DE68913498T2 - 1,1-dioxo-cephem-4-carbothiolsäure-derivate. - Google Patents

1,1-dioxo-cephem-4-carbothiolsäure-derivate.

Info

Publication number
DE68913498T2
DE68913498T2 DE68913498T DE68913498T DE68913498T2 DE 68913498 T2 DE68913498 T2 DE 68913498T2 DE 68913498 T DE68913498 T DE 68913498T DE 68913498 T DE68913498 T DE 68913498T DE 68913498 T2 DE68913498 T2 DE 68913498T2
Authority
DE
Germany
Prior art keywords
cephem
dioxo
acid derivatives
carbothiolic acid
carbothiolic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68913498T
Other languages
English (en)
Other versions
DE68913498D1 (en
Inventor
Marco Alpegiani
Pierluigi Bissolino
Ettore Perrone
Matteo Francesco Di
Piergiuseppe Orezzi
Giuseppe Cassinelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Publication of DE68913498D1 publication Critical patent/DE68913498D1/de
Application granted granted Critical
Publication of DE68913498T2 publication Critical patent/DE68913498T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE68913498T 1988-05-13 1989-05-08 1,1-dioxo-cephem-4-carbothiolsäure-derivate. Expired - Fee Related DE68913498T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888811388A GB8811388D0 (en) 1988-05-13 1988-05-13 1,1-dioxo-cephem-4-carbothiolic acid derivatives
PCT/EP1989/000505 WO1989010926A1 (en) 1988-05-13 1989-05-08 1,1-dioxo-cephem-4-carbothiolic acid derivatives

Publications (2)

Publication Number Publication Date
DE68913498D1 DE68913498D1 (en) 1994-04-07
DE68913498T2 true DE68913498T2 (de) 1994-06-09

Family

ID=10636869

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68913498T Expired - Fee Related DE68913498T2 (de) 1988-05-13 1989-05-08 1,1-dioxo-cephem-4-carbothiolsäure-derivate.

Country Status (19)

Country Link
US (1) US5356888A (de)
EP (1) EP0378604B1 (de)
JP (1) JPH02504285A (de)
KR (1) KR0147300B1 (de)
AU (1) AU628821B2 (de)
DE (1) DE68913498T2 (de)
DK (1) DK10190A (de)
ES (1) ES2016017A6 (de)
FI (1) FI94642C (de)
GB (1) GB8811388D0 (de)
GR (1) GR1002249B (de)
HU (1) HU208141B (de)
IE (1) IE66309B1 (de)
IL (1) IL90231A0 (de)
NZ (1) NZ229023A (de)
PT (1) PT90530B (de)
RU (1) RU2091383C1 (de)
WO (1) WO1989010926A1 (de)
ZA (1) ZA893569B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE174919T1 (de) * 1989-10-06 1999-01-15 Synphar Lab Inc 2-spirocyclopropylcephalosporinderivate und verfahren zu ihrer herstellung
US5264429A (en) * 1989-10-06 1993-11-23 Synphar Laboratories, Inc. 2-spirocyclopropyl cephalosporin sulfone derivatives
US5258377A (en) * 1991-04-08 1993-11-02 Taiho Pharmaceutical Co., Ltd. 2-spirocyclopropyl 4-acylcephems
US5446037A (en) * 1991-12-05 1995-08-29 Synphar Laboratories, Inc. 2-[(substituted) methylene]cephalosporin sulfones as antiinflammatory, antidegenerative and antithrombin agents
US5439904A (en) * 1993-12-07 1995-08-08 Synphar Laboratories, Inc. 2-spiro(2'-spirocycloalkyl)cyclopropyl cephalosporin sulfones as antiinflammatory and antigenerative agents
US5629306A (en) 1994-12-09 1997-05-13 Research Corporation Technologies, Inc. 7-alkylidene cephalosporanic acid derivatives and methods of using the same
WO1997008174A1 (en) * 1995-08-31 1997-03-06 Smithkline Beecham Corporation Interleukin converting enzyme and apoptosis
US5760027A (en) * 1996-12-06 1998-06-02 Research Corporation Technologies, Inc. Use of 7-alkylidene cephalosporins to inhibit elastase activity
US6407091B1 (en) * 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1187323A (en) * 1967-06-26 1970-04-08 Fujisawa Pharmaceutical Co Sydnone and Sydnone Imine Derivatives of 7-Aminocephalosporanic Acids and Preparation thereof
US4547371A (en) * 1983-04-18 1985-10-15 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
US4623645A (en) * 1983-04-18 1986-11-18 Merck & Co., Inc. Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents
EP0124081A3 (de) * 1983-05-02 1986-11-26 Merck & Co. Inc. Substituierte Cephalosporinsulfone mit Antientzündungs- und Antidegenerativwirkung, sie enthaltende Zusammensetzungen und Verfahren zur Herstellung
US4699904A (en) * 1985-07-01 1987-10-13 Merck & Co., Inc. Tetrazolyl derivatives of β-lactams useful as elastase inhibitors
DE3751700D1 (de) * 1986-11-12 1996-03-21 Merck & Co Inc Substituierte Cephalosporinsulfone als anti-entzündliche und anti-degenerative Mittel
GB8808701D0 (en) * 1988-04-13 1988-05-18 Erba Carlo Spa Beta-lactam derivatives
US5258377A (en) * 1991-04-08 1993-11-02 Taiho Pharmaceutical Co., Ltd. 2-spirocyclopropyl 4-acylcephems

Also Published As

Publication number Publication date
HUT54166A (en) 1991-01-28
NZ229023A (en) 1990-09-26
PT90530B (pt) 1994-11-30
US5356888A (en) 1994-10-18
ZA893569B (en) 1990-01-31
IE66309B1 (en) 1995-12-27
RU2091383C1 (ru) 1997-09-27
DE68913498D1 (en) 1994-04-07
FI94642C (fi) 1995-10-10
AU3579289A (en) 1989-11-29
FI900145A0 (fi) 1990-01-11
FI94642B (fi) 1995-06-30
KR0147300B1 (ko) 1998-08-17
GR1002249B (en) 1996-04-23
GB8811388D0 (en) 1988-06-15
DK10190A (da) 1990-01-15
FI900145A (fi) 1990-01-11
DK10190D0 (da) 1990-01-12
IL90231A0 (en) 1989-12-15
EP0378604A1 (de) 1990-07-25
ES2016017A6 (es) 1990-10-01
PT90530A (pt) 1989-11-30
GR890100309A (el) 1990-03-12
EP0378604B1 (de) 1994-03-02
HU893631D0 (en) 1990-11-28
JPH02504285A (ja) 1990-12-06
HU208141B (en) 1993-08-30
KR900701800A (ko) 1990-12-04
WO1989010926A1 (en) 1989-11-16
IE891550L (en) 1989-11-13
AU628821B2 (en) 1992-09-24

Similar Documents

Publication Publication Date Title
LV5742B4 (lv) 3,5-divalizvietoti pirokatehina atvasinajumi
DE3669876D1 (de) 3,4-dihydrobenzopyranderivate.
DE3763411D1 (de) 1,2,3,6-tetrahydro-5-nitro-pyrimidin-derivate.
DE68913498T2 (de) 1,1-dioxo-cephem-4-carbothiolsäure-derivate.
DE3887281D1 (de) 1,2,3,4-Tetrahydro-5-nitro-pyrimidin-Derivate.
DE3765646D1 (de) 2,5,6,7-tetranor-4,8-inter-m-phenylen-pgi2-derivate.
NO892728L (no) Aminoalkyl-aminokarbonyl-aminodiolaminosyre derivater somanti-hypertensive midler.
DE3886959T2 (de) 1,2-Propandiolderivate.
DE69122555D1 (de) 2,4-Dihydroxyadipinsäurederivate
DE3585315D1 (de) 5,6,7,8-tetrafluoranthrachinonderivate.
DE3888097D1 (de) 1,2,3,4-Tetrahydro-5-nitro-pyrimidin-Derivate.
DE68909873T2 (de) 1,4-Dihydropyridin-Derivate.
DE58903154D1 (de) 2,2-difluorcyclopropyl-derivate.
DE3586745D1 (de) 9,11-epoxy-21-hydroxypregnan-derivate.
FI894455A0 (fi) 1,4-dihydropyridinderivat.
DE3586541T2 (de) 1,3-dithiol-2-ylidenderivate.
DE68903983D1 (de) 1,6-diazaspiro(4,4)nonan-2,7-dion-derivate.
ES2015605B3 (es) 3,4-dihidro-2h-piranos.
NO880088D0 (no) 2,1-benzotiazepin-2,2-dioksyd-5-karboksylsyrederivater.
DE3788163T2 (de) 1,3,5-Trithian-Derivate.
DE3874027D1 (de) 1,3-dithiol-2-yliden-derivate.
DE3780162T2 (de) Heribizide 4,5-dihydro-1h-1,2,4-triazol-3-carboxamid-derivate.
ATE102207T1 (de) 1,1-dioxo-cephem-4-carbothiolsaeure-derivate.
DE3668890D1 (de) 3,4-dihydro-4-oxo-2h-1-benzopyranyloxy-alkansaeure-derivate.
ATE54146T1 (de) 1,2,3,6-tetrahydro-5-nitro-pyrimidin-derivate.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee