DE69111512T2 - Impulsfeldkapillarelektrophorese. - Google Patents

Impulsfeldkapillarelektrophorese.

Info

Publication number
DE69111512T2
DE69111512T2 DE69111512T DE69111512T DE69111512T2 DE 69111512 T2 DE69111512 T2 DE 69111512T2 DE 69111512 T DE69111512 T DE 69111512T DE 69111512 T DE69111512 T DE 69111512T DE 69111512 T2 DE69111512 T2 DE 69111512T2
Authority
DE
Germany
Prior art keywords
capillary electrophoresis
pulse field
field capillary
pulse
electrophoresis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69111512T
Other languages
English (en)
Other versions
DE69111512D1 (de
Inventor
Barry L Karger
Aharon S Cohen
David Noah Heiger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northeastern University Boston
Original Assignee
Northeastern University Boston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northeastern University Boston filed Critical Northeastern University Boston
Application granted granted Critical
Publication of DE69111512D1 publication Critical patent/DE69111512D1/de
Publication of DE69111512T2 publication Critical patent/DE69111512T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44773—Multi-stage electrophoresis, e.g. two-dimensional electrophoresis
DE69111512T 1990-05-18 1991-05-15 Impulsfeldkapillarelektrophorese. Expired - Fee Related DE69111512T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/525,532 US5122248A (en) 1990-05-18 1990-05-18 Pulsed field capillary electrophoresis

Publications (2)

Publication Number Publication Date
DE69111512D1 DE69111512D1 (de) 1995-08-31
DE69111512T2 true DE69111512T2 (de) 1996-01-18

Family

ID=24093649

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69111512T Expired - Fee Related DE69111512T2 (de) 1990-05-18 1991-05-15 Impulsfeldkapillarelektrophorese.

Country Status (4)

Country Link
US (1) US5122248A (de)
EP (1) EP0457748B1 (de)
JP (1) JPH05107226A (de)
DE (1) DE69111512T2 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992019960A1 (en) 1991-05-09 1992-11-12 Nanophore, Inc. Methods for the electrophoretic separation of nucleic acids and other linear macromolecules in gel media with restrictive pore diameters
US5178737A (en) * 1991-12-04 1993-01-12 The University Of North Carolina At Chapel Hill Electrophoretic resolution of single strand DNA by asymmetric field inversion
US5296116A (en) * 1992-06-17 1994-03-22 Beckman Instruments, Inc. Capillary electrophoresis using time-varying field strength
US5958202A (en) * 1992-09-14 1999-09-28 Perseptive Biosystems, Inc. Capillary electrophoresis enzyme immunoassay
AU4850793A (en) * 1992-09-14 1994-04-12 Purdue Research Foundation Electrophoretically mediated chemical analysis
US5292416A (en) * 1992-11-13 1994-03-08 Indiana University Foundation Pulsed-field separation of polysaccharides in capillaries
US5376249A (en) * 1992-11-25 1994-12-27 Perseptive Biosystems, Inc. Analysis utilizing isoelectric focusing
US5286356A (en) * 1993-01-21 1994-02-15 Millipore Corporation Method for sample analysis using capillary electrophoresis
US5342492A (en) * 1993-09-01 1994-08-30 The Board Of Trustees Of The Leland Stanford Junior University System for electrokinetic separation and detection where detection is performed at other than separation electric field
US5374834A (en) * 1993-10-12 1994-12-20 Massachusetts Institute Of Technology Ionic liquid-channel charge-coupled device
US5429734A (en) * 1993-10-12 1995-07-04 Massachusetts Institute Of Technology Monolithic capillary electrophoretic device
US6225059B1 (en) 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US6331274B1 (en) 1993-11-01 2001-12-18 Nanogen, Inc. Advanced active circuits and devices for molecular biological analysis and diagnostics
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5453170A (en) * 1994-09-26 1995-09-26 Ati Orion Off-column detector for ion separation techniques
US5630924A (en) * 1995-04-20 1997-05-20 Perseptive Biosystems, Inc. Compositions, methods and apparatus for ultrafast electroseparation analysis
US5814199A (en) * 1995-09-21 1998-09-29 Texas Tech University Forming thin film interfaced samples for analysis with capillary separation systems
SE506461C2 (sv) * 1996-01-19 1997-12-15 Johan Roeraade Förfarande för storleksfraktionering av molekyler med hög molekylvikt, med användande av elektroosmotiskt flöde i en kapillärtub
AU727083B2 (en) * 1997-04-25 2000-11-30 Caliper Life Sciences, Inc. Microfluidic devices incorporating improved channel geometries
DE10023422A1 (de) * 2000-05-12 2001-11-15 Smtech Biovision Holding Ag Ec Verfahren und Vorrichtung zur Auftrennung von markierten Biopolymeren
JPWO2002044708A1 (ja) * 2000-11-29 2004-04-02 科学技術振興事業団 核酸の分析方法
JP2004518663A (ja) * 2000-12-18 2004-06-24 トラスティーズ オブ プリンストン ユニバーシティ 非対称なパルスフィールド電気泳動を使用した巨大分子の分画
US7597791B2 (en) * 2001-10-19 2009-10-06 The Trustees Of Princeton University Method and apparatus for generating electric fields and flow distributions for rapidly separating molecules
WO2003072228A1 (en) 2002-02-25 2003-09-04 Qualicon, Inc. Process for preparing processed sample liquid solution for electrophoresis
US8241883B2 (en) * 2002-04-24 2012-08-14 Caliper Life Sciences, Inc. High throughput mobility shift
AU2010257118B2 (en) 2009-06-04 2014-08-28 Lockheed Martin Corporation Multiple-sample microfluidic chip for DNA analysis
WO2011108540A1 (ja) 2010-03-03 2011-09-09 国立大学法人大阪大学 ヌクレオチドを識別する方法および装置、ならびにポリヌクレオチドのヌクレオチド配列を決定する方法および装置
CA2814720C (en) 2010-10-15 2016-12-13 Lockheed Martin Corporation Micro fluidic optic design
US9140666B2 (en) 2012-03-15 2015-09-22 Advanced Analytical Technologies, Inc. Capillary electrophoresis system
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
US11016057B2 (en) * 2012-03-15 2021-05-25 Agilent Technologies, Inc. Pulse-field multiplex capillary electrophoresis system
US20160109406A1 (en) * 2012-03-15 2016-04-21 Advanced Analytical Technologies, LLC Pulse-field multiplex capillary electrophoresis system
US11340191B2 (en) 2012-03-15 2022-05-24 Agilent Technologies, Inc. UV-absorbance multichannel capillary electrophoresis system
US9535033B2 (en) 2012-08-17 2017-01-03 Quantum Biosystems Inc. Sample analysis method
JP6282036B2 (ja) 2012-12-27 2018-02-21 クオンタムバイオシステムズ株式会社 物質の移動速度の制御方法および制御装置
EP3578987A1 (de) 2013-09-18 2019-12-11 Quantum Biosystems Inc. Biomolekülsequenzierungsvorrichtungen, -systeme und -verfahren
JP2015077652A (ja) 2013-10-16 2015-04-23 クオンタムバイオシステムズ株式会社 ナノギャップ電極およびその製造方法
US10438811B1 (en) 2014-04-15 2019-10-08 Quantum Biosystems Inc. Methods for forming nano-gap electrodes for use in nanosensors
WO2017117616A1 (en) * 2015-12-30 2017-07-06 Advanced Analytical Technologies, Inc. Pulse-field multiplex capillary electrophoresis system
WO2019005907A1 (en) 2017-06-27 2019-01-03 Advanced Analytical Technologies, Inc. PULSED FIELD MULTIPLEX CAPILLARY ELECTROPHORESIS SYSTEM

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506554A (en) * 1968-03-15 1970-04-14 Samuel Raymond Apparatus for separating electrophoretically active substances
JPH0610664B2 (ja) * 1983-09-09 1994-02-09 株式会社日立製作所 電気泳動装置
US4985128A (en) * 1984-04-27 1991-01-15 E. I. Du Pont De Nemours And Company Process for preparation of electrophoresis
US4737251A (en) * 1985-09-27 1988-04-12 Washington University Field-inversion gel electrophoresis
JPS6291851A (ja) * 1985-10-18 1987-04-27 Yokogawa Electric Corp サンプル注入装置
US4865706A (en) * 1986-10-21 1989-09-12 Northeastern University High performance microcapillary gel electrophoresis
JPH01267450A (ja) * 1988-04-19 1989-10-25 Fuji Photo Film Co Ltd 電気泳動方法及び装置
EP0339779B1 (de) * 1988-04-29 1995-11-22 Beckman Instruments, Inc. Automatische Vorrichtung für kapillare Elektrophorese
US4909919A (en) * 1988-11-22 1990-03-20 The Regents Of The University Of Michigan Velocity modulated capillary electrophoresis analysis system
US4911807A (en) * 1989-09-05 1990-03-27 Bio-Rad Laboratories, Inc. Fractionation and sample loading by cassette in capillary electrophoresis
US5015350A (en) * 1989-11-06 1991-05-14 Applied Biosystems, Inc. Flow-rate-controlled surface-charge coating for capillary electrophoresis
JP2946596B2 (ja) * 1990-01-31 1999-09-06 株式会社島津製作所 電気泳動装置
JP2722752B2 (ja) * 1990-02-21 1998-03-09 株式会社島津製作所 Ｄｎａの検出方法

Also Published As

Publication number Publication date
US5122248A (en) 1992-06-16
EP0457748B1 (de) 1995-07-26
EP0457748A1 (de) 1991-11-21
JPH05107226A (ja) 1993-04-27
DE69111512D1 (de) 1995-08-31

Similar Documents

Publication Publication Date Title
DE69111512T2 (de) Impulsfeldkapillarelektrophorese.
NO892844D0 (no) Engangsforskalingselement.
DE68919375D1 (de) Elektroforesegerät.
DE69115213D1 (de) Elektrode.
FI910548A (fi) Pipett.
DE69108336D1 (de) Lötmittelaufbringung.
NO930684D0 (no) Fryse-tine-stabile polyakrylamidemulsjoner
DE69109700T2 (de) Kapillarelektrophoreseverfahren.
DE69105726T2 (de) Pipette.
DK0581523T3 (da) Injektionssprøjte.
DE59103989D1 (de) Fahrschemel.
DE69111304T2 (de) Elektroden.
DE69316332D1 (de) Kapillar-Elektrophorese
DE361750T1 (de) Kapillares elektrophoretisches system.
DE68907989T2 (de) Elektroforesevorrichtung.
DK0460746T3 (da) Elektroforeseapparater
FI915041A0 (fi) Fukt avkaennande element.
NO885637D0 (no) Forheng.
FI904803A0 (fi) Intermittent epicyklisk malapparat.
FI920786A0 (fi) Faestsystem foer element.
FI921660A0 (fi) Faestsystem foer element.
FI891579A0 (fi) Element foer faestande.
FI900998A0 (fi) Sjaelvbaerande medelst undertryck formbart element.
FI894510A (fi) Formelement.
FI911453A0 (fi) Formelement.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee