DE69113893D1 - 6,7-Disubstituierte 2-Aminotetraline als Immunomodulatoren und pharmazeutische Zusammensetzungen davon. - Google Patents

6,7-Disubstituierte 2-Aminotetraline als Immunomodulatoren und pharmazeutische Zusammensetzungen davon.

Info

Publication number
DE69113893D1
DE69113893D1 DE69113893T DE69113893T DE69113893D1 DE 69113893 D1 DE69113893 D1 DE 69113893D1 DE 69113893 T DE69113893 T DE 69113893T DE 69113893 T DE69113893 T DE 69113893T DE 69113893 D1 DE69113893 D1 DE 69113893D1
Authority
DE
Germany
Prior art keywords
disubstituted
aminotetralins
immunomodulators
pharmaceutical compositions
propyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69113893T
Other languages
English (en)
Other versions
DE69113893T2 (de
Inventor
Piero Foresta
Mauro Marzi
Maria Ornella Tinti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of DE69113893D1 publication Critical patent/DE69113893D1/de
Publication of DE69113893T2 publication Critical patent/DE69113893T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69113893T 1990-06-15 1991-06-13 6,7-Disubstituierte 2-Aminotetraline als Immunomodulatoren und pharmazeutische Zusammensetzungen davon. Expired - Fee Related DE69113893T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48066A IT1241988B (it) 1990-06-15 1990-06-15 2- amminotetraline-6, 7-sostituite attive come immunomodulanti e composizioni farmaceutiche che le contengono

Publications (2)

Publication Number Publication Date
DE69113893D1 true DE69113893D1 (de) 1995-11-23
DE69113893T2 DE69113893T2 (de) 1996-04-04

Family

ID=11264323

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69113893T Expired - Fee Related DE69113893T2 (de) 1990-06-15 1991-06-13 6,7-Disubstituierte 2-Aminotetraline als Immunomodulatoren und pharmazeutische Zusammensetzungen davon.

Country Status (10)

Country Link
US (2) US5637614A (de)
EP (1) EP0466662B1 (de)
JP (1) JP2875061B2 (de)
AT (1) ATE129232T1 (de)
DE (1) DE69113893T2 (de)
DK (1) DK0466662T3 (de)
ES (1) ES2078497T3 (de)
GR (1) GR3017813T3 (de)
HK (1) HK1005862A1 (de)
IT (1) IT1241988B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1278045B1 (it) * 1995-03-09 1997-11-17 Sigma Tau Ind Farmaceuti Uso di 2-amminotetraline-6,7-sostituite per la preparazione di composizioni farmaceutiche atte al trattamento dello shock, e di
IT1290910B1 (it) * 1997-02-03 1998-12-14 Sigma Tau Ind Farmaceuti 2-amminotetralina otticamente attiva, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono, attive
AUPO565997A0 (en) * 1997-03-17 1997-04-10 Fujisawa Pharmaceutical Co., Ltd. Propanolamine derivatives
IT1294932B1 (it) * 1997-09-22 1999-04-23 Sigma Tau Ind Farmaceuti Uso di 2-amminotetraline-6,7 sostituite per la preparazione di composizioni farmaceutiche atte al trattamento di patologie
IT1294931B1 (it) * 1997-09-22 1999-04-23 Sigma Tau Ind Farmaceuti Derivati della 2-amminotetralina procedimento per la loro preparazione e composizioni farmaceutiche che li contengono, attive nella
US7125904B2 (en) 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2803582A1 (de) * 1978-01-27 1979-08-02 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
DE2965841D1 (en) * 1978-07-14 1983-08-18 American Hospital Supply Corp 2-alpha-methyl-dopaminimino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene, its salts, and a process for preparation thereof
US4885308A (en) * 1984-08-13 1989-12-05 Nelson Research & Development Co. Method and compositions for treatment of parkinsonism syndrome in mammals
US4593042A (en) * 1985-10-18 1986-06-03 G. D. Searle & Co. Bicyclo-substituted phenylacetonitrile derivatives
US4975461A (en) * 1986-06-19 1990-12-04 E. R. Squibb & Sons, Inc. P-aminophenols, derivatives thereof and method of use
IT1199339B (it) * 1986-12-23 1988-12-30 Sigma Tau Ind Farmaceuti N-alchil derivati della 2-ammino-6,7-dimetossi tetralina,procedimenti per la loro preparazione e composizioni farmaceutiche ad attivita'an tiipertensiva che li contengono

Also Published As

Publication number Publication date
IT9048066A0 (it) 1990-06-15
EP0466662A2 (de) 1992-01-15
US5962525A (en) 1999-10-05
EP0466662A3 (en) 1992-12-09
ES2078497T3 (es) 1995-12-16
EP0466662B1 (de) 1995-10-18
JPH04230247A (ja) 1992-08-19
IT9048066A1 (it) 1991-12-15
DK0466662T3 (da) 1995-11-27
DE69113893T2 (de) 1996-04-04
HK1005862A1 (en) 1999-01-29
ATE129232T1 (de) 1995-11-15
JP2875061B2 (ja) 1999-03-24
IT1241988B (it) 1994-02-02
US5637614A (en) 1997-06-10
GR3017813T3 (en) 1996-01-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee