ES2089305T3 - Procedimiento para la preparacion de acido 5-(2',4'-difluorofenil)-salicilico en forma pura ii. - Google Patents

Procedimiento para la preparacion de acido 5-(2',4'-difluorofenil)-salicilico en forma pura ii.

Info

Publication number
ES2089305T3
ES2089305T3 ES92112205T ES92112205T ES2089305T3 ES 2089305 T3 ES2089305 T3 ES 2089305T3 ES 92112205 T ES92112205 T ES 92112205T ES 92112205 T ES92112205 T ES 92112205T ES 2089305 T3 ES2089305 T3 ES 2089305T3
Authority
ES
Spain
Prior art keywords
acid
salicilico
difluorofenil
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92112205T
Other languages
English (en)
Inventor
Claudio Giordano
Maurizio Paiocchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon Group SpA
Zambon SpA
Original Assignee
Zambon Group SpA
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Group SpA, Zambon SpA filed Critical Zambon Group SpA
Application granted granted Critical
Publication of ES2089305T3 publication Critical patent/ES2089305T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBE UN PROCESO DE CRISTALIZACION DE ACIDO 5-(2'',4''DIFLUOROFENIL)-SALICILICO CRUDO A PARTIR DE UNA MEZCLA DE UN HIDROCARBONO AROMATICO Y UNA ACETONA ALIFATICA PARA LA PREPARACION DE ACIDO 5-(2'',4''-DIFLUOROFENIL)-SALICILICO EN FORMA II SUBSTANCIALMENTE PURA.
ES92112205T 1991-08-01 1992-08-01 Procedimiento para la preparacion de acido 5-(2',4'-difluorofenil)-salicilico en forma pura ii. Expired - Lifetime ES2089305T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI912152A IT1250736B (it) 1991-08-01 1991-08-01 Processo per la preparazione dell'acido 5-(2',4'-difluorofenil) salicilico in forma ii pura

Publications (1)

Publication Number Publication Date
ES2089305T3 true ES2089305T3 (es) 1996-10-01

Family

ID=11360489

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92112205T Expired - Lifetime ES2089305T3 (es) 1991-08-01 1992-08-01 Procedimiento para la preparacion de acido 5-(2',4'-difluorofenil)-salicilico en forma pura ii.

Country Status (9)

Country Link
US (1) US5183935A (es)
EP (1) EP0529279B1 (es)
JP (1) JPH07179395A (es)
AT (1) ATE139763T1 (es)
DE (1) DE69211788T2 (es)
DK (1) DK0529279T3 (es)
ES (1) ES2089305T3 (es)
GR (1) GR3020799T3 (es)
IT (1) IT1250736B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100353A (en) * 1991-01-08 1997-06-10 Zambon Spa Preparation of 5-(2, 4-difluorophenyl)-salicylic acid and novel 2,4-difluorophenyl-boronic acid derivatives being intermediates therefor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1175212A (en) * 1967-03-09 1969-12-23 Merck & Co Inc Halo-Substituted 5-Phenylbenzoic Acids and their Derivatives
US4131618A (en) * 1977-12-29 1978-12-26 Merck & Co., Inc. Preparation of salicylic acid and derivatives
US4225730A (en) * 1978-05-11 1980-09-30 Merck & Co., Inc. Process for preparing 4-(2,4-difluorophenyl)-salicyclic acid
US4237315A (en) * 1979-11-02 1980-12-02 Merck & Co., Inc. Preparation of 5(halophenyl)salicylic acid compounds
IT1190926B (it) * 1982-07-22 1988-02-24 Zambon Spa Procedimento per preparare l'acido 2',4'-difluoro-4-idrossi-(1,1'-difenil)-3-carbossilico
IT1196485B (it) * 1986-07-14 1988-11-16 Zambon Spa Derivati dell'acido tiazolidin-4-carbossilico ad attivita' farmaceutica
US4847442A (en) * 1988-07-18 1989-07-11 Allied-Signal Inc. Process for the preparation of difluorobenzenes
US4996047A (en) * 1988-11-02 1991-02-26 Richardson-Vicks, Inc. Sustained release drug-resin complexes
JPH0768234B2 (ja) * 1989-12-14 1995-07-26 久光製薬株式会社 コウジ酸エステル誘導体

Also Published As

Publication number Publication date
IT1250736B (it) 1995-04-21
JPH07179395A (ja) 1995-07-18
ITMI912152A1 (it) 1993-02-02
ATE139763T1 (de) 1996-07-15
GR3020799T3 (en) 1996-11-30
DK0529279T3 (da) 1996-07-29
DE69211788T2 (de) 1996-10-31
EP0529279B1 (en) 1996-06-26
DE69211788D1 (de) 1996-08-01
US5183935A (en) 1993-02-02
ITMI912152A0 (it) 1991-08-01
EP0529279A1 (en) 1993-03-03

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