DE68916850T2 - Antikoagulierende Peptid-Alkohole. - Google Patents

Antikoagulierende Peptid-Alkohole.

Info

Publication number
DE68916850T2
DE68916850T2 DE68916850T DE68916850T DE68916850T2 DE 68916850 T2 DE68916850 T2 DE 68916850T2 DE 68916850 T DE68916850 T DE 68916850T DE 68916850 T DE68916850 T DE 68916850T DE 68916850 T2 DE68916850 T2 DE 68916850T2
Authority
DE
Germany
Prior art keywords
anticoagulant peptide
peptide alcohols
alcohols
anticoagulant
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68916850T
Other languages
English (en)
Other versions
DE68916850D1 (de
Inventor
John L Krstenansky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE68916850D1 publication Critical patent/DE68916850D1/de
Application granted granted Critical
Publication of DE68916850T2 publication Critical patent/DE68916850T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/815Protease inhibitors from leeches, e.g. hirudin, eglin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/02Peptides of undefined number of amino acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE68916850T 1988-05-10 1989-05-05 Antikoagulierende Peptid-Alkohole. Expired - Fee Related DE68916850T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19240988A 1988-05-10 1988-05-10

Publications (2)

Publication Number Publication Date
DE68916850D1 DE68916850D1 (de) 1994-08-25
DE68916850T2 true DE68916850T2 (de) 1994-10-27

Family

ID=22709524

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68916850T Expired - Fee Related DE68916850T2 (de) 1988-05-10 1989-05-05 Antikoagulierende Peptid-Alkohole.

Country Status (18)

Country Link
EP (1) EP0341607B1 (de)
JP (1) JP2916164B2 (de)
KR (1) KR0131378B1 (de)
CN (1) CN1041157A (de)
AT (1) ATE108801T1 (de)
AU (1) AU626070B2 (de)
CA (1) CA1341354C (de)
DE (1) DE68916850T2 (de)
DK (1) DK226889A (de)
ES (1) ES2060689T3 (de)
FI (1) FI892222A (de)
HU (1) HU202556B (de)
IL (1) IL90220A0 (de)
NO (1) NO891894L (de)
NZ (1) NZ228995A (de)
PH (1) PH26973A (de)
PT (1) PT90504B (de)
ZA (1) ZA893346B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU633128B2 (en) * 1987-01-23 1993-01-21 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
US5574012A (en) * 1990-07-24 1996-11-12 Merrell Pharmaceuticals Inc. Analogs of hirudin having anti-platelet activity
HUT63180A (en) * 1990-07-24 1993-07-28 Merrell Dow Pharma Process for producing anticoagulant peptides
ZA915658B (en) * 1990-07-24 1992-05-27 Merrell Dow Pharma Analogs of hirudin having antiplatelet activity
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
ES2199963T3 (es) * 1993-06-11 2004-03-01 Merrell Pharmaceuticals Inc. Peptidos trifuncionales antitrombina y antiplaquetarios.
GB9426038D0 (en) 1994-12-22 1995-02-22 Iaf Biochem Int Low molecular weight bicyclic thrombin inhibitors
US6057314A (en) * 1995-12-21 2000-05-02 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
ZA883443B (en) * 1987-05-21 1988-11-16 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
CA1328540C (en) * 1987-05-21 1994-04-12 John L. Krstenansky Cyclic anticoagulant peptides

Also Published As

Publication number Publication date
ES2060689T3 (es) 1994-12-01
IL90220A0 (en) 1989-12-15
DE68916850D1 (de) 1994-08-25
NO891894L (no) 1989-11-13
FI892222A (fi) 1989-11-11
HUT51295A (en) 1990-04-28
AU3451789A (en) 1989-11-16
EP0341607B1 (de) 1994-07-20
ZA893346B (en) 1990-01-31
AU626070B2 (en) 1992-07-23
NZ228995A (en) 1992-03-26
CN1041157A (zh) 1990-04-11
DK226889D0 (da) 1989-05-09
CA1341354C (en) 2002-04-02
NO891894D0 (no) 1989-05-09
KR0131378B1 (ko) 1998-04-11
DK226889A (da) 1989-11-11
PH26973A (en) 1992-12-28
HU202556B (en) 1991-03-28
ATE108801T1 (de) 1994-08-15
EP0341607A2 (de) 1989-11-15
EP0341607A3 (de) 1991-03-27
FI892222A0 (fi) 1989-05-09
JPH01313500A (ja) 1989-12-18
KR900018138A (ko) 1990-12-20
PT90504B (pt) 1994-08-31
PT90504A (pt) 1989-11-30
JP2916164B2 (ja) 1999-07-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee