DE68923603T2 - Nukleotid Sonden. - Google Patents
Nukleotid Sonden.Info
- Publication number
- DE68923603T2 DE68923603T2 DE68923603T DE68923603T DE68923603T2 DE 68923603 T2 DE68923603 T2 DE 68923603T2 DE 68923603 T DE68923603 T DE 68923603T DE 68923603 T DE68923603 T DE 68923603T DE 68923603 T2 DE68923603 T2 DE 68923603T2
- Authority
- DE
- Germany
- Prior art keywords
- nucleotide probes
- moiety
- moieties
- producing
- signal generating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/285,274 US5324829A (en) | 1988-12-16 | 1988-12-16 | High specific activity nucleic acid probes having target recognition and signal generating moieties |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68923603D1 DE68923603D1 (de) | 1995-08-31 |
DE68923603T2 true DE68923603T2 (de) | 1996-01-04 |
Family
ID=23093537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68923603T Expired - Lifetime DE68923603T2 (de) | 1988-12-16 | 1989-12-15 | Nukleotid Sonden. |
Country Status (8)
Country | Link |
---|---|
US (3) | US5324829A (de) |
EP (1) | EP0373956B1 (de) |
JP (1) | JPH02245663A (de) |
AT (1) | ATE125545T1 (de) |
CA (1) | CA2005557A1 (de) |
DE (1) | DE68923603T2 (de) |
ES (1) | ES2076219T3 (de) |
GR (1) | GR890100824A (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5324829A (en) * | 1988-12-16 | 1994-06-28 | Ortho Diagnostic Systems, Inc. | High specific activity nucleic acid probes having target recognition and signal generating moieties |
US5258507A (en) * | 1990-11-08 | 1993-11-02 | Amoco Corporation | Labeling reagents useful for the chemical attachment of nitrophenyl derivative ligands to DNA probes |
DE69132510T2 (de) * | 1990-11-08 | 2001-05-03 | Hybridon Inc | Verbindung von mehrfachreportergruppen auf synthetischen oligonukleotiden |
EP0599337B1 (de) * | 1992-11-27 | 2006-03-08 | Canon Kabushiki Kaisha | Verfahren und Sonde zum Nachweis von Nukleinsäuren |
FR2710075B1 (fr) * | 1993-09-15 | 1995-10-27 | Bio Merieux | Réactif et procédé pour la détection d'une séquence nucléotidique avec amplification de signal. |
EP0684239B1 (de) * | 1994-05-26 | 2003-12-10 | Canon Kabushiki Kaisha | Verfahren zum Nachweis von einer Zielsubstanz in einer Probe mit Hilfe von Pyryliumverbindung |
US5871902A (en) * | 1994-12-09 | 1999-02-16 | The Gene Pool, Inc. | Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids |
US20030104361A1 (en) | 1997-09-29 | 2003-06-05 | Susan Weininger | Method of detection of nucleic acids with a specific sequence composition |
FR2733765B1 (fr) * | 1995-05-02 | 1997-07-25 | Genset Sa | Methode de couplage specifique de la coiffe de l'extremite 5' d'un fragment d'arnm |
FR2733762B1 (fr) * | 1995-05-02 | 1997-08-01 | Genset Sa | Methode de couplage specifique de la coiffe de l'extremite 5' d'un fragment d'arnm et preparation d'arnm et d'adnc complet |
FR2746413B1 (fr) * | 1996-03-19 | 1998-04-24 | Bio Merieux | Detection d'une sequence nucleotidique avec amplification de signal |
US5853993A (en) * | 1996-10-21 | 1998-12-29 | Hewlett-Packard Company | Signal enhancement method and kit |
CA2377707A1 (en) * | 1999-06-22 | 2000-12-28 | Invitrogen Corporation | Improved primers and methods for the detection and discrimination of nucleic acids |
JP4986367B2 (ja) * | 2000-09-15 | 2012-07-25 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | イン・サイチュー解析のためのオリゴヌクレオチドプローブおよびタンパク質を標識するためのオリゴヌクレオチド配列式 |
EP1401850A1 (de) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nukleosidderivate zur herstellung einer verbindungsbibliothek |
US7161013B2 (en) * | 2001-09-12 | 2007-01-09 | Pusan National University Industry-University Cooperation Foundation | Terthiophene-3-carboxylic acid compound and fabricating method thereof, functionalized conductive terthiophene polymer with the compound as a monomer, process for DNA hybridization detection using the polymer, and fabricating method of probe DNA |
DE10228260A1 (de) * | 2002-06-25 | 2004-01-22 | Bayer Ag | Methode und Vorrichtung zum impedimetrischen Nachweis eines oder mehrerer Analyten in einer Probe |
EP1539980B1 (de) | 2002-08-01 | 2016-02-17 | Nuevolution A/S | MEHRSTUFENSYNTHESE VON MIT MATRIZEN ASSOZIIERTE MOLEKüLEN |
JP4895608B2 (ja) * | 2002-10-30 | 2012-03-14 | ヌエヴォリューション・アクティーゼルスカブ | 二官能性複合体の合成方法 |
EP1756277B1 (de) * | 2002-12-19 | 2009-12-02 | Nuevolution A/S | Durch quasizufallsstrukturen und funktionen geführte synthesemethode |
WO2004074429A2 (en) | 2003-02-21 | 2004-09-02 | Nuevolution A/S | Method for producing second-generation library |
WO2005026387A1 (en) | 2003-09-18 | 2005-03-24 | Nuevolution A/S | A method for obtaining structural information concerning an encoded molecule and method for selecting compounds |
DK1957644T3 (da) * | 2005-12-01 | 2011-03-28 | Nuevolution As | Enzymatiske kodnings metoder til effektiv syntese af store biblioteker |
DE102006028101B4 (de) * | 2006-06-19 | 2014-02-13 | Siemens Aktiengesellschaft | Verfahren zur Analyse von amplifizierten Nukleinsäuren |
US8150101B2 (en) | 2006-11-13 | 2012-04-03 | Cybernet Systems Corporation | Orientation invariant object identification using model-based image processing |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4458066A (en) * | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
US4358535A (en) * | 1980-12-08 | 1982-11-09 | Board Of Regents Of The University Of Washington | Specific DNA probes in diagnostic microbiology |
US4711955A (en) * | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
US4717653A (en) * | 1981-09-25 | 1988-01-05 | Webster John A Jr | Method for identifying and characterizing organisms |
FI63596C (fi) * | 1981-10-16 | 1983-07-11 | Orion Yhtymae Oy | Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser |
FR2519005B1 (fr) * | 1981-12-29 | 1985-10-25 | Pasteur Institut | Fragments d'adn marques a l'une au moins de leurs extremites par des ribonucleotides modifies reconnaissables par des molecules affines et procede pour realiser une analyse de tels fragments d'adn |
CA1223831A (en) * | 1982-06-23 | 1987-07-07 | Dean Engelhardt | Modified nucleotides, methods of preparing and utilizing and compositions containing the same |
US4556643A (en) * | 1982-07-26 | 1985-12-03 | Agracetus | Assay method and probe for polynucleotide sequences |
JPS5984162A (ja) * | 1982-11-05 | 1984-05-15 | Toshiba Corp | 免疫分析法 |
IL70765A (en) * | 1983-01-27 | 1988-07-31 | Enzo Biochem Inc | Substrates containing non-radioactive chemically-labeled polynucleotides and methods using them |
US4605735A (en) * | 1983-02-14 | 1986-08-12 | Wakunaga Seiyaku Kabushiki Kaisha | Oligonucleotide derivatives |
EP0135587B2 (de) * | 1983-02-22 | 2002-12-18 | Syngene, Inc. | Einzelstrang-oligonukleotide bestimmter sequenz, markergruppen enthaltend, verfahren zu deren chemischer synthese und nukleotide zur verwendung darin |
GB8306426D0 (en) * | 1983-03-09 | 1983-04-13 | Malcolm A D B | Detecting polynucleotide sequence |
CA1254525A (en) * | 1983-04-13 | 1989-05-23 | Christine L. Brakel | Kit for terminally chemically labeling dna |
DK188184A (da) * | 1983-04-20 | 1984-10-21 | Enzo Biochem Inc | Fremgangsmaade til dannelse af et kompleks af biologisk aktive eller funktionelle forbindelser og anvendelse af forbindelserne |
US4533628A (en) * | 1983-08-03 | 1985-08-06 | New York University | Colony hybridization method |
US5015733A (en) * | 1983-12-20 | 1991-05-14 | California Institute Of Technology | Nucleosides possessing blocked aliphatic amino groups |
US4707440A (en) * | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Nucleic acid hybridization assay and detectable molecules useful in such assay |
EP0177497A4 (de) * | 1984-04-05 | 1987-07-06 | Life Technologies Inc | Immobilisierung von nukleinsäuren. |
US4957858A (en) * | 1986-04-16 | 1990-09-18 | The Salk Instute For Biological Studies | Replicative RNA reporter systems |
FR2567541B1 (fr) * | 1984-07-13 | 1987-02-06 | Pasteur Institut | Sonde d'adn et procede pour la detection de " shigelles " et des souches entero-invasives de escherichia coli |
US5118605A (en) * | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
US4670379A (en) * | 1984-12-19 | 1987-06-02 | E. I. Du Pont De Nemours And Company | Polynucleotide hydridization assays employing catalyzed luminescence |
CA1278755C (en) * | 1985-03-15 | 1991-01-08 | William J. Knowles | Labelling of oligonucleotides |
CA1295559C (en) * | 1985-08-13 | 1992-02-11 | Jannis Stavrianopoulos | Method for labeling polynucleotide sequences |
US4806546A (en) * | 1985-09-30 | 1989-02-21 | Miles Inc. | Immobilization of nucleic acids on derivatized nylon supports |
US4806631A (en) * | 1985-09-30 | 1989-02-21 | Miles Inc. | Immobilization of nucleic acids on solvolyzed nylon supports |
EP0224126A3 (de) * | 1985-11-25 | 1989-02-01 | The University of Calgary | Kovalent gekoppelte komplementäre Oligodeoxynukleotide zur Verwendung als "Primer Linkers" bei Sequenzierung von Nukleinsäuren |
JP3293820B2 (ja) * | 1985-12-13 | 2002-06-17 | エンゾ− バイオケム インコ−ポレイテツド | 標的ポリヌクレオチドにハイブリツド形成するための新規な一工程方法とポリヌクレオチド化合物 |
US4882269A (en) * | 1985-12-13 | 1989-11-21 | Princeton University | Amplified hybridization assay |
EP0286642A4 (de) * | 1985-12-17 | 1990-06-27 | Genetics Inst | Testverfahren mittels polynukleotiden versetzung und reagenzkomplex. |
ATE88761T1 (de) * | 1986-01-10 | 1993-05-15 | Amoco Corp | Kompetitiver homogener test. |
US4900659A (en) * | 1986-01-30 | 1990-02-13 | Enzo Biochem, Inc. | Nucleotide sequence composition and method for detection of Neisseria gonorrhoeae and method for screening for a nucleotide sequence that is specific for a genetically distinct group |
NO870613L (no) * | 1986-03-05 | 1987-09-07 | Molecular Diagnostics Inc | Deteksjon av mikroorganismer i en prve inneholdende nukleinsyre. |
US4851331A (en) * | 1986-05-16 | 1989-07-25 | Allied Corporation | Method and kit for polynucleotide assay including primer-dependant DNA polymerase |
EP0276302B1 (de) * | 1986-08-11 | 1993-04-28 | Siska Diagnostics,Inc. | Methoden und zusammensetzungen für tests mit nukleinsäuresonden |
US4794082A (en) * | 1987-02-17 | 1988-12-27 | Hoechst Celanese Corporation | Biotinylating agents |
IL86164A0 (en) * | 1987-04-28 | 1988-11-15 | Tamir Biotechnology Ltd | Improved dna probes |
EP0310312A3 (de) * | 1987-10-02 | 1990-08-16 | M.L. Technology Ventures, L.P. | Nichtnukleotide Reagenzien für Endsubstituierung von Oligonukleotiden |
US5324829A (en) * | 1988-12-16 | 1994-06-28 | Ortho Diagnostic Systems, Inc. | High specific activity nucleic acid probes having target recognition and signal generating moieties |
-
1988
- 1988-12-16 US US07/285,274 patent/US5324829A/en not_active Expired - Lifetime
-
1989
- 1989-12-14 CA CA002005557A patent/CA2005557A1/en not_active Abandoned
- 1989-12-15 DE DE68923603T patent/DE68923603T2/de not_active Expired - Lifetime
- 1989-12-15 GR GR890100824A patent/GR890100824A/el unknown
- 1989-12-15 ES ES89313143T patent/ES2076219T3/es not_active Expired - Lifetime
- 1989-12-15 AT AT89313143T patent/ATE125545T1/de not_active IP Right Cessation
- 1989-12-15 EP EP89313143A patent/EP0373956B1/de not_active Expired - Lifetime
- 1989-12-16 JP JP1324916A patent/JPH02245663A/ja active Pending
-
1993
- 1993-10-25 US US08/142,232 patent/US5521298A/en not_active Expired - Lifetime
-
1996
- 1996-03-21 US US08/620,025 patent/US5783685A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0373956A2 (de) | 1990-06-20 |
US5324829A (en) | 1994-06-28 |
GR890100824A (el) | 1991-03-15 |
JPH02245663A (ja) | 1990-10-01 |
ES2076219T3 (es) | 1995-11-01 |
EP0373956B1 (de) | 1995-07-26 |
ATE125545T1 (de) | 1995-08-15 |
US5783685A (en) | 1998-07-21 |
DE68923603D1 (de) | 1995-08-31 |
EP0373956A3 (de) | 1991-01-30 |
CA2005557A1 (en) | 1990-06-16 |
US5521298A (en) | 1996-05-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN |