ATE129232T1 - 6,7-disubstituierte 2-aminotetraline als immunomodulatoren und pharmazeutische zusammensetzungen davon. - Google Patents
6,7-disubstituierte 2-aminotetraline als immunomodulatoren und pharmazeutische zusammensetzungen davon.Info
- Publication number
- ATE129232T1 ATE129232T1 AT91830261T AT91830261T ATE129232T1 AT E129232 T1 ATE129232 T1 AT E129232T1 AT 91830261 T AT91830261 T AT 91830261T AT 91830261 T AT91830261 T AT 91830261T AT E129232 T1 ATE129232 T1 AT E129232T1
- Authority
- AT
- Austria
- Prior art keywords
- aminotetralines
- disubstituted
- immunomodulators
- pharmaceutical compositions
- propyl
- Prior art date
Links
- 239000002955 immunomodulating agent Substances 0.000 title abstract 2
- 229940121354 immunomodulator Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 6,7-disubstituted-2-aminotetralines Chemical class 0.000 abstract 5
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000002584 immunomodulator Effects 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT48066A IT1241988B (it) | 1990-06-15 | 1990-06-15 | 2- amminotetraline-6, 7-sostituite attive come immunomodulanti e composizioni farmaceutiche che le contengono |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE129232T1 true ATE129232T1 (de) | 1995-11-15 |
Family
ID=11264323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91830261T ATE129232T1 (de) | 1990-06-15 | 1991-06-13 | 6,7-disubstituierte 2-aminotetraline als immunomodulatoren und pharmazeutische zusammensetzungen davon. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5637614A (de) |
| EP (1) | EP0466662B1 (de) |
| JP (1) | JP2875061B2 (de) |
| AT (1) | ATE129232T1 (de) |
| DE (1) | DE69113893T2 (de) |
| DK (1) | DK0466662T3 (de) |
| ES (1) | ES2078497T3 (de) |
| GR (1) | GR3017813T3 (de) |
| IT (1) | IT1241988B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1278045B1 (it) * | 1995-03-09 | 1997-11-17 | Sigma Tau Ind Farmaceuti | Uso di 2-amminotetraline-6,7-sostituite per la preparazione di composizioni farmaceutiche atte al trattamento dello shock, e di |
| IT1290910B1 (it) * | 1997-02-03 | 1998-12-14 | Sigma Tau Ind Farmaceuti | 2-amminotetralina otticamente attiva, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono, attive |
| AUPO565997A0 (en) * | 1997-03-17 | 1997-04-10 | Fujisawa Pharmaceutical Co., Ltd. | Propanolamine derivatives |
| IT1294931B1 (it) | 1997-09-22 | 1999-04-23 | Sigma Tau Ind Farmaceuti | Derivati della 2-amminotetralina procedimento per la loro preparazione e composizioni farmaceutiche che li contengono, attive nella |
| IT1294932B1 (it) * | 1997-09-22 | 1999-04-23 | Sigma Tau Ind Farmaceuti | Uso di 2-amminotetraline-6,7 sostituite per la preparazione di composizioni farmaceutiche atte al trattamento di patologie |
| US7125904B2 (en) | 2002-10-11 | 2006-10-24 | Portela & C.A., S.A. | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2803582A1 (de) * | 1978-01-27 | 1979-08-02 | Sandoz Ag | Neue tetralinderivate, ihre herstellung und verwendung |
| WO1980000251A1 (en) * | 1978-07-14 | 1980-02-21 | American Hospital Supply Corp | Derivatives of 2-amino-6,7-dihydroxytetrahydronaphthalene(adtn) |
| US4885308A (en) * | 1984-08-13 | 1989-12-05 | Nelson Research & Development Co. | Method and compositions for treatment of parkinsonism syndrome in mammals |
| US4593042A (en) * | 1985-10-18 | 1986-06-03 | G. D. Searle & Co. | Bicyclo-substituted phenylacetonitrile derivatives |
| US4975461A (en) * | 1986-06-19 | 1990-12-04 | E. R. Squibb & Sons, Inc. | P-aminophenols, derivatives thereof and method of use |
| IT1199339B (it) * | 1986-12-23 | 1988-12-30 | Sigma Tau Ind Farmaceuti | N-alchil derivati della 2-ammino-6,7-dimetossi tetralina,procedimenti per la loro preparazione e composizioni farmaceutiche ad attivita'an tiipertensiva che li contengono |
-
1990
- 1990-06-15 IT IT48066A patent/IT1241988B/it active IP Right Grant
-
1991
- 1991-06-13 ES ES91830261T patent/ES2078497T3/es not_active Expired - Lifetime
- 1991-06-13 AT AT91830261T patent/ATE129232T1/de not_active IP Right Cessation
- 1991-06-13 DE DE69113893T patent/DE69113893T2/de not_active Expired - Fee Related
- 1991-06-13 DK DK91830261.3T patent/DK0466662T3/da active
- 1991-06-13 EP EP91830261A patent/EP0466662B1/de not_active Expired - Lifetime
- 1991-06-14 JP JP3143211A patent/JP2875061B2/ja not_active Expired - Fee Related
-
1995
- 1995-10-19 GR GR950401870T patent/GR3017813T3/el unknown
-
1996
- 1996-04-29 US US08/639,431 patent/US5637614A/en not_active Expired - Fee Related
-
1997
- 1997-06-09 US US08/871,050 patent/US5962525A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2875061B2 (ja) | 1999-03-24 |
| DE69113893D1 (de) | 1995-11-23 |
| GR3017813T3 (en) | 1996-01-31 |
| IT9048066A1 (it) | 1991-12-15 |
| ES2078497T3 (es) | 1995-12-16 |
| IT9048066A0 (it) | 1990-06-15 |
| US5637614A (en) | 1997-06-10 |
| IT1241988B (it) | 1994-02-02 |
| JPH04230247A (ja) | 1992-08-19 |
| HK1005862A1 (en) | 1999-01-29 |
| US5962525A (en) | 1999-10-05 |
| DK0466662T3 (da) | 1995-11-27 |
| EP0466662A2 (de) | 1992-01-15 |
| EP0466662A3 (en) | 1992-12-09 |
| DE69113893T2 (de) | 1996-04-04 |
| EP0466662B1 (de) | 1995-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |