DE69127757D1 - Thrombolytisches peptid, seine produktion und thrombolisches agens - Google Patents

Thrombolytisches peptid, seine produktion und thrombolisches agens

Info

Publication number
DE69127757D1
DE69127757D1 DE69127757T DE69127757T DE69127757D1 DE 69127757 D1 DE69127757 D1 DE 69127757D1 DE 69127757 T DE69127757 T DE 69127757T DE 69127757 T DE69127757 T DE 69127757T DE 69127757 D1 DE69127757 D1 DE 69127757D1
Authority
DE
Germany
Prior art keywords
sak
peptide
thrombolic
agent
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69127757T
Other languages
English (en)
Other versions
DE69127757T2 (de
Inventor
Osamu - Matsuo
Masashi Kabushiki Kaisha Sakai
Kisaku Kabushiki Kaish Shimura
Hiroshi Kabushiki Kais Sansawa
Tsunekazu Watanabe
Tsumeo Kabushiki Kai Matsumoto
Yoshiyuki Kabushiki K Shishido
Shusuke Kabushiki Ka Hashimoto
Teruo Kabushiki Kaish Yokokura
Masaharu Kabushiki Kaish Onoue
Tomoyuki Kabushiki Kaisha Sako
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yakult Honsha Co Ltd
Original Assignee
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Co Ltd filed Critical Yakult Honsha Co Ltd
Publication of DE69127757D1 publication Critical patent/DE69127757D1/de
Application granted granted Critical
Publication of DE69127757T2 publication Critical patent/DE69127757T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69127757T 1990-12-17 1991-12-17 Thrombolytisches peptid, seine produktion und thrombolisches agens Expired - Lifetime DE69127757T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP41106390 1990-12-17
PCT/JP1991/001722 WO1992011356A1 (fr) 1990-12-17 1991-12-17 Peptide thrombolytique, sa production et agent thrombolytique

Publications (2)

Publication Number Publication Date
DE69127757D1 true DE69127757D1 (de) 1997-10-30
DE69127757T2 DE69127757T2 (de) 1998-03-12

Family

ID=18520124

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69127757T Expired - Lifetime DE69127757T2 (de) 1990-12-17 1991-12-17 Thrombolytisches peptid, seine produktion und thrombolisches agens

Country Status (11)

Country Link
US (1) US5475089A (de)
EP (1) EP0563385B1 (de)
JP (1) JP2895626B2 (de)
KR (1) KR100221571B1 (de)
AT (1) ATE158613T1 (de)
AU (1) AU665935B2 (de)
CA (1) CA2098588C (de)
DE (1) DE69127757T2 (de)
DK (1) DK0563385T3 (de)
ES (1) ES2107525T3 (de)
WO (1) WO1992011356A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0621899B1 (de) * 1991-12-30 1996-06-19 Medac Gesellschaft für klinische Spezialpräparate mbH Expression signalpeptid-freier staphylokinasen
US6383483B1 (en) * 1995-01-06 2002-05-07 Désiré José Collen Staphylokinase derivatives with cysteine substitutions
US5951980A (en) * 1995-01-06 1999-09-14 Leuven Research & Development Vzw Identification, production and use of new staphylokinase derivatives with reduced immunogenicity
CN100342007C (zh) * 2000-01-28 2007-10-10 复旦大学 一种新型重组葡激酶及其制备方法
CN110105428B (zh) * 2015-06-23 2022-08-05 首都医科大学 Leu-Arg-Ala-Pro-Leu-Tyr-Val七肽,其合成,活性和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68912383T3 (de) * 1988-04-14 1999-06-02 Yakult Honsha Kk Plasminogenaktivator und thrombolytischer Wirkstoff.
JP2707273B2 (ja) * 1988-04-14 1998-01-28 株式会社ヤクルト本社 血栓溶解剤

Also Published As

Publication number Publication date
ES2107525T3 (es) 1997-12-01
DK0563385T3 (da) 1998-05-04
KR100221571B1 (ko) 1999-10-01
EP0563385A1 (de) 1993-10-06
CA2098588A1 (en) 1992-06-18
EP0563385A4 (en) 1994-07-06
ATE158613T1 (de) 1997-10-15
KR930703437A (ko) 1993-11-30
US5475089A (en) 1995-12-12
WO1992011356A1 (fr) 1992-07-09
JP2895626B2 (ja) 1999-05-24
AU9083791A (en) 1992-07-22
EP0563385B1 (de) 1997-09-24
DE69127757T2 (de) 1998-03-12
CA2098588C (en) 2003-08-19
AU665935B2 (en) 1996-01-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition