DE69009667T2 - Verfahren zur Herstellung von Protease-Inhibitoren. - Google Patents

Verfahren zur Herstellung von Protease-Inhibitoren.

Info

Publication number
DE69009667T2
DE69009667T2 DE69009667T DE69009667T DE69009667T2 DE 69009667 T2 DE69009667 T2 DE 69009667T2 DE 69009667 T DE69009667 T DE 69009667T DE 69009667 T DE69009667 T DE 69009667T DE 69009667 T2 DE69009667 T2 DE 69009667T2
Authority
DE
Germany
Prior art keywords
serum
protease inhibitors
chromatography
isoelectric
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69009667T
Other languages
German (de)
English (en)
Other versions
DE69009667D1 (de
Inventor
Thierry Prof Dr Appelboom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SEROLAB SA
Original Assignee
SEROLAB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SEROLAB SA filed Critical SEROLAB SA
Publication of DE69009667D1 publication Critical patent/DE69009667D1/de
Application granted granted Critical
Publication of DE69009667T2 publication Critical patent/DE69009667T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8132—Plasminogen activator inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69009667T 1989-10-16 1990-10-10 Verfahren zur Herstellung von Protease-Inhibitoren. Expired - Fee Related DE69009667T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH3760/89A CH679673A5 (enExample) 1989-10-16 1989-10-16

Publications (2)

Publication Number Publication Date
DE69009667D1 DE69009667D1 (de) 1994-07-14
DE69009667T2 true DE69009667T2 (de) 1994-09-29

Family

ID=4262910

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69009667T Expired - Fee Related DE69009667T2 (de) 1989-10-16 1990-10-10 Verfahren zur Herstellung von Protease-Inhibitoren.

Country Status (5)

Country Link
EP (1) EP0424318B1 (enExample)
AT (1) ATE106894T1 (enExample)
CH (1) CH679673A5 (enExample)
DE (1) DE69009667T2 (enExample)
DK (1) DK0424318T3 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2271507A (en) * 1992-09-04 1994-04-20 Summit Technology Ireland Bv Compositions containing plasmin activity inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3983001A (en) * 1972-05-10 1976-09-28 Ceskoslovenska Akademie Ved Isolation of biologically active compounds by affinity chromatography

Also Published As

Publication number Publication date
EP0424318A1 (fr) 1991-04-24
CH679673A5 (enExample) 1992-03-31
DE69009667D1 (de) 1994-07-14
ATE106894T1 (de) 1994-06-15
DK0424318T3 (da) 1994-06-08
EP0424318B1 (fr) 1994-06-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee