DE69028920T2 - Verfahren zur Herstellung von (1R,5S,6S)-2-[(6,7-Dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-Carbonsäureester und deren Ausgangsverbindungen - Google Patents

Verfahren zur Herstellung von (1R,5S,6S)-2-[(6,7-Dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-Carbonsäureester und deren Ausgangsverbindungen

Info

Publication number
DE69028920T2
DE69028920T2 DE69028920T DE69028920T DE69028920T2 DE 69028920 T2 DE69028920 T2 DE 69028920T2 DE 69028920 T DE69028920 T DE 69028920T DE 69028920 T DE69028920 T DE 69028920T DE 69028920 T2 DE69028920 T2 DE 69028920T2
Authority
DE
Germany
Prior art keywords
pyrazolo
dihydro
triazolium
thio
hydroxyethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69028920T
Other languages
German (de)
English (en)
Other versions
DE69028920D1 (de
Inventor
Satoshi Tamai
Takao Abe
Yunosuke Nagase
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Japan Inc
Original Assignee
Lederle Japan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lederle Japan Ltd filed Critical Lederle Japan Ltd
Publication of DE69028920D1 publication Critical patent/DE69028920D1/de
Application granted granted Critical
Publication of DE69028920T2 publication Critical patent/DE69028920T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69028920T 1990-10-12 1990-12-28 Verfahren zur Herstellung von (1R,5S,6S)-2-[(6,7-Dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-Carbonsäureester und deren Ausgangsverbindungen Expired - Lifetime DE69028920T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP27242690 1990-10-12
JP27242790 1990-10-12
JP27242890 1990-10-12

Publications (2)

Publication Number Publication Date
DE69028920D1 DE69028920D1 (de) 1996-11-21
DE69028920T2 true DE69028920T2 (de) 1997-02-13

Family

ID=27335996

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69028920T Expired - Lifetime DE69028920T2 (de) 1990-10-12 1990-12-28 Verfahren zur Herstellung von (1R,5S,6S)-2-[(6,7-Dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-Carbonsäureester und deren Ausgangsverbindungen

Country Status (13)

Country Link
EP (1) EP0480100B1 (no)
KR (1) KR970011387B1 (no)
AT (1) ATE144260T1 (no)
AU (1) AU627970B2 (no)
CA (1) CA2033479C (no)
DE (1) DE69028920T2 (no)
DK (1) DK0480100T3 (no)
ES (1) ES2093010T3 (no)
FI (1) FI906464A (no)
GR (1) GR3021807T3 (no)
IL (1) IL96843A (no)
NO (1) NO176102C (no)
TW (1) TW239142B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0776574A (ja) * 1993-09-06 1995-03-20 Wako Pure Chem Ind Ltd ジスルフィド化合物の製造法
CN101768174B (zh) * 2009-01-07 2012-08-08 四川科伦药业股份有限公司 一种比阿培南的制备方法
CN103497207B (zh) * 2011-01-29 2015-09-30 正大天晴药业集团股份有限公司 比阿培南b型结晶
CN102731534B (zh) * 2011-04-13 2016-02-03 石药集团中奇制药技术（石家庄）有限公司 一种比阿培南的制备方法
CN102268025A (zh) * 2011-07-15 2011-12-07 海南美兰史克制药有限公司 一种比阿培南化合物及其制法
CN103965220A (zh) * 2013-02-01 2014-08-06 上海医药工业研究院 一种制备高纯度比阿培南的方法
CN103570750A (zh) * 2013-11-15 2014-02-12 安徽悦康凯悦制药有限公司 一种比阿培南的制备工艺
CN105481883A (zh) * 2015-10-26 2016-04-13 山东鲁抗生物制造有限公司 一种高纯度比阿培南的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE851586L (en) * 1984-07-02 1986-01-02 Interchem Internat S A I methylcarbapenems having a 2-quaternary¹heteroarylalkylthio substituent
JPS6425779A (en) * 1987-04-11 1989-01-27 Lederle Japan Ltd (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative
US5102877A (en) * 1989-04-28 1992-04-07 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
JPH02292269A (ja) * 1989-05-06 1990-12-03 Lederle Japan Ltd 活性アミド化合物

Also Published As

Publication number Publication date
NO905625D0 (no) 1990-12-28
AU627970B2 (en) 1992-09-03
NO176102B (no) 1994-10-24
EP0480100A2 (en) 1992-04-15
FI906464A0 (fi) 1990-12-31
DE69028920D1 (de) 1996-11-21
CA2033479C (en) 2001-01-23
DK0480100T3 (da) 1996-11-18
GR3021807T3 (en) 1997-02-28
EP0480100B1 (en) 1996-10-16
IL96843A0 (en) 1991-09-16
KR920008039A (ko) 1992-05-27
EP0480100A3 (en) 1992-10-21
NO176102C (no) 1995-02-01
IL96843A (en) 1995-07-31
TW239142B (no) 1995-01-21
AU6862891A (en) 1992-06-11
KR970011387B1 (ko) 1997-07-10
NO905625L (no) 1992-04-13
CA2033479A1 (en) 1992-04-13
ATE144260T1 (de) 1996-11-15
FI906464A (fi) 1992-04-13
ES2093010T3 (es) 1996-12-16

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Owner name: WYETH K.K., TOKIO/TOKYO, JP