DE69020277D1 - (+)-Isomere von Endoetheno/Endoethano-epoxymorphinan-Derivaten als Mittel gegen Husten. - Google Patents

(+)-Isomere von Endoetheno/Endoethano-epoxymorphinan-Derivaten als Mittel gegen Husten.

Info

Publication number
DE69020277D1
DE69020277D1 DE69020277T DE69020277T DE69020277D1 DE 69020277 D1 DE69020277 D1 DE 69020277D1 DE 69020277 T DE69020277 T DE 69020277T DE 69020277 T DE69020277 T DE 69020277T DE 69020277 D1 DE69020277 D1 DE 69020277D1
Authority
DE
Germany
Prior art keywords
alkyl
hydrido
phenyl
endoetheno
endoethano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69020277T
Other languages
English (en)
Other versions
DE69020277T2 (de
Inventor
Kenner C Rice
John M Farah
Neile A Grayson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institutes of Health NIH
GD Searle LLC
Original Assignee
National Institutes of Health NIH
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Institutes of Health NIH, GD Searle LLC filed Critical National Institutes of Health NIH
Publication of DE69020277D1 publication Critical patent/DE69020277D1/de
Application granted granted Critical
Publication of DE69020277T2 publication Critical patent/DE69020277T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Resins (AREA)
  • Epoxy Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69020277T 1989-08-24 1990-08-24 (+)-Isomere von Endoetheno/Endoethano-epoxymorphinan-Derivaten als Mittel gegen Husten. Expired - Fee Related DE69020277T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39821389A 1989-08-24 1989-08-24
US56873290A 1990-08-20 1990-08-20

Publications (2)

Publication Number Publication Date
DE69020277D1 true DE69020277D1 (de) 1995-07-27
DE69020277T2 DE69020277T2 (de) 1995-12-21

Family

ID=27016167

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69020277T Expired - Fee Related DE69020277T2 (de) 1989-08-24 1990-08-24 (+)-Isomere von Endoetheno/Endoethano-epoxymorphinan-Derivaten als Mittel gegen Husten.

Country Status (11)

Country Link
EP (1) EP0418591B1 (de)
JP (1) JP3313361B2 (de)
KR (1) KR0172596B1 (de)
AT (1) ATE124046T1 (de)
CA (1) CA2023858C (de)
DE (1) DE69020277T2 (de)
DK (1) DK0418591T3 (de)
ES (1) ES2072946T3 (de)
GR (1) GR3017445T3 (de)
IE (1) IE67526B1 (de)
PT (1) PT95069B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE166229T1 (de) * 1992-12-22 1998-06-15 Toray Industries Antitussivum
KR100204659B1 (ko) * 1996-05-28 1999-06-15 강재헌 신규한 부프레노핀계 진통제용 화합물
DE69838662T2 (de) 1997-03-27 2008-08-28 Toray Industries, Inc. Morphinanderivate und ihre medizinische Anwendung
JP2009522357A (ja) * 2006-01-05 2009-06-11 マリンクロッド・インコーポレイテッド ブプレノルフィンのための出発物質としてのオリパビンの使用
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
WO2008048711A1 (en) 2006-10-17 2008-04-24 Penick Corporation Process for preparing oxymorphone
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
EP2703404A1 (de) 2008-07-30 2014-03-05 Purdue Pharma L.P. Buprenorphinanaloga
ES2560537T5 (es) 2008-09-30 2022-01-21 SpecGx LLC Procesos para aumentar el rendimiento de la hidrólisis del grupo 3-O-metilo y 17-N-nitrilo en la preparación de derivados alcaloides opiáceos
TWI630208B (zh) 2008-12-08 2018-07-21 歐陸斯迪公司 二氫羥戊甲嗎啡
EP2398805A1 (de) 2009-02-23 2011-12-28 Mallinckrodt LLC Quaternäre (+)-morphinaniumsalze und verfahren zu ihrer herstellung
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
WO2010096791A1 (en) * 2009-02-23 2010-08-26 Mallinckrodt Inc. (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8563727B2 (en) 2009-02-23 2013-10-22 Mallinckrodt Llc (+)-morphinanium N-oxides and processes for their production
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
WO2011009015A1 (en) * 2009-07-16 2011-01-20 Mallinckrodt Inc. (+) - morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CA2768199C (en) 2010-07-16 2018-08-28 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
ES2566620T3 (es) 2011-09-08 2016-04-14 Mallinckrodt Llc Procesamiento de alcaloides sin el aislamiento de intermedios
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
GB201309654D0 (en) 2013-05-30 2013-07-17 Euro Celtique Sa Method
IL274610B2 (en) 2017-12-12 2023-12-01 Xalud Therapeutics Inc Halogen derivatives of morphinans and their uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) * 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
GB1178537A (en) * 1966-10-20 1970-01-21 Reckitt & Sons Ltd Antitussive and Analgesic Compositions
GB1300419A (en) * 1969-05-16 1972-12-20 Organon Labor Ltd New morphinone derivatives and their preparation
US4521601A (en) * 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
US4806543A (en) * 1986-11-25 1989-02-21 Board Of Trustees Of The Leland Stanford Junior University Method and compositions for reducing neurotoxic injury

Also Published As

Publication number Publication date
EP0418591A3 (en) 1991-08-07
IE903099A1 (en) 1991-02-27
IE67526B1 (en) 1996-04-03
EP0418591A2 (de) 1991-03-27
GR3017445T3 (en) 1995-12-31
EP0418591B1 (de) 1995-06-21
PT95069A (pt) 1991-04-18
CA2023858A1 (en) 1991-02-25
ATE124046T1 (de) 1995-07-15
DE69020277T2 (de) 1995-12-21
JPH03163083A (ja) 1991-07-15
JP3313361B2 (ja) 2002-08-12
PT95069B (pt) 1997-10-31
KR910004625A (ko) 1991-03-29
KR0172596B1 (ko) 1999-02-01
DK0418591T3 (da) 1995-08-14
ES2072946T3 (es) 1995-08-01
CA2023858C (en) 2002-01-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee