ZA919762B - Bicyclic and polycyclic amidic derivatives of glutamic,aspartic and 2-amino adipic acids with antigastrin activity and a method for their preparation - Google Patents

Bicyclic and polycyclic amidic derivatives of glutamic,aspartic and 2-amino adipic acids with antigastrin activity and a method for their preparation

Info

Publication number
ZA919762B
ZA919762B ZA919762A ZA919762A ZA919762B ZA 919762 B ZA919762 B ZA 919762B ZA 919762 A ZA919762 A ZA 919762A ZA 919762 A ZA919762 A ZA 919762A ZA 919762 B ZA919762 B ZA 919762B
Authority
ZA
South Africa
Prior art keywords
pct
aspartic
glutamic
adipic acids
polycyclic
Prior art date
Application number
ZA919762A
Other languages
English (en)
Inventor
Francesco Makovec
Makovec Francesco
Luigi Angelo Rovati
Angelo Rovati Luigi
Claudio Lucio Rovati
Lucio Rovati Claudio
Original Assignee
Rotta Research Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Lab filed Critical Rotta Research Lab
Publication of ZA919762B publication Critical patent/ZA919762B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/94—Spiro compounds containing "free" spiro atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA919762A 1990-12-11 1991-12-11 Bicyclic and polycyclic amidic derivatives of glutamic,aspartic and 2-amino adipic acids with antigastrin activity and a method for their preparation ZA919762B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT67995A IT1241029B (it) 1990-12-11 1990-12-11 Derivati amidici biciclici e policiclici degli acidi glutammico, aspartico e 2-ammino adipico ad attivita' antigastrinica e procedimento per la loro preparazione

Publications (1)

Publication Number Publication Date
ZA919762B true ZA919762B (en) 1992-09-30

Family

ID=11307048

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA919762A ZA919762B (en) 1990-12-11 1991-12-11 Bicyclic and polycyclic amidic derivatives of glutamic,aspartic and 2-amino adipic acids with antigastrin activity and a method for their preparation

Country Status (14)

Country Link
US (1) US5500430A (de)
EP (1) EP0561863B1 (de)
JP (1) JPH06503557A (de)
AT (1) ATE113583T1 (de)
AU (1) AU654312B2 (de)
CA (1) CA2097069A1 (de)
DE (1) DE69104996T2 (de)
DK (1) DK0561863T3 (de)
ES (1) ES2064159T3 (de)
IE (1) IE74250B1 (de)
IT (1) IT1241029B (de)
PT (1) PT99745A (de)
WO (1) WO1992010479A1 (de)
ZA (1) ZA919762B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE912285A1 (en) * 1990-07-12 1992-01-15 Black James Foundation Amino acid derivatives
IT1264765B1 (it) * 1993-03-10 1996-10-04 Rotta Research Lab Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la
IT1261255B (it) * 1993-09-09 1996-05-09 Rotta Research Lab Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico.
IT1276462B1 (it) * 1995-07-03 1997-10-31 Rotta Research Lab Diamidi aromatiche acide ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico
WO1997044341A1 (en) * 1996-05-17 1997-11-27 Rotta Research Laboratorium S.P.A. Cyclic polyamides of glutamic acid and aspartic acid with anti-gastrin activity, a method for their preparation and their pharmaceutical use
WO1997045415A1 (en) * 1996-05-28 1997-12-04 Rotta Research Laboratorium S.P.A. Polyamide derivatives or ornithine, lysine and analogous substances with cck-b and gastrin-antagonistic activity
IT1286141B1 (it) * 1996-07-02 1998-07-07 Rotta Research Lab Derivati diammidici dell'acido antranilico ad attivita' antigastrinica procedimento per la loro preparazione e loro uso farmaceutico.
US6365128B1 (en) * 1998-12-18 2002-04-02 Medical Defence Technologies, Llc Monitoring gastrointestinal function to guide care of high risk patients
EP2720605B1 (de) 2011-06-14 2020-03-11 Gravitas Medical Inc. Vorrichtung zur durchführung einer medizinischen versorgung auf basis einer erkannten magenfunktion

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ212436A (en) * 1984-06-25 1989-04-26 Rotta Research Lab D,l-glutamic and d,l-aspartic acid derivatives and pharmaceutical compositions
FR2643371B1 (fr) * 1989-02-17 1993-11-05 Roussel Uclaf Nouveaux derives de l'acide 2-amino pentanedioique, leur procede de preparation et leur application comme medicaments
IT1238664B (it) * 1989-11-02 1993-09-01 Rotta Research Lab Derivati degli acidi glutammico ed aspartico ad attivita' antigastrinica e procedimento per la loro preparazione

Also Published As

Publication number Publication date
ATE113583T1 (de) 1994-11-15
US5500430A (en) 1996-03-19
EP0561863A1 (de) 1993-09-29
DK0561863T3 (da) 1994-11-28
DE69104996T2 (de) 1995-04-20
AU9045691A (en) 1992-07-08
DE69104996D1 (de) 1994-12-08
PT99745A (pt) 1992-12-31
CA2097069A1 (en) 1992-06-12
JPH06503557A (ja) 1994-04-21
AU654312B2 (en) 1994-11-03
IT1241029B (it) 1993-12-27
WO1992010479A1 (en) 1992-06-25
IT9067995A0 (it) 1990-12-11
IT9067995A1 (it) 1992-06-12
EP0561863B1 (de) 1994-11-02
ES2064159T3 (es) 1995-01-16
IE74250B1 (en) 1997-07-16
IE914291A1 (en) 1992-06-17

Similar Documents

Publication Publication Date Title
EG20280A (en) Process for preparing of fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles
DE10299048I1 (de) Verwendung von Adamantan-Derivaten zur Praevention und Behandlung der cerebralen Ischaemie
TW369526B (en) Diazabicyclic neurokinin antagonists
ES8603501A1 (es) Un procedimiento para preparar un derivado de 1,8-naftiridina
GR3021110T3 (en) Novel phosphono-succinic acid derivatives, process for producing them and medicaments containing these compounds.
ZA919762B (en) Bicyclic and polycyclic amidic derivatives of glutamic,aspartic and 2-amino adipic acids with antigastrin activity and a method for their preparation
TW368501B (en) 7-(2-aminoethyl)-benzothiazolones
HU9200477D0 (en) New intermediates, their production and use
DE69411000D1 (de) Verfahren zur herstellung von beta-phenylisoserin-derivaten
ES8802524A1 (es) Un procedimiento para la preparacion de derivados de beta-lactama.
ATE75470T1 (de) Tricyclische 5,6,7,8-tetrahydro-naphtho (2,3b>2,3-dihydrofuran- und 6,7,8,9-tetrahydro-5hbenzocyclohepta (2,3b>-2,3dihydrofuranaminderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ATE126230T1 (de) Cephalosporinderivate und verfahren zur herstellung von cephem-verbindungen.
HU9202886D0 (en) Method for producing new imidazolyl-methyl-pyridine derivatives
DE68906122D1 (de) Verbindungen zur behandlung von harninkontinenz.
HU9500180D0 (en) Novel acyclic amidine-grour-containing diphosphonic acid derivatives, process for producing them and medicaments containing these compounds
NZ331180A (en) Specific immunophilin ligands with indole structure as antiasthmatics and immunosuppressants
DK0662952T3 (da) Fremgangsmåde til stereoselektiv syntese af 3-substituerede 2-sulfonylmethylpropionsyrer samt mellemprodukter
ATE154024T1 (de) Neue bis(aminomethyl)phosphinsäure-derivate und verfahren zur herstellung von bis(aminomethyl)phosphinsäure-derivaten
HU913281D0 (en) Process for the production of new benzoheterocyclyl-alkyl-amino-alcane-diphosphonic acids
ES8706615A1 (es) Un procedimiento para la preparacion de nuevos derivados de diamina.
DK0578080T3 (da) 3,9-disubstituerede spiro 5.5 undecaner med aktivitet på det cardiovaskulære system, fremgangsmåde til fremstilling af disse og farmaceutisk præparat indeholdende disse
KR970009589B1 (en) Novel pyridone carboxylic acid derivatives and their preparation process