DE69031984D1 - Ein nichtinvasives verfahren zur trennung und zum nachweis von fetaler dna - Google Patents
Ein nichtinvasives verfahren zur trennung und zum nachweis von fetaler dnaInfo
- Publication number
- DE69031984D1 DE69031984D1 DE69031984T DE69031984T DE69031984D1 DE 69031984 D1 DE69031984 D1 DE 69031984D1 DE 69031984 T DE69031984 T DE 69031984T DE 69031984 T DE69031984 T DE 69031984T DE 69031984 D1 DE69031984 D1 DE 69031984D1
- Authority
- DE
- Germany
- Prior art keywords
- fetal
- fetal dna
- separating
- dna
- invasive method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6879—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for sex determination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5002—Partitioning blood components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56977—HLA or MHC typing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43605789A | 1989-11-13 | 1989-11-13 | |
PCT/US1990/006623 WO1991007660A1 (en) | 1989-11-13 | 1990-11-13 | Non-invasive method for isolation and detection of fetal dna |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69031984D1 true DE69031984D1 (de) | 1998-02-26 |
DE69031984T2 DE69031984T2 (de) | 1998-09-10 |
Family
ID=23730928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69031984T Expired - Lifetime DE69031984T2 (de) | 1989-11-13 | 1990-11-13 | Ein nichtinvasives verfahren zur trennung und zum nachweis von fetaler dna |
Country Status (6)
Country | Link |
---|---|
EP (2) | EP0500727B1 (de) |
JP (1) | JPH05501612A (de) |
AT (1) | ATE162631T1 (de) |
AU (3) | AU658132B2 (de) |
DE (1) | DE69031984T2 (de) |
WO (1) | WO1991007660A1 (de) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05507404A (ja) * | 1990-04-23 | 1993-10-28 | セルプロ インコーポレイティド | 母体血液からの胎児細胞の富化のための方法 |
EP0610359A1 (de) * | 1991-10-23 | 1994-08-17 | Cellpro Incorporated | Verfahren zur einrichtung fetaler stammzellen von mütterlichem blut |
FR2685777A1 (fr) * | 1991-12-31 | 1993-07-02 | Bertin & Cie | Procede de depistage prenatal d'anomalies fóoetales et procede de depistage prenatal du sexe. |
US5629147A (en) * | 1992-07-17 | 1997-05-13 | Aprogenex, Inc. | Enriching and identifying fetal cells in maternal blood for in situ hybridization |
US5457024A (en) * | 1993-01-22 | 1995-10-10 | Aprogenex, Inc. | Isolation of fetal erythrocytes |
AU6773994A (en) * | 1993-04-23 | 1994-11-21 | Cellpro, Incorporated | Methods for enriching fetal progenitor cells from maternal blood |
IL110364A0 (en) * | 1993-07-19 | 1994-10-21 | Aprogenex Inc | Enriching and identifying fetal nucleated erythrocytes in maternal blood for in situ hybridization |
US5714325A (en) * | 1993-09-24 | 1998-02-03 | New England Medical Center Hospitals | Prenatal diagnosis by isolation of fetal granulocytes from maternal blood |
FR2711671A1 (fr) * | 1993-10-22 | 1995-05-05 | Centre Nat Rech Scient | Procédé de détection et de quantification d'une séquence nucléotidique dans une population cellulaire. |
US5432054A (en) * | 1994-01-31 | 1995-07-11 | Applied Imaging | Method for separating rare cells from a population of cells |
US5489386A (en) * | 1994-01-31 | 1996-02-06 | Applied Imaging | Density gradient medium for the separation of cells |
US5663051A (en) * | 1994-08-31 | 1997-09-02 | Activated Cell Therapy, Inc. | Separation apparatus and method |
US5648223A (en) * | 1994-08-31 | 1997-07-15 | Activated Cell Therapy, Inc. | Methods for enriching breast tumor cells |
US5840502A (en) * | 1994-08-31 | 1998-11-24 | Activated Cell Therapy, Inc. | Methods for enriching specific cell-types by density gradient centrifugation |
US5646004A (en) * | 1994-08-31 | 1997-07-08 | Activated Cell Therapy, Inc. | Methods for enriching fetal cells from maternal body fluids |
GB9422504D0 (en) * | 1994-11-08 | 1995-01-04 | Robertson Patricia M B | Blood testing |
US5750339A (en) * | 1994-11-30 | 1998-05-12 | Thomas Jefferson University | Methods for identifying fetal cells |
GB9425138D0 (en) | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
GB9603249D0 (en) * | 1996-02-16 | 1996-04-17 | Univ Nottingham | Foetal cell analysis |
EP0891550A1 (de) * | 1996-04-05 | 1999-01-20 | The Johns Hopkins University School Of Medicine | Verfahren zur anreicherung von seltenen zellen |
IT1294964B1 (it) * | 1996-07-12 | 1999-04-23 | Domenico Valerio | Isolamento e cultura di cellule fetali dal sangue periferico materno |
US5731156A (en) * | 1996-10-21 | 1998-03-24 | Applied Imaging, Inc. | Use of anti-embryonic hemoglobin antibodies to identify fetal cells |
US6087134A (en) * | 1997-01-14 | 2000-07-11 | Applied Imaging Corporation | Method for analyzing DNA from a rare cell in a cell population |
CA2283416A1 (en) * | 1997-03-08 | 1998-09-17 | The University Of Dundee | Prenatal diagnostic methods |
US5962234A (en) * | 1997-10-20 | 1999-10-05 | Applied Imaging Corporation | Use of anti-embryonic epsilon hemoglobin antibodies to identify fetal cells |
US6677123B1 (en) * | 1998-02-03 | 2004-01-13 | Wako Pure Chemical Industries, Ltd. | Process for detecting increased risk of fetal chromosomal abnormality |
WO2000071987A2 (en) * | 1999-05-25 | 2000-11-30 | John Philip | Isolation and culturing of fetal cells |
US6692965B1 (en) * | 1999-11-23 | 2004-02-17 | Chromocell Corporation | Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences |
JP4229237B2 (ja) * | 2001-12-11 | 2009-02-25 | 株式会社ネーテック | 血液細胞分離システム |
EP1978108A3 (de) | 2002-01-08 | 2009-01-07 | Siemens Healthcare Diagnostics GmbH | Einzelnukleotidpolymorphismen zur Vorhersage kardiovaskulärer Erkrankungen und Medikationswirkung |
CA2494262A1 (en) | 2002-07-31 | 2004-02-05 | University Of Southern California | Polymorphisms for predicting disease and treatment outcome |
EP2359689B1 (de) | 2002-09-27 | 2015-08-26 | The General Hospital Corporation | Mikrofluid-Vorrichtung zur Zelltrennung, sowie Verwendung derselben |
EP2806035B1 (de) | 2004-02-18 | 2017-09-13 | Chromocell Corporation | Verfahren und Materialien, die Signalsonden verwenden |
ITBO20040420A1 (it) | 2004-07-07 | 2004-10-07 | Type S R L | Macchina per taglio e formatura di piattine metalliche |
US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
ITBO20050481A1 (it) | 2005-07-19 | 2007-01-20 | Silicon Biosystems S R L | Metodo ed apparato per la manipolazione e/o l'individuazione di particelle |
US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
ITBO20050646A1 (it) | 2005-10-26 | 2007-04-27 | Silicon Biosystem S R L | Metodo ed apparato per la caratterizzazione ed il conteggio di particelle |
ITTO20060226A1 (it) | 2006-03-27 | 2007-09-28 | Silicon Biosystem S P A | Metodo ed apparato per il processamento e o l'analisi e o la selezione di particelle, in particolare particelle biologiche |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
US20080070792A1 (en) | 2006-06-14 | 2008-03-20 | Roland Stoughton | Use of highly parallel snp genotyping for fetal diagnosis |
US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
US8372584B2 (en) | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
ITTO20070771A1 (it) | 2007-10-29 | 2009-04-30 | Silicon Biosystems Spa | Metodo e apparato per la identificazione e manipolazione di particelle |
ES2620012T3 (es) | 2008-09-20 | 2017-06-27 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnóstico no invasivo de la aneuploidia fetal por secuenciación |
IT1391619B1 (it) | 2008-11-04 | 2012-01-11 | Silicon Biosystems Spa | Metodo per l'individuazione, selezione e analisi di cellule tumorali |
US10895575B2 (en) | 2008-11-04 | 2021-01-19 | Menarini Silicon Biosystems S.P.A. | Method for identification, selection and analysis of tumour cells |
JP5834001B2 (ja) | 2009-03-17 | 2015-12-16 | シリコン・バイオシステムズ・ソシエタ・ペル・アチオニ | 細胞を分離するためのマイクロ流体デバイス |
IT1403518B1 (it) | 2010-12-22 | 2013-10-31 | Silicon Biosystems Spa | Dispositivo microfluidico per la manipolazione di particelle |
ITTO20110990A1 (it) | 2011-10-28 | 2013-04-29 | Silicon Biosystems Spa | Metodo ed apparato per l'analisi ottica di particelle a basse temperature |
ITBO20110766A1 (it) | 2011-12-28 | 2013-06-29 | Silicon Biosystems Spa | Dispositivi, apparato, kit e metodo per il trattamento di un campione biologico |
WO2013192620A1 (en) | 2012-06-22 | 2013-12-27 | Quantrx Biomedical Corporation | Method for obtaining fetal cells and fetal cellular components |
US9823238B2 (en) | 2013-03-15 | 2017-11-21 | Menarini Silicon Biosystems, Inc. | Molecular characterization of circulating tumor cells |
EP3298166B1 (de) | 2015-05-22 | 2020-02-12 | Nipd Genetics Public Company Limited | Multiplexierte parallelanalyse von gezielten genomregionen für nicht-invasive pränatale tests |
WO2017180909A1 (en) | 2016-04-13 | 2017-10-19 | Nextgen Jane, Inc. | Sample collection and preservation devices, systems and methods |
EP3999856A1 (de) * | 2019-07-15 | 2022-05-25 | Menarini Biomarkers Singapore Pte Ltd | Zusammensetzungen und verfahren zur isolierung, detektion und analyse von fetalen zellen |
WO2023158732A1 (en) | 2022-02-16 | 2023-08-24 | Dana-Farber Cancer Institute, Inc. | Methods for decreasing pathologic alpha-synuclein using agents that modulate fndc5 or biologically active fragments thereof |
WO2023201226A1 (en) | 2022-04-11 | 2023-10-19 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for universal tumor cell killing |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE161960T1 (de) * | 1988-12-06 | 1998-01-15 | Flinders Technologies Pty Ltd | Isolierung von fetalen zellen aus mütterlichem blut zur ausführung von pränataler diagnostik |
AU621694B2 (en) * | 1988-12-06 | 1992-03-19 | Flinders Technologies Pty Ltd | Isolation of fetal cells from maternal blood to enable prenatal diagnosis |
US5153117A (en) * | 1990-03-27 | 1992-10-06 | Genetype A.G. | Fetal cell recovery method |
-
1990
- 1990-11-13 EP EP90917320A patent/EP0500727B1/de not_active Expired - Lifetime
- 1990-11-13 AT AT90917320T patent/ATE162631T1/de not_active IP Right Cessation
- 1990-11-13 AU AU67505/90A patent/AU658132B2/en not_active Ceased
- 1990-11-13 WO PCT/US1990/006623 patent/WO1991007660A1/en active IP Right Grant
- 1990-11-13 JP JP3500565A patent/JPH05501612A/ja active Pending
- 1990-11-13 EP EP97200874A patent/EP0791659A3/de not_active Ceased
- 1990-11-13 DE DE69031984T patent/DE69031984T2/de not_active Expired - Lifetime
-
1995
- 1995-07-06 AU AU24870/95A patent/AU2487095A/en not_active Abandoned
-
1998
- 1998-05-21 AU AU68026/98A patent/AU6802698A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0500727A1 (de) | 1992-09-02 |
JPH05501612A (ja) | 1993-03-25 |
EP0500727B1 (de) | 1998-01-21 |
EP0791659A2 (de) | 1997-08-27 |
ATE162631T1 (de) | 1998-02-15 |
WO1991007660A1 (en) | 1991-05-30 |
EP0791659A3 (de) | 1997-09-17 |
AU2487095A (en) | 1995-12-07 |
AU6750590A (en) | 1991-06-13 |
AU6802698A (en) | 1998-07-16 |
AU658132B2 (en) | 1995-04-06 |
DE69031984T2 (de) | 1998-09-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69031984D1 (de) | Ein nichtinvasives verfahren zur trennung und zum nachweis von fetaler dna | |
HK1031255A1 (en) | Use of anti-embryonic hemoglobin antibodies to identify fetal cells | |
IL72499A (en) | Kit and method for the detection of bacteria in a biological test sample by nucleic acid hybridization | |
DE69033796D1 (de) | Verfahren und gerät zum nachweis und zur quantifizierung von glukose in körperflüssigkeiten | |
DE3485653D1 (de) | Verfahren und vorrichtung zur messung des reaktionsgrades zwischen antigenen und zell-leukozytenantikoerpern. | |
ATE194166T1 (de) | Verfahren zur gewinnung fötaler zellen | |
CA2140278A1 (en) | Enriching and identyfing fetal cells in maternal blood for in situ hybridization | |
DE3671534D1 (de) | Verfahren zum nachweis von agglutinierten erythrozyten. | |
EP0353985A3 (de) | Nukleinsäureprobe zur Detektion von Neisseria gonorrhoea | |
DE69739072D1 (de) | Pränatales down-syndrom-testverfahren unter benutzung von hyperglykosyliertem gonadotropin | |
GB2326943B (en) | Detection of fetal red cells in maternal blood | |
MXPA96004278A (es) | Expansion diferencial de celulas de baston fetalesen la circulacion materna para usarse en analisisgenetico prenatal. | |
ES8501886A1 (es) | Metodo de analisis para diagonosticar la parasitosis y alergias. | |
ATE142332T1 (de) | Verfahren zum sichten von zellen oder geformten körpern mit ausgewählten eigenschaften unter benutzung eines nachweisparameters | |
Parks et al. | Fetal cells from maternal blood: their selection and prospects for use in prenatal diagnosis | |
CA2068660A1 (en) | Non-invasive method for isolation and detection of fetal dna | |
ATE108279T1 (de) | Verfahren zum schnellen mischen kleiner volumina zur verbesserung biologischer reaktionen. | |
NZ337700A (en) | Prenatal diagnostic methods by separating maternal from fetal blood using conventional chromatographis techniques followed by typing fetal blood for genatic defects | |
JPS5779450A (en) | Method and device for analysis based on amynological agglutination reaction | |
WO2000071987A3 (en) | Isolation and culturing of fetal cells | |
Hercher et al. | Rapid identification of micro-organisms | |
PARKS et al. | Fetal Cells from Maternal Blood: Their | |
HK182496A (en) | Method and apparatus for measuring the degree of reaction between a foreign entity and a subject's blood cells |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |