DE68902036T2 - Verwendung von acetogeninen in der therapie als antiparasitaere substanzen. - Google Patents
Verwendung von acetogeninen in der therapie als antiparasitaere substanzen.Info
- Publication number
- DE68902036T2 DE68902036T2 DE8989402004T DE68902036T DE68902036T2 DE 68902036 T2 DE68902036 T2 DE 68902036T2 DE 8989402004 T DE8989402004 T DE 8989402004T DE 68902036 T DE68902036 T DE 68902036T DE 68902036 T2 DE68902036 T2 DE 68902036T2
- Authority
- DE
- Germany
- Prior art keywords
- group
- tetrahydrofuranyl
- mixture
- formula
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000126 substance Substances 0.000 title claims abstract description 14
- 238000002560 therapeutic procedure Methods 0.000 title description 2
- 230000002141 anti-parasite Effects 0.000 claims abstract description 10
- 239000003096 antiparasitic agent Substances 0.000 claims abstract description 10
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims abstract description 10
- 230000003287 optical effect Effects 0.000 claims description 9
- -1 Acetogenin compound Chemical class 0.000 claims description 7
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- QUHYUSAHBDACNG-UHFFFAOYSA-N acerogenin 3 Natural products C1=CC(O)=CC=C1CCCCC(=O)CCC1=CC=C(O)C=C1 QUHYUSAHBDACNG-UHFFFAOYSA-N 0.000 claims description 6
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- 230000001225 therapeutic effect Effects 0.000 claims description 6
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- 201000004409 schistosomiasis Diseases 0.000 claims description 4
- 208000004554 Leishmaniasis Diseases 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- DUMLCORUFXTMAR-UHFFFAOYSA-N 2-methyl-4-[2,9,13-trihydroxy-13-[5-[5-(1-hydroxyundecyl)oxolan-2-yl]oxolan-2-yl]tridecyl]-2h-furan-5-one Chemical compound O1C(C(O)CCCCCCCCCC)CCC1C1OC(C(O)CCCC(O)CCCCCCC(O)CC=2C(OC(C)C=2)=O)CC1 DUMLCORUFXTMAR-UHFFFAOYSA-N 0.000 claims 1
- MBABCNBNDNGODA-UHFFFAOYSA-N trilobacin Chemical compound O1C(C(O)CCCCCCCCCC)CCC1C1OC(C(O)CCCCCCCCCCC(O)CC=2C(OC(C)C=2)=O)CC1 MBABCNBNDNGODA-UHFFFAOYSA-N 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract description 27
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004043 oxo group Chemical group O=* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004185 ester group Chemical group 0.000 abstract 2
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 54
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 45
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 43
- 239000000203 mixture Substances 0.000 description 41
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 36
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 24
- 150000001875 compounds Chemical class 0.000 description 21
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- FQKFPCDOMQNMHI-FBWZOCKYSA-N asimicin Natural products CCCCCCCCC[C@@H](O)[C@H]1CC[C@@H](O1)[C@H]2CC[C@@H](O2)[C@H](O)CCCCCCCCCC[C@@H](O)CC3=C[C@H](C)OC3=O FQKFPCDOMQNMHI-FBWZOCKYSA-N 0.000 description 4
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- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
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- 125000001424 substituent group Chemical group 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
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- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 1
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8809674A FR2634123A1 (fr) | 1988-07-18 | 1988-07-18 | Utilisation d'acetogenines en therapeutique en tant que substances antiparasitaires |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68902036D1 DE68902036D1 (de) | 1992-08-13 |
| DE68902036T2 true DE68902036T2 (de) | 1992-12-10 |
Family
ID=9368499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8989402004T Expired - Lifetime DE68902036T2 (de) | 1988-07-18 | 1989-07-12 | Verwendung von acetogeninen in der therapie als antiparasitaere substanzen. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0363230B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JPH0259525A (cg-RX-API-DMAC10.html) |
| AT (1) | ATE77949T1 (cg-RX-API-DMAC10.html) |
| DE (1) | DE68902036T2 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2052044T3 (cg-RX-API-DMAC10.html) |
| FR (1) | FR2634123A1 (cg-RX-API-DMAC10.html) |
| GR (1) | GR3005890T3 (cg-RX-API-DMAC10.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0640861A (ja) * | 1992-04-23 | 1994-02-15 | Shiseido Co Ltd | 頭部用組成物 |
| DE19826499A1 (de) * | 1998-06-13 | 1999-12-16 | Beiersdorf Ag | Gegen Bakterien, Mycota, Viren, Parasiten und Protozoen wirksame Substanzen |
| JP5747660B2 (ja) | 2010-07-16 | 2015-07-15 | 株式会社リコー | 画像形成システム |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4721727A (en) * | 1986-05-06 | 1988-01-26 | The United States Of America As Represented By The Secretary Of Agriculture | Control of pests with annonaceous acetogenins |
| CA1328661C (en) * | 1987-07-09 | 1994-04-19 | George Robert Pettit | Rolliniastatin 1 and means and methods for inhibiting cell growth therewith |
-
1988
- 1988-07-18 FR FR8809674A patent/FR2634123A1/fr active Pending
-
1989
- 1989-07-12 AT AT89402004T patent/ATE77949T1/de not_active IP Right Cessation
- 1989-07-12 DE DE8989402004T patent/DE68902036T2/de not_active Expired - Lifetime
- 1989-07-12 ES ES89402004T patent/ES2052044T3/es not_active Expired - Lifetime
- 1989-07-12 EP EP89402004A patent/EP0363230B1/fr not_active Expired - Lifetime
- 1989-07-18 JP JP1185818A patent/JPH0259525A/ja active Pending
-
1992
- 1992-10-06 GR GR920402223T patent/GR3005890T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2052044T3 (es) | 1994-07-01 |
| GR3005890T3 (cg-RX-API-DMAC10.html) | 1993-06-07 |
| DE68902036D1 (de) | 1992-08-13 |
| EP0363230B1 (fr) | 1992-07-08 |
| FR2634123A1 (fr) | 1990-01-19 |
| EP0363230A2 (fr) | 1990-04-11 |
| JPH0259525A (ja) | 1990-02-28 |
| EP0363230A3 (en) | 1990-07-11 |
| ATE77949T1 (de) | 1992-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |