DE69006799D1 - Spirocyclische antipsychotische Mittel. - Google Patents
Spirocyclische antipsychotische Mittel.Info
- Publication number
- DE69006799D1 DE69006799D1 DE90202012T DE69006799T DE69006799D1 DE 69006799 D1 DE69006799 D1 DE 69006799D1 DE 90202012 T DE90202012 T DE 90202012T DE 69006799 T DE69006799 T DE 69006799T DE 69006799 D1 DE69006799 D1 DE 69006799D1
- Authority
- DE
- Germany
- Prior art keywords
- spirocyclic
- antipsychotic agents
- spiro
- piperidine
- dihydronaphthalene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000164 antipsychotic agent Substances 0.000 title 1
- 125000003003 spiro group Chemical group 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Lubricants (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898917069A GB8917069D0 (en) | 1989-07-26 | 1989-07-26 | Therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69006799D1 true DE69006799D1 (de) | 1994-03-31 |
| DE69006799T2 DE69006799T2 (de) | 1994-08-11 |
Family
ID=10660644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69006799T Expired - Fee Related DE69006799T2 (de) | 1989-07-26 | 1990-07-23 | Spirocyclische antipsychotische Mittel. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0414289B1 (de) |
| JP (1) | JPH03184959A (de) |
| KR (1) | KR910002444A (de) |
| AT (1) | ATE101854T1 (de) |
| AU (1) | AU628612B2 (de) |
| CA (1) | CA2021736A1 (de) |
| DE (1) | DE69006799T2 (de) |
| DK (1) | DK0414289T3 (de) |
| ES (1) | ES2062303T3 (de) |
| FI (1) | FI903728A0 (de) |
| GB (1) | GB8917069D0 (de) |
| IE (1) | IE902706A1 (de) |
| IL (1) | IL95124A0 (de) |
| NO (1) | NO903315L (de) |
| NZ (1) | NZ234557A (de) |
| PT (1) | PT94806A (de) |
| ZA (1) | ZA905841B (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0445974A3 (en) * | 1990-03-05 | 1992-04-29 | Merck Sharp & Dohme Ltd. | Spirocyclic antipsychotic agents |
| NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| DK78692D0 (da) * | 1992-06-12 | 1992-06-12 | Lundbeck & Co As H | Dimere piperidin- og piperazinderivater |
| WO1994007496A1 (en) * | 1992-10-07 | 1994-04-14 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| US5670509A (en) * | 1993-09-27 | 1997-09-23 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| AU2223495A (en) * | 1994-04-15 | 1995-11-10 | Yamanouchi Pharmaceutical Co., Ltd. | Spiro compound and medicinal composition thereof |
| AU6428400A (en) * | 1999-06-07 | 2000-12-28 | Warner-Lambert Company | Tricyclic analgesics |
| US7045527B2 (en) | 2002-09-24 | 2006-05-16 | Amgen Inc. | Piperidine derivatives |
| EP1737809B1 (de) | 2004-02-27 | 2013-09-18 | Amgen, Inc | Verbindungen, pharmazeutische zusammensetzungen und verfahren zur verwendung bei der behandlung von stoffwechselstörungen |
| US7786141B2 (en) | 2004-08-19 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Dihydrospiroindene modulators of muscarinic receptors |
| EP1781288A2 (de) | 2004-08-19 | 2007-05-09 | Vertex Pharmaceuticals Incorporated | Modulatoren von muskarinischen rezeptoren |
| CA2577089A1 (en) | 2004-08-27 | 2006-03-02 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
| MX2007002341A (es) | 2004-08-27 | 2007-09-25 | Esteve Labor Dr | Inhibidores del receptor sigma. |
| BRPI0514692A (pt) | 2004-08-27 | 2008-06-17 | Esteve Labor Dr | inibidores do receptor sigma |
| EP1634873A1 (de) | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Sigmarezeptor-Inhibitoren |
| NZ555444A (en) | 2004-11-29 | 2011-01-28 | Vertex Pharma | Modulators of muscarinic receptors |
| WO2007033002A1 (en) | 2005-09-14 | 2007-03-22 | Amgen Inc. | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
| RU2008130094A (ru) | 2005-12-22 | 2010-01-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы мускариновых рецепторов |
| WO2007100670A1 (en) | 2006-02-22 | 2007-09-07 | Vertex Pharmaceuticals Incorporated | Spiro condensed piperidnes as modulators of muscarinic receptors |
| CN101426499A (zh) | 2006-02-22 | 2009-05-06 | 弗特克斯药品有限公司 | 毒蕈碱受体调节剂 |
| EP1829875A1 (de) | 2006-03-01 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Pyrazolderivate als Inhibitoren des Sigma-Rezeptors |
| MX2008011016A (es) | 2006-03-01 | 2008-09-08 | Esteve Labor Dr | Inhibidores de receptor sigma. |
| EP1829866A1 (de) | 2006-03-02 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Inhibitoren von Sigmarezeptoren |
| EP1829867A1 (de) | 2006-03-03 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Gegenüber dem Sigmarezeptor pharmazeutisch aktive Imidazolverbindungen |
| CA2656183A1 (en) | 2006-06-29 | 2008-01-10 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| CN101553231A (zh) | 2006-08-15 | 2009-10-07 | 弗特克斯药品有限公司 | 毒蕈碱受体调节剂 |
| CA2660974A1 (en) | 2006-08-18 | 2008-02-21 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| WO2008030520A1 (en) | 2006-09-07 | 2008-03-13 | Amgen Inc. | Heterocyclic gpr40 modulators |
| US7687526B2 (en) | 2006-09-07 | 2010-03-30 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
| US7572934B2 (en) | 2007-04-16 | 2009-08-11 | Amgen Inc. | Substituted biphenyl GPR40 modulators |
| AU2008307440A1 (en) | 2007-10-03 | 2009-04-09 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| WO2009048527A1 (en) | 2007-10-10 | 2009-04-16 | Amgen Inc. | Substituted biphenyl gpr40 modulators |
| JP2011515341A (ja) | 2008-03-06 | 2011-05-19 | アムジエン・インコーポレーテツド | 代謝障害の治療に有用な立体配座的に制限されたカルボン酸誘導体 |
| EP2116539A1 (de) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-Aryl-3-Amino-alkoxy-pyrazole als Sigma-Liganden zur Verbesserung der analgetischen Wirkung von Opioiden und zur Schwächung der Abhängigkeit davon |
| AU2009303475B2 (en) | 2008-10-15 | 2012-09-13 | Amgen Inc. | Spirocyclic GPR40 modulators |
| EP2353591A1 (de) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma-Liganden zur Verstärkung der analgesischen Wirkung von Opioden und Opiaten bei postoperativem Schmerz und zur Schwächung der Abhängigkeit davon |
| EP2353598A1 (de) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma-Liganden zur Anwendung in der Vorbeugung und/oder Behandlung von postoperativem Schmerz |
| EP2388005A1 (de) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma-Liganden zur Vorbeugung und/oder Behandlung von Erbrechen infolge von Chemotherapie oder Strahlentherapie |
| EP2395003A1 (de) | 2010-05-27 | 2011-12-14 | Laboratorios Del. Dr. Esteve, S.A. | Pyrazolverbindungen als Sigmarezeptor-Inhibitoren |
| EP2415471A1 (de) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Verwendung von Sigmaliganden bei opioidinduzierter Hyperalgesie |
| EP2524694A1 (de) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Verwendung von Sigmaliganden bei Schmerz im Zusammenhang mit Typ-2-Diabetes |
| KR20160097366A (ko) | 2013-12-17 | 2016-08-17 | 라보라토리오스 델 드라. 에스테브.에스.에이. | 세로토닌-노르에피네프린 재흡수 억제제들(SNRIs) 및 시그마 리셉터 리간드들 조합 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3985888A (en) * | 1969-07-24 | 1976-10-12 | Richardson-Merrell Inc. | Methods of inducing sedation using certain spiroalkanone-imides |
-
1989
- 1989-07-26 GB GB898917069A patent/GB8917069D0/en active Pending
-
1990
- 1990-07-18 NZ NZ234557A patent/NZ234557A/xx unknown
- 1990-07-19 IL IL95124A patent/IL95124A0/xx unknown
- 1990-07-23 EP EP90202012A patent/EP0414289B1/de not_active Expired - Lifetime
- 1990-07-23 AT AT90202012T patent/ATE101854T1/de not_active IP Right Cessation
- 1990-07-23 DK DK90202012.2T patent/DK0414289T3/da active
- 1990-07-23 CA CA002021736A patent/CA2021736A1/en not_active Abandoned
- 1990-07-23 DE DE69006799T patent/DE69006799T2/de not_active Expired - Fee Related
- 1990-07-23 ES ES90202012T patent/ES2062303T3/es not_active Expired - Lifetime
- 1990-07-24 PT PT94806A patent/PT94806A/pt not_active Application Discontinuation
- 1990-07-25 IE IE270690A patent/IE902706A1/en unknown
- 1990-07-25 AU AU59844/90A patent/AU628612B2/en not_active Ceased
- 1990-07-25 ZA ZA905841A patent/ZA905841B/xx unknown
- 1990-07-25 NO NO90903315A patent/NO903315L/no unknown
- 1990-07-25 FI FI903728A patent/FI903728A0/fi not_active IP Right Cessation
- 1990-07-26 KR KR1019900011368A patent/KR910002444A/ko not_active Application Discontinuation
- 1990-07-26 JP JP2196403A patent/JPH03184959A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0414289B1 (de) | 1994-02-23 |
| NZ234557A (en) | 1992-12-23 |
| FI903728A0 (fi) | 1990-07-25 |
| DK0414289T3 (da) | 1994-04-11 |
| AU628612B2 (en) | 1992-09-17 |
| GB8917069D0 (en) | 1989-09-13 |
| IE902706A1 (en) | 1991-02-27 |
| KR910002444A (ko) | 1991-02-25 |
| ZA905841B (en) | 1991-06-26 |
| ES2062303T3 (es) | 1994-12-16 |
| CA2021736A1 (en) | 1991-01-27 |
| JPH03184959A (ja) | 1991-08-12 |
| IL95124A0 (en) | 1991-06-10 |
| AU5984490A (en) | 1991-01-31 |
| NO903315D0 (no) | 1990-07-25 |
| NO903315L (no) | 1991-01-28 |
| PT94806A (pt) | 1991-03-20 |
| ATE101854T1 (de) | 1994-03-15 |
| DE69006799T2 (de) | 1994-08-11 |
| EP0414289A1 (de) | 1991-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |