ES2078497T3 - 6,7-disubstituidas-2-aminotetralinas activas como inmunomoduladores y composiciones farmaceuticas que las contienen. - Google Patents

6,7-disubstituidas-2-aminotetralinas activas como inmunomoduladores y composiciones farmaceuticas que las contienen.

Info

Publication number
ES2078497T3
ES2078497T3 ES91830261T ES91830261T ES2078497T3 ES 2078497 T3 ES2078497 T3 ES 2078497T3 ES 91830261 T ES91830261 T ES 91830261T ES 91830261 T ES91830261 T ES 91830261T ES 2078497 T3 ES2078497 T3 ES 2078497T3
Authority
ES
Spain
Prior art keywords
disubstituidas
aminotetralinas
immunomodulators
contain
active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91830261T
Other languages
English (en)
Inventor
Piero Foresta
Mauro Marzi
Maria Ornella Tinti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of ES2078497T3 publication Critical patent/ES2078497T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

2-AMINOTETRALINAS-6, 7-DISUSTITUIDAS QUE TIENEN LA FORMULA GENERAL (1) Y SUS SALES FARMACOLOGICAMENTE ACEPTABLES, EN DONDE X E Y, IDENTICOS O DIFERENTES, SON SELECCIONADOS DEL GRUPO QUE CONSISTE EN METOXI, ACETOXI Y FLUOR; Y R Y R SUB 1, IDENTICOS O DIFERENTES, SON SELECCIONADOS DEL GRUPO QUE CONSISTE EN HIDROGENO, ETILO, PROPILO, CICLOPROPILMETILO, 2-HIDROXI-2 -FENILETILO, 2-HIDROXI-2-(4-METILFENIL) ETILO Y 2-HIDROXI-3 -(4-METOXIFENOXI) PRO ESTAN DOTADAS DE ACTIVIDAD INMUNOMODULADORA.
ES91830261T 1990-06-15 1991-06-13 6,7-disubstituidas-2-aminotetralinas activas como inmunomoduladores y composiciones farmaceuticas que las contienen. Expired - Lifetime ES2078497T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48066A IT1241988B (it) 1990-06-15 1990-06-15 2- amminotetraline-6, 7-sostituite attive come immunomodulanti e composizioni farmaceutiche che le contengono

Publications (1)

Publication Number Publication Date
ES2078497T3 true ES2078497T3 (es) 1995-12-16

Family

ID=11264323

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91830261T Expired - Lifetime ES2078497T3 (es) 1990-06-15 1991-06-13 6,7-disubstituidas-2-aminotetralinas activas como inmunomoduladores y composiciones farmaceuticas que las contienen.

Country Status (10)

Country Link
US (2) US5637614A (es)
EP (1) EP0466662B1 (es)
JP (1) JP2875061B2 (es)
AT (1) ATE129232T1 (es)
DE (1) DE69113893T2 (es)
DK (1) DK0466662T3 (es)
ES (1) ES2078497T3 (es)
GR (1) GR3017813T3 (es)
HK (1) HK1005862A1 (es)
IT (1) IT1241988B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1278045B1 (it) * 1995-03-09 1997-11-17 Sigma Tau Ind Farmaceuti Uso di 2-amminotetraline-6,7-sostituite per la preparazione di composizioni farmaceutiche atte al trattamento dello shock, e di
IT1290910B1 (it) * 1997-02-03 1998-12-14 Sigma Tau Ind Farmaceuti 2-amminotetralina otticamente attiva, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono, attive
AUPO565997A0 (en) * 1997-03-17 1997-04-10 Fujisawa Pharmaceutical Co., Ltd. Propanolamine derivatives
IT1294932B1 (it) * 1997-09-22 1999-04-23 Sigma Tau Ind Farmaceuti Uso di 2-amminotetraline-6,7 sostituite per la preparazione di composizioni farmaceutiche atte al trattamento di patologie
IT1294931B1 (it) * 1997-09-22 1999-04-23 Sigma Tau Ind Farmaceuti Derivati della 2-amminotetralina procedimento per la loro preparazione e composizioni farmaceutiche che li contengono, attive nella
US7125904B2 (en) 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2803582A1 (de) * 1978-01-27 1979-08-02 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
JPS639500B2 (es) * 1978-07-14 1988-02-29 Amerikan Hosupitaru Sapurai Corp
US4885308A (en) * 1984-08-13 1989-12-05 Nelson Research & Development Co. Method and compositions for treatment of parkinsonism syndrome in mammals
US4593042A (en) * 1985-10-18 1986-06-03 G. D. Searle & Co. Bicyclo-substituted phenylacetonitrile derivatives
US4975461A (en) * 1986-06-19 1990-12-04 E. R. Squibb & Sons, Inc. P-aminophenols, derivatives thereof and method of use
IT1199339B (it) * 1986-12-23 1988-12-30 Sigma Tau Ind Farmaceuti N-alchil derivati della 2-ammino-6,7-dimetossi tetralina,procedimenti per la loro preparazione e composizioni farmaceutiche ad attivita'an tiipertensiva che li contengono

Also Published As

Publication number Publication date
IT9048066A0 (it) 1990-06-15
DK0466662T3 (da) 1995-11-27
EP0466662A3 (en) 1992-12-09
GR3017813T3 (en) 1996-01-31
JPH04230247A (ja) 1992-08-19
ATE129232T1 (de) 1995-11-15
US5637614A (en) 1997-06-10
EP0466662B1 (en) 1995-10-18
DE69113893T2 (de) 1996-04-04
JP2875061B2 (ja) 1999-03-24
US5962525A (en) 1999-10-05
HK1005862A1 (en) 1999-01-29
IT9048066A1 (it) 1991-12-15
IT1241988B (it) 1994-02-02
DE69113893D1 (de) 1995-11-23
EP0466662A2 (en) 1992-01-15

Similar Documents

Publication Publication Date Title
ES2179071T3 (es) Agentes vasodilatadores perifericos que comprenden como principio activo derivados de la piperidina 4-amino n-acilada.
ES2172585T3 (es) Derivado de benzoimidazol.
PT750618E (pt) Derivados de oxazolidinona e composicoes farmaceuticas que os contem
DE3868076D1 (de) Heterocyclische derivate, verfahren zu ihrer herstellung und diese derivate als aktive bestandteile enthaltende fungizide.
CO4290356A1 (es) Derivados de 1-aminoetilindol
ES2040838T3 (es) Compuestos piperazinil-heterociclicos.
ES2137628T3 (es) Derivados de estilbeno y composiciones farmaceuticas que los contienen.
ES2054944T3 (es) Bis-(tri-t-alquilfenoxi) difosfaespiroundecanos.
MX9204730A (es) Novedosas ureas 4-oxociclicas utiles como agentes antiarritmicos y antifibralatorios.
ES2119046T3 (es) Compuestos dihalopropenos, insecticidas/acaricidas que los contienen como agentes activos y compuestos intermediarios para uso en su produccion.
ES2078497T3 (es) 6,7-disubstituidas-2-aminotetralinas activas como inmunomoduladores y composiciones farmaceuticas que las contienen.
ES2124327T3 (es) Derivados de sulfonamida aminometileno como inmunosupresores.
ES2100689T3 (es) Asociacion sinergizante que tiene un efecto antagonista de los receptores nk1 y nk2.
ES2124861T3 (es) Derivados de aminoacidos y su utilizacion como inhibidores de la encefalinasa.
ES2127263T3 (es) Nuevos trien-derivados cromenicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ITMI921559A1 (it) Esteri amminoalchilcarbammici dell'eserolina atti all'impiego come anticolinesterasici e relativo procedimento di preparazione
ES2133918T3 (es) Nuevos esteroides seco-d activos en el sistema cardiovascular y composiciones farmaceuticas que los contienen.
ES2054186T3 (es) Composicion antihepatopatica.
PT86771A (pt) Process for preparing 4-substituted benzamide derivatives with anticonvulsant activity
AR221573A1 (es) Composiciones herbicidas que como sustancia activa contienen derivados de piridazona-(6)"
ES2124267T3 (es) Derivados macrolidas de 16 eslabones con una actividad antibacteriana prolongada en el plasma, intermediarios de sintesis y procedimiento de preparacion.
ES2101738T3 (es) Tintes de benzoxacina.
DE60016908D1 (de) Verwendung von Sulfoquinovosyldiacylglycerol Derivativen als Immunosuppresssiva
MX169371B (es) Agentes para lavar, estables en almacenamiento y procedimieto para su preparacion
SE8500822D0 (sv) Diazepinoindoles, their production and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 466662

Country of ref document: ES