ATE101854T1 - Spirocyclische antipsychotische mittel. - Google Patents
Spirocyclische antipsychotische mittel.Info
- Publication number
- ATE101854T1 ATE101854T1 AT90202012T AT90202012T ATE101854T1 AT E101854 T1 ATE101854 T1 AT E101854T1 AT 90202012 T AT90202012 T AT 90202012T AT 90202012 T AT90202012 T AT 90202012T AT E101854 T1 ATE101854 T1 AT E101854T1
- Authority
- AT
- Austria
- Prior art keywords
- sychotic
- spirocyclic
- agents
- spiro
- piperidine
- Prior art date
Links
- 125000003003 spiro group Chemical group 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Lubricants (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898917069A GB8917069D0 (en) | 1989-07-26 | 1989-07-26 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE101854T1 true ATE101854T1 (de) | 1994-03-15 |
Family
ID=10660644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90202012T ATE101854T1 (de) | 1989-07-26 | 1990-07-23 | Spirocyclische antipsychotische mittel. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0414289B1 (de) |
| JP (1) | JPH03184959A (de) |
| KR (1) | KR910002444A (de) |
| AT (1) | ATE101854T1 (de) |
| AU (1) | AU628612B2 (de) |
| CA (1) | CA2021736A1 (de) |
| DE (1) | DE69006799T2 (de) |
| DK (1) | DK0414289T3 (de) |
| ES (1) | ES2062303T3 (de) |
| FI (1) | FI903728A7 (de) |
| GB (1) | GB8917069D0 (de) |
| IE (1) | IE902706A1 (de) |
| IL (1) | IL95124A0 (de) |
| NO (1) | NO903315L (de) |
| NZ (1) | NZ234557A (de) |
| PT (1) | PT94806A (de) |
| ZA (1) | ZA905841B (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0445974A3 (en) * | 1990-03-05 | 1992-04-29 | Merck Sharp & Dohme Ltd. | Spirocyclic antipsychotic agents |
| NZ243065A (en) | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| DK78692D0 (da) * | 1992-06-12 | 1992-06-12 | Lundbeck & Co As H | Dimere piperidin- og piperazinderivater |
| WO1994007496A1 (en) * | 1992-10-07 | 1994-04-14 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| US5670509A (en) * | 1993-09-27 | 1997-09-23 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| WO1995028389A1 (en) * | 1994-04-15 | 1995-10-26 | Yamanouchi Pharmaceutical Co., Ltd. | Spiro compound and medicinal composition thereof |
| JP2003513006A (ja) * | 1999-06-07 | 2003-04-08 | ワーナー−ランバート・カンパニー | 三環性鎮痛薬 |
| US7045527B2 (en) | 2002-09-24 | 2006-05-16 | Amgen Inc. | Piperidine derivatives |
| CA2558585C (en) | 2004-02-27 | 2010-10-12 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders |
| US7786141B2 (en) | 2004-08-19 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Dihydrospiroindene modulators of muscarinic receptors |
| EP2374455A3 (de) * | 2004-08-19 | 2012-03-28 | Vertex Pharmaceuticals Incorporated | Modulatoren von muskarinischen Rezeptoren |
| SI1781618T1 (sl) | 2004-08-27 | 2013-01-31 | Laboratorios Del Dr. Esteve, S.A. | Inhibitorji sigma receptorja |
| CA2576144C (en) | 2004-08-27 | 2012-12-11 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
| ATE520668T1 (de) | 2004-08-27 | 2011-09-15 | Esteve Labor Dr | Sigmarezeptor-inhibitoren |
| EP1634873A1 (de) | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Sigmarezeptor-Inhibitoren |
| RU2007124373A (ru) | 2004-11-29 | 2009-01-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы мускариновых рецептеров |
| EP1924546A1 (de) | 2005-09-14 | 2008-05-28 | Amgen, Inc | Konformationseingeschränkte 3- (4-hydroxy-phenyl) substitutierte propansäuren zur behandlung von stoffwechselstörungen |
| AU2006330866A1 (en) | 2005-12-22 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| KR20080098070A (ko) | 2006-02-22 | 2008-11-06 | 버텍스 파마슈티칼스 인코포레이티드 | 무스카린성 수용체의 조절제로서의 스피로 축합된 피페리딘 |
| AU2007221214A1 (en) | 2006-02-22 | 2007-09-07 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| JP2009528315A (ja) * | 2006-03-01 | 2009-08-06 | ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ | シグマ受容体阻害剤としてのピラゾール誘導体 |
| EP1829875A1 (de) | 2006-03-01 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Pyrazolderivate als Inhibitoren des Sigma-Rezeptors |
| EP1829866A1 (de) | 2006-03-02 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Inhibitoren von Sigmarezeptoren |
| EP1829867A1 (de) | 2006-03-03 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Gegenüber dem Sigmarezeptor pharmazeutisch aktive Imidazolverbindungen |
| CN101500565A (zh) | 2006-06-29 | 2009-08-05 | 弗特克斯药品有限公司 | 毒蕈碱性受体的调节剂 |
| AU2007284548A1 (en) | 2006-08-15 | 2008-02-21 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| CA2660974A1 (en) | 2006-08-18 | 2008-02-21 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| CA2662242C (en) | 2006-09-07 | 2012-06-12 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
| EP2064193A1 (de) | 2006-09-07 | 2009-06-03 | Amgen, Inc | Heterozyklische gpr40-modulatoren |
| AU2008241490B2 (en) | 2007-04-16 | 2011-07-21 | Amgen Inc. | Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid GPR40 modulators |
| JP2010540640A (ja) | 2007-10-03 | 2010-12-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン作用性レセプターのモジュレーター |
| US8030354B2 (en) | 2007-10-10 | 2011-10-04 | Amgen Inc. | Substituted biphenyl GPR40 modulators |
| WO2009111056A1 (en) | 2008-03-06 | 2009-09-11 | Amgen Inc. | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders |
| EP2116539A1 (de) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-Aryl-3-Amino-alkoxy-pyrazole als Sigma-Liganden zur Verbesserung der analgetischen Wirkung von Opioiden und zur Schwächung der Abhängigkeit davon |
| AU2009303475B2 (en) | 2008-10-15 | 2012-09-13 | Amgen Inc. | Spirocyclic GPR40 modulators |
| EP2353598A1 (de) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma-Liganden zur Anwendung in der Vorbeugung und/oder Behandlung von postoperativem Schmerz |
| EP2353591A1 (de) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma-Liganden zur Verstärkung der analgesischen Wirkung von Opioden und Opiaten bei postoperativem Schmerz und zur Schwächung der Abhängigkeit davon |
| EP2388005A1 (de) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma-Liganden zur Vorbeugung und/oder Behandlung von Erbrechen infolge von Chemotherapie oder Strahlentherapie |
| EP2395003A1 (de) | 2010-05-27 | 2011-12-14 | Laboratorios Del. Dr. Esteve, S.A. | Pyrazolverbindungen als Sigmarezeptor-Inhibitoren |
| EP2415471A1 (de) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Verwendung von Sigmaliganden bei opioidinduzierter Hyperalgesie |
| EP2524694A1 (de) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Verwendung von Sigmaliganden bei Schmerz im Zusammenhang mit Typ-2-Diabetes |
| TN2016000228A1 (en) | 2013-12-17 | 2017-10-06 | Esteve Labor Dr | SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs) AND SIGMA RECEPTOR LIGANDS COMBINATIONS. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3985888A (en) * | 1969-07-24 | 1976-10-12 | Richardson-Merrell Inc. | Methods of inducing sedation using certain spiroalkanone-imides |
-
1989
- 1989-07-26 GB GB898917069A patent/GB8917069D0/en active Pending
-
1990
- 1990-07-18 NZ NZ234557A patent/NZ234557A/xx unknown
- 1990-07-19 IL IL95124A patent/IL95124A0/xx unknown
- 1990-07-23 EP EP90202012A patent/EP0414289B1/de not_active Expired - Lifetime
- 1990-07-23 AT AT90202012T patent/ATE101854T1/de not_active IP Right Cessation
- 1990-07-23 DE DE69006799T patent/DE69006799T2/de not_active Expired - Fee Related
- 1990-07-23 DK DK90202012.2T patent/DK0414289T3/da active
- 1990-07-23 CA CA002021736A patent/CA2021736A1/en not_active Abandoned
- 1990-07-23 ES ES90202012T patent/ES2062303T3/es not_active Expired - Lifetime
- 1990-07-24 PT PT94806A patent/PT94806A/pt not_active Application Discontinuation
- 1990-07-25 AU AU59844/90A patent/AU628612B2/en not_active Ceased
- 1990-07-25 FI FI903728A patent/FI903728A7/fi not_active IP Right Cessation
- 1990-07-25 ZA ZA905841A patent/ZA905841B/xx unknown
- 1990-07-25 IE IE270690A patent/IE902706A1/en unknown
- 1990-07-25 NO NO90903315A patent/NO903315L/no unknown
- 1990-07-26 JP JP2196403A patent/JPH03184959A/ja active Pending
- 1990-07-26 KR KR1019900011368A patent/KR910002444A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU5984490A (en) | 1991-01-31 |
| JPH03184959A (ja) | 1991-08-12 |
| GB8917069D0 (en) | 1989-09-13 |
| EP0414289A1 (de) | 1991-02-27 |
| IL95124A0 (en) | 1991-06-10 |
| PT94806A (pt) | 1991-03-20 |
| FI903728A7 (fi) | 1991-01-27 |
| DE69006799D1 (de) | 1994-03-31 |
| AU628612B2 (en) | 1992-09-17 |
| NO903315L (no) | 1991-01-28 |
| CA2021736A1 (en) | 1991-01-27 |
| FI903728A0 (fi) | 1990-07-25 |
| ZA905841B (en) | 1991-06-26 |
| DE69006799T2 (de) | 1994-08-11 |
| ES2062303T3 (es) | 1994-12-16 |
| NO903315D0 (no) | 1990-07-25 |
| KR910002444A (ko) | 1991-02-25 |
| IE902706A1 (en) | 1991-02-27 |
| NZ234557A (en) | 1992-12-23 |
| DK0414289T3 (da) | 1994-04-11 |
| EP0414289B1 (de) | 1994-02-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE101854T1 (de) | Spirocyclische antipsychotische mittel. | |
| DE69022567D1 (de) | Polycarbonat-polydimethylsiloxan copolymer und herstellungsverfahren. | |
| DE69014357D1 (de) | Fahrzeug-Steuervorrichtung und Steuerverfahren. | |
| DE68905846D1 (de) | Gesaettigte laugen zur behandlung von bohrloechern und additive dafuer. | |
| DE69203928D1 (de) | Fahrzeugmontageverfahren und Fahrzeugkarosserie. | |
| DE68912148D1 (de) | Fahrzeug-Wechselstromgenerator und Herstellungsverfahren. | |
| DE69000467D1 (de) | Bis-aza-bicyclische anxiolytica und antidepressiva. | |
| DE3886557D1 (de) | Kraftfahrzeugaufhängung mit regelbarer Vorrichtung und Regelvorrichtung dafür. | |
| ATE47853T1 (de) | 5,6-difluornaphtyridine und 5,6,8trifluorchinoline verwendbar als antibakterielle mittel. | |
| DE58900363D1 (de) | Vorrichtung zum aufrichten und aufreihen von formteilen. | |
| DE69002528D1 (de) | Bremse mit selbsttaetig nachstellender oeffnung und verschleissnachstellvorrichtung. | |
| DE69003548D1 (de) | Transparente schweisshemmende mittel und herstellungsverfahren. | |
| EP0410535A3 (de) | Octahydrobenzisochinolin-Derivate als antipsychotische Mittel | |
| DE69637363D1 (de) | 1,3-dihydro-1-(phenylalkenyl)-2h-imidazol-2 on-derivate mit pde iv und cytokin-inhibirendes aktivität | |
| DE3887345D1 (de) | Fluoriertes copolymer und sperrschichten. | |
| DE68908037D1 (de) | Polyaetherimid-mischungen und formverfahren. | |
| DE68921157D1 (de) | Aufzeichnungskopf und Aufzeichnungsvorrichtung, die damit versehen ist. | |
| ATA242390A (de) | Vorrichtung zum arretieren von toren und dgl. | |
| DE3853296D1 (de) | Blätterverteilungsverfahren und vorrichtung. | |
| ES2044100T4 (es) | Ciertas combinaciones de antagonistas del "paf" y antihistaminicos y metodos. | |
| ATE69235T1 (de) | Erythromycin-a-derivate, modifiziert in position- c-12. | |
| ATE100094T1 (de) | Imidazolantiarrythmische mittel. | |
| DE59001699D1 (de) | Vorrichtung zum querschneiden und querschweissen von bahnen. | |
| DE3769329D1 (de) | Alpha-(2-alkoxyphenyl)-alpha-alkyl-1h-1,2,4-triazol-1-propannitrile und derivate. | |
| DE68919512D1 (de) | Chinoxalin-Derivate und antiulzerierendes Mittel. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |