DE69133218T2 - Methode und filtersystem zur entfernung von leukozyten - Google Patents
Methode und filtersystem zur entfernung von leukozyten Download PDFInfo
- Publication number
- DE69133218T2 DE69133218T2 DE69133218T DE69133218T DE69133218T2 DE 69133218 T2 DE69133218 T2 DE 69133218T2 DE 69133218 T DE69133218 T DE 69133218T DE 69133218 T DE69133218 T DE 69133218T DE 69133218 T2 DE69133218 T2 DE 69133218T2
- Authority
- DE
- Germany
- Prior art keywords
- leukocyte
- filter
- filter element
- leukocytes
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000000265 leukocyte Anatomy 0.000 title claims abstract description 233
- 238000000034 method Methods 0.000 title claims abstract description 37
- 239000000835 fiber Substances 0.000 claims abstract description 148
- 239000008280 blood Substances 0.000 claims abstract description 107
- 210000004369 blood Anatomy 0.000 claims abstract description 106
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 42
- 238000011144 upstream manufacturing Methods 0.000 claims abstract description 17
- 239000002759 woven fabric Substances 0.000 claims abstract description 14
- 238000001914 filtration Methods 0.000 claims description 80
- 210000003743 erythrocyte Anatomy 0.000 claims description 69
- 239000000047 product Substances 0.000 claims description 50
- 238000012856 packing Methods 0.000 claims description 49
- 239000010836 blood and blood product Substances 0.000 claims description 47
- 229940125691 blood product Drugs 0.000 claims description 47
- 239000012141 concentrate Substances 0.000 claims description 32
- 239000011148 porous material Substances 0.000 claims description 30
- 238000005534 hematocrit Methods 0.000 claims description 10
- 210000004027 cell Anatomy 0.000 claims description 4
- 238000005119 centrifugation Methods 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 230000010100 anticoagulation Effects 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 8
- 238000011045 prefiltration Methods 0.000 description 33
- 239000007788 liquid Substances 0.000 description 32
- 238000011084 recovery Methods 0.000 description 24
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- 210000003714 granulocyte Anatomy 0.000 description 8
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- 230000000694 effects Effects 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 238000001179 sorption measurement Methods 0.000 description 5
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- 229920001917 Ficoll Polymers 0.000 description 4
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000012594 Earle’s Balanced Salt Solution Substances 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- GKXJWSZPLIKUPS-IUNAMMOKSA-N N-[(2Z,6Z)-2,6-bis(hydroxyimino)cyclohexylidene]hydroxylamine Chemical compound O\N=C1\CCC\C(=N\O)C1=NO GKXJWSZPLIKUPS-IUNAMMOKSA-N 0.000 description 2
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- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 1
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 1
- 208000009746 Adult T-Cell Leukemia-Lymphoma Diseases 0.000 description 1
- 208000016683 Adult T-cell leukemia/lymphoma Diseases 0.000 description 1
- BZUNJUAMQZRJIP-UHFFFAOYSA-N CPDA Natural products OCCCCCCCCCCCCCCC(O)=O BZUNJUAMQZRJIP-UHFFFAOYSA-N 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
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- 239000004793 Polystyrene Substances 0.000 description 1
- 208000003441 Transfusion reaction Diseases 0.000 description 1
- DPKHZNPWBDQZCN-UHFFFAOYSA-N acridine orange free base Chemical compound C1=CC(N(C)C)=CC2=NC3=CC(N(C)C)=CC=C3C=C21 DPKHZNPWBDQZCN-UHFFFAOYSA-N 0.000 description 1
- 201000006966 adult T-cell leukemia Diseases 0.000 description 1
- VBIXEXWLHSRNKB-UHFFFAOYSA-N ammonium oxalate Chemical compound [NH4+].[NH4+].[O-]C(=O)C([O-])=O VBIXEXWLHSRNKB-UHFFFAOYSA-N 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 238000002617 apheresis Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000004760 aramid Substances 0.000 description 1
- 229920003235 aromatic polyamide Polymers 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- DZBUGLKDJFMEHC-UHFFFAOYSA-N benzoquinolinylidene Natural products C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
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- 239000006285 cell suspension Substances 0.000 description 1
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- 238000013461 design Methods 0.000 description 1
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- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 238000010528 free radical solution polymerization reaction Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 210000003677 hemocyte Anatomy 0.000 description 1
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- 239000000178 monomer Substances 0.000 description 1
- GISJHCLTIVIGLX-UHFFFAOYSA-N n-[4-[(4-chlorophenyl)methoxy]pyridin-2-yl]-2-(2,6-difluorophenyl)acetamide Chemical compound FC1=CC=CC(F)=C1CC(=O)NC1=CC(OCC=2C=CC(Cl)=CC=2)=CC=N1 GISJHCLTIVIGLX-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3368—Temperature
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Biotechnology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- External Artificial Organs (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Filtering Materials (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25199890 | 1990-09-25 | ||
| JP25199890 | 1990-09-25 | ||
| PCT/JP1991/001277 WO1992004906A1 (fr) | 1990-09-25 | 1991-09-25 | Procede et systeme de filtres d'extraction de leucocytes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69133218D1 DE69133218D1 (de) | 2003-04-24 |
| DE69133218T2 true DE69133218T2 (de) | 2004-02-12 |
Family
ID=17231132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69133218T Expired - Lifetime DE69133218T2 (de) | 1990-09-25 | 1991-09-25 | Methode und filtersystem zur entfernung von leukozyten |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5298165A (OSRAM) |
| EP (1) | EP0502213B1 (OSRAM) |
| AT (1) | ATE234621T1 (OSRAM) |
| DE (1) | DE69133218T2 (OSRAM) |
| ES (1) | ES2189787T3 (OSRAM) |
| WO (1) | WO1992004906A1 (OSRAM) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPN271295A0 (en) * | 1995-05-02 | 1995-05-25 | Gropep Pty Ltd | Method of treatment |
| US5935092A (en) * | 1990-12-20 | 1999-08-10 | Baxter International Inc. | Systems and methods for removing free and entrained contaminants in plasma |
| EP0554460B1 (en) * | 1991-08-22 | 2000-11-15 | Asahi Medical Co., Ltd. | Filter medium for selective removal of leukocytes and device packed therewith |
| DE4143639C2 (de) * | 1991-12-02 | 2002-10-24 | Qiagen Gmbh | Verfahren zur Isolierung und Reinigung von Nukleinsäuren |
| EP0587832B1 (en) * | 1992-02-10 | 2001-07-11 | Baxter International Inc. | Method for testing blood units for viral contamination |
| US5686238A (en) * | 1992-02-10 | 1997-11-11 | Baxter International Inc. | Method and device for testing blood units for viral contamination |
| US5403272A (en) * | 1992-05-29 | 1995-04-04 | Baxter International Inc. | Apparatus and methods for generating leukocyte free platelet concentrate |
| US5663045A (en) * | 1993-03-24 | 1997-09-02 | Baxter International Inc. | Method for testing blood units for viral contamination |
| CA2155642A1 (en) * | 1993-12-22 | 1995-06-29 | Shmuel Sternberg | Methods for characterizing complex filtration media |
| JPH08509991A (ja) * | 1993-12-22 | 1996-10-22 | バクスター、インターナショナル、インコーポレイテッド | 白血球濾過のための濾過媒体および装置 |
| WO1996003194A1 (en) | 1994-07-28 | 1996-02-08 | Pall Corporation | Fibrous web and process of preparing same |
| US5582907A (en) * | 1994-07-28 | 1996-12-10 | Pall Corporation | Melt-blown fibrous web |
| US5728306A (en) * | 1994-12-23 | 1998-03-17 | Baxter International Inc. | Leukodepletion filter and method for filtering leukocytes from freshly drawn blood |
| US5916521A (en) * | 1995-01-04 | 1999-06-29 | Spectral Diagnostics, Inc. | Lateral flow filter devices for separation of body fluids from particulate materials |
| EP0811412B1 (en) * | 1995-12-26 | 2003-07-30 | Asahi Medical Co., Ltd. | Filter medium for leukocyte removal |
| US5865785A (en) * | 1996-02-23 | 1999-02-02 | Baxter International Inc. | Systems and methods for on line finishing of cellular blood products like platelets harvested for therapeutic purposes |
| US6190855B1 (en) | 1996-10-28 | 2001-02-20 | Baxter International Inc. | Systems and methods for removing viral agents from blood |
| US6168718B1 (en) | 1996-11-08 | 2001-01-02 | Pall Corporation | Method for purifying blood plasma and apparatus suitable therefor |
| DE19804372A1 (de) * | 1998-02-04 | 1999-08-05 | Michael W Dr Dr Dahm | Verfahren zur quantitativen Bestimmung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits |
| US6274041B1 (en) | 1998-12-18 | 2001-08-14 | Kimberly-Clark Worldwide, Inc. | Integrated filter combining physical adsorption and electrokinetic adsorption |
| US6537614B1 (en) | 1998-12-18 | 2003-03-25 | Kimberly-Clark Worldwide, Inc. | Cationically charged coating on hydrophobic polymer fibers with poly (vinyl alcohol) assist |
| US6337026B1 (en) | 1999-03-08 | 2002-01-08 | Whatman Hemasure, Inc. | Leukocyte reduction filtration media |
| US7445756B2 (en) * | 1999-06-03 | 2008-11-04 | Fenwal, Inc. | Fluid processing sets and organizers for the same |
| US7025877B1 (en) | 1999-06-03 | 2006-04-11 | Baxter International Inc. | Processing set for processing and treating a biological fluid |
| US6645388B2 (en) | 1999-12-22 | 2003-11-11 | Kimberly-Clark Corporation | Leukocyte depletion filter media, filter produced therefrom, method of making same and method of using same |
| EP1377617B1 (en) * | 2001-03-13 | 2004-10-06 | E.I. Dupont De Nemours And Company | High build dispersions |
| ITTO20020736A1 (it) * | 2002-08-21 | 2004-02-22 | Fresenius Hemocare Italia Srl | Filtro per leucociti e suo impiego per l'impoverimento di prodotti del sangue da leucociti. |
| ITTO20020820A1 (it) * | 2002-09-20 | 2004-03-21 | Fresenius Hemocare Italia S R L | Dispositivo e procedimento per separare il sangue in componenti del sangue impoveriti di leucociti. |
| JP4646114B2 (ja) | 2002-10-16 | 2011-03-09 | 旭化成メディカル株式会社 | 血漿製剤または血清製剤、及びその製造方法 |
| TW200505394A (en) | 2003-06-06 | 2005-02-16 | Asahi Medical Co | Material promoting wound healing |
| US8999167B2 (en) * | 2003-08-07 | 2015-04-07 | Asahi Kasei Medical Co., Ltd. | Composite porous membrane and process for producing the same |
| JP4587959B2 (ja) * | 2003-10-10 | 2010-11-24 | 旭化成クラレメディカル株式会社 | 細胞濃縮物の調製方法および細胞組成物 |
| AU2005323672B2 (en) * | 2005-01-06 | 2008-12-18 | Asahi Kasei Medical Co., Ltd. | Method of removing leukocyte |
| WO2007025738A2 (en) * | 2005-08-31 | 2007-03-08 | Gambro Lundia Ab | Cyclic olefin copolymer as a leukoreduction material |
| US7993523B2 (en) | 2007-03-06 | 2011-08-09 | E. I. Du Pont De Nemours And Company | Liquid filtration media |
| US8562876B2 (en) * | 2007-11-30 | 2013-10-22 | Baxter International Inc. | Multizone polymer membrane and dialyzer |
| US20100270232A1 (en) * | 2007-12-27 | 2010-10-28 | Toray Industries, Inc. | Fiber construct for treating biological components |
| EP2633871B1 (en) * | 2010-10-25 | 2019-02-13 | Kaneka Corporation | Novel leucocyte removal filter |
| ES2809211T3 (es) * | 2011-07-08 | 2021-03-03 | Emd Millipore Corp | Filtros de profundidad mejorados para procesos biotecnológicos desechables |
| RU2521378C2 (ru) * | 2012-02-06 | 2014-06-27 | Общество С Ограниченной Ответственностью "Эфтэк" | Фильтрующий материал |
| US10376627B2 (en) | 2014-03-24 | 2019-08-13 | Fenwal, Inc. | Flexible biological fluid filters |
| US9968738B2 (en) | 2014-03-24 | 2018-05-15 | Fenwal, Inc. | Biological fluid filters with molded frame and methods for making such filters |
| US9796166B2 (en) | 2014-03-24 | 2017-10-24 | Fenwal, Inc. | Flexible biological fluid filters |
| US10159778B2 (en) | 2014-03-24 | 2018-12-25 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
| US9782707B2 (en) | 2014-03-24 | 2017-10-10 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
| JP6499296B2 (ja) * | 2014-12-30 | 2019-04-10 | コーロン インダストリーズ インク | 血液フィルター及びその製造方法 |
| CN111821535B (zh) * | 2020-07-23 | 2023-06-02 | 中国人民解放军总医院第八医学中心 | 一种血液用病毒过滤管及血液用病毒过滤装置 |
| DE102020216578B4 (de) | 2020-12-28 | 2023-02-09 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein | Vorrichtung und Verfahren zur Separation von unterschiedlich großen Partikeln in einer Flüssigkeit und Verwendungen der Vorrichtung |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS603367B2 (ja) * | 1979-10-09 | 1985-01-28 | 旭化成株式会社 | 白血球分離法および白血球分離材 |
| JPS60203267A (ja) * | 1984-03-27 | 1985-10-14 | 旭メデイカル株式会社 | 白血球除去用フイルタ−装置 |
| US4701267B1 (en) * | 1984-03-15 | 1996-03-12 | Asahi Medical Co | Method for removing leukocytes |
| EP0267286B1 (en) * | 1986-03-28 | 1993-05-26 | ASAHI MEDICAL Co., Ltd. | Filter medium for selectively removing leucocytes |
| JPS62243561A (ja) * | 1986-04-15 | 1987-10-24 | 旭メデイカル株式会社 | 白血球除去フイルタ−装置 |
| JPS63255070A (ja) * | 1987-04-14 | 1988-10-21 | テルモ株式会社 | 血液成分分離器 |
| JP2503505B2 (ja) * | 1987-04-22 | 1996-06-05 | 東洋紡績株式会社 | 白血球除去フィルタ− |
| US4925572A (en) * | 1987-10-20 | 1990-05-15 | Pall Corporation | Device and method for depletion of the leukocyte content of blood and blood components |
| JP2559615B2 (ja) * | 1988-03-16 | 1996-12-04 | 旭メディカル株式会社 | 濃厚赤血球用白血球捕捉フィルター |
-
1991
- 1991-09-25 EP EP91916945A patent/EP0502213B1/en not_active Expired - Lifetime
- 1991-09-25 ES ES91916945T patent/ES2189787T3/es not_active Expired - Lifetime
- 1991-09-25 AT AT91916945T patent/ATE234621T1/de not_active IP Right Cessation
- 1991-09-25 DE DE69133218T patent/DE69133218T2/de not_active Expired - Lifetime
- 1991-09-25 WO PCT/JP1991/001277 patent/WO1992004906A1/ja not_active Ceased
- 1991-09-25 US US07/838,268 patent/US5298165A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0502213B1 (en) | 2003-03-19 |
| ES2189787T3 (es) | 2003-07-16 |
| DE69133218D1 (de) | 2003-04-24 |
| WO1992004906A1 (fr) | 1992-04-02 |
| US5298165A (en) | 1994-03-29 |
| EP0502213A1 (en) | 1992-09-09 |
| EP0502213A4 (OSRAM) | 1994-02-16 |
| ATE234621T1 (de) | 2003-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: ASAHI KASEI MEDICAL CO.,LTD., TOKIO, JP |