DE69131325T2 - Zwischenverbindungen zur herstellung von thioalkylthio cephalosporinderivaten - Google Patents

Zwischenverbindungen zur herstellung von thioalkylthio cephalosporinderivaten

Info

Publication number
DE69131325T2
DE69131325T2 DE69131325T DE69131325T DE69131325T2 DE 69131325 T2 DE69131325 T2 DE 69131325T2 DE 69131325 T DE69131325 T DE 69131325T DE 69131325 T DE69131325 T DE 69131325T DE 69131325 T2 DE69131325 T2 DE 69131325T2
Authority
DE
Germany
Prior art keywords
thioalkylthio
production
intermediate connections
cephalosporine derivatives
het
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69131325T
Other languages
English (en)
Other versions
DE69131325D1 (de
Inventor
Tadatoshi Kubota
Masaharu Kume
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of DE69131325D1 publication Critical patent/DE69131325D1/de
Publication of DE69131325T2 publication Critical patent/DE69131325T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69131325T 1990-07-19 1991-07-16 Zwischenverbindungen zur herstellung von thioalkylthio cephalosporinderivaten Expired - Fee Related DE69131325T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP19188990 1990-07-19
JP28977290 1990-10-25
JP31957890 1990-11-21
JP14735791 1991-06-19

Publications (2)

Publication Number Publication Date
DE69131325D1 DE69131325D1 (de) 1999-07-15
DE69131325T2 true DE69131325T2 (de) 1999-12-02

Family

ID=27472779

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69131325T Expired - Fee Related DE69131325T2 (de) 1990-07-19 1991-07-16 Zwischenverbindungen zur herstellung von thioalkylthio cephalosporinderivaten
DE69103490T Expired - Fee Related DE69103490T2 (de) 1990-07-19 1991-07-16 Cephalosporinderivate mit in der Lage 3 eine Thioalkylthiogruppe.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69103490T Expired - Fee Related DE69103490T2 (de) 1990-07-19 1991-07-16 Cephalosporinderivate mit in der Lage 3 eine Thioalkylthiogruppe.

Country Status (22)

Country Link
US (2) US5214037A (de)
EP (2) EP0594263B1 (de)
JP (1) JP2618119B2 (de)
KR (1) KR100203726B1 (de)
CN (1) CN1034504C (de)
AT (2) ATE181066T1 (de)
AU (1) AU634074B2 (de)
CA (2) CA2047347C (de)
DE (2) DE69131325T2 (de)
DK (2) DK0594263T3 (de)
ES (1) ES2062688T3 (de)
FI (1) FI110322B (de)
HU (2) HU222727B1 (de)
IE (1) IE65926B1 (de)
IL (1) IL98745A (de)
MX (1) MX9100227A (de)
NO (1) NO178544C (de)
NZ (1) NZ238838A (de)
PH (1) PH31091A (de)
PL (3) PL167091B1 (de)
PT (1) PT98362B (de)
RU (2) RU2071963C1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100576A (en) * 1991-01-18 1995-11-27 Eli Lilley And Company Cephalosporin antibiotics
TW307769B (de) * 1992-07-31 1997-06-11 Shionogi & Co
JP3238209B2 (ja) * 1992-09-30 2001-12-10 塩野義製薬株式会社 チオメチルチオカルバセファロスポリン誘導体
KR100377559B1 (ko) * 1998-08-31 2003-03-26 주식회사 엘지생명과학 경구투여 가능한 세팔로스포린계 화합물 및 이의 제조방법
CA2287663C (en) * 1998-11-02 2008-04-08 Isao Kurimoto Process for producing 2-alkylidene-4-bromoacetoacetic acid ester
RU2218338C2 (ru) * 1998-11-12 2003-12-10 Сумитомо Кемикал Компани, Лимитед Получение z-изомера бромоводородной соли производного 2-аминотиазола
CA2411714A1 (en) * 2000-06-28 2002-01-03 Lg Life Sciences Ltd. Novel cephalosporin compounds and process for preparing the same
KR20020085181A (ko) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 신규 세팔로스포린계 항생제 및 이의 제조 방법
KR20020085178A (ko) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 신규 세팔로스포린계 항생제 및 이의 제조 방법
KR20030076759A (ko) * 2002-03-21 2003-09-29 주식회사 엘지생명과학 신규 세팔로스포린 화합물 및 그의 제조 방법
US7161024B2 (en) * 2003-07-10 2007-01-09 Schering Corporation Process for the preparation and purification of 2-(alkoxyalkylidene)-3-ketoalkanoic acid esters from 3-ketoalkanoic acid esters
RU2277908C1 (ru) * 2005-11-25 2006-06-20 Закрытое акционерное общество "БиоАргоФарм" Водорастворимое средство, обладающее противовирусной активностью, на основе соединения серебра с цистином и способ его получения
CN103193731B (zh) * 2012-01-09 2015-04-22 华东理工大学 一种制备顺式-2-(2-叔丁氧甲酰胺基噻唑-4-基)-2-戊烯酸的方法
CN106831639B (zh) * 2016-12-31 2019-03-19 山东金城柯瑞化学有限公司 头孢卡品侧链酸的制备方法
SG11201911980WA (en) * 2017-12-22 2020-01-30 Illumina Inc Catalytically active substances
CN108440442A (zh) * 2018-05-08 2018-08-24 湖北凌晟药业有限公司 一种bapa的合成方法
EP3818691B1 (de) 2018-10-04 2024-04-10 Samsung Electronics Co., Ltd. Verfahren und system zur aufnahme eines super-zeitlupe-videos in einer tragbaren elektronischen vorrichtung
CN111395694A (zh) * 2020-04-09 2020-07-10 安徽扬子地板股份有限公司 一种基于石墨烯的防霉导热地板

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1595995A1 (de) * 1966-04-23 1970-02-12 Merck Ag E Fungizides Mittel
US4482565A (en) * 1980-02-22 1984-11-13 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
GB8314803D0 (en) * 1983-05-27 1983-07-06 Hoechst Uk Ltd 7-oxo-4-thia-1 azabicyclo 3.2.0 heptene derivatives
US4812562A (en) * 1985-07-25 1989-03-14 Taisho Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4921953A (en) * 1988-02-18 1990-05-01 Taisho Pharmaceutical Co., Ltd. Cephalosporin derivatives

Also Published As

Publication number Publication date
CA2047347C (en) 2002-03-19
HU222727B1 (hu) 2003-09-29
IL98745A0 (en) 1992-07-15
PL291129A1 (en) 1992-04-06
RU2071963C1 (ru) 1997-01-20
DE69103490T2 (de) 1994-12-15
PT98362A (pt) 1992-05-29
CN1034504C (zh) 1997-04-09
FI913458A0 (fi) 1991-07-18
EP0467647A2 (de) 1992-01-22
DE69131325D1 (de) 1999-07-15
DK0594263T3 (da) 1999-11-15
IE65926B1 (en) 1995-11-29
CA2359026A1 (en) 1992-01-20
ATE181066T1 (de) 1999-06-15
EP0594263A1 (de) 1994-04-27
AU634074B2 (en) 1993-02-11
CA2047347A1 (en) 1992-01-20
PT98362B (pt) 1999-01-29
PL167099B1 (en) 1995-07-31
FI110322B (fi) 2002-12-31
HU912409D0 (en) 1991-12-30
EP0467647A3 (en) 1992-08-12
ES2062688T3 (es) 1994-12-16
MX9100227A (es) 1993-01-01
NO178544B (no) 1996-01-08
KR100203726B1 (ko) 1999-06-15
AU8110291A (en) 1992-01-23
US5352792A (en) 1994-10-04
NO912821D0 (no) 1991-07-18
US5214037A (en) 1993-05-25
PH31091A (en) 1998-02-05
IL98745A (en) 1997-03-18
NZ238838A (en) 1992-08-26
KR920002609A (ko) 1992-02-28
NO912821L (no) 1992-01-20
DK0467647T3 (da) 1994-12-05
HUT60274A (en) 1992-08-28
CN1058595A (zh) 1992-02-12
EP0467647B1 (de) 1994-08-17
PL167119B1 (pl) 1995-07-31
EP0594263B1 (de) 1999-06-09
IE912321A1 (en) 1992-01-29
FI913458A (fi) 1992-01-20
NO178544C (no) 1996-04-17
JP2618119B2 (ja) 1997-06-11
DE69103490D1 (de) 1994-09-22
JPH0559066A (ja) 1993-03-09
ATE110081T1 (de) 1994-09-15
PL167091B1 (pl) 1995-07-31
RU2060993C1 (ru) 1996-05-27

Similar Documents

Publication Publication Date Title
DE69131325T2 (de) Zwischenverbindungen zur herstellung von thioalkylthio cephalosporinderivaten
DK0582788T3 (da) 7-(Substituerede)-9-[(substitueret glycyl)-amido]-demethyl-6-deoxytetracycliner
MY115311A (en) Optically active 2 - imidazoline - 5 - one derivatives as fungicides.
ES2088537T3 (es) Derivados de piranil cianoguanidina.
ATE117681T1 (de) Chinolinderivate, ihre herstellung und verwendung.
DK0918776T3 (da) Totalsyntese af antitumor acylfulvener
DK0490566T3 (da) Fremstilling og anvendelse af N-iodpropargyloxycarbonylaminosyreestere og derivater som antimikrobielle midler
PE34996A1 (es) Nuevo derivado de pirrocarbazol
DK328188D0 (da) Pyridinderivater, deres fremstilling og laegemidler indeholdende forbindelserne
DE69434198D1 (de) Verfahren zur senkung des serumcholesterinspiegels mit 2,6-dialkyl-4 silyl-phenol derivaten
ES2077697T3 (es) Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee