ZA893346B - Anticoagulant peptide alcohols - Google Patents

Anticoagulant peptide alcohols

Info

Publication number
ZA893346B
ZA893346B ZA893346A ZA893346A ZA893346B ZA 893346 B ZA893346 B ZA 893346B ZA 893346 A ZA893346 A ZA 893346A ZA 893346 A ZA893346 A ZA 893346A ZA 893346 B ZA893346 B ZA 893346B
Authority
ZA
South Africa
Prior art keywords
anticoagulant peptide
peptide alcohols
alcohols
anticoagulant
formula
Prior art date
Application number
ZA893346A
Other languages
English (en)
Inventor
John Leonard Krstenansky
Leonard Krstenansky John
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA893346B publication Critical patent/ZA893346B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA893346A 1988-05-10 1989-05-05 Anticoagulant peptide alcohols ZA893346B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19240988A 1988-05-10 1988-05-10

Publications (1)

Publication Number Publication Date
ZA893346B true ZA893346B (en) 1990-01-31

Family

ID=22709524

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA893346A ZA893346B (en) 1988-05-10 1989-05-05 Anticoagulant peptide alcohols

Country Status (18)

Country Link
EP (1) EP0341607B1 (de)
JP (1) JP2916164B2 (de)
KR (1) KR0131378B1 (de)
CN (1) CN1041157A (de)
AT (1) ATE108801T1 (de)
AU (1) AU626070B2 (de)
CA (1) CA1341354C (de)
DE (1) DE68916850T2 (de)
DK (1) DK226889A (de)
ES (1) ES2060689T3 (de)
FI (1) FI892222A (de)
HU (1) HU202556B (de)
IL (1) IL90220A0 (de)
NO (1) NO891894L (de)
NZ (1) NZ228995A (de)
PH (1) PH26973A (de)
PT (1) PT90504B (de)
ZA (1) ZA893346B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU633128B2 (en) * 1987-01-23 1993-01-21 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
AU640502B2 (en) * 1990-07-24 1993-08-26 Merrell Dow Pharmaceuticals Inc. Analogs of hirudin having antiplatelet activity
WO1992001710A1 (en) * 1990-07-24 1992-02-06 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
US5574012A (en) * 1990-07-24 1996-11-12 Merrell Pharmaceuticals Inc. Analogs of hirudin having anti-platelet activity
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
CN1124964A (zh) * 1993-06-11 1996-06-19 默里尔药物公司 三功能抗凝血酶和抗血小板的肽
GB9426038D0 (en) 1994-12-22 1995-02-22 Iaf Biochem Int Low molecular weight bicyclic thrombin inhibitors
US6057314A (en) * 1995-12-21 2000-05-02 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
ZA883443B (en) * 1987-05-21 1988-11-16 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
ZA883444B (de) * 1987-05-21 1988-11-16

Also Published As

Publication number Publication date
NO891894L (no) 1989-11-13
NZ228995A (en) 1992-03-26
EP0341607B1 (de) 1994-07-20
FI892222A0 (fi) 1989-05-09
AU3451789A (en) 1989-11-16
ES2060689T3 (es) 1994-12-01
EP0341607A2 (de) 1989-11-15
CA1341354C (en) 2002-04-02
KR900018138A (ko) 1990-12-20
CN1041157A (zh) 1990-04-11
AU626070B2 (en) 1992-07-23
FI892222A (fi) 1989-11-11
EP0341607A3 (de) 1991-03-27
ATE108801T1 (de) 1994-08-15
DK226889A (da) 1989-11-11
KR0131378B1 (ko) 1998-04-11
NO891894D0 (no) 1989-05-09
JP2916164B2 (ja) 1999-07-05
DK226889D0 (da) 1989-05-09
HU202556B (en) 1991-03-28
HUT51295A (en) 1990-04-28
DE68916850T2 (de) 1994-10-27
PT90504A (pt) 1989-11-30
PH26973A (en) 1992-12-28
PT90504B (pt) 1994-08-31
JPH01313500A (ja) 1989-12-18
DE68916850D1 (de) 1994-08-25
IL90220A0 (en) 1989-12-15

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