DE69125764D1 - Verfahren zur Herstellung des Von Willebrand-Faktors von höchster Reinheit - Google Patents

Verfahren zur Herstellung des Von Willebrand-Faktors von höchster Reinheit

Info

Publication number
DE69125764D1
DE69125764D1 DE69125764T DE69125764T DE69125764D1 DE 69125764 D1 DE69125764 D1 DE 69125764D1 DE 69125764 T DE69125764 T DE 69125764T DE 69125764 T DE69125764 T DE 69125764T DE 69125764 D1 DE69125764 D1 DE 69125764D1
Authority
DE
Germany
Prior art keywords
von willebrand
willebrand factor
factor
producing
highest purity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69125764T
Other languages
English (en)
Other versions
DE69125764T2 (de
Inventor
Bernard Dazey
Mohamed Hamsany
Gerard Vezon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AQUITAINE DEV TRANSF SANGUINE
Original Assignee
AQUITAINE DEV TRANSF SANGUINE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9399373&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69125764(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AQUITAINE DEV TRANSF SANGUINE filed Critical AQUITAINE DEV TRANSF SANGUINE
Application granted granted Critical
Publication of DE69125764D1 publication Critical patent/DE69125764D1/de
Publication of DE69125764T2 publication Critical patent/DE69125764T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69125764T 1990-08-02 1991-07-30 Verfahren zur Herstellung des Von Willebrand-Faktors von höchster Reinheit Expired - Fee Related DE69125764T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9009917A FR2665449B1 (fr) 1990-08-02 1990-08-02 Procede de fabrication de facteur von willebrand ayant une tres haute purete, depourvu en majeure partie de facteur antihemophilique (fviiic), et facteur von willebrand ainsi obtenu, ainsi qu'une composition pharmaceutique le contenant.

Publications (2)

Publication Number Publication Date
DE69125764D1 true DE69125764D1 (de) 1997-05-28
DE69125764T2 DE69125764T2 (de) 1997-11-13

Family

ID=9399373

Family Applications (2)

Application Number Title Priority Date Filing Date
DE199191402124T Pending DE469985T1 (de) 1990-08-02 1991-07-30 Verfahren zur herstellung des von willebrand-faktors von hoechster reinheit.
DE69125764T Expired - Fee Related DE69125764T2 (de) 1990-08-02 1991-07-30 Verfahren zur Herstellung des Von Willebrand-Faktors von höchster Reinheit

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE199191402124T Pending DE469985T1 (de) 1990-08-02 1991-07-30 Verfahren zur herstellung des von willebrand-faktors von hoechster reinheit.

Country Status (9)

Country Link
US (1) US5252710A (de)
EP (1) EP0469985B1 (de)
JP (1) JP2559645B2 (de)
AT (1) ATE152128T1 (de)
DE (2) DE469985T1 (de)
DK (1) DK0469985T3 (de)
ES (1) ES2038095T3 (de)
FR (1) FR2665449B1 (de)
GR (1) GR3024115T3 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760183A (en) * 1989-02-17 1998-06-02 Association D'aquitaine Pour De Developpment De La Transfusion Sanguine Et Des Recherches Hematologiques Process for the manufacture of very high-purity antithaemophilic factor (FVIIIC), and von Willebrand factor, and pharmaceutical compositions containing same
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
DE4435485C1 (de) * 1994-10-04 1996-03-21 Immuno Ag Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor
DE4435392B4 (de) * 1994-10-04 2008-02-07 Immuno Ag Verfahren zur Trennung von vWF in hochmolekularen vWF und niedermolekularen vWF
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
US6005077A (en) * 1995-11-10 1999-12-21 Immuno Aktiengesellschaft Use of von willebrand factor and pharmaceutical formulation
KR970060724A (ko) * 1996-01-16 1997-08-12 김광호 백업용 배터리 동작의 표시방법 및 그 감지회로
AT405403B (de) * 1997-02-27 1999-08-25 Immuno Ag Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie
AT406867B (de) 1997-02-27 2000-10-25 Immuno Ag Verfahren zur gewinnung von hochreinem vwf oder faktor viii/vwf-komplex
US6531577B1 (en) * 1997-12-15 2003-03-11 Hemasure Denmark A/S von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations
DK2130554T3 (da) 1999-02-22 2012-12-03 Univ Connecticut Albuminfrie faktor VIII-præparater
WO2001047547A1 (fr) * 1999-12-24 2001-07-05 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Compositions medicinales de prevention et de traitement de maladies hemorragiques associant la thrombopathie
JP4663837B2 (ja) * 1999-12-24 2011-04-06 一般財団法人化学及血清療法研究所 第▲ｖｉｉｉ▼因子を主成分とする血小板減少に伴う出血疾患の予防・治療用医薬組成物
DE602004025949D1 (de) 2003-07-22 2010-04-22 Nektar Therapeutics Verfahren zur herstellung von funktionalisierten polymeren aus polymeralkoholen
FR2874216B1 (fr) * 2004-08-16 2006-11-03 Lab Francais Du Fractionnement Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu
US8568705B2 (en) * 2005-07-18 2013-10-29 Nektar Therapeutics Method for preparing branched functionalized polymers using branched polyol cores
AU2009256093A1 (en) * 2008-06-04 2009-12-10 Bayer Healthcare Llc FVIII muteins for treatment of von Willebrand disease
EP2385825B1 (de) 2008-11-07 2018-10-10 University of Connecticut Faktor-viii-formulierungen
IT1396528B1 (it) 2009-01-19 2012-12-14 Kedrion Spa Nuovo processo di purificazione altamente selettivo di due proteine plasmatiche: von willebrand factor (vwf) e fibronectina (fn).

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4170590A (en) * 1974-12-14 1979-10-09 Biotest-Serum-Institut Gmbh Ion exchanger treatment of citrate-stabilized plasma
US4508709A (en) * 1983-12-05 1985-04-02 Armour Pharmaceutical Company Process for purifying factor VIII:C
FR2570276B1 (fr) * 1984-09-18 1987-09-04 Immunotech Sa Procede d'obtention du complexe fviii/vwf a usage therapeutique et produits en resultant
JPS63108000A (ja) * 1986-05-15 1988-05-12 Green Cross Corp:The 第８因子の精製方法
US4774323A (en) * 1987-06-29 1988-09-27 Rorer Pharmaceutical Corporation Purification of von Willebrand Factor solutions using gel permeation chromatography
NL8701915A (nl) * 1987-08-14 1989-03-01 Waander Riethorst Adsorbensmateriaal en toepassing daarvan voor het isoleren van stollingsfaktoren.
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
FR2644064B1 (fr) * 1989-02-17 1994-05-27 Aquitaine Dev Transf Sanguine Procede de fabrication du facteur antihemophilique fviiic ayant une tres haute purete et facteur antihemophilique fviiic ainsi obtenu, ainsi que composition pharmaceutique le contenant
FR2650393A1 (fr) * 1989-07-28 1991-02-01 Herault Ctre Rgl Transfusion S Methode de purification du facteur vii (f viii) par chromatographie echangeuse d'ions

Also Published As

Publication number Publication date
DE69125764T2 (de) 1997-11-13
ES2038095T3 (es) 1997-09-16
JPH04234400A (ja) 1992-08-24
JP2559645B2 (ja) 1996-12-04
GR3024115T3 (en) 1997-10-31
FR2665449A1 (fr) 1992-02-07
US5252710A (en) 1993-10-12
DK0469985T3 (da) 1997-10-20
EP0469985A1 (de) 1992-02-05
ATE152128T1 (de) 1997-05-15
EP0469985B1 (de) 1997-04-23
ES2038095T1 (es) 1993-07-16
FR2665449B1 (fr) 1995-04-14
DE469985T1 (de) 1992-10-15

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8339 Ceased/non-payment of the annual fee