DE69211788D1 - Verfahren zur Herstellung von 5-(2',4'-Difluorphenyl)-Salizylsäure in reiner Form II - Google Patents

Verfahren zur Herstellung von 5-(2',4'-Difluorphenyl)-Salizylsäure in reiner Form II

Info

Publication number
DE69211788D1
DE69211788D1 DE69211788T DE69211788T DE69211788D1 DE 69211788 D1 DE69211788 D1 DE 69211788D1 DE 69211788 T DE69211788 T DE 69211788T DE 69211788 T DE69211788 T DE 69211788T DE 69211788 D1 DE69211788 D1 DE 69211788D1
Authority
DE
Germany
Prior art keywords
salicylic acid
difluorophenyl
preparation
pure form
diflurophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69211788T
Other languages
English (en)
Other versions
DE69211788T2 (de
Inventor
Claudio Giordano
Maurizio Paiocchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon SpA
Original Assignee
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon SpA filed Critical Zambon SpA
Application granted granted Critical
Publication of DE69211788D1 publication Critical patent/DE69211788D1/de
Publication of DE69211788T2 publication Critical patent/DE69211788T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69211788T 1991-08-01 1992-08-01 Verfahren zur Herstellung von 5-(2',4'-Difluorphenyl)-Salizylsäure in reiner Form II Expired - Fee Related DE69211788T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI912152A IT1250736B (it) 1991-08-01 1991-08-01 Processo per la preparazione dell'acido 5-(2',4'-difluorofenil) salicilico in forma ii pura

Publications (2)

Publication Number Publication Date
DE69211788D1 true DE69211788D1 (de) 1996-08-01
DE69211788T2 DE69211788T2 (de) 1996-10-31

Family

ID=11360489

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69211788T Expired - Fee Related DE69211788T2 (de) 1991-08-01 1992-08-01 Verfahren zur Herstellung von 5-(2',4'-Difluorphenyl)-Salizylsäure in reiner Form II

Country Status (9)

Country Link
US (1) US5183935A (de)
EP (1) EP0529279B1 (de)
JP (1) JPH07179395A (de)
AT (1) ATE139763T1 (de)
DE (1) DE69211788T2 (de)
DK (1) DK0529279T3 (de)
ES (1) ES2089305T3 (de)
GR (1) GR3020799T3 (de)
IT (1) IT1250736B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100353A (en) * 1991-01-08 1997-06-10 Zambon Spa Preparation of 5-(2, 4-difluorophenyl)-salicylic acid and novel 2,4-difluorophenyl-boronic acid derivatives being intermediates therefor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1175212A (en) * 1967-03-09 1969-12-23 Merck & Co Inc Halo-Substituted 5-Phenylbenzoic Acids and their Derivatives
US4131618A (en) * 1977-12-29 1978-12-26 Merck & Co., Inc. Preparation of salicylic acid and derivatives
US4225730A (en) * 1978-05-11 1980-09-30 Merck & Co., Inc. Process for preparing 4-(2,4-difluorophenyl)-salicyclic acid
US4237315A (en) * 1979-11-02 1980-12-02 Merck & Co., Inc. Preparation of 5(halophenyl)salicylic acid compounds
IT1190926B (it) * 1982-07-22 1988-02-24 Zambon Spa Procedimento per preparare l'acido 2',4'-difluoro-4-idrossi-(1,1'-difenil)-3-carbossilico
IT1196485B (it) * 1986-07-14 1988-11-16 Zambon Spa Derivati dell'acido tiazolidin-4-carbossilico ad attivita' farmaceutica
US4847442A (en) * 1988-07-18 1989-07-11 Allied-Signal Inc. Process for the preparation of difluorobenzenes
US4996047A (en) * 1988-11-02 1991-02-26 Richardson-Vicks, Inc. Sustained release drug-resin complexes
JPH0768234B2 (ja) * 1989-12-14 1995-07-26 久光製薬株式会社 コウジ酸エステル誘導体

Also Published As

Publication number Publication date
IT1250736B (it) 1995-04-21
JPH07179395A (ja) 1995-07-18
ITMI912152A1 (it) 1993-02-02
ATE139763T1 (de) 1996-07-15
GR3020799T3 (en) 1996-11-30
DK0529279T3 (da) 1996-07-29
DE69211788T2 (de) 1996-10-31
EP0529279B1 (de) 1996-06-26
ES2089305T3 (es) 1996-10-01
US5183935A (en) 1993-02-02
ITMI912152A0 (it) 1991-08-01
EP0529279A1 (de) 1993-03-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee