AU651262B2 - New pyrrolidine compounds, process for preparing them and pharmaceutical compositions containing them - Google Patents

New pyrrolidine compounds, process for preparing them and pharmaceutical compositions containing them Download PDF

Info

Publication number
AU651262B2
AU651262B2 AU30204/92A AU3020492A AU651262B2 AU 651262 B2 AU651262 B2 AU 651262B2 AU 30204/92 A AU30204/92 A AU 30204/92A AU 3020492 A AU3020492 A AU 3020492A AU 651262 B2 AU651262 B2 AU 651262B2
Authority
AU
Australia
Prior art keywords
formula
group
branched
linear
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU30204/92A
Other languages
English (en)
Other versions
AU3020492A (en
Inventor
Patrick Hautefaye
Michel Laubie
Gilbert Lavielle
Tony Verbeuren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of AU3020492A publication Critical patent/AU3020492A/en
Application granted granted Critical
Publication of AU651262B2 publication Critical patent/AU651262B2/en
Assigned to LES LABORATOIRES SERVIER reassignment LES LABORATOIRES SERVIER Alteration of Name(s) in Register under S187 Assignors: ADIR ET COMPAGNIE
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU30204/92A 1991-12-20 1992-12-17 New pyrrolidine compounds, process for preparing them and pharmaceutical compositions containing them Ceased AU651262B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9115851 1991-12-20
FR9115851A FR2685325B1 (fr) 1991-12-20 1991-12-20 Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (2)

Publication Number Publication Date
AU3020492A AU3020492A (en) 1993-06-24
AU651262B2 true AU651262B2 (en) 1994-07-14

Family

ID=9420272

Family Applications (1)

Application Number Title Priority Date Filing Date
AU30204/92A Ceased AU651262B2 (en) 1991-12-20 1992-12-17 New pyrrolidine compounds, process for preparing them and pharmaceutical compositions containing them

Country Status (13)

Country Link
US (1) US5296494A (enExample)
EP (1) EP0549407B1 (enExample)
JP (1) JPH0678302B2 (enExample)
AT (1) ATE143360T1 (enExample)
AU (1) AU651262B2 (enExample)
CA (1) CA2085570C (enExample)
DE (1) DE69214113T2 (enExample)
DK (1) DK0549407T3 (enExample)
ES (1) ES2094324T3 (enExample)
FR (1) FR2685325B1 (enExample)
GR (1) GR3021766T3 (enExample)
NZ (1) NZ245519A (enExample)
ZA (1) ZA929855B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687146B1 (fr) * 1992-02-12 1994-04-01 Adir Cie Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
HUT69381A (en) * 1993-12-09 1995-09-28 Egyt Gyogyszervegyeszeti Gyar Process for producing (2-chloro pyridyl)-7-azabicyclo [2.2.1.]heptane
US5792776A (en) * 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5856309A (en) * 1994-10-14 1999-01-05 Boehringer Mannheim Gmbh Amidinopyrroline derivatives, processes for their production and pharmaceutical agents containing these compounds
US6124341A (en) * 1996-02-13 2000-09-26 Abbott Laboratories Endothelin antagonists
MY118876A (en) * 1996-03-29 2005-02-28 Tanabe Seiyaku Co Butadiene derivatives and process for preparing thereof
TW575561B (en) 1999-03-25 2004-02-11 Hoffmann La Roche 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives
AU2001264729A1 (en) * 2000-05-22 2001-12-03 Nitromed, Inc. Thromboxane inhibitors, compositions and methods of use related applications
CN103214407B (zh) * 2013-05-07 2015-11-18 北京大学 制备四氢吡咯类衍生物的方法
US20170362173A1 (en) * 2014-12-15 2017-12-21 The Regents Of The University Of California Anti-arrhythmicity agents
EP3980409A1 (en) * 2019-06-07 2022-04-13 Eli Lilly And Company Pyrrolidine compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3301093A (en) * 1992-02-12 1993-08-19 Les Laboratoires Servier New pyrrolidine compounds, process for preparing them and pharmaceutical compositions containing them

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2054729T3 (es) * 1987-05-01 1994-08-16 Fujisawa Pharmaceutical Co Derivados de pirrolidina.
JPH0798795B2 (ja) * 1987-05-08 1995-10-25 塩野義製薬株式会社 スルホンアミド置換不飽和脂肪酸
EP0312906A3 (en) * 1987-10-23 1990-09-05 Ono Pharmaceutical Co., Ltd. Novel sulfonamide derivatives
US5130323A (en) * 1988-10-31 1992-07-14 Fujisawa Pharmaceutical Co., Ltd. Pyrrolidine derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3301093A (en) * 1992-02-12 1993-08-19 Les Laboratoires Servier New pyrrolidine compounds, process for preparing them and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ZA929855B (en) 1994-01-13
EP0549407B1 (fr) 1996-09-25
NZ245519A (en) 1994-08-26
EP0549407A1 (fr) 1993-06-30
FR2685325A1 (fr) 1993-06-25
JPH05262723A (ja) 1993-10-12
US5296494A (en) 1994-03-22
ATE143360T1 (de) 1996-10-15
ES2094324T3 (es) 1997-01-16
AU3020492A (en) 1993-06-24
DE69214113T2 (de) 1997-04-10
JPH0678302B2 (ja) 1994-10-05
GR3021766T3 (en) 1997-02-28
DE69214113D1 (de) 1996-10-31
DK0549407T3 (enExample) 1997-03-10
CA2085570C (fr) 2001-10-23
CA2085570A1 (fr) 1993-06-21
FR2685325B1 (fr) 1994-02-04

Similar Documents

Publication Publication Date Title
KR101903304B1 (ko) 마이크로솜 프로스타글란딘 e2 신타제-1을 억제하는데 유용한 신규한 카르복실산 화합물
JP3176365B2 (ja) ベンゼンスルホンアミド誘導体
US5395840A (en) Heterocyclically substituted phenyl-cyclohexane-carboxylic acid derivatives
AU683460B2 (en) Propenoic acid derivatives
PL191115B1 (pl) Podstawione N-[(aminoiminometylo- lub aminometylo)fenylo]-propyloamidy, kompozycja farmaceutyczna zawierająca te związki oraz ich zastosowanie
JPH08208605A (ja) 治療用複素環式化合物
AU651262B2 (en) New pyrrolidine compounds, process for preparing them and pharmaceutical compositions containing them
US5352687A (en) Substituted phenylacetamides
JPH0673038A (ja) ビフェニル誘導体、これらの化合物を含む医薬組成物及びそれらの調製法
EA005367B1 (ru) Замещенные пиридоны, их применение, композиция и способ ингибирования тромботических состояний и способы профилактики и лечения
JPH05213879A (ja) 新規（２‐アルキル‐３‐ピリジル）メチルピペラジン誘導体
HUP0200213A2 (en) Alkynyl containing hydroxamic acid compounds as tace inhibitors, process for their preparation and pharmaceutical compositions containing them
JPH047348B2 (enExample)
US5283252A (en) Thiazolyl-substituted quinolylmethoxyphenylacetic acid derivatives
HUT64039A (en) Process for producing imidazole-substituted phenylacetamide derivatives and pharmaceutical compositions comprising same
US5407946A (en) Pyrrolidine compounds which are useful as thromboxane AZ-inhibitors
US5478836A (en) Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives
US5155121A (en) Phenylsulphonamide substituted pyridinealkene- and aminooxyalkanecarboxylic acid derivatives
JP2009511516A (ja) ＴＡＦＩａのインヒビターとしてのイミダゾール誘導体
CZ276092A3 (en) Heterocyclically substituted quinolylmethoxy-phenyl acetamides
US4921866A (en) 1,3-dioxanes
US5602149A (en) 1-OXO-2-(phenylsulphonylamino)pentypiperidine derivatives, their preparation and their therapeutic application
US4599336A (en) Derivatives of (E)-3-(4-oxo-4H-quinazolin-3-yl)-2-propenamide
FI89799C (fi) Foerfarande foer framstaellning av terapeutiskt aktiva 2,5-diazabicyklo/2.2.1/heptanderivat
JPH0673016A (ja) イミダゾリル置換シクロヘキサン誘導体

Legal Events

Date Code Title Description
PC Assignment registered

Owner name: LES LABORATOIRES SERVIER

Free format text: FORMER OWNER WAS: ADIR ET COMPAGNIE

MK14 Patent ceased section 143(a) (annual fees not paid) or expired