ATE101854T1 - Spirocyclische antipsychotische mittel. - Google Patents
Spirocyclische antipsychotische mittel.Info
- Publication number
- ATE101854T1 ATE101854T1 AT90202012T AT90202012T ATE101854T1 AT E101854 T1 ATE101854 T1 AT E101854T1 AT 90202012 T AT90202012 T AT 90202012T AT 90202012 T AT90202012 T AT 90202012T AT E101854 T1 ATE101854 T1 AT E101854T1
- Authority
- AT
- Austria
- Prior art keywords
- sychotic
- spirocyclic
- agents
- spiro
- piperidine
- Prior art date
Links
- 125000003003 spiro group Chemical group 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Lubricants (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898917069A GB8917069D0 (en) | 1989-07-26 | 1989-07-26 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE101854T1 true ATE101854T1 (de) | 1994-03-15 |
Family
ID=10660644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90202012T ATE101854T1 (de) | 1989-07-26 | 1990-07-23 | Spirocyclische antipsychotische mittel. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0414289B1 (de) |
| JP (1) | JPH03184959A (de) |
| KR (1) | KR910002444A (de) |
| AT (1) | ATE101854T1 (de) |
| AU (1) | AU628612B2 (de) |
| CA (1) | CA2021736A1 (de) |
| DE (1) | DE69006799T2 (de) |
| DK (1) | DK0414289T3 (de) |
| ES (1) | ES2062303T3 (de) |
| FI (1) | FI903728A7 (de) |
| GB (1) | GB8917069D0 (de) |
| IE (1) | IE902706A1 (de) |
| IL (1) | IL95124A0 (de) |
| NO (1) | NO903315L (de) |
| NZ (1) | NZ234557A (de) |
| PT (1) | PT94806A (de) |
| ZA (1) | ZA905841B (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0445974A3 (en) * | 1990-03-05 | 1992-04-29 | Merck Sharp & Dohme Ltd. | Spirocyclic antipsychotic agents |
| NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| DK78692D0 (da) * | 1992-06-12 | 1992-06-12 | Lundbeck & Co As H | Dimere piperidin- og piperazinderivater |
| JPH08502474A (ja) * | 1992-10-07 | 1996-03-19 | メルク エンド カンパニー インコーポレーテッド | トコリティックオキシトシンレセプターアンタゴニスト |
| US5670509A (en) * | 1993-09-27 | 1997-09-23 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| WO1995028389A1 (en) * | 1994-04-15 | 1995-10-26 | Yamanouchi Pharmaceutical Co., Ltd. | Spiro compound and medicinal composition thereof |
| SK17512001A3 (sk) * | 1999-06-07 | 2002-11-06 | Warner-Lambert Company | Tricyklické analgetiká |
| US7045527B2 (en) | 2002-09-24 | 2006-05-16 | Amgen Inc. | Piperidine derivatives |
| EA011010B1 (ru) | 2004-02-27 | 2008-12-30 | Эмджен, Инк. | Соединения, модулирующие рецептор gpr40, фармацевтическая композиция, способ лечения заболеваний, чувствительных к модулированию рецептора gpr40 (варианты), способ модулирования функции gpr40 (варианты) и способ модулирования циркулирующей концентрации инсулина |
| US7786141B2 (en) | 2004-08-19 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Dihydrospiroindene modulators of muscarinic receptors |
| KR20070046929A (ko) * | 2004-08-19 | 2007-05-03 | 버텍스 파마슈티칼스 인코포레이티드 | 무스카린 수용체 조절제 |
| BRPI0514736A (pt) | 2004-08-27 | 2008-06-24 | Esteve Labor Dr | inibidores do receptor sigma |
| EP1781618B1 (de) | 2004-08-27 | 2012-10-03 | Laboratorios Del Dr. Esteve, S.A. | Sigmarezeptor-inhibitoren |
| EP1634873A1 (de) | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Sigmarezeptor-Inhibitoren |
| RU2417987C2 (ru) | 2004-08-27 | 2011-05-10 | Лабораторьос Дель Др.Эстеве, С.А. | Ингибиторы сигма-рецептора |
| RU2007124373A (ru) | 2004-11-29 | 2009-01-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы мускариновых рецептеров |
| EP1924546A1 (de) | 2005-09-14 | 2008-05-28 | Amgen, Inc | Konformationseingeschränkte 3- (4-hydroxy-phenyl) substitutierte propansäuren zur behandlung von stoffwechselstörungen |
| JP2009521483A (ja) | 2005-12-22 | 2009-06-04 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体のモジュレーター |
| EP1987034B1 (de) | 2006-02-22 | 2011-07-20 | Vertex Pharmceuticals Incorporated | Kondensierte spiropiperidine als modulatoren muskarinartiger rezeptoren |
| AU2007221214A1 (en) | 2006-02-22 | 2007-09-07 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| JP2009528315A (ja) | 2006-03-01 | 2009-08-06 | ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ | シグマ受容体阻害剤としてのピラゾール誘導体 |
| EP1829875A1 (de) | 2006-03-01 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Pyrazolderivate als Inhibitoren des Sigma-Rezeptors |
| EP1829866A1 (de) | 2006-03-02 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Inhibitoren von Sigmarezeptoren |
| EP1829867A1 (de) | 2006-03-03 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Gegenüber dem Sigmarezeptor pharmazeutisch aktive Imidazolverbindungen |
| CN101500565A (zh) | 2006-06-29 | 2009-08-05 | 弗特克斯药品有限公司 | 毒蕈碱性受体的调节剂 |
| AU2007284548A1 (en) | 2006-08-15 | 2008-02-21 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| EP2051715A2 (de) | 2006-08-18 | 2009-04-29 | Vertex Pharmceuticals Incorporated | Modulatoren muskarinischer rezeptoren |
| AU2007293028B2 (en) | 2006-09-07 | 2012-05-31 | Amgen Inc. | Heterocyclic GPR40 modulators |
| US7687526B2 (en) | 2006-09-07 | 2010-03-30 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
| CA2683751C (en) | 2007-04-16 | 2013-01-08 | Amgen Inc. | Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators |
| US7973162B2 (en) | 2007-10-03 | 2011-07-05 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| KR20100090249A (ko) | 2007-10-10 | 2010-08-13 | 암젠 인크 | 치환된 비페닐 ｇｒｐ４０ 조절제 |
| US8450522B2 (en) | 2008-03-06 | 2013-05-28 | Amgen Inc. | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders |
| EP2116539A1 (de) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-Aryl-3-Amino-alkoxy-pyrazole als Sigma-Liganden zur Verbesserung der analgetischen Wirkung von Opioiden und zur Schwächung der Abhängigkeit davon |
| US8748462B2 (en) | 2008-10-15 | 2014-06-10 | Amgen Inc. | Spirocyclic GPR40 modulators |
| EP2353591A1 (de) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma-Liganden zur Verstärkung der analgesischen Wirkung von Opioden und Opiaten bei postoperativem Schmerz und zur Schwächung der Abhängigkeit davon |
| EP2353598A1 (de) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma-Liganden zur Anwendung in der Vorbeugung und/oder Behandlung von postoperativem Schmerz |
| EP2388005A1 (de) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma-Liganden zur Vorbeugung und/oder Behandlung von Erbrechen infolge von Chemotherapie oder Strahlentherapie |
| EP2395003A1 (de) | 2010-05-27 | 2011-12-14 | Laboratorios Del. Dr. Esteve, S.A. | Pyrazolverbindungen als Sigmarezeptor-Inhibitoren |
| EP2415471A1 (de) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Verwendung von Sigmaliganden bei opioidinduzierter Hyperalgesie |
| EP2524694A1 (de) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Verwendung von Sigmaliganden bei Schmerz im Zusammenhang mit Typ-2-Diabetes |
| TW201607538A (zh) | 2013-12-17 | 2016-03-01 | 以斯提夫博士實驗室股份有限公司 | 血清素－去甲腎上腺素再攝取抑制劑（ＳＮＲＩＳ）和σ受體配體組合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3985888A (en) * | 1969-07-24 | 1976-10-12 | Richardson-Merrell Inc. | Methods of inducing sedation using certain spiroalkanone-imides |
-
1989
- 1989-07-26 GB GB898917069A patent/GB8917069D0/en active Pending
-
1990
- 1990-07-18 NZ NZ234557A patent/NZ234557A/xx unknown
- 1990-07-19 IL IL95124A patent/IL95124A0/xx unknown
- 1990-07-23 DK DK90202012.2T patent/DK0414289T3/da active
- 1990-07-23 EP EP90202012A patent/EP0414289B1/de not_active Expired - Lifetime
- 1990-07-23 AT AT90202012T patent/ATE101854T1/de not_active IP Right Cessation
- 1990-07-23 DE DE69006799T patent/DE69006799T2/de not_active Expired - Fee Related
- 1990-07-23 CA CA002021736A patent/CA2021736A1/en not_active Abandoned
- 1990-07-23 ES ES90202012T patent/ES2062303T3/es not_active Expired - Lifetime
- 1990-07-24 PT PT94806A patent/PT94806A/pt not_active Application Discontinuation
- 1990-07-25 IE IE270690A patent/IE902706A1/en unknown
- 1990-07-25 AU AU59844/90A patent/AU628612B2/en not_active Ceased
- 1990-07-25 NO NO90903315A patent/NO903315L/no unknown
- 1990-07-25 ZA ZA905841A patent/ZA905841B/xx unknown
- 1990-07-25 FI FI903728A patent/FI903728A7/fi not_active IP Right Cessation
- 1990-07-26 KR KR1019900011368A patent/KR910002444A/ko not_active Withdrawn
- 1990-07-26 JP JP2196403A patent/JPH03184959A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FI903728A0 (fi) | 1990-07-25 |
| NZ234557A (en) | 1992-12-23 |
| IE902706A1 (en) | 1991-02-27 |
| ES2062303T3 (es) | 1994-12-16 |
| NO903315L (no) | 1991-01-28 |
| EP0414289B1 (de) | 1994-02-23 |
| PT94806A (pt) | 1991-03-20 |
| EP0414289A1 (de) | 1991-02-27 |
| DK0414289T3 (da) | 1994-04-11 |
| GB8917069D0 (en) | 1989-09-13 |
| NO903315D0 (no) | 1990-07-25 |
| IL95124A0 (en) | 1991-06-10 |
| AU628612B2 (en) | 1992-09-17 |
| ZA905841B (en) | 1991-06-26 |
| CA2021736A1 (en) | 1991-01-27 |
| FI903728A7 (fi) | 1991-01-27 |
| KR910002444A (ko) | 1991-02-25 |
| JPH03184959A (ja) | 1991-08-12 |
| AU5984490A (en) | 1991-01-31 |
| DE69006799T2 (de) | 1994-08-11 |
| DE69006799D1 (de) | 1994-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |