PT95069A - Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicos - Google Patents
Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicosInfo
- Publication number
- PT95069A PT95069A PT95069A PT9506990A PT95069A PT 95069 A PT95069 A PT 95069A PT 95069 A PT95069 A PT 95069A PT 9506990 A PT9506990 A PT 9506990A PT 95069 A PT95069 A PT 95069A
- Authority
- PT
- Portugal
- Prior art keywords
- alkyl
- hydrido
- phenyl
- derivatives
- agents
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000001145 hydrido group Chemical group *[H] 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 229940124584 antitussives Drugs 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005157 alkyl carboxy group Chemical group 0.000 abstract 1
- 230000000954 anitussive effect Effects 0.000 abstract 1
- 239000003434 antitussive agent Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 abstract 1
- PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 230000003533 narcotic effect Effects 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
- Epoxy Resins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39821389A | 1989-08-24 | 1989-08-24 | |
| US56873290A | 1990-08-20 | 1990-08-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT95069A true PT95069A (pt) | 1991-04-18 |
| PT95069B PT95069B (pt) | 1997-10-31 |
Family
ID=27016167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT95069A PT95069B (pt) | 1989-08-24 | 1990-08-22 | Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicos |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0418591B1 (pt) |
| JP (1) | JP3313361B2 (pt) |
| KR (1) | KR0172596B1 (pt) |
| AT (1) | ATE124046T1 (pt) |
| CA (1) | CA2023858C (pt) |
| DE (1) | DE69020277T2 (pt) |
| DK (1) | DK0418591T3 (pt) |
| ES (1) | ES2072946T3 (pt) |
| GR (1) | GR3017445T3 (pt) |
| IE (1) | IE67526B1 (pt) |
| PT (1) | PT95069B (pt) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994014445A1 (fr) * | 1992-12-22 | 1994-07-07 | Toray Industries, Inc. | Antitussif |
| KR100204659B1 (ko) * | 1996-05-28 | 1999-06-15 | 강재헌 | 신규한 부프레노핀계 진통제용 화합물 |
| ES2297882T3 (es) * | 1997-03-27 | 2008-05-01 | Toray Industries, Inc. | Derivados de morfinano y usos medicos de los mismos. |
| CA2636271A1 (en) * | 2006-01-05 | 2007-07-19 | Mallinckrodt Inc. | The use of oripavine as a starting material for buprenorphine |
| ES2392594T3 (es) | 2006-10-17 | 2012-12-12 | Penick Corporation | Procedimiento para preparar oximorfona |
| US20080125592A1 (en) | 2006-10-17 | 2008-05-29 | Penick Corporation | Process for preparing oxymorphone, naltrexone, and buprenorphine |
| CA2674915C (en) | 2006-10-17 | 2015-06-30 | Penick Corporation | Process for preparing oxymorphone |
| KR101343395B1 (ko) | 2008-07-30 | 2013-12-19 | 퍼듀 퍼머 엘피 | 부프레노르핀 유사체 |
| ES2560537T5 (es) | 2008-09-30 | 2022-01-21 | SpecGx LLC | Procesos para aumentar el rendimiento de la hidrólisis del grupo 3-O-metilo y 17-N-nitrilo en la preparación de derivados alcaloides opiáceos |
| TWI541246B (zh) | 2008-12-08 | 2016-07-11 | 歐陸斯迪公司 | 二氫羥戊甲嗎啡 |
| US8563727B2 (en) | 2009-02-23 | 2013-10-22 | Mallinckrodt Llc | (+)-morphinanium N-oxides and processes for their production |
| US8563724B2 (en) | 2009-02-23 | 2013-10-22 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| CN102325776A (zh) * | 2009-02-23 | 2012-01-18 | 马林克罗特公司 | (+)-吗啡喃*季盐及其制备方法 |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| TR201809739T4 (tr) * | 2009-07-16 | 2018-07-23 | Mallinckrodt Llc | Toll benzeri reseptör 9 antagonistleri olarak (+)-morfinanlar ve bunların terapötik amaçlı kullanımları. |
| EP2593095B1 (en) | 2010-07-16 | 2019-03-27 | Mallinckrodt LLC | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| PL2753622T3 (pl) | 2011-09-08 | 2016-07-29 | SpecGx LLC | Wytwarzanie alkaloidów bez oddzielania związków pośrednich |
| US8969358B2 (en) | 2013-03-15 | 2015-03-03 | Purdue Pharma L.P. | Buprenorphine analogs |
| GB201309654D0 (en) | 2013-05-30 | 2013-07-17 | Euro Celtique Sa | Method |
| BR112020010901A2 (pt) | 2017-12-12 | 2020-11-17 | Xalud Therapeutics, Inc. | derivados halogenados de morfinanos e usos dos mesmos |
| EP4125990A4 (en) * | 2020-03-24 | 2024-07-03 | University of Padova | MORPHINE ISOMERS AND THEIR STRUCTURAL MODIFICATIONS AS NMDAR ANTAGONISTS AND NEUROPLASTIGENS |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3474101A (en) * | 1960-09-05 | 1969-10-21 | Reckitt & Sons Ltd | Thebaine and oripavine derivatives |
| GB1178537A (en) * | 1966-10-20 | 1970-01-21 | Reckitt & Sons Ltd | Antitussive and Analgesic Compositions |
| GB1300419A (en) * | 1969-05-16 | 1972-12-20 | Organon Labor Ltd | New morphinone derivatives and their preparation |
| US4521601A (en) * | 1981-05-20 | 1985-06-04 | The United States Of America As Represented By The Department Of Health & Human Services | Practical total synthesis unnatural enantiomers of opium-derived morphinans |
| US4806543A (en) * | 1986-11-25 | 1989-02-21 | Board Of Trustees Of The Leland Stanford Junior University | Method and compositions for reducing neurotoxic injury |
-
1990
- 1990-08-22 PT PT95069A patent/PT95069B/pt not_active IP Right Cessation
- 1990-08-23 CA CA002023858A patent/CA2023858C/en not_active Expired - Fee Related
- 1990-08-24 IE IE309990A patent/IE67526B1/en not_active IP Right Cessation
- 1990-08-24 ES ES90116248T patent/ES2072946T3/es not_active Expired - Lifetime
- 1990-08-24 JP JP22414290A patent/JP3313361B2/ja not_active Expired - Fee Related
- 1990-08-24 AT AT90116248T patent/ATE124046T1/de not_active IP Right Cessation
- 1990-08-24 DE DE69020277T patent/DE69020277T2/de not_active Expired - Fee Related
- 1990-08-24 EP EP90116248A patent/EP0418591B1/en not_active Expired - Lifetime
- 1990-08-24 DK DK90116248.7T patent/DK0418591T3/da active
- 1990-08-24 KR KR1019900013140A patent/KR0172596B1/ko not_active Expired - Fee Related
-
1995
- 1995-09-20 GR GR950402571T patent/GR3017445T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR910004625A (ko) | 1991-03-29 |
| CA2023858C (en) | 2002-01-01 |
| PT95069B (pt) | 1997-10-31 |
| GR3017445T3 (en) | 1995-12-31 |
| JP3313361B2 (ja) | 2002-08-12 |
| KR0172596B1 (ko) | 1999-02-01 |
| EP0418591A3 (en) | 1991-08-07 |
| EP0418591A2 (en) | 1991-03-27 |
| DE69020277T2 (de) | 1995-12-21 |
| IE903099A1 (en) | 1991-02-27 |
| JPH03163083A (ja) | 1991-07-15 |
| ATE124046T1 (de) | 1995-07-15 |
| DE69020277D1 (de) | 1995-07-27 |
| CA2023858A1 (en) | 1991-02-25 |
| ES2072946T3 (es) | 1995-08-01 |
| IE67526B1 (en) | 1996-04-03 |
| DK0418591T3 (da) | 1995-08-14 |
| EP0418591B1 (en) | 1995-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19901204 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19970708 |
|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20070108 |