DE68916918D1 - Chinindolinderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen. - Google Patents

Chinindolinderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen.

Info

Publication number
DE68916918D1
DE68916918D1 DE68916918T DE68916918T DE68916918D1 DE 68916918 D1 DE68916918 D1 DE 68916918D1 DE 68916918 T DE68916918 T DE 68916918T DE 68916918 T DE68916918 T DE 68916918T DE 68916918 D1 DE68916918 D1 DE 68916918D1
Authority
DE
Germany
Prior art keywords
alkyl
optionally substituted
phenyl
cycloalkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68916918T
Other languages
English (en)
Other versions
DE68916918T2 (de
Inventor
Ian Thomson Beecham Pha Forbes
Roger Thomas Beecham Ph Martin
Mervyn Beecham Pharma Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of DE68916918D1 publication Critical patent/DE68916918D1/de
Application granted granted Critical
Publication of DE68916918T2 publication Critical patent/DE68916918T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Pyrrole Compounds (AREA)
DE68916918T 1988-12-09 1989-12-07 Chinindolinderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen. Expired - Fee Related DE68916918T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888828806A GB8828806D0 (en) 1988-12-09 1988-12-09 Novel compounds

Publications (2)

Publication Number Publication Date
DE68916918D1 true DE68916918D1 (de) 1994-08-25
DE68916918T2 DE68916918T2 (de) 1994-11-03

Family

ID=10648253

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68916918T Expired - Fee Related DE68916918T2 (de) 1988-12-09 1989-12-07 Chinindolinderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen.

Country Status (12)

Country Link
US (1) US5079246A (de)
EP (1) EP0372962B1 (de)
JP (1) JPH02184687A (de)
AT (1) ATE108792T1 (de)
AU (1) AU629578B2 (de)
CA (1) CA2004893A1 (de)
DE (1) DE68916918T2 (de)
DK (1) DK618389A (de)
GB (1) GB8828806D0 (de)
NZ (1) NZ231667A (de)
PT (1) PT92524B (de)
ZA (1) ZA899356B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW313589B (de) * 1991-12-12 1997-08-21 Wacker Chemie Gmbh
US5856148A (en) * 1991-12-12 1999-01-05 Wacker Chemie Gmbh Materials and methods for biosynthesis of serine and serine-related products
GB9309179D0 (en) * 1993-05-05 1993-06-16 Smithkline Beecham Plc New use
IL152682A0 (en) 2000-05-31 2003-06-24 Astrazeneca Ab Indole derivatives with vascular damaging activity
US20030096833A1 (en) * 2001-08-31 2003-05-22 Jagtap Prakash G. Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof
US6956035B2 (en) * 2001-08-31 2005-10-18 Inotek Pharmaceuticals Corporation Isoquinoline derivatives and methods of use thereof
JP2005532280A (ja) 2002-04-03 2005-10-27 アストラゼネカ アクチボラグ 化合物
WO2005009398A2 (en) * 2003-02-28 2005-02-03 Inotek Pharmaceuticals Corporation Tetracyclic benzamide derivatives and methods of use thereof
BRPI0508233A (pt) * 2004-02-26 2007-07-17 Inotek Pharmaceuticals Corp derivados de isoquinolina e métodos para emprego destes
KR20060130681A (ko) * 2004-02-26 2006-12-19 이노텍 파마슈티컬스 코포레이션 테트라사이클릭 락탐 유도체 및 이것의 용도
CA2571001A1 (en) * 2004-06-16 2006-01-26 Inotek Pharmaceuticals Corporation Methods for treating or preventing erectile dysfunction or urinary incontinence
US20060287311A1 (en) * 2005-02-25 2006-12-21 Inotek Pharmaceuticals Corporation Tetracyclic Sulfonamide Compounds and methods of use thereof
RU2007135355A (ru) * 2005-02-25 2009-03-27 Инотек Фармасьютикалз Корпорейшн (Us) Производные изохинолина и способы их применения
RU2007135362A (ru) * 2005-02-25 2009-03-27 Инотек Фармасьютикалз Корпорейшн (Us) Тетрациклические амино- и карбоксамидосоединения и способ их применения
CA2620052A1 (en) * 2005-08-24 2007-03-01 Inotek Pharmaceuticals Corporation Indenoisoquinolinone analogs and methods of use thereof
AU2008221358A1 (en) * 2007-02-28 2008-09-04 Inotek Pharmaceuticals Corporation Indenoisoquinolinone analogs and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600651D0 (en) * 1986-01-11 1986-02-19 Beecham Group Plc Compounds
GB8610980D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Heterocyclic fused tricyclic compounds

Also Published As

Publication number Publication date
GB8828806D0 (en) 1989-01-18
EP0372962A3 (de) 1991-07-31
EP0372962A2 (de) 1990-06-13
JPH02184687A (ja) 1990-07-19
AU4596089A (en) 1990-06-14
AU629578B2 (en) 1992-10-08
ATE108792T1 (de) 1994-08-15
DE68916918T2 (de) 1994-11-03
PT92524A (pt) 1990-06-29
EP0372962B1 (de) 1994-07-20
DK618389D0 (da) 1989-12-07
US5079246A (en) 1992-01-07
ZA899356B (en) 1990-10-31
DK618389A (da) 1990-06-10
PT92524B (pt) 1995-08-09
CA2004893A1 (en) 1990-06-09
NZ231667A (en) 1992-11-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee