DE69121018D1 - Lipopeptid Deacylase - Google Patents

Lipopeptid Deacylase

Info

Publication number
DE69121018D1
DE69121018D1 DE69121018T DE69121018T DE69121018D1 DE 69121018 D1 DE69121018 D1 DE 69121018D1 DE 69121018 T DE69121018 T DE 69121018T DE 69121018 T DE69121018 T DE 69121018T DE 69121018 D1 DE69121018 D1 DE 69121018D1
Authority
DE
Germany
Prior art keywords
enzyme
deacylase
lipid
cyclicpeptide
aculeacin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69121018T
Other languages
English (en)
Other versions
DE69121018T2 (de
Inventor
Adam Joseph Kreusman
Wu-Kuang Yeh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE69121018D1 publication Critical patent/DE69121018D1/de
Publication of DE69121018T2 publication Critical patent/DE69121018T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Peptides Or Proteins (AREA)
  • Prostheses (AREA)
  • External Artificial Organs (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
DE69121018T 1990-06-07 1991-06-03 Lipopeptid Deacylase Expired - Fee Related DE69121018T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53439490A 1990-06-07 1990-06-07

Publications (2)

Publication Number Publication Date
DE69121018D1 true DE69121018D1 (de) 1996-08-29
DE69121018T2 DE69121018T2 (de) 1996-12-19

Family

ID=24129856

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69121018T Expired - Fee Related DE69121018T2 (de) 1990-06-07 1991-06-03 Lipopeptid Deacylase

Country Status (14)

Country Link
US (1) US5573936A (de)
EP (1) EP0460882B1 (de)
JP (1) JP2994486B2 (de)
KR (1) KR0169994B1 (de)
AT (1) ATE140728T1 (de)
CA (1) CA2043762C (de)
DE (1) DE69121018T2 (de)
DK (1) DK0460882T3 (de)
ES (1) ES2089133T3 (de)
GR (1) GR3021292T3 (de)
HU (1) HU215232B (de)
IE (1) IE75885B1 (de)
IL (1) IL98349A (de)
TW (1) TW197471B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743777B1 (en) 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
JP3123078B2 (ja) * 1996-03-08 2001-01-09 藤沢薬品工業株式会社 環状リポペプチド物質の脱アシル化法
WO1997047738A1 (fr) * 1996-06-13 1997-12-18 Fujisawa Pharmaceutical Co., Ltd. Acylase des lipopeptides cycliques
US6153410A (en) * 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
US6361988B1 (en) 1997-03-25 2002-03-26 California Institute Of Technology ECB deacylase mutants
US5936074A (en) * 1997-04-17 1999-08-10 Eli Lilly And Company Teicoplanin deacylation process and product
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
CA2353930A1 (en) 1998-12-09 2000-06-15 Eli Lilly And Company Purification of echinocandin cyclopeptide compounds
AU771727B2 (en) 1999-03-03 2004-04-01 Eli Lilly And Company Processes for making pharmaceutical oral ECB formulations and compositions
ATE338060T1 (de) 1999-03-03 2006-09-15 Lilly Co Eli Bildung und anionenaustausch von inneren kristallinen ammoniumsalzen des echinocandins b
WO2000051564A1 (en) 1999-03-03 2000-09-08 Eli Lilly And Company Echinocandin pharmaceutical formulations containing micelle-forming surfactants
KR20020003864A (ko) 1999-03-03 2002-01-15 피터 지. 스트링거 에키노칸딘/탄수화물 착물
BR0012481A (pt) * 1999-07-15 2002-04-02 Lilly Co Eli Processo para desacilação de lipodepsipeptìdeos
EP1240181A2 (de) 1999-12-15 2002-09-18 Cubist Pharmaceuticals, Inc. Daptomycin analoge und deren verwendung als antibakterielle verbindungen
US7408025B2 (en) * 1999-12-15 2008-08-05 Cubist Pharmaceuticals, Inc. Lipopeptides as antibacterial agents
KR20020063230A (ko) * 1999-12-15 2002-08-01 큐비스트 파마슈티컬즈 인코포레이티드 항균제로서의 신규한 리포펩티드
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
NZ531493A (en) * 2001-08-06 2006-03-31 Cubist Pharm Inc Novel depsipeptides and process for preparing same, useful in the treatment of bacterial infection
US6991800B2 (en) 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
DE102004060750A1 (de) 2004-12-15 2006-07-13 Sanofi-Aventis Deutschland Gmbh Verfahren zur Deacylierung von Lipopeptiden
PL2379580T3 (pl) * 2008-12-22 2014-05-30 Merck Sharp & Dohme Nowe środki przeciwbakteryjne do leczenia zakażeń wywołanych bakteriami Gram-dodatnimi
US9394340B2 (en) * 2009-03-24 2016-07-19 Cadila Healthcare Limited Purification process for lipopeptides
US20150218221A1 (en) 2012-09-24 2015-08-06 Dsm Sinochem Pharmaceuticals Netherlands B.V. Method for producing a cyclic peptide
KR101425108B1 (ko) * 2012-09-25 2014-07-31 동국제약 주식회사 탈아실화된 환상 리포펩티드의 제조방법
CN108410929B (zh) * 2018-05-30 2024-01-26 博瑞生物医药（苏州）股份有限公司 阿尼芬净前体的制备方法
CN109593809A (zh) * 2018-12-07 2019-04-09 成都雅途生物技术有限公司 一种固定化微生物酶转化棘白菌素b的方法
CN113215185B (zh) * 2021-04-22 2022-04-29 浙江工业大学 一种用于重组表达棘白菌素b脱酰基酶的重组基因序列

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1159450A (en) * 1979-12-13 1983-12-27 Manuel Debono Process for the preparation of derivatives of cyclic peptide nuclei

Also Published As

Publication number Publication date
IL98349A (en) 1995-05-26
KR920000919A (ko) 1992-01-29
TW197471B (de) 1993-01-01
HUT61587A (en) 1993-01-28
IE75885B1 (en) 1997-09-24
ATE140728T1 (de) 1996-08-15
EP0460882A3 (en) 1992-04-22
DE69121018T2 (de) 1996-12-19
JPH04228072A (ja) 1992-08-18
ES2089133T3 (es) 1996-10-01
JP2994486B2 (ja) 1999-12-27
EP0460882A2 (de) 1991-12-11
CA2043762A1 (en) 1991-12-08
CA2043762C (en) 2001-05-29
HU911897D0 (en) 1991-12-30
KR0169994B1 (ko) 1999-02-01
DK0460882T3 (da) 1996-08-26
IL98349A0 (en) 1992-07-15
EP0460882B1 (de) 1996-07-24
GR3021292T3 (en) 1997-01-31
HU215232B (hu) 1998-11-30
IE911939A1 (en) 1991-12-18
US5573936A (en) 1996-11-12

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