DE69104996T2 - Amidoderivate von glutamin-, asparagin- und 2-aminoadipinsäuren mit antigastrin-wirkung. - Google Patents

Amidoderivate von glutamin-, asparagin- und 2-aminoadipinsäuren mit antigastrin-wirkung.

Info

Publication number
DE69104996T2
DE69104996T2 DE69104996T DE69104996T DE69104996T2 DE 69104996 T2 DE69104996 T2 DE 69104996T2 DE 69104996 T DE69104996 T DE 69104996T DE 69104996 T DE69104996 T DE 69104996T DE 69104996 T2 DE69104996 T2 DE 69104996T2
Authority
DE
Germany
Prior art keywords
pct
group
date jun
antigastrine
asparagine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69104996T
Other languages
English (en)
Other versions
DE69104996D1 (de
Inventor
Francesco Makovec
Luigi Rovati
Lucio Claudio Rovati
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rottapharm SpA
Original Assignee
Rotta Research Laboratorium SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Laboratorium SpA filed Critical Rotta Research Laboratorium SpA
Publication of DE69104996D1 publication Critical patent/DE69104996D1/de
Application granted granted Critical
Publication of DE69104996T2 publication Critical patent/DE69104996T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/94—Spiro compounds containing "free" spiro atoms
DE69104996T 1990-12-11 1991-12-06 Amidoderivate von glutamin-, asparagin- und 2-aminoadipinsäuren mit antigastrin-wirkung. Expired - Fee Related DE69104996T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT67995A IT1241029B (it) 1990-12-11 1990-12-11 Derivati amidici biciclici e policiclici degli acidi glutammico, aspartico e 2-ammino adipico ad attivita' antigastrinica e procedimento per la loro preparazione
PCT/EP1991/002342 WO1992010479A1 (en) 1990-12-11 1991-12-06 Amidic derivatives of glutamic, aspartic and 2-amino adipic acids with antigastrin activity

Publications (2)

Publication Number Publication Date
DE69104996D1 DE69104996D1 (de) 1994-12-08
DE69104996T2 true DE69104996T2 (de) 1995-04-20

Family

ID=11307048

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69104996T Expired - Fee Related DE69104996T2 (de) 1990-12-11 1991-12-06 Amidoderivate von glutamin-, asparagin- und 2-aminoadipinsäuren mit antigastrin-wirkung.

Country Status (14)

Country Link
US (1) US5500430A (de)
EP (1) EP0561863B1 (de)
JP (1) JPH06503557A (de)
AT (1) ATE113583T1 (de)
AU (1) AU654312B2 (de)
CA (1) CA2097069A1 (de)
DE (1) DE69104996T2 (de)
DK (1) DK0561863T3 (de)
ES (1) ES2064159T3 (de)
IE (1) IE74250B1 (de)
IT (1) IT1241029B (de)
PT (1) PT99745A (de)
WO (1) WO1992010479A1 (de)
ZA (1) ZA919762B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE912285A1 (en) * 1990-07-12 1992-01-15 Black James Foundation Amino acid derivatives
IT1264765B1 (it) * 1993-03-10 1996-10-04 Rotta Research Lab Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la
IT1261255B (it) * 1993-09-09 1996-05-09 Rotta Research Lab Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico.
IT1276462B1 (it) * 1995-07-03 1997-10-31 Rotta Research Lab Diamidi aromatiche acide ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico
WO1997044341A1 (en) * 1996-05-17 1997-11-27 Rotta Research Laboratorium S.P.A. Cyclic polyamides of glutamic acid and aspartic acid with anti-gastrin activity, a method for their preparation and their pharmaceutical use
WO1997045415A1 (en) * 1996-05-28 1997-12-04 Rotta Research Laboratorium S.P.A. Polyamide derivatives or ornithine, lysine and analogous substances with cck-b and gastrin-antagonistic activity
IT1286141B1 (it) * 1996-07-02 1998-07-07 Rotta Research Lab Derivati diammidici dell'acido antranilico ad attivita' antigastrinica procedimento per la loro preparazione e loro uso farmaceutico.
US6365128B1 (en) * 1998-12-18 2002-04-02 Medical Defence Technologies, Llc Monitoring gastrointestinal function to guide care of high risk patients
EP2720605B1 (de) 2011-06-14 2020-03-11 Gravitas Medical Inc. Vorrichtung zur durchführung einer medizinischen versorgung auf basis einer erkannten magenfunktion

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ212436A (en) * 1984-06-25 1989-04-26 Rotta Research Lab D,l-glutamic and d,l-aspartic acid derivatives and pharmaceutical compositions
FR2643371B1 (fr) * 1989-02-17 1993-11-05 Roussel Uclaf Nouveaux derives de l'acide 2-amino pentanedioique, leur procede de preparation et leur application comme medicaments
IT1238664B (it) * 1989-11-02 1993-09-01 Rotta Research Lab Derivati degli acidi glutammico ed aspartico ad attivita' antigastrinica e procedimento per la loro preparazione

Also Published As

Publication number Publication date
DE69104996D1 (de) 1994-12-08
EP0561863B1 (de) 1994-11-02
PT99745A (pt) 1992-12-31
US5500430A (en) 1996-03-19
IT1241029B (it) 1993-12-27
IE914291A1 (en) 1992-06-17
IE74250B1 (en) 1997-07-16
AU654312B2 (en) 1994-11-03
ATE113583T1 (de) 1994-11-15
WO1992010479A1 (en) 1992-06-25
EP0561863A1 (de) 1993-09-29
DK0561863T3 (da) 1994-11-28
AU9045691A (en) 1992-07-08
CA2097069A1 (en) 1992-06-12
ES2064159T3 (es) 1995-01-16
IT9067995A1 (it) 1992-06-12
JPH06503557A (ja) 1994-04-21
ZA919762B (en) 1992-09-30
IT9067995A0 (it) 1990-12-11

Similar Documents

Publication Publication Date Title
TW369526B (en) Diazabicyclic neurokinin antagonists
DK0652871T3 (da) Absorberende artikel med fastgøringssystem, der tilvejebringer dynamisk tilpasning af elasticeret linning
FI941212A0 (fi) Fuusioituneet trisykliset, typpeä sisältävät heterosykliset yhdisteet
ATE94384T1 (de) Verwendung von adamantan-derivaten zur praevention und behandlung der cerebralen ischaemie.
DK0589924T3 (da) Fluoralkoxybenzylaminoderivater af nitrogenholdige heterocyclusser
DE69104996D1 (de) Amidoderivate von glutamin-, asparagin- und 2-aminoadipinsäuren mit antigastrin-wirkung.
MX174596B (es) Procedimiento para la preparacion de derivados enol-eter de oxicams
PL327002A1 (en) Novel derivatives of chromene, method of obtaining them and pharmaceutic composition containing such compounds
GR3026008T3 (en) Ampa antagonists and a method of treatment therewith
DE3372364D1 (en) 1-carboxyalkanoylperhydroindole-2-carboxylic acids and derivatives
ATE167179T1 (de) Verfahren zur herstellung von beta-phenylisoserin-derivaten
TW333532B (en) Benzopyrans
DE68906122D1 (de) Verbindungen zur behandlung von harninkontinenz.
DE69310066T2 (de) Herstellung von Aspartinsäure von Ammonium-Aspartat
DK0662952T3 (da) Fremgangsmåde til stereoselektiv syntese af 3-substituerede 2-sulfonylmethylpropionsyrer samt mellemprodukter
DE69013476T2 (de) Anwendung von Naphthoxazinen.
DK0578080T3 (da) 3,9-disubstituerede spiro 5.5 undecaner med aktivitet på det cardiovaskulære system, fremgangsmåde til fremstilling af disse og farmaceutisk præparat indeholdende disse
ES8701716A1 (es) Un procedimiento para la preparacion de derivados del acido ((1,3-dioxo-1,3-propanodiil)diimino-benzoico
KR970009589B1 (en) Novel pyridone carboxylic acid derivatives and their preparation process

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee