DE69121562T3 - Kontrastmittel enthaltend einen nicht-ionischen kontrast Wirkstoff und Sodium und Kalzium Sälze - Google Patents

Kontrastmittel enthaltend einen nicht-ionischen kontrast Wirkstoff und Sodium und Kalzium Sälze

Info

Publication number
DE69121562T3
DE69121562T3 DE69121562T DE69121562T DE69121562T3 DE 69121562 T3 DE69121562 T3 DE 69121562T3 DE 69121562 T DE69121562 T DE 69121562T DE 69121562 T DE69121562 T DE 69121562T DE 69121562 T3 DE69121562 T3 DE 69121562T3
Authority
DE
Germany
Prior art keywords
contrast agent
sodium
concn
esp
calcium salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69121562T
Other languages
English (en)
Other versions
DE69121562D1 (de
DE69121562T2 (de
Inventor
Torsten Almen
Lars Baath
Audun Nesheim Oksendal
Per Jynge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed Imaging AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10682193&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69121562(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP90200580A external-priority patent/EP0390242B1/de
Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS
Publication of DE69121562D1 publication Critical patent/DE69121562D1/de
Application granted granted Critical
Publication of DE69121562T2 publication Critical patent/DE69121562T2/de
Publication of DE69121562T3 publication Critical patent/DE69121562T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0452—Solutions, e.g. for injection

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Liquid Crystal (AREA)
  • Devices For Indicating Variable Information By Combining Individual Elements (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Paints Or Removers (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Lubricants (AREA)
DE69121562T 1990-03-09 1991-03-07 Kontrastmittel enthaltend einen nicht-ionischen kontrast Wirkstoff und Sodium und Kalzium Sälze Expired - Lifetime DE69121562T3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP90200580A EP0390242B1 (de) 1989-03-17 1990-03-09 Kontrastmittel
GB909020091A GB9020091D0 (en) 1990-09-14 1990-09-14 Contrast media
PCT/EP1991/000425 WO1991013636A1 (en) 1990-03-09 1991-03-07 Contrast media

Publications (3)

Publication Number Publication Date
DE69121562D1 DE69121562D1 (de) 1996-09-26
DE69121562T2 DE69121562T2 (de) 1997-01-16
DE69121562T3 true DE69121562T3 (de) 2000-11-23

Family

ID=10682193

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69121562T Expired - Lifetime DE69121562T3 (de) 1990-03-09 1991-03-07 Kontrastmittel enthaltend einen nicht-ionischen kontrast Wirkstoff und Sodium und Kalzium Sälze

Country Status (32)

Country Link
US (2) US5328680A (de)
EP (1) EP0521880B2 (de)
JP (1) JP3215703B2 (de)
KR (1) KR100189271B1 (de)
CN (1) CN1055864C (de)
AT (1) ATE141519T1 (de)
CA (1) CA2076861A1 (de)
CZ (1) CZ285071B6 (de)
DE (1) DE69121562T3 (de)
DK (1) DK0521880T4 (de)
DZ (1) DZ1506A1 (de)
EG (1) EG19889A (de)
ES (1) ES2090315T5 (de)
FI (1) FI100698B (de)
GB (1) GB9020091D0 (de)
GE (1) GEP19971155B (de)
GR (2) GR3020842T3 (de)
HK (1) HK1003563A1 (de)
HR (1) HRP930773B1 (de)
HU (1) HU217075B (de)
IE (1) IE76916B1 (de)
IL (1) IL97455A (de)
LV (1) LV10058B (de)
MY (1) MY105493A (de)
NO (1) NO304352B1 (de)
OA (1) OA09667A (de)
PT (1) PT96978B (de)
RO (1) RO111543B1 (de)
SK (1) SK278621B6 (de)
TR (1) TR25738A (de)
WO (1) WO1991013636A1 (de)
YU (1) YU48683B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1256248B (it) * 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x
GB9419206D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
GB9419203D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
PL328199A1 (en) 1996-01-25 1999-01-18 Schering Ag Improved concentrated intravascular injection and infusion solutions
DE19648650C2 (de) * 1996-01-29 1998-07-02 Schering Ag Puffersysteme und deren Verwendung zur Stabilisierung pharmazeutischer Zubereitung
DE10126405A1 (de) * 2001-05-22 2003-02-27 Trommsdorff Gmbh & Co Physiologisch verträgliche Kalium- und Magnesiumsalze enthaltendes pharmazeutisches Präparat sowie dessen Verwendung zur Prophylaxe und/oder Therapie von QT-Zeitverlängerungen
US7498018B2 (en) * 2003-10-03 2009-03-03 Bracco Diagnostics Inc. Contrast media for use in medical and diagnostic procedures and methods of using the same
DE102005028882A1 (de) * 2005-06-22 2007-01-04 Siemens Ag Lösung und Verfahren zum Unterstützen der Bildgebung an einem Patienten
WO2007094683A1 (en) 2006-02-15 2007-08-23 Ge Healthcare As Contrast agents
EP1998813A2 (de) * 2006-03-29 2008-12-10 GE Healthcare AS Verfahren zur herstellung hyperpolaisierter carboxylate und sulfonate in gegenwart von anorganischen kationen
FR2899581B1 (fr) * 2006-04-07 2008-06-27 Guerbet Sa Procede d'atomisation du ioxilan
US7662859B2 (en) 2007-02-16 2010-02-16 Ge Healthcare As Contrast agents
AU2008273037B2 (en) 2007-07-12 2012-11-15 Ge Healthcare As Contrast agents
JP2011500533A (ja) 2007-10-12 2011-01-06 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
WO2009047318A1 (en) 2007-10-12 2009-04-16 Ge Healthcare As Contrast agents
ES2389974T3 (es) 2007-10-12 2012-11-05 Ge Healthcare As Agentes de contraste
US20100209356A1 (en) 2007-10-12 2010-08-19 Duncan George Wynn Contrast agents
JP2012514622A (ja) 2009-01-09 2012-06-28 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影製剤組成物
EP2243767A1 (de) 2009-04-21 2010-10-27 Bracco Imaging S.p.A Verfahren zur Iodierung aromatischer Verbindungen
NZ598540A (en) 2009-10-29 2014-03-28 Ge Healthcare As Diagnostic composition comprising plasma cations having superior safety profile
CN102114249B (zh) * 2009-12-30 2013-01-30 四川大学华西医院 一种携氧冠脉造影剂及其制备方法
US20140065076A1 (en) * 2012-08-30 2014-03-06 Otsuka Pharmaceutical Co. Ltd. Container with concentrated substance and method of using the same
KR20150134346A (ko) 2013-03-27 2015-12-01 지이 헬스케어 에이에스 진단 조성물을 제조하기 위한 방법 및 시약
SG11201604507RA (en) * 2013-12-04 2016-07-28 Hovione Scientia Ltd Contrast media taste masking formulations

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1858142A (en) * 1928-01-21 1932-05-10 Nat Aniline & Chem Co Inc Colloidal mono-sodium tetraiodophenolphthalein
NL127881C (de) * 1963-03-25
US3175952A (en) * 1963-05-29 1965-03-30 Sterling Drug Inc Aqueous radiopaque solutions containing sodium and calcium ions
GB1069437A (en) * 1963-10-23 1967-05-17 Nyegaard & Co As Injectable x-ray contrast media
DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
DE2928417A1 (de) * 1979-07-12 1981-01-29 Schering Ag Trijodierte basen
DE3038853A1 (de) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US4649050A (en) * 1984-06-22 1987-03-10 Veech Richard L Electrolyte solutions containing polyanionic materials
ATE82500T1 (de) * 1984-06-22 1992-12-15 Richard L Veech Elektrolytloesungen und deren (in vivo) verwendung.
US4863714A (en) * 1987-02-05 1989-09-05 Cook Imaging Corporation Sterilization of compositions of limited stability
EP0410974A4 (en) * 1988-03-01 1991-09-11 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
US5011925A (en) * 1989-03-09 1991-04-30 Mallinckrodt, Inc. Morpholinoamido EDTA derivatives
GB8906130D0 (en) * 1989-03-17 1989-05-04 Nycomed As Compositions

Also Published As

Publication number Publication date
WO1991013636A1 (en) 1991-09-19
IE910775A1 (en) 1991-09-11
RO111543B1 (ro) 1996-11-29
LV10058A (lv) 1994-05-10
HRP930773B1 (en) 2000-10-31
HK1003563A1 (en) 1998-10-30
IL97455A (en) 1995-11-27
IE76916B1 (en) 1997-11-05
CA2076861A1 (en) 1991-09-10
FI100698B (fi) 1998-02-13
EP0521880B2 (de) 2000-05-31
GR3033898T3 (en) 2000-11-30
YU40891A (sh) 1994-04-05
NO923485D0 (no) 1992-09-08
KR100189271B1 (ko) 1999-06-01
AU7345191A (en) 1991-10-10
US5328680A (en) 1994-07-12
HUT62490A (en) 1993-05-28
IL97455A0 (en) 1992-06-21
ES2090315T3 (es) 1996-10-16
CN1056058A (zh) 1991-11-13
ATE141519T1 (de) 1996-09-15
EP0521880A1 (de) 1993-01-13
CN1055864C (zh) 2000-08-30
TR25738A (tr) 1993-09-01
YU48683B (sh) 1999-06-15
EP0521880B1 (de) 1996-08-21
SK278621B6 (en) 1997-11-05
AU645544B2 (en) 1994-01-20
USRE36418E (en) 1999-11-30
GR3020842T3 (en) 1996-11-30
FI923962A0 (fi) 1992-09-04
DK0521880T4 (da) 2000-09-04
EG19889A (en) 1996-03-31
LV10058B (en) 1994-10-20
DE69121562D1 (de) 1996-09-26
GB9020091D0 (en) 1990-10-24
FI923962A (fi) 1992-09-04
NO304352B1 (no) 1998-12-07
CZ285071B6 (cs) 1999-05-12
NO923485L (no) 1992-11-05
DZ1506A1 (fr) 2004-09-13
PT96978A (pt) 1991-10-31
JP3215703B2 (ja) 2001-10-09
OA09667A (en) 1993-05-15
MY105493A (en) 1994-10-31
HU217075B (hu) 1999-11-29
PT96978B (pt) 2001-07-31
HRP930773A2 (en) 1997-10-31
CS9100619A2 (en) 1991-09-15
HU9202870D0 (en) 1992-11-30
JPH05504953A (ja) 1993-07-29
ES2090315T5 (es) 2000-08-01
DK0521880T3 (da) 1996-09-09
DE69121562T2 (de) 1997-01-16
GEP19971155B (en) 1997-08-11

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: AMERSHAM HEALTH AS, OSLO, NO

8327 Change in the person/name/address of the patent owner

Owner name: GE HEALTHCARE AS, OSLO, NO

8328 Change in the person/name/address of the agent

Representative=s name: HAMMONDS LLP, LONDON, GB