 1997-03-18
NO923297D0 (no) 1992-08-21
DK0529715T3 (da) 1997-09-08
CA2076063C (en) 2003-12-30
ZA926029B (en) 1993-03-10
AU2121892A (en) 1993-02-25
HUT62594A (en) 1993-05-28
KR930004324A (ko) 1993-03-22
GR3023580T3 (en) 1997-08-29
KR100274115B1 (ko) 2000-12-15
CA2076063A1 (en) 1993-02-24
BR1100632A (pt) 2000-06-13
AU656610B2 (en) 1995-02-09
TW213470B (https=) 1993-09-21
EP0529715A1 (en) 1993-03-03
NO179452C (no) 1996-10-09
ATE149504T1 (de) 1997-03-15
HK1002032A1 (en) 1998-07-24
ES2101026T3 (es) 1997-07-01
NZ244057A (en) 1995-05-26
NO923297L (no) 1993-02-24
JPH05194602A (ja) 1993-08-03
IL102758A0 (en) 1993-01-31
JP3048198B2 (ja) 2000-06-05
DE69217774D1 (de) 1997-04-10
FI111726B (fi) 2003-09-15
FI923726A0 (fi) 1992-08-19
FI923726L (fi) 1993-02-24
EP0529715B1 (en) 1997-03-05
HU211738A9 (en) 1995-12-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AKZO NOBEL N.V., ARNHEIM/ARNHEM, NL SANOFI-SYNTHEL

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR

R071 Expiry of right

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