ATE125545T1 - Nukleotid sonden. - Google Patents

Nukleotid sonden.

Info

Publication number
ATE125545T1
ATE125545T1 AT89313143T AT89313143T ATE125545T1 AT E125545 T1 ATE125545 T1 AT E125545T1 AT 89313143 T AT89313143 T AT 89313143T AT 89313143 T AT89313143 T AT 89313143T AT E125545 T1 ATE125545 T1 AT E125545T1
Authority
AT
Austria
Prior art keywords
nucleotide probe
moiety
moieties
producing
signal generating
Prior art date
Application number
AT89313143T
Other languages
English (en)
Inventor
Chandler Dr Bahl
Leopoldo Mendoza
Original Assignee
Ortho Diagnostic Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Diagnostic Systems Inc filed Critical Ortho Diagnostic Systems Inc
Application granted granted Critical
Publication of ATE125545T1 publication Critical patent/ATE125545T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT89313143T 1988-12-16 1989-12-15 Nukleotid sonden. ATE125545T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/285,274 US5324829A (en) 1988-12-16 1988-12-16 High specific activity nucleic acid probes having target recognition and signal generating moieties

Publications (1)

Publication Number Publication Date
ATE125545T1 true ATE125545T1 (de) 1995-08-15

Family

ID=23093537

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89313143T ATE125545T1 (de) 1988-12-16 1989-12-15 Nukleotid sonden.

Country Status (8)

Country Link
US (3) US5324829A (de)
EP (1) EP0373956B1 (de)
JP (1) JPH02245663A (de)
AT (1) ATE125545T1 (de)
CA (1) CA2005557A1 (de)
DE (1) DE68923603T2 (de)
ES (1) ES2076219T3 (de)
GR (1) GR890100824A (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5324829A (en) * 1988-12-16 1994-06-28 Ortho Diagnostic Systems, Inc. High specific activity nucleic acid probes having target recognition and signal generating moieties
US5258507A (en) * 1990-11-08 1993-11-02 Amoco Corporation Labeling reagents useful for the chemical attachment of nitrophenyl derivative ligands to DNA probes
ATE198598T1 (de) * 1990-11-08 2001-01-15 Hybridon Inc Verbindung von mehrfachreportergruppen auf synthetischen oligonukleotiden
EP0599337B1 (de) * 1992-11-27 2006-03-08 Canon Kabushiki Kaisha Verfahren und Sonde zum Nachweis von Nukleinsäuren
FR2710075B1 (fr) * 1993-09-15 1995-10-27 Bio Merieux Réactif et procédé pour la détection d'une séquence nucléotidique avec amplification de signal.
EP0684239B1 (de) * 1994-05-26 2003-12-10 Canon Kabushiki Kaisha Verfahren zum Nachweis von einer Zielsubstanz in einer Probe mit Hilfe von Pyryliumverbindung
US5871902A (en) * 1994-12-09 1999-02-16 The Gene Pool, Inc. Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids
US20030104361A1 (en) * 1997-09-29 2003-06-05 Susan Weininger Method of detection of nucleic acids with a specific sequence composition
FR2733765B1 (fr) * 1995-05-02 1997-07-25 Genset Sa Methode de couplage specifique de la coiffe de l'extremite 5' d'un fragment d'arnm
FR2733762B1 (fr) * 1995-05-02 1997-08-01 Genset Sa Methode de couplage specifique de la coiffe de l'extremite 5' d'un fragment d'arnm et preparation d'arnm et d'adnc complet
FR2746413B1 (fr) * 1996-03-19 1998-04-24 Bio Merieux Detection d'une sequence nucleotidique avec amplification de signal
US5853993A (en) * 1996-10-21 1998-12-29 Hewlett-Packard Company Signal enhancement method and kit
NZ528967A (en) * 1999-06-22 2005-03-24 Invitrogen Corp Improved primers and methods for the amplification and discrimination of nucleic acids
CA2703141C (en) * 2000-09-15 2014-10-21 Ventana Medical Systems, Inc. Oligonucleotide sequence formula for labeling oligonucleotide probes and proteins for in situ analysis
EP1401850A1 (de) 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
EP1425275B1 (de) * 2001-09-12 2007-11-28 Pusan National University Industry-University Cooperation Foundation Neue terthiophen-3-carbonsäure verbindung und verfahren zu deren herstellung, funktionalisierter leitender terthiophenpolymer mit der verbindung als monomer und verfahren zum nachweis von dna-hybridisierung unter anwendung des polymers
DE10228260A1 (de) * 2002-06-25 2004-01-22 Bayer Ag Methode und Vorrichtung zum impedimetrischen Nachweis eines oder mehrerer Analyten in einer Probe
US10730906B2 (en) 2002-08-01 2020-08-04 Nuevolutions A/S Multi-step synthesis of templated molecules
EP1558744B1 (de) * 2002-10-30 2011-06-15 Nuevolution A/S Enzymatisches codieren
WO2004056994A2 (en) * 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
EP1670939B1 (de) 2003-09-18 2009-11-04 Nuevolution A/S Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
EP2341140B1 (de) 2005-12-01 2017-07-19 Nuevolution A/S Enzymvermittelnde Kodierungsmethoden für eine effiziente Synthese von grossen Bibliotheken
DE102006028101B4 (de) * 2006-06-19 2014-02-13 Siemens Aktiengesellschaft Verfahren zur Analyse von amplifizierten Nukleinsäuren
US8150101B2 (en) 2006-11-13 2012-04-03 Cybernet Systems Corporation Orientation invariant object identification using model-based image processing

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US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4358535A (en) * 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4717653A (en) * 1981-09-25 1988-01-05 Webster John A Jr Method for identifying and characterizing organisms
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
FR2519005B1 (fr) * 1981-12-29 1985-10-25 Pasteur Institut Fragments d'adn marques a l'une au moins de leurs extremites par des ribonucleotides modifies reconnaissables par des molecules affines et procede pour realiser une analyse de tels fragments d'adn
CA1223831A (en) * 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4556643A (en) * 1982-07-26 1985-12-03 Agracetus Assay method and probe for polynucleotide sequences
JPS5984162A (ja) * 1982-11-05 1984-05-15 Toshiba Corp 免疫分析法
CA1309672C (en) * 1983-01-27 1992-11-03 Jannis G. Stavrianopoulos Methods and structures employing non-radioactive chemically-labeled polynucleotide probes
US4605735A (en) * 1983-02-14 1986-08-12 Wakunaga Seiyaku Kabushiki Kaisha Oligonucleotide derivatives
AU596068B2 (en) * 1983-02-22 1990-04-26 Syngene, Inc. Defined sequence single strand oligonucleotides incorporating reporter groups, process for the chemical synthesis thereof, and nucleosides useful in such synthesis
GB8306426D0 (en) * 1983-03-09 1983-04-13 Malcolm A D B Detecting polynucleotide sequence
CA1254525A (en) * 1983-04-13 1989-05-23 Christine L. Brakel Kit for terminally chemically labeling dna
DK188184A (da) * 1983-04-20 1984-10-21 Enzo Biochem Inc Fremgangsmaade til dannelse af et kompleks af biologisk aktive eller funktionelle forbindelser og anvendelse af forbindelserne
US4533628A (en) * 1983-08-03 1985-08-06 New York University Colony hybridization method
US5015733A (en) * 1983-12-20 1991-05-14 California Institute Of Technology Nucleosides possessing blocked aliphatic amino groups
US4707440A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
EP0177497A4 (de) * 1984-04-05 1987-07-06 Life Technologies Inc Immobilisierung von nukleinsäuren.
US4957858A (en) * 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
FR2567541B1 (fr) * 1984-07-13 1987-02-06 Pasteur Institut Sonde d'adn et procede pour la detection de " shigelles " et des souches entero-invasives de escherichia coli
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US4670379A (en) * 1984-12-19 1987-06-02 E. I. Du Pont De Nemours And Company Polynucleotide hydridization assays employing catalyzed luminescence
CA1278755C (en) * 1985-03-15 1991-01-08 William J. Knowles Labelling of oligonucleotides
CA1295559C (en) * 1985-08-13 1992-02-11 Jannis Stavrianopoulos Method for labeling polynucleotide sequences
US4806546A (en) * 1985-09-30 1989-02-21 Miles Inc. Immobilization of nucleic acids on derivatized nylon supports
US4806631A (en) * 1985-09-30 1989-02-21 Miles Inc. Immobilization of nucleic acids on solvolyzed nylon supports
EP0224126A3 (de) * 1985-11-25 1989-02-01 The University of Calgary Kovalent gekoppelte komplementäre Oligodeoxynukleotide zur Verwendung als "Primer Linkers" bei Sequenzierung von Nukleinsäuren
JP3293820B2 (ja) * 1985-12-13 2002-06-17 エンゾ− バイオケム インコ−ポレイテツド 標的ポリヌクレオチドにハイブリツド形成するための新規な一工程方法とポリヌクレオチド化合物
US4882269A (en) * 1985-12-13 1989-11-21 Princeton University Amplified hybridization assay
WO1987003911A1 (en) * 1985-12-17 1987-07-02 Genetics Institute, Inc. Displacement polynucleotide method and reagent complex
ATE88761T1 (de) * 1986-01-10 1993-05-15 Amoco Corp Kompetitiver homogener test.
US4900659A (en) * 1986-01-30 1990-02-13 Enzo Biochem, Inc. Nucleotide sequence composition and method for detection of Neisseria gonorrhoeae and method for screening for a nucleotide sequence that is specific for a genetically distinct group
NO870613L (no) * 1986-03-05 1987-09-07 Molecular Diagnostics Inc Deteksjon av mikroorganismer i en prŸve inneholdende nukleinsyre.
US4851331A (en) * 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
EP0276302B1 (de) * 1986-08-11 1993-04-28 Siska Diagnostics,Inc. Methoden und zusammensetzungen für tests mit nukleinsäuresonden
US4794082A (en) * 1987-02-17 1988-12-27 Hoechst Celanese Corporation Biotinylating agents
IL86164A0 (en) * 1987-04-28 1988-11-15 Tamir Biotechnology Ltd Improved dna probes
EP0310312A3 (de) * 1987-10-02 1990-08-16 M.L. Technology Ventures, L.P. Nichtnukleotide Reagenzien für Endsubstituierung von Oligonukleotiden
US5324829A (en) * 1988-12-16 1994-06-28 Ortho Diagnostic Systems, Inc. High specific activity nucleic acid probes having target recognition and signal generating moieties

Also Published As

Publication number Publication date
CA2005557A1 (en) 1990-06-16
DE68923603T2 (de) 1996-01-04
ES2076219T3 (es) 1995-11-01
GR890100824A (el) 1991-03-15
JPH02245663A (ja) 1990-10-01
EP0373956A2 (de) 1990-06-20
US5783685A (en) 1998-07-21
EP0373956A3 (de) 1991-01-30
US5521298A (en) 1996-05-28
DE68923603D1 (de) 1995-08-31
EP0373956B1 (de) 1995-07-26
US5324829A (en) 1994-06-28

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time