DE69214113T2 - Neue Pyrrolidinderivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel - Google Patents

Neue Pyrrolidinderivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

Info

Publication number
DE69214113T2
DE69214113T2 DE69214113T DE69214113T DE69214113T2 DE 69214113 T2 DE69214113 T2 DE 69214113T2 DE 69214113 T DE69214113 T DE 69214113T DE 69214113 T DE69214113 T DE 69214113T DE 69214113 T2 DE69214113 T2 DE 69214113T2
Authority
DE
Germany
Prior art keywords
formula
group
branched
straight
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69214113T
Other languages
German (de)
English (en)
Other versions
DE69214113D1 (de
Inventor
Patrick Hautefaye
Michel Laubie
Gilbert Lavielle
Tony Verbeuren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of DE69214113D1 publication Critical patent/DE69214113D1/de
Publication of DE69214113T2 publication Critical patent/DE69214113T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69214113T 1991-12-20 1992-12-15 Neue Pyrrolidinderivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel Expired - Fee Related DE69214113T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9115851A FR2685325B1 (fr) 1991-12-20 1991-12-20 Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (2)

Publication Number Publication Date
DE69214113D1 DE69214113D1 (de) 1996-10-31
DE69214113T2 true DE69214113T2 (de) 1997-04-10

Family

ID=9420272

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69214113T Expired - Fee Related DE69214113T2 (de) 1991-12-20 1992-12-15 Neue Pyrrolidinderivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

Country Status (13)

Country Link
US (1) US5296494A (enExample)
EP (1) EP0549407B1 (enExample)
JP (1) JPH0678302B2 (enExample)
AT (1) ATE143360T1 (enExample)
AU (1) AU651262B2 (enExample)
CA (1) CA2085570C (enExample)
DE (1) DE69214113T2 (enExample)
DK (1) DK0549407T3 (enExample)
ES (1) ES2094324T3 (enExample)
FR (1) FR2685325B1 (enExample)
GR (1) GR3021766T3 (enExample)
NZ (1) NZ245519A (enExample)
ZA (1) ZA929855B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687146B1 (fr) * 1992-02-12 1994-04-01 Adir Cie Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
HUT69381A (en) * 1993-12-09 1995-09-28 Egyt Gyogyszervegyeszeti Gyar Process for producing (2-chloro pyridyl)-7-azabicyclo [2.2.1.]heptane
US5792776A (en) * 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5856309A (en) * 1994-10-14 1999-01-05 Boehringer Mannheim Gmbh Amidinopyrroline derivatives, processes for their production and pharmaceutical agents containing these compounds
US6124341A (en) * 1996-02-13 2000-09-26 Abbott Laboratories Endothelin antagonists
MY118876A (en) * 1996-03-29 2005-02-28 Tanabe Seiyaku Co Butadiene derivatives and process for preparing thereof
TW575561B (en) 1999-03-25 2004-02-11 Hoffmann La Roche 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives
AU2001264729A1 (en) * 2000-05-22 2001-12-03 Nitromed, Inc. Thromboxane inhibitors, compositions and methods of use related applications
CN103214407B (zh) * 2013-05-07 2015-11-18 北京大学 制备四氢吡咯类衍生物的方法
US20170362173A1 (en) * 2014-12-15 2017-12-21 The Regents Of The University Of California Anti-arrhythmicity agents
EP3980409A1 (en) * 2019-06-07 2022-04-13 Eli Lilly And Company Pyrrolidine compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2054729T3 (es) * 1987-05-01 1994-08-16 Fujisawa Pharmaceutical Co Derivados de pirrolidina.
JPH0798795B2 (ja) * 1987-05-08 1995-10-25 塩野義製薬株式会社 スルホンアミド置換不飽和脂肪酸
EP0312906A3 (en) * 1987-10-23 1990-09-05 Ono Pharmaceutical Co., Ltd. Novel sulfonamide derivatives
US5130323A (en) * 1988-10-31 1992-07-14 Fujisawa Pharmaceutical Co., Ltd. Pyrrolidine derivatives
FR2687146B1 (fr) * 1992-02-12 1994-04-01 Adir Cie Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
ZA929855B (en) 1994-01-13
EP0549407B1 (fr) 1996-09-25
NZ245519A (en) 1994-08-26
EP0549407A1 (fr) 1993-06-30
FR2685325A1 (fr) 1993-06-25
JPH05262723A (ja) 1993-10-12
US5296494A (en) 1994-03-22
ATE143360T1 (de) 1996-10-15
AU651262B2 (en) 1994-07-14
ES2094324T3 (es) 1997-01-16
AU3020492A (en) 1993-06-24
JPH0678302B2 (ja) 1994-10-05
GR3021766T3 (en) 1997-02-28
DE69214113D1 (de) 1996-10-31
DK0549407T3 (enExample) 1997-03-10
CA2085570C (fr) 2001-10-23
CA2085570A1 (fr) 1993-06-21
FR2685325B1 (fr) 1994-02-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LES LABORATOIRES SERVIER, NEUILLY SUR SEINE, FR

8339 Ceased/non-payment of the annual fee