DE68923260D1 - Verfahren zur Herstellung eines Derivates der 3,5,6-Trihydroxyhexansäure. - Google Patents

Verfahren zur Herstellung eines Derivates der 3,5,6-Trihydroxyhexansäure.

Info

Publication number
DE68923260D1
DE68923260D1 DE68923260T DE68923260T DE68923260D1 DE 68923260 D1 DE68923260 D1 DE 68923260D1 DE 68923260 T DE68923260 T DE 68923260T DE 68923260 T DE68923260 T DE 68923260T DE 68923260 D1 DE68923260 D1 DE 68923260D1
Authority
DE
Germany
Prior art keywords
derivative
preparation
trihydroxyhexanoic acid
trihydroxyhexanoic
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68923260T
Other languages
English (en)
Other versions
DE68923260T2 (de
Inventor
Kenji Inoue
Satomi Takahashi
Keiichi Yonetsu
Noboru Ueyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Publication of DE68923260D1 publication Critical patent/DE68923260D1/de
Application granted granted Critical
Publication of DE68923260T2 publication Critical patent/DE68923260T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/14—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and esterified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE68923260T 1988-12-21 1989-12-21 Verfahren zur Herstellung eines Derivates der 3,5,6-Trihydroxyhexansäure. Expired - Fee Related DE68923260T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP32393588 1988-12-21

Publications (2)

Publication Number Publication Date
DE68923260D1 true DE68923260D1 (de) 1995-08-03
DE68923260T2 DE68923260T2 (de) 1996-01-11

Family

ID=18160273

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68923260T Expired - Fee Related DE68923260T2 (de) 1988-12-21 1989-12-21 Verfahren zur Herstellung eines Derivates der 3,5,6-Trihydroxyhexansäure.

Country Status (7)

Country Link
US (1) US4983759A (de)
EP (1) EP0374922B1 (de)
JP (1) JPH02262537A (de)
CA (1) CA2005993A1 (de)
DE (1) DE68923260T2 (de)
ES (1) ES2076196T3 (de)
IE (1) IE894067L (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189164A (en) * 1989-05-22 1993-02-23 Sandoz Ltd. Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof
US5391785A (en) * 1990-01-16 1995-02-21 La Jolla Pharmaceutial Company Intermediates for providing functional groups on the 5' end of oligonucleotides
US5214197A (en) * 1990-07-06 1993-05-25 Kanegafuchi Chemical Industry Co., Ltd. 2,4-dihydroxyadipic acid derivative
DE4128345C1 (en) * 1991-08-27 1993-06-09 Hoechst Ag, 6230 Frankfurt, De 3R,5S 3,5,6-tri:hydroxy-hexanoic acid isopropylidene ketal derivs. prepn. - from 7-benzyl:oxy 4,6-di:hydroxy:heptene by multistage process
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
JP3076154B2 (ja) * 1992-08-13 2000-08-14 高砂香料工業株式会社 （３ｒ，５ｓ）−３，５，６−トリヒドロキシヘキサン酸誘導体及びその製造方法
SE515968C2 (sv) * 1999-06-29 2001-11-05 Akzo Nobel Nv Föreningar från epoxiderade nitriler, deras tillverkningsprocess och användning som rengöringsmedel
AU6269201A (en) * 2000-06-05 2001-12-17 Kaneka Corporation Process for preparing optically active 2-(6-(hydroxy-methyl)-1,3-dioxan-4-yl)acetic acid derivatives
JP3844112B2 (ja) 2000-08-23 2006-11-08 高砂香料工業株式会社 ３，５，６−トリヒドロキシヘキサン酸アンモニウム塩誘導体、及びその製造方法
DE60225825T2 (de) * 2001-10-24 2009-04-16 Kaneka Corp. Verfahren zur herstellung eines optisch aktiven 3,5-dihydroxycarbonsäurederivats
CN100429212C (zh) * 2006-06-30 2008-10-29 浙江东港药业有限公司 一种(4R-cis)-6-甲酰基-2,2-二甲基-1,3-二氧己环-4-乙酸叔丁酯的合成方法
CN101747312B (zh) * 2008-12-11 2013-02-06 上海医药工业研究院 (3r,5s)-3,5,6-三羟基己酸乙酯衍生物的制备方法
CN101538261B (zh) * 2009-04-28 2012-11-07 中国医药集团总公司四川抗菌素工业研究所 制备(3r,5s)-3,5-o-亚异丙基-3,5,6-三羟基己酸衍生物的方法
US9072682B2 (en) 2012-12-31 2015-07-07 Mylan Inc. Transdermal dosage form for low-melting point active agent

Also Published As

Publication number Publication date
CA2005993A1 (en) 1990-06-21
EP0374922A2 (de) 1990-06-27
JPH02262537A (ja) 1990-10-25
ES2076196T3 (es) 1995-11-01
EP0374922B1 (de) 1995-06-28
IE894067L (en) 1990-06-21
EP0374922A3 (de) 1991-11-27
DE68923260T2 (de) 1996-01-11
US4983759A (en) 1991-01-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee